Compile Data Set for Download or QSAR
Found 80 Enz. Inhib. hit(s) with all data for entry = 50005830
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038051(CHEMBL3094016)
Show SMILES NC(=O)COc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H14ClNO5/c19-12-3-1-2-11(6-12)9-23-13-4-5-14-15(24-10-17(20)21)8-18(22)25-16(14)7-13/h1-8H,9-10H2,(H2,20,21)
Affinity DataIC50: 3.10nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038051(CHEMBL3094016)
Show SMILES NC(=O)COc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H14ClNO5/c19-12-3-1-2-11(6-12)9-23-13-4-5-14-15(24-10-17(20)21)8-18(22)25-16(14)7-13/h1-8H,9-10H2,(H2,20,21)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038179(CHEMBL3094037)
Show SMILES OCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H13ClO4/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-8,19H,9-10H2
Affinity DataIC50: 5.20nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038156(CHEMBL3093993)
Show SMILES COc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C17H13BrO4/c1-20-15-9-17(19)22-16-8-13(5-6-14(15)16)21-10-11-3-2-4-12(18)7-11/h2-9H,10H2,1H3
Affinity DataIC50: 5.80nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038080(CHEMBL575934)
Show SMILES Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H13ClO3/c1-11-7-17(19)21-16-9-14(5-6-15(11)16)20-10-12-3-2-4-13(18)8-12/h2-9H,10H2,1H3
Affinity DataIC50: 7.40nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038158(CHEMBL3093992)
Show SMILES COc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H13ClO4/c1-20-15-9-17(19)22-16-8-13(5-6-14(15)16)21-10-11-3-2-4-12(18)7-11/h2-9H,10H2,1H3
Affinity DataIC50: 7.80nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038062(CHEMBL3094007)
Show SMILES CNc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H14ClNO3/c1-19-15-9-17(20)22-16-8-13(5-6-14(15)16)21-10-11-3-2-4-12(18)7-11/h2-9,19H,10H2,1H3
Affinity DataIC50: 8.70nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038050(CHEMBL3094017)
Show SMILES NC(=O)COc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C18H14BrNO5/c19-12-3-1-2-11(6-12)9-23-13-4-5-14-15(24-10-17(20)21)8-18(22)25-16(14)7-13/h1-8H,9-10H2,(H2,20,21)
Affinity DataIC50: 8.90nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038173(CHEMBL3139169)
Show SMILES CNCc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C18H16BrNO3/c1-20-10-13-8-18(21)23-17-9-15(5-6-16(13)17)22-11-12-3-2-4-14(19)7-12/h2-9,20H,10-11H2,1H3
Affinity DataIC50: 11nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM19188(7-(3-chlorobenzyloxy)-4-(methylamino)methyl-coumar...)
Show SMILES CNCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H16ClNO3/c1-20-10-13-8-18(21)23-17-9-15(5-6-16(13)17)22-11-12-3-2-4-14(19)7-12/h2-9,20H,10-11H2,1H3
Affinity DataIC50: 13nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038177(CHEMBL3094038)
Show SMILES OCc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C17H13BrO4/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-8,19H,9-10H2
Affinity DataIC50: 14nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299435(4-(Aminomethyl)-7-[(3-chlorobenzyl)oxy]-2H-chromen...)
Show SMILES NCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H14ClNO3/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-8H,9-10,19H2
Affinity DataIC50: 15nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299457(CHEMBL575093 | {7-[(3-Chlorobenzyl)oxy]-2-oxo-2H-c...)
Show SMILES Clc1cccc(COc2ccc3c(CC#N)cc(=O)oc3c2)c1
Show InChI InChI=1S/C18H12ClNO3/c19-14-3-1-2-12(8-14)11-22-15-4-5-16-13(6-7-20)9-18(21)23-17(16)10-15/h1-5,8-10H,6,11H2
Affinity DataIC50: 16nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038032(CHEMBL3094021)
Show SMILES Clc1cccc(COc2ccc3ccc(=O)oc3c2)c1
Show InChI InChI=1S/C16H11ClO3/c17-13-3-1-2-11(8-13)10-19-14-6-4-12-5-7-16(18)20-15(12)9-14/h1-9H,10H2
Affinity DataIC50: 17nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038077(CHEMBL3094024)
Show SMILES Clc1cccc(COc2ccc3c(Cl)cc(=O)oc3c2)c1
Show InChI InChI=1S/C16H10Cl2O3/c17-11-3-1-2-10(6-11)9-20-12-4-5-13-14(18)8-16(19)21-15(13)7-12/h1-8H,9H2
Affinity DataIC50: 21nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299458(2-{7-[(3-Chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl}-...)
Show SMILES CNC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C19H16ClNO4/c1-21-18(22)8-13-9-19(23)25-17-10-15(5-6-16(13)17)24-11-12-3-2-4-14(20)7-12/h2-7,9-10H,8,11H2,1H3,(H,21,22)
Affinity DataIC50: 24nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038054(CHEMBL3091489)
Show SMILES CC(=O)COc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C19H15ClO5/c1-12(21)10-24-17-9-19(22)25-18-8-15(5-6-16(17)18)23-11-13-3-2-4-14(20)7-13/h2-9H,10-11H2,1H3
Affinity DataIC50: 27nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038061(CHEMBL3094008)
Show SMILES CCNc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H16ClNO3/c1-2-20-16-10-18(21)23-17-9-14(6-7-15(16)17)22-11-12-4-3-5-13(19)8-12/h3-10,20H,2,11H2,1H3
Affinity DataIC50: 28nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038079(CHEMBL3094022)
Show SMILES CCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H15ClO3/c1-2-13-9-18(20)22-17-10-15(6-7-16(13)17)21-11-12-4-3-5-14(19)8-12/h3-10H,2,11H2,1H3
Affinity DataIC50: 29nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299451(2-{7-[(3-Chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl}a...)
Show SMILES NC(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H14ClNO4/c19-13-3-1-2-11(6-13)10-23-14-4-5-15-12(7-17(20)21)8-18(22)24-16(15)9-14/h1-6,8-9H,7,10H2,(H2,20,21)
Affinity DataIC50: 30nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038049(CHEMBL3094018)
Show SMILES CNC(=O)COc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C19H16ClNO5/c1-21-18(22)11-25-16-9-19(23)26-17-8-14(5-6-15(16)17)24-10-12-3-2-4-13(20)7-12/h2-9H,10-11H2,1H3,(H,21,22)
Affinity DataIC50: 34nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038164(CHEMBL3093991)
Show SMILES COc1cc(=O)oc2cc(OCc3cccc(F)c3)ccc12
Show InChI InChI=1S/C17H13FO4/c1-20-15-9-17(19)22-16-8-13(5-6-14(15)16)21-10-11-3-2-4-12(18)7-11/h2-9H,10H2,1H3
Affinity DataIC50: 36nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038058(CHEMBL3094011)
Show SMILES CC(=O)Nc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H14ClNO4/c1-11(21)20-16-9-18(22)24-17-8-14(5-6-15(16)17)23-10-12-3-2-4-13(19)7-12/h2-9H,10H2,1H3,(H,20,21)
Affinity DataIC50: 39nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038186(CHEMBL3094031)
Show SMILES CC(=O)c1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H13ClO4/c1-11(20)16-9-18(21)23-17-8-14(5-6-15(16)17)22-10-12-3-2-4-13(19)7-12/h2-9H,10H2,1H3
Affinity DataIC50: 40nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299423(2-{7-[(3-Chlorobenzyl)oxy]-2-oxo-2H-chromen-4-yl}-...)
Show SMILES CN(C)C(=O)Cc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C20H18ClNO4/c1-22(2)19(23)9-14-10-20(24)26-18-11-16(6-7-17(14)18)25-12-13-4-3-5-15(21)8-13/h3-8,10-11H,9,12H2,1-2H3
Affinity DataIC50: 40nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038207(CHEMBL3094025)
Show SMILES ClCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H12Cl2O3/c18-9-12-7-17(20)22-16-8-14(4-5-15(12)16)21-10-11-2-1-3-13(19)6-11/h1-8H,9-10H2
Affinity DataIC50: 44nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038071(CHEMBL3094005)
Show SMILES Clc1cccc(COc2ccc3c(OCC#N)cc(=O)oc3c2)c1
Show InChI InChI=1S/C18H12ClNO4/c19-13-3-1-2-12(8-13)11-23-14-4-5-15-16(22-7-6-20)10-18(21)24-17(15)9-14/h1-5,8-10H,7,11H2
Affinity DataIC50: 46nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038187(CHEMBL3094030)
Show SMILES Nc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C16H12ClNO3/c17-11-3-1-2-10(6-11)9-20-12-4-5-13-14(18)8-16(19)21-15(13)7-12/h1-8H,9,18H2
Affinity DataIC50: 48nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM19189(7-(3-Chlorobenzyloxy)-4-carboxaldehyde-coumarin, 3...)
Show SMILES Clc1cccc(COc2ccc3c(C=O)cc(=O)oc3c2)c1
Show InChI InChI=1S/C17H11ClO4/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-9H,10H2
Affinity DataIC50: 52nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038076(CHEMBL3094000)
Show SMILES CCCOc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C19H17ClO4/c1-2-8-22-17-11-19(21)24-18-10-15(6-7-16(17)18)23-12-13-4-3-5-14(20)9-13/h3-7,9-11H,2,8,12H2,1H3
Affinity DataIC50: 62nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038075(CHEMBL3094001)
Show SMILES CCCOc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C19H17BrO4/c1-2-8-22-17-11-19(21)24-18-10-15(6-7-16(17)18)23-12-13-4-3-5-14(20)9-13/h3-7,9-11H,2,8,12H2,1H3
Affinity DataIC50: 74nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038174(CHEMBL3094039)
Show SMILES CC(O)c1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H15ClO4/c1-11(20)16-9-18(21)23-17-8-14(5-6-15(16)17)22-10-12-3-2-4-13(19)7-12/h2-9,11,20H,10H2,1H3
Affinity DataIC50: 78nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038165(CHEMBL3093990)
Show SMILES COc1cc(=O)oc2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C17H14O4/c1-19-15-10-17(18)21-16-9-13(7-8-14(15)16)20-11-12-5-3-2-4-6-12/h2-10H,11H2,1H3
Affinity DataIC50: 100nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038073(CHEMBL3094003)
Show SMILES COCOc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H15ClO5/c1-21-11-23-16-9-18(20)24-17-8-14(5-6-15(16)17)22-10-12-3-2-4-13(19)7-12/h2-9H,10-11H2,1H3
Affinity DataIC50: 100nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038181(CHEMBL3094035)
Show SMILES Clc1cccc(COc2ccc3c(cc(=O)oc3c2)C#N)c1
Show InChI InChI=1S/C17H10ClNO3/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-8H,10H2
Affinity DataIC50: 102nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038084(CHEMBL3093996)
Show SMILES CCOc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H15ClO4/c1-2-21-16-10-18(20)23-17-9-14(6-7-15(16)17)22-11-12-4-3-5-13(19)8-12/h3-10H,2,11H2,1H3
Affinity DataIC50: 115nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038083(CHEMBL3093997)
Show SMILES CCOc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C18H15BrO4/c1-2-21-16-10-18(20)23-17-9-14(6-7-15(16)17)22-11-12-4-3-5-13(19)8-12/h3-10H,2,11H2,1H3
Affinity DataIC50: 126nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038172(CHEMBL3139148)
Show SMILES CCCNCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C20H20ClNO3/c1-2-8-22-12-15-10-20(23)25-19-11-17(6-7-18(15)19)24-13-14-4-3-5-16(21)9-14/h3-7,9-11,22H,2,8,12-13H2,1H3
Affinity DataIC50: 204nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038204(CHEMBL3094026)
Show SMILES ClCc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C17H12BrClO3/c18-13-3-1-2-11(6-13)10-21-14-4-5-15-12(9-19)7-17(20)22-16(15)8-14/h1-8H,9-10H2
Affinity DataIC50: 209nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038180(CHEMBL3094036)
Show SMILES O\N=C\c1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H12ClNO4/c18-13-3-1-2-11(6-13)10-22-14-4-5-15-12(9-19-21)7-17(20)23-16(15)8-14/h1-9,21H,10H2/b19-9+
Affinity DataIC50: 219nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038182(CHEMBL3094034)
Show SMILES NC(=O)c1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C17H12ClNO4/c18-11-3-1-2-10(6-11)9-22-12-4-5-13-14(17(19)21)8-16(20)23-15(13)7-12/h1-8H,9H2,(H2,19,21)
Affinity DataIC50: 234nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038085(CHEMBL3093995)
Show SMILES CCOc1cc(=O)oc2cc(OCc3cccc(F)c3)ccc12
Show InChI InChI=1S/C18H15FO4/c1-2-21-16-10-18(20)23-17-9-14(6-7-15(16)17)22-11-12-4-3-5-13(19)8-12/h3-10H,2,11H2,1H3
Affinity DataIC50: 263nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038058(CHEMBL3094011)
Show SMILES CC(=O)Nc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H14ClNO4/c1-11(21)20-16-9-18(22)24-17-8-14(5-6-15(16)17)23-10-12-3-2-4-13(19)7-12/h2-9H,10H2,1H3,(H,20,21)
Affinity DataIC50: 282nMAssay Description:Inhibition of Sprague-Dawley rat MAO-A using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038072(CHEMBL3094004)
Show SMILES CSCOc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C18H15ClO4S/c1-24-11-22-16-9-18(20)23-17-8-14(5-6-15(16)17)21-10-12-3-2-4-13(19)7-12/h2-9H,10-11H2,1H3
Affinity DataIC50: 316nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038081(CHEMBL3093999)
Show SMILES CCCOc1cc(=O)oc2cc(OCc3cccc(F)c3)ccc12
Show InChI InChI=1S/C19H17FO4/c1-2-8-22-17-11-19(21)24-18-10-15(6-7-16(17)18)23-12-13-4-3-5-14(20)9-13/h3-7,9-11H,2,8,12H2,1H3
Affinity DataIC50: 407nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038183(CHEMBL3094033)
Show SMILES CCOC(=O)c1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C19H15ClO5/c1-2-23-19(22)16-10-18(21)25-17-9-14(6-7-15(16)17)24-11-12-4-3-5-13(20)8-12/h3-10H,2,11H2,1H3
Affinity DataIC50: 417nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038170(CHEMBL3139072)
Show SMILES CCCCNCc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C21H22ClNO3/c1-2-3-9-23-13-16-11-21(24)26-20-12-18(7-8-19(16)20)25-14-15-5-4-6-17(22)10-15/h4-8,10-12,23H,2-3,9,13-14H2,1H3
Affinity DataIC50: 447nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] A(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50299457(CHEMBL575093 | {7-[(3-Chlorobenzyl)oxy]-2-oxo-2H-c...)
Show SMILES Clc1cccc(COc2ccc3c(CC#N)cc(=O)oc3c2)c1
Show InChI InChI=1S/C18H12ClNO3/c19-14-3-1-2-12(8-14)11-22-15-4-5-16-13(6-7-20)9-18(21)23-17(16)10-15/h1-5,8-10H,6,11H2
Affinity DataIC50: 468nMAssay Description:Inhibition of Sprague-Dawley rat MAO-A using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038196(CHEMBL3094028)
Show SMILES Oc1cc(=O)oc2cc(OCc3cccc(Cl)c3)ccc12
Show InChI InChI=1S/C16H11ClO4/c17-11-3-1-2-10(6-11)9-20-12-4-5-13-14(18)8-16(19)21-15(13)7-12/h1-8,18H,9H2
Affinity DataIC50: 479nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
TargetAmine oxidase [flavin-containing] B(Rattus norvegicus (rat))
Universit£ degli Studi di Bari "Aldo Moro"

Curated by ChEMBL
LigandPNGBDBM50038188(CHEMBL3094029)
Show SMILES Oc1cc(=O)oc2cc(OCc3cccc(Br)c3)ccc12
Show InChI InChI=1S/C16H11BrO4/c17-11-3-1-2-10(6-11)9-20-12-4-5-13-14(18)8-16(19)21-15(13)7-12/h1-8,18H,9H2
Affinity DataIC50: 490nMAssay Description:Inhibition of Sprague-Dawley rat MAO-B using Kynuramine as substrate assessed as formation of 4-hydroxyquinoline preincubated for 5 mins prior to sub...More data for this Ligand-Target Pair
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