Compile Data Set for Download or QSAR
Found 7 Enz. Inhib. hit(s) with all data for entry = 50006479
TargetLipoprotein lipase(Bos taurus)
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500148(CHEMBL3746381)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)N2C(=O)c3ccc(cc3C2=O)C(O)=O)cc1
Show InChI InChI=1S/C28H25N3O5/c1-17-5-8-19(9-6-17)29-25(32)23-16-20(10-12-24(23)30-13-3-2-4-14-30)31-26(33)21-11-7-18(28(35)36)15-22(21)27(31)34/h5-12,15-16H,2-4,13-14H2,1H3,(H,29,32)(H,35,36)
Affinity DataEC50:  6.60E+3nMAssay Description:Induction of bovine LPL stabilization using intralipid as substrate preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate add...More data for this Ligand-Target Pair
TargetLipoprotein lipase(Bos taurus)
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500149(CHEMBL3747367)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3cc(ccc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-8-21(9-6-18)28-26(32)23-16-22(10-12-25(23)30-13-3-2-4-14-30)31-17-20-15-19(27(33)34)7-11-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50:  5.00E+3nMAssay Description:Induction of bovine LPL stabilization using intralipid as substrate preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBile acid receptor(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500150(CHEMBL3746821)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3ccc(cc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-9-21(10-6-18)28-26(32)23-16-22(11-12-25(23)30-13-3-2-4-14-30)31-17-20-8-7-19(27(33)34)15-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at FXR (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetLipoprotein lipase(Bos taurus)
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500150(CHEMBL3746821)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3ccc(cc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-9-21(10-6-18)28-26(32)23-16-22(11-12-25(23)30-13-3-2-4-14-30)31-17-20-8-7-19(27(33)34)15-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50:  6.00E+3nMAssay Description:Induction of bovine LPL stabilization using intralipid as substrate preincubated for 10 mins with human recombinant ANGPTL4 followed by substrate add...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500150(CHEMBL3746821)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3ccc(cc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-9-21(10-6-18)28-26(32)23-16-22(11-12-25(23)30-13-3-2-4-14-30)31-17-20-8-7-19(27(33)34)15-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at PPARgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetRetinoic acid receptor RXR-alpha(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500150(CHEMBL3746821)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3ccc(cc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-9-21(10-6-18)28-26(32)23-16-22(11-12-25(23)30-13-3-2-4-14-30)31-17-20-8-7-19(27(33)34)15-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at RXRalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Ume£ University

Curated by ChEMBL
LigandPNGBDBM50500150(CHEMBL3746821)
Show SMILES Cc1ccc(NC(=O)c2cc(ccc2N2CCCCC2)-n2cc3ccc(cc3n2)C(O)=O)cc1
Show InChI InChI=1S/C27H26N4O3/c1-18-5-9-21(10-6-18)28-26(32)23-16-22(11-12-25(23)30-13-3-2-4-14-30)31-17-20-8-7-19(27(33)34)15-24(20)29-31/h5-12,15-17H,2-4,13-14H2,1H3,(H,28,32)(H,33,34)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at PPARalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid