Compile Data Set for Download or QSAR
Found 61 Enz. Inhib. hit(s) with all data for entry = 10745
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563267(US11407740, Compound 169)
Show SMILES C[C@@H](CO)NCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563273(US11407740, Compound 191)
Show SMILES Oc1c(CC(N2Cc3cc(cn3C2=O)C#Cc2ccc(CN3CCOCC3)cc2)C(=O)NCC(F)F)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563268(US11407740, Compound 171)
Show SMILES C[C@H](CO)NCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563263(US11407740, Compound 141)
Show SMILES CC(CF)NC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563262(US11407740, Compound 139)
Show SMILES Oc1c(CC(NCCCF)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563124(US11407740, Compound 7)
Show SMILES Oc1c(CC(CNCCF)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563269(US11407740, Compound 172)
Show SMILES Oc1c(CC(NCCCCl)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563259(US11407740, Compound 130)
Show SMILES Oc1c(CC(CNCCC#N)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563146(US11407740, Compound 19 | US11407740, Compound 20)
Show SMILES Oc1c(CC(C(=O)NCCF)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563294(US11407740, Compound 289)
Show SMILES CS(=O)(=O)NC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563144(US11407740, Compound 17)
Show SMILES C[C@H](CF)NCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563255(US11407740, Compound 65)
Show SMILES NC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563298(US11407740, Compound 299)
Show SMILES COC1CN(Cc2ccc(cc2)C#Cc2ccc(cc2)[C@@H](Cc2nc[nH]c(=O)c2O)NS(C)(=O)=O)C1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563289(US11407740, Compound 240 | US11407740, Compound 24...)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCC(CC2)NC(=O)CO)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563275(US11407740, Compound 193)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)N1Cc2cc(cn2C1=O)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563154(US11407740, Compound 38)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CNC2CCS(=O)(=O)C2)cc1
Affinity DataIC50: 10nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563265(US11407740, Compound 148)
Show SMILES NC[C@H]1CCCN1Cc1ccc(cc1)C#Cc1ccc(cc1)C(CO)Cc1nc[nH]c(=O)c1O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563261(US11407740, Compound 138)
Show SMILES CC(F)CNCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CCN2CCOCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563258(US11407740, Compound 101)
Show SMILES COC1CN(Cc2ccc(cc2)C#Cc2ccc(cc2)C(CNCC(C)F)Cc2nc[nH]c(=O)c2O)C1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563257(US11407740, Compound 71)
Show SMILES COC1CN(CC(Cc2nc[nH]c(=O)c2O)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)C1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563256(6-(3-(((S)-1-fluoropropan-2-yl)amino)-2-(4-((4-((3...)
Show SMILES COC1CN(Cc2ccc(cc2)C#Cc2ccc(cc2)C(CN[C@@H](C)CF)Cc2nc[nH]c(=O)c2O)C1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563254(US11407740, Compound 64)
Show SMILES NC1(Cc2ccc(cc2)C#Cc2ccc(cc2)C(CO)Cc2nc[nH]c(=O)c2O)CCOCC1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563180(US11407740, Compound 60)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CNC2CCS(=O)C2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563175(US11407740, Compound 57)
Show SMILES COCCNCc1ccc(cc1)C#Cc1ccc(cc1)C(CO)Cc1nc[nH]c(=O)c1O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563174(US11407740, Compound 56)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CNC2CCS(=N)(=O)C2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563160(US11407740, Compound 54)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCNCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563156(US11407740, Compound 44)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN[C@@H]2CCN(C2)C(=O)CO)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563155(US11407740, Compound 43)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CCN[C@H]2CCOC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563152(US11407740, Compound 23)
Show SMILES CNC(=O)C(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563125(US11407740, Compound 14)
Show SMILES C[C@@H](CF)NCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563296(US11407740, Compound 297)
Show SMILES CS(=O)(=O)N[C@@H](Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCNC[C@H]2CO)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563295(US11407740, Compound 296)
Show SMILES CS(=O)(=O)N[C@@H](Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(cc1)C1(O)CCNCC1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563293(US11407740, Compound 288)
Show SMILES COC[C@@H](Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN[C@@H]2CCNC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563292(US11407740, Compound 287)
Show SMILES COC[C@@H](Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN[C@H]2CCNC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563289(US11407740, Compound 240 | US11407740, Compound 24...)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCC(CC2)NC(=O)CO)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563289(US11407740, Compound 240 | US11407740, Compound 24...)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN2CCC(CC2)NC(=O)CO)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563287(US11407740, Compound 211)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)n1ccc(cc1=O)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563286(US11407740, Compound 210)
Show SMILES Oc1c(CC2NC(=O)c3cc(ccc23)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563285(US11407740, Compound 209)
Show SMILES Oc1c(CC2CCc3cc(ccc23)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563280(US11407740, Compound 202)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1cnn(c1)C1CCOCC1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563279(US11407740, Compound 201)
Show SMILES NC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1cnn(c1)C1COC1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563277(US11407740, Compound 199)
Show SMILES Cn1cc(cn1)C#Cc1ccc(cc1)C(CNCCF)Cc1nc[nH]c(=O)c1O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563276(US11407740, Compound 194)
Show SMILES OCC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1cnn(CC2CCOCC2)c1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563270(US11407740, Compound 173)
Show SMILES NC(Cc1nc[nH]c(=O)c1O)c1ccc(cc1)C#Cc1ccc(CN[C@@H]2CCOC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563271(US11407740, Compound 174)
Show SMILES COC1CCN(Cc2ccc(cc2)C#Cc2ccc(cc2)C(N)Cc2nc[nH]c(=O)c2O)CC1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563272(US11407740, Compound 177)
Show SMILES Oc1c(CC(CN2CCC2)c2ccc(cc2)C#Cc2ccc(CN3CCOCC3)cc2)nc[nH]c1=O
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563274(US11407740, Compound 192)
Show SMILES COC(=O)C(Cc1nc[nH]c(=O)c1O)N1Cc2cc(cn2C1=O)C#Cc1ccc(CN2CCOCC2)cc1
Affinity DataIC50: 30nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563284(US11407740, Compound 208)
Show SMILES Oc1c(CC(CNCCF)c2ccc(cc2)C#Cc2cnn(c2)C2COC2)nc[nH]c1=O
Affinity DataIC50: 75nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563224(US11407740, Compound 61)
Show SMILES CNCc1ccc(cc1)C#Cc1ccc(cc1)C(CO)Cc1nc[nH]c(=O)c1O
Affinity DataIC50: 75nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetUDP-3-O-acyl-N-acetylglucosamine deacetylase(Escherichia coli)
FORGE THERAPEUTICS, INC.

US Patent
LigandPNGBDBM563278(US11407740, Compound 200)
Show SMILES Cn1cc(cn1)C#Cc1ccc(cc1)C(N)Cc1nc[nH]c(=O)c1O
Affinity DataIC50: 550nMAssay Description:IC50 values against E. coli LpxC were determined using a Rapid Fire MS assay as previously described J. Med. Chem. 2012, 55, 1662-1670.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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