Compile Data Set for Download or QSAR
Found 41 Enz. Inhib. hit(s) with all data for entry = 3107
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28104(3-cyanoquinoline, 29 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nc(C)c(C)n5CC)c(Cl)c4)c3cc2OC)CC1
Show InChI InChI=1S/C33H40ClN7O2S/c1-6-39-12-14-40(15-13-39)11-8-16-43-30-19-28-26(18-29(30)42-5)32(24(20-35)21-36-28)38-25-9-10-31(27(34)17-25)44-33-37-22(3)23(4)41(33)7-2/h9-10,17-19,21H,6-8,11-16H2,1-5H3,(H,36,38)
Affinity DataIC50: 9nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28091(3-cyanoquinoline, 16 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCN(C)C)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C29H34ClN7OS/c1-7-37-19(3)18(2)34-29(37)39-27-10-9-21(13-23(27)30)35-28-20(16-31)17-33-24-15-25(26(38-6)14-22(24)28)32-11-8-12-36(4)5/h9-10,13-15,17,32H,7-8,11-12H2,1-6H3,(H,33,35)
Affinity DataIC50: 10nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28105(3-cyanoquinoline, 30 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCN(CCO)CC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H40ClN7O3S/c1-5-41-23(3)22(2)37-33(41)45-31-8-7-25(17-27(31)34)38-32-24(20-35)21-36-28-19-30(29(43-4)18-26(28)32)44-16-6-9-39-10-12-40(13-11-39)14-15-42/h7-8,17-19,21,42H,5-6,9-16H2,1-4H3,(H,36,38)
Affinity DataIC50: 11nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28112(3-cyanoquinoline, 37 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN(C)CCC4OCCO4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H39ClN6O4S/c1-6-40-22(3)21(2)37-33(40)45-30-9-8-24(16-26(30)34)38-32-23(19-35)20-36-27-18-29(28(41-5)17-25(27)32)42-13-7-11-39(4)12-10-31-43-14-15-44-31/h8-9,16-18,20,31H,6-7,10-15H2,1-5H3,(H,36,38)
Affinity DataIC50: 13nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28110(3-cyanoquinoline, 35 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN(C)CC(O)CO)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H37ClN6O4S/c1-6-38-20(3)19(2)35-31(38)43-29-9-8-22(12-25(29)32)36-30-21(15-33)16-34-26-14-28(27(41-5)13-24(26)30)42-11-7-10-37(4)17-23(40)18-39/h8-9,12-14,16,23,39-40H,6-7,10-11,17-18H2,1-5H3,(H,34,36)
Affinity DataIC50: 14nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28106(3-cyanoquinoline, 31 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN(C)CCO)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C30H35ClN6O3S/c1-6-37-20(3)19(2)34-30(37)41-28-9-8-22(14-24(28)31)35-29-21(17-32)18-33-25-16-27(26(39-5)15-23(25)29)40-13-7-10-36(4)11-12-38/h8-9,14-16,18,38H,6-7,10-13H2,1-5H3,(H,33,35)
Affinity DataIC50: 14nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28111(3-cyanoquinoline, 36 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCOCC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H35ClN6O3S/c1-5-38-21(3)20(2)35-31(38)42-29-8-7-23(15-25(29)32)36-30-22(18-33)19-34-26-17-28(27(39-4)16-24(26)30)41-12-6-9-37-10-13-40-14-11-37/h7-8,15-17,19H,5-6,9-14H2,1-4H3,(H,34,36)
Affinity DataIC50: 15nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28115(3-cyanoquinoline, 40 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCN4CCN(C)CC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C32H39ClN8OS/c1-6-41-22(3)21(2)37-32(41)43-30-9-8-24(16-26(30)33)38-31-23(19-34)20-36-27-18-28(29(42-5)17-25(27)31)35-10-7-11-40-14-12-39(4)13-15-40/h8-9,16-18,20,35H,6-7,10-15H2,1-5H3,(H,36,38)
Affinity DataIC50: 16nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28114(3-cyanoquinoline, 39 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCN(CC4)C(C)=O)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H38ClN7O3S/c1-6-41-22(3)21(2)37-33(41)45-31-9-8-25(16-27(31)34)38-32-24(19-35)20-36-28-18-30(29(43-5)17-26(28)32)44-15-7-10-39-11-13-40(14-12-39)23(4)42/h8-9,16-18,20H,6-7,10-15H2,1-5H3,(H,36,38)
Affinity DataIC50: 16nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28109(3-cyanoquinoline, 34 | {2-[4-(3-{[4-({3-chloro-4-[...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCN(CCOC(N)=O)CC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C34H41ClN8O4S/c1-5-43-23(3)22(2)39-34(43)48-31-8-7-25(17-27(31)35)40-32-24(20-36)21-38-28-19-30(29(45-4)18-26(28)32)46-15-6-9-41-10-12-42(13-11-41)14-16-47-33(37)44/h7-8,17-19,21H,5-6,9-16H2,1-4H3,(H2,37,44)(H,38,40)
Affinity DataIC50: 17nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28107(3-cyanoquinoline, 32 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCC(O)C4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H35ClN6O3S/c1-5-38-20(3)19(2)35-31(38)42-29-8-7-22(13-25(29)32)36-30-21(16-33)17-34-26-15-28(27(40-4)14-24(26)30)41-12-6-10-37-11-9-23(39)18-37/h7-8,13-15,17,23,39H,5-6,9-12,18H2,1-4H3,(H,34,36)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28095(3-cyanoquinoline, 20 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCN4CCOCC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H36ClN7O2S/c1-5-39-21(3)20(2)36-31(39)42-29-8-7-23(15-25(29)32)37-30-22(18-33)19-35-26-17-27(28(40-4)16-24(26)30)34-9-6-10-38-11-13-41-14-12-38/h7-8,15-17,19,34H,5-6,9-14H2,1-4H3,(H,35,37)
Affinity DataIC50: 20nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28098(3-cyanoquinoline, 23 | 7-{3-[tert-butyl(2-hydroxye...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN(CCO)C(C)(C)C)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H41ClN6O3S/c1-8-40-22(3)21(2)37-32(40)44-30-11-10-24(16-26(30)34)38-31-23(19-35)20-36-27-18-29(28(42-7)17-25(27)31)43-15-9-12-39(13-14-41)33(4,5)6/h10-11,16-18,20,41H,8-9,12-15H2,1-7H3,(H,36,38)
Affinity DataIC50: 24nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28096(3-cyanoquinoline, 21 | 7-({3-[bis(2-hydroxyethyl)a...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCN(CCO)CCO)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H38ClN7O3S/c1-5-39-21(3)20(2)36-31(39)43-29-8-7-23(15-25(29)32)37-30-22(18-33)19-35-26-17-27(28(42-4)16-24(26)30)34-9-6-10-38(11-13-40)12-14-41/h7-8,15-17,19,34,40-41H,5-6,9-14H2,1-4H3,(H,35,37)
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28088(3-cyanoquinoline, 13 | 4-({3-chloro-4-[(1,4,5-trim...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C)c(Cl)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C28H32ClN7OS/c1-17-18(2)36(5)28(33-17)38-26-9-8-20(12-22(26)29)34-27-19(15-30)16-32-23-14-24(25(37-6)13-21(23)27)31-10-7-11-35(3)4/h8-9,12-14,16,31H,7,10-11H2,1-6H3,(H,32,34)
Affinity DataIC50: 26nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28099(3-cyanoquinoline, 24 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN(C)C)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C29H33ClN6O2S/c1-7-36-19(3)18(2)33-29(36)39-27-10-9-21(13-23(27)30)34-28-20(16-31)17-32-24-15-26(25(37-6)14-22(24)28)38-12-8-11-35(4)5/h9-10,13-15,17H,7-8,11-12H2,1-6H3,(H,32,34)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28092(3-cyanoquinoline, 17 | 4-({3-bromo-4-[(1,4,5-trime...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C)c(Br)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C28H32BrN7OS/c1-17-18(2)36(5)28(33-17)38-26-9-8-20(12-22(26)29)34-27-19(15-30)16-32-23-14-24(25(37-6)13-21(23)27)31-10-7-11-35(3)4/h8-9,12-14,16,31H,7,10-11H2,1-6H3,(H,32,34)
Affinity DataIC50: 30nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28103(3-cyanoquinoline, 28 | N-(3-{[4-({3-chloro-4-[(1-e...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCNS(C)(=O)=O)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C28H31ClN6O4S2/c1-6-35-18(3)17(2)33-28(35)40-26-9-8-20(12-22(26)29)34-27-19(15-30)16-31-23-14-25(24(38-4)13-21(23)27)39-11-7-10-32-41(5,36)37/h8-9,12-14,16,32H,6-7,10-11H2,1-5H3,(H,31,34)
Affinity DataIC50: 31nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28101(3-cyanoquinoline, 26 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCC1CCCCN1CCCOc1cc2ncc(C#N)c(Nc3ccc(Sc4nc(C)c(C)n4CC)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C34H41ClN6O2S/c1-6-26-11-8-9-14-40(26)15-10-16-43-31-19-29-27(18-30(31)42-5)33(24(20-36)21-37-29)39-25-12-13-32(28(35)17-25)44-34-38-22(3)23(4)41(34)7-2/h12-13,17-19,21,26H,6-11,14-16H2,1-5H3,(H,37,39)
Affinity DataIC50: 32nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28100(3-cyanoquinoline, 25 | 4-(3-{[4-({3-chloro-4-[(1-e...)
Show SMILES CCNC(=O)N1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nc(C)c(C)n5CC)c(Cl)c4)c3cc2OC)CC1
Show InChI InChI=1S/C34H41ClN8O3S/c1-6-37-33(44)42-14-12-41(13-15-42)11-8-16-46-30-19-28-26(18-29(30)45-5)32(24(20-36)21-38-28)40-25-9-10-31(27(35)17-25)47-34-39-22(3)23(4)43(34)7-2/h9-10,17-19,21H,6-8,11-16H2,1-5H3,(H,37,44)(H,38,40)
Affinity DataIC50: 45nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28113(3-cyanoquinoline, 38 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCC(O)CC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C32H37ClN6O3S/c1-5-39-21(3)20(2)36-32(39)43-30-8-7-23(15-26(30)33)37-31-22(18-34)19-35-27-17-29(28(41-4)16-25(27)31)42-14-6-11-38-12-9-24(40)10-13-38/h7-8,15-17,19,24,40H,5-6,9-14H2,1-4H3,(H,35,37)
Affinity DataIC50: 47nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28118(3-cyanoquinoline, 3 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES CCN1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nccn5C)c(Cl)c4)c3cc2OC)CC1
Show InChI InChI=1S/C30H34ClN7O2S/c1-4-37-11-13-38(14-12-37)9-5-15-40-27-18-25-23(17-26(27)39-3)29(21(19-32)20-34-25)35-22-6-7-28(24(31)16-22)41-30-33-8-10-36(30)2/h6-8,10,16-18,20H,4-5,9,11-15H2,1-3H3,(H,34,35)
Affinity DataIC50: 50nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28089(3-cyanoquinoline, 14 | 4-({4-[(1-benzyl-4,5-dimeth...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4Cc4ccccc4)c(Cl)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C34H36ClN7OS/c1-22-23(2)42(21-24-10-7-6-8-11-24)34(39-22)44-32-13-12-26(16-28(32)35)40-33-25(19-36)20-38-29-18-30(31(43-5)17-27(29)33)37-14-9-15-41(3)4/h6-8,10-13,16-18,20,37H,9,14-15,21H2,1-5H3,(H,38,40)
Affinity DataIC50: 65nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28123(3-cyanoquinoline, 8 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C28H29ClN6O3S/c1-34-8-6-31-28(34)39-26-5-4-20(14-22(26)29)33-27-19(17-30)18-32-23-16-25(24(36-2)15-21(23)27)38-11-3-7-35-9-12-37-13-10-35/h4-6,8,14-16,18H,3,7,9-13H2,1-2H3,(H,32,33)
Affinity DataIC50: 66nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28108(3-cyanoquinoline, 33 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCN4CCCC4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C31H35ClN6O2S/c1-5-38-21(3)20(2)35-31(38)41-29-10-9-23(15-25(29)32)36-30-22(18-33)19-34-26-17-28(27(39-4)16-24(26)30)40-14-8-13-37-11-6-7-12-37/h9-10,15-17,19H,5-8,11-14H2,1-4H3,(H,34,36)
Affinity DataIC50: 67nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28117(3-cyanoquinoline, 42 | 4-[(3-chloro-4-{[4,5-dimeth...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C(C)C)c(Cl)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C30H36ClN7OS/c1-18(2)38-20(4)19(3)35-30(38)40-28-10-9-22(13-24(28)31)36-29-21(16-32)17-34-25-15-26(27(39-7)14-23(25)29)33-11-8-12-37(5)6/h9-10,13-15,17-18,33H,8,11-12H2,1-7H3,(H,34,36)
Affinity DataIC50: 79nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28119(3-cyanoquinoline, 4 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1OCCCN1CCCC1)C#N
Show InChI InChI=1S/C28H29ClN6O2S/c1-34-12-8-31-28(34)38-26-7-6-20(14-22(26)29)33-27-19(17-30)18-32-23-16-25(24(36-2)15-21(23)27)37-13-5-11-35-9-3-4-10-35/h6-8,12,14-16,18H,3-5,9-11,13H2,1-2H3,(H,32,33)
Affinity DataIC50: 88nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28102(3-cyanoquinoline, 27 | ethyl 1-(3-{[4-({3-chloro-4...)
Show SMILES CCOC(=O)C1CCN(CCCOc2cc3ncc(C#N)c(Nc4ccc(Sc5nc(C)c(C)n5CC)c(Cl)c4)c3cc2OC)CC1
Show InChI InChI=1S/C35H41ClN6O4S/c1-6-42-23(4)22(3)39-35(42)47-32-10-9-26(17-28(32)36)40-33-25(20-37)21-38-29-19-31(30(44-5)18-27(29)33)46-16-8-13-41-14-11-24(12-15-41)34(43)45-7-2/h9-10,17-19,21,24H,6-8,11-16H2,1-5H3,(H,38,40)
Affinity DataIC50: 135nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28087(3-cyanoquinoline, 2 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1OCCCN(C)CCO)C#N
Show InChI InChI=1S/C27H29ClN6O3S/c1-33(10-11-35)8-4-12-37-24-15-22-20(14-23(24)36-3)26(18(16-29)17-31-22)32-19-5-6-25(21(28)13-19)38-27-30-7-9-34(27)2/h5-7,9,13-15,17,35H,4,8,10-12H2,1-3H3,(H,31,32)
Affinity DataIC50: 140nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28121(3-cyanoquinoline, 6 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1N(C)CCCN(C)C)C#N
Show InChI InChI=1S/C27H30ClN7OS/c1-33(2)10-6-11-34(3)23-15-22-20(14-24(23)36-5)26(18(16-29)17-31-22)32-19-7-8-25(21(28)13-19)37-27-30-9-12-35(27)4/h7-9,12-15,17H,6,10-11H2,1-5H3,(H,31,32)
Affinity DataIC50: 150nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28120(3-cyanoquinoline, 5 | 4-({3-chloro-4-[(1-methyl-1H...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C26H28ClN7OS/c1-33(2)10-5-8-29-22-14-21-19(13-23(22)35-4)25(17(15-28)16-31-21)32-18-6-7-24(20(27)12-18)36-26-30-9-11-34(26)3/h6-7,9,11-14,16,29H,5,8,10H2,1-4H3,(H,31,32)
Affinity DataIC50: 151nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28116(3-cyanoquinoline, 41 | 4-({3-chloro-4-[(4,5-dimeth...)
Show SMILES CCCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCN(C)C)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C30H36ClN7OS/c1-7-12-38-20(3)19(2)35-30(38)40-28-10-9-22(14-24(28)31)36-29-21(17-32)18-34-25-16-26(27(39-6)15-23(25)29)33-11-8-13-37(4)5/h9-10,14-16,18,33H,7-8,11-13H2,1-6H3,(H,34,36)
Affinity DataIC50: 189nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28090(3-cyanoquinoline, 15 | 4-({3-chloro-4-[(1,5-dimeth...)
Show SMILES COc1cc2c(Nc3ccc(Sc4ncc(C)n4C)c(Cl)c3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C27H30ClN7OS/c1-17-15-32-27(35(17)4)37-25-8-7-19(11-21(25)28)33-26-18(14-29)16-31-22-13-23(24(36-5)12-20(22)26)30-9-6-10-34(2)3/h7-8,11-13,15-16,30H,6,9-10H2,1-5H3,(H,31,33)
Affinity DataIC50: 291nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28093(3-cyanoquinoline, 18 | 7-{[3-(dimethylamino)propyl...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nc(C)c(C)n4C)cc3)c(cnc2cc1NCCCN(C)C)C#N
Show InChI InChI=1S/C28H33N7OS/c1-18-19(2)35(5)28(32-18)37-22-10-8-21(9-11-22)33-27-20(16-29)17-31-24-15-25(26(36-6)14-23(24)27)30-12-7-13-34(3)4/h8-11,14-15,17,30H,7,12-13H2,1-6H3,(H,31,33)
Affinity DataIC50: 394nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28127(3-cyanoquinoline, 12 | 4-({3-chloro-4-[(1-methyl-1...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c(cnc2cc1N1CCN(C)CC1)C#N
Show InChI InChI=1S/C26H26ClN7OS/c1-32-8-10-34(11-9-32)22-14-21-19(13-23(22)35-3)25(17(15-28)16-30-21)31-18-4-5-24(20(27)12-18)36-26-29-6-7-33(26)2/h4-7,12-14,16H,8-11H2,1-3H3,(H,30,31)
Affinity DataIC50: 600nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28126(3-cyanoquinoline, 11 | 4-({3-chloro-4-[(1-methyl-1...)
Show SMILES COc1cc2ncc(C#N)c(Nc3ccc(Sc4nccn4C)c(Cl)c3)c2cc1OC
Show InChI InChI=1S/C22H18ClN5O2S/c1-28-7-6-25-22(28)31-20-5-4-14(8-16(20)23)27-21-13(11-24)12-26-17-10-19(30-3)18(29-2)9-15(17)21/h4-10,12H,1-3H3,(H,26,27)
Affinity DataIC50: 847nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28122(3-cyanoquinoline, 7 | 6-methoxy-4-({4-[(1-methyl-1...)
Show SMILES COc1cc2c(Nc3ccc(Sc4nccn4C)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C28H30N6O3S/c1-33-10-8-30-28(33)38-22-6-4-21(5-7-22)32-27-20(18-29)19-31-24-17-26(25(35-2)16-23(24)27)37-13-3-9-34-11-14-36-15-12-34/h4-8,10,16-17,19H,3,9,11-15H2,1-2H3,(H,31,32)
Affinity DataIC50: 1.00E+3nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28124(3-cyanoquinoline, 9 | 6-methoxy-7-[3-(morpholin-4-...)
Show SMILES COc1cc2c(Nc3ccc(Sc4ccccc4)cc3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C30H30N4O3S/c1-35-28-18-26-27(19-29(28)37-15-5-12-34-13-16-36-17-14-34)32-21-22(20-31)30(26)33-23-8-10-25(11-9-23)38-24-6-3-2-4-7-24/h2-4,6-11,18-19,21H,5,12-17H2,1H3,(H,32,33)
Affinity DataIC50: 1.09E+3nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28097(3-cyanoquinoline, 22 | N-(3-{[4-({3-chloro-4-[(1-e...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(OCCCNS(=O)(=O)c4ccccc4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H33ClN6O4S2/c1-5-40-22(3)21(2)38-33(40)45-31-13-12-24(16-27(31)34)39-32-23(19-35)20-36-28-18-30(29(43-4)17-26(28)32)44-15-9-14-37-46(41,42)25-10-7-6-8-11-25/h6-8,10-13,16-18,20,37H,5,9,14-15H2,1-4H3,(H,36,39)
Affinity DataIC50: 3.88E+3nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28125(3-cyanoquinoline, 10 | 4-{[3-chloro-4-(pyridin-2-y...)
Show SMILES COc1cc2c(Nc3ccc(Sc4ccccn4)c(Cl)c3)c(cnc2cc1OCCCN1CCOCC1)C#N
Show InChI InChI=1S/C29H28ClN5O3S/c1-36-25-16-22-24(17-26(25)38-12-4-9-35-10-13-37-14-11-35)33-19-20(18-31)29(22)34-21-6-7-27(23(30)15-21)39-28-5-2-3-8-32-28/h2-3,5-8,15-17,19H,4,9-14H2,1H3,(H,33,34)
Affinity DataIC50: 1.00E+4nMAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM28094(3-cyanoquinoline, 19 | 4-({3-chloro-4-[(1-ethyl-4,...)
Show SMILES CCn1c(C)c(C)nc1Sc1ccc(Nc2c(cnc3cc(NCCCc4ccccc4)c(OC)cc23)C#N)cc1Cl
Show InChI InChI=1S/C33H33ClN6OS/c1-5-40-22(3)21(2)38-33(40)42-31-14-13-25(16-27(31)34)39-32-24(19-35)20-37-28-18-29(30(41-4)17-26(28)32)36-15-9-12-23-10-7-6-8-11-23/h6-8,10-11,13-14,16-18,20,36H,5,9,12,15H2,1-4H3,(H,37,39)
Affinity DataIC50: 1.37E+4nMpH: 7.5 T: 2°CAssay Description:Assays were performed in microtiter plates in reaction buffer containing biotinylated substrate, ATP, and purified kinase in the presence of test com...More data for this Ligand-Target Pair