Compile Data Set for Download or QSAR
Found 72 Enz. Inhib. hit(s) with all data for entry = 50000305
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245752(CHEMBL4098958)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C14H10IN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  0.570nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245818(CHEMBL4077440)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Br)cccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  0.820nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245748(CHEMBL4079984)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  0.980nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245751(CHEMBL4075893)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Br)ccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  1.10nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245752(CHEMBL4098958)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C14H10IN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  1.5nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245758(CHEMBL4075913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(F)ccc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  1.90nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245751(CHEMBL4075893)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Br)ccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245818(CHEMBL4077440)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Br)cccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  2.60nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245758(CHEMBL4075913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(F)ccc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  2.70nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245757(CHEMBL4076110)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  3.20nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245750(CHEMBL4103504)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Cl)cccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  3.5nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245818(CHEMBL4077440)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Br)cccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245757(CHEMBL4076110)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  4.40nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245805(CHEMBL4071020)
Show SMILES COc1cc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2cc1OC
Show InChI InChI=1S/C16H15N3O5S2/c1-23-13-7-11-12(8-14(13)24-2)18-16(25)19(15(11)20)9-4-3-5-10(6-9)26(17,21)22/h3-8H,1-2H3,(H,18,25)(H2,17,21,22)
Affinity DataKi:  4.70nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  5.70nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245748(CHEMBL4079984)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  5.80nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245820(CHEMBL4059641)
Show SMILES COc1cc2c(nc(S)n(-c3cccc(c3)S(N)(=O)=O)c2=O)c(OC)c1OC
Show InChI InChI=1S/C17H17N3O6S2/c1-24-12-8-11-13(15(26-3)14(12)25-2)19-17(27)20(16(11)21)9-5-4-6-10(7-9)28(18,22)23/h4-8H,1-3H3,(H,19,27)(H2,18,22,23)
Affinity DataKi:  6nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245758(CHEMBL4075913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(F)ccc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  6.60nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245757(CHEMBL4076110)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(F)cc2c1=O
Show InChI InChI=1S/C14H10FN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  7nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245759(CHEMBL4085469)
Show SMILES Cc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O3S2/c1-9-4-2-7-12-13(9)17-15(22)18(14(12)19)10-5-3-6-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  7.60nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245750(CHEMBL4103504)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Cl)cccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  9.5nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245802(CHEMBL4099863)
Show SMILES Cc1cc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2cc1C
Show InChI InChI=1S/C16H15N3O3S2/c1-9-6-13-14(7-10(9)2)18-16(23)19(15(13)20)11-4-3-5-12(8-11)24(17,21)22/h3-8H,1-2H3,(H,18,23)(H2,17,21,22)
Affinity DataKi:  9.80nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245750(CHEMBL4103504)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2c(Cl)cccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-11-6-2-5-10-12(11)17-14(22)18(13(10)19)8-3-1-4-9(7-8)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245747(CHEMBL4068913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccccc2c1=O
Show InChI InChI=1S/C14H11N3O3S2/c15-22(19,20)10-5-3-4-9(8-10)17-13(18)11-6-1-2-7-12(11)16-14(17)21/h1-8H,(H,16,21)(H2,15,19,20)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245819(CHEMBL4059504)
Show SMILES COc1ccc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2c1
Show InChI InChI=1S/C15H13N3O4S2/c1-22-10-5-6-13-12(8-10)14(19)18(15(23)17-13)9-3-2-4-11(7-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  11nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245749(CHEMBL4091026)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  12nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  12nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245819(CHEMBL4059504)
Show SMILES COc1ccc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2c1
Show InChI InChI=1S/C15H13N3O4S2/c1-22-10-5-6-13-12(8-10)14(19)18(15(23)17-13)9-3-2-4-11(7-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  13nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245748(CHEMBL4079984)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Cl)ccc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245747(CHEMBL4068913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccccc2c1=O
Show InChI InChI=1S/C14H11N3O3S2/c15-22(19,20)10-5-3-4-9(8-10)17-13(18)11-6-1-2-7-12(11)16-14(17)21/h1-8H,(H,16,21)(H2,15,19,20)
Affinity DataKi:  15nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245804(CHEMBL4098104)
Show SMILES COc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O4S2/c1-22-12-7-3-6-11-13(12)17-15(23)18(14(11)19)9-4-2-5-10(8-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  16nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245751(CHEMBL4075893)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2cc(Br)ccc2c1=O
Show InChI InChI=1S/C14H10BrN3O3S2/c15-8-4-5-11-12(6-8)17-14(22)18(13(11)19)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  17nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245806(CHEMBL4062609)
Show SMILES Cc1ccc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2c1
Show InChI InChI=1S/C15H13N3O3S2/c1-9-5-6-13-12(7-9)14(19)18(15(22)17-13)10-3-2-4-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  19nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245820(CHEMBL4059641)
Show SMILES COc1cc2c(nc(S)n(-c3cccc(c3)S(N)(=O)=O)c2=O)c(OC)c1OC
Show InChI InChI=1S/C17H17N3O6S2/c1-24-12-8-11-13(15(26-3)14(12)25-2)19-17(27)20(16(11)21)9-5-4-6-10(7-9)28(18,22)23/h4-8H,1-3H3,(H,19,27)(H2,18,22,23)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245805(CHEMBL4071020)
Show SMILES COc1cc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2cc1OC
Show InChI InChI=1S/C16H15N3O5S2/c1-23-13-7-11-12(8-14(13)24-2)18-16(25)19(15(11)20)9-4-3-5-10(6-9)26(17,21)22/h3-8H,1-2H3,(H,18,25)(H2,17,21,22)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245749(CHEMBL4091026)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  20nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245803(CHEMBL4082241)
Show SMILES COc1ccc2c(c1)nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O4S2/c1-22-10-5-6-12-13(8-10)17-15(23)18(14(12)19)9-3-2-4-11(7-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  23nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245804(CHEMBL4098104)
Show SMILES COc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O4S2/c1-22-12-7-3-6-11-13(12)17-15(23)18(14(11)19)9-4-2-5-10(8-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  24nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245803(CHEMBL4082241)
Show SMILES COc1ccc2c(c1)nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O4S2/c1-22-10-5-6-12-13(8-10)17-15(23)18(14(12)19)9-3-2-4-11(7-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245759(CHEMBL4085469)
Show SMILES Cc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O3S2/c1-9-4-2-7-12-13(9)17-15(22)18(14(12)19)10-5-3-6-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  25nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245752(CHEMBL4098958)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(I)cc2c1=O
Show InChI InChI=1S/C14H10IN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  28nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245802(CHEMBL4099863)
Show SMILES Cc1cc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2cc1C
Show InChI InChI=1S/C16H15N3O3S2/c1-9-6-13-14(7-10(9)2)18-16(23)19(15(13)20)11-4-3-5-12(8-11)24(17,21)22/h3-8H,1-2H3,(H,18,23)(H2,17,21,22)
Affinity DataKi:  35nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245749(CHEMBL4091026)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccc(Cl)cc2c1=O
Show InChI InChI=1S/C14H10ClN3O3S2/c15-8-4-5-12-11(6-8)13(19)18(14(22)17-12)9-2-1-3-10(7-9)23(16,20)21/h1-7H,(H,17,22)(H2,16,20,21)
Affinity DataKi:  45nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 12(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245806(CHEMBL4062609)
Show SMILES Cc1ccc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2c1
Show InChI InChI=1S/C15H13N3O3S2/c1-9-5-6-13-12(7-9)14(19)18(15(22)17-13)10-3-2-4-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  45nMAssay Description:Inhibition of recombinant human carbonic anhydrase 12 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245806(CHEMBL4062609)
Show SMILES Cc1ccc2nc(S)n(-c3cccc(c3)S(N)(=O)=O)c(=O)c2c1
Show InChI InChI=1S/C15H13N3O3S2/c1-9-5-6-13-12(7-9)14(19)18(15(22)17-13)10-3-2-4-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  59nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245759(CHEMBL4085469)
Show SMILES Cc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O3S2/c1-9-4-2-7-12-13(9)17-15(22)18(14(12)19)10-5-3-6-11(8-10)23(16,20)21/h2-8H,1H3,(H,17,22)(H2,16,20,21)
Affinity DataKi:  65nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 9(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245747(CHEMBL4068913)
Show SMILES NS(=O)(=O)c1cccc(c1)-n1c(S)nc2ccccc2c1=O
Show InChI InChI=1S/C14H11N3O3S2/c15-22(19,20)10-5-3-4-9(8-10)17-13(18)11-6-1-2-7-12(11)16-14(17)21/h1-8H,(H,16,21)(H2,15,19,20)
Affinity DataKi:  76nMAssay Description:Inhibition of recombinant human carbonic anhydrase 9 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245820(CHEMBL4059641)
Show SMILES COc1cc2c(nc(S)n(-c3cccc(c3)S(N)(=O)=O)c2=O)c(OC)c1OC
Show InChI InChI=1S/C17H17N3O6S2/c1-24-12-8-11-13(15(26-3)14(12)25-2)19-17(27)20(16(11)21)9-5-4-6-10(7-9)28(18,22)23/h4-8H,1-3H3,(H,19,27)(H2,18,22,23)
Affinity DataKi:  77nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
Universit£ degli Studi di Firenze

Curated by ChEMBL
LigandPNGBDBM50245804(CHEMBL4098104)
Show SMILES COc1cccc2c1nc(S)n(-c1cccc(c1)S(N)(=O)=O)c2=O
Show InChI InChI=1S/C15H13N3O4S2/c1-22-12-7-3-6-11-13(12)17-15(23)18(14(11)19)9-4-2-5-10(8-9)24(16,20)21/h2-8H,1H3,(H,17,23)(H2,16,20,21)
Affinity DataKi:  78nMAssay Description:Inhibition of recombinant human carbonic anhydrase 2 incubated for 15 mins prior to testing by stopped flow CO2 hydration assayMore data for this Ligand-Target Pair
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