Compile Data Set for Download or QSAR
Found 19 Enz. Inhib. hit(s) with all data for entry = 50004656
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485304(CHEMBL2048305)
Show SMILES CNc1ccc(-c2nc3ccc(OC)cc3s2)c(F)n1
Show InChI InChI=1S/C14H12FN3OS/c1-16-12-6-4-9(13(15)18-12)14-17-10-5-3-8(19-2)7-11(10)20-14/h3-7H,1-2H3,(H,16,18)
Affinity DataIC50: 14nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50129793(2-(4''-methylaminophenyl)-6-hydroxybenzothiazole |...)
Show SMILES CNc1ccc(cc1)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C14H12N2OS/c1-15-10-4-2-9(3-5-10)14-16-12-7-6-11(17)8-13(12)18-14/h2-8,15,17H,1H3
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485297(CHEMBL2048309)
Show SMILES CNc1ccc(-c2cc3cc(ccc3o2)C(N)=O)c(F)n1
Show InChI InChI=1S/C15H12FN3O2/c1-18-13-5-3-10(14(16)19-13)12-7-9-6-8(15(17)20)2-4-11(9)21-12/h2-7H,1H3,(H2,17,20)(H,18,19)
Affinity DataIC50: 19nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481119(AZD-2184 | CHEMBL570378)
Show SMILES CNc1ccc(cn1)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C13H11N3OS/c1-14-12-5-2-8(7-15-12)13-16-10-4-3-9(17)6-11(10)18-13/h2-7,17H,1H3,(H,14,15)
Affinity DataIC50: 22nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485310(FLUTAFURANOL)
Show SMILES CNc1ccc(-c2cc3cc(O)ccc3o2)c(F)n1
Show InChI InChI=1S/C14H11FN2O2/c1-16-13-5-3-10(14(15)17-13)12-7-8-6-9(18)2-4-11(8)19-12/h2-7,18H,1H3,(H,16,17)
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50481120(Flutemetamol | [3H]-Flutemetamol)
Show SMILES CNc1ccc(cc1F)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C14H11FN2OS/c1-16-11-4-2-8(6-10(11)15)14-17-12-5-3-9(18)7-13(12)19-14/h2-7,16,18H,1H3
Affinity DataIC50: 24nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485308(CHEMBL2048310)
Show SMILES CNc1ncc(cc1F)-c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C14H11FN2O2/c1-16-14-11(15)5-9(7-17-14)13-6-8-4-10(18)2-3-12(8)19-13/h2-7,18H,1H3,(H,16,17)
Affinity DataIC50: 30nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485300(CHEMBL2048314)
Show SMILES CNc1ccc(nc1F)-c1cc2cc(ccc2o1)C(N)=O
Show InChI InChI=1S/C15H12FN3O2/c1-18-11-4-3-10(19-14(11)16)13-7-9-6-8(15(17)20)2-5-12(9)21-13/h2-7,18H,1H3,(H2,17,20)
Affinity DataIC50: 32nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485298(CHEMBL2048311)
Show SMILES COc1ccc2oc(cc2c1)-c1ccc(nc1F)C(N)=O
Show InChI InChI=1S/C15H11FN2O3/c1-20-9-2-5-12-8(6-9)7-13(21-12)10-3-4-11(15(17)19)18-14(10)16/h2-7H,1H3,(H2,17,19)
Affinity DataIC50: 32nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485303(CHEMBL2048302)
Show SMILES Oc1ccc2nc(sc2c1)-c1ccc(NCCF)nc1
Show InChI InChI=1S/C14H12FN3OS/c15-5-6-16-13-4-1-9(8-17-13)14-18-11-3-2-10(19)7-12(11)20-14/h1-4,7-8,19H,5-6H2,(H,16,17)
Affinity DataIC50: 33nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485309(CHEMBL2048313)
Show SMILES CNc1ccc(nc1F)-c1cc2cc(O)ccc2o1
Show InChI InChI=1S/C14H11FN2O2/c1-16-11-4-3-10(17-14(11)15)13-7-8-6-9(18)2-5-12(8)19-13/h2-7,16,18H,1H3
Affinity DataIC50: 35nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485305(CHEMBL2048300)
Show SMILES COc1ccc2nc(oc2c1)-c1ccc(NCCF)nc1
Show InChI InChI=1S/C15H14FN3O2/c1-20-11-3-4-12-13(8-11)21-15(19-12)10-2-5-14(18-9-10)17-7-6-16/h2-5,8-9H,6-7H2,1H3,(H,17,18)
Affinity DataIC50: 35nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485299(CHEMBL2048312)
Show SMILES NC(=O)c1ccc(-c2cc3cc(O)ccc3o2)c(F)n1
Show InChI InChI=1S/C14H9FN2O3/c15-13-9(2-3-10(17-13)14(16)19)12-6-7-5-8(18)1-4-11(7)20-12/h1-6,18H,(H2,16,19)
Affinity DataIC50: 44nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485295(CHEMBL2048304)
Show SMILES CNc1ccc(nc1F)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C13H10FN3OS/c1-15-9-4-5-10(16-12(9)14)13-17-8-3-2-7(18)6-11(8)19-13/h2-6,15,18H,1H3
Affinity DataIC50: 44nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485306(CHEMBL2048303)
Show SMILES Oc1ccc2nc(sc2c1)-c1ccc(NCCCF)nc1
Show InChI InChI=1S/C15H14FN3OS/c16-6-1-7-17-14-5-2-10(9-18-14)15-19-12-4-3-11(20)8-13(12)21-15/h2-5,8-9,20H,1,6-7H2,(H,17,18)
Affinity DataIC50: 66nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485307(CHEMBL2048307)
Show SMILES CNc1ncc(cc1F)-c1nc2ccc(O)cc2s1
Show InChI InChI=1S/C13H10FN3OS/c1-15-12-9(14)4-7(6-16-12)13-17-10-3-2-8(18)5-11(10)19-13/h2-6,18H,1H3,(H,15,16)
Affinity DataIC50: 98nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485296(CHEMBL2048306)
Show SMILES CNc1ccc(-c2nc3ccc(O)cc3s2)c(F)n1
Show InChI InChI=1S/C13H10FN3OS/c1-15-11-5-3-8(12(14)17-11)13-16-9-4-2-7(18)6-10(9)19-13/h2-6,18H,1H3,(H,15,17)
Affinity DataIC50: 124nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485301(CHEMBL2048299)
Show SMILES Oc1ccc2nc(oc2c1)-c1ccc(NCCF)nc1
Show InChI InChI=1S/C14H12FN3O2/c15-5-6-16-13-4-1-9(8-17-13)14-18-11-3-2-10(19)7-12(11)20-14/h1-4,7-8,19H,5-6H2,(H,16,17)
Affinity DataIC50: 158nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50485302(CHEMBL2048301)
Show SMILES Oc1ccc2nc(oc2c1)-c1ccc(NCCCF)nc1
Show InChI InChI=1S/C15H14FN3O2/c16-6-1-7-17-14-5-2-10(9-18-14)15-19-12-4-3-11(20)8-13(12)21-15/h2-5,8-9,20H,1,6-7H2,(H,17,18)
Affinity DataIC50: 395nMAssay Description:Displacement of [3H]AZD2184 from human amyloid beta(1 to 40)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid