Compile Data Set for Download or QSAR
Found 84 Enz. Inhib. hit(s) with all data for entry = 50007550
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510385(CHEMBL4462979)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3OC)c21
Show InChI InChI=1S/C23H21FN4O4S2/c1-31-15-4-6-16(7-5-15)34(29,30)28-10-9-17-20(12-28)33-23-21(17)22(25-13-26-23)27-18-8-3-14(24)11-19(18)32-2/h3-8,11,13H,9-10,12H2,1-2H3,(H,25,26,27)
Affinity DataIC50: 650nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510412(CHEMBL4532338)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3F)c21
Show InChI InChI=1S/C22H18F2N4O3S2/c1-31-14-3-5-15(6-4-14)33(29,30)28-9-8-16-19(11-28)32-22-20(16)21(25-12-26-22)27-18-7-2-13(23)10-17(18)24/h2-7,10,12H,8-9,11H2,1H3,(H,25,26,27)
Affinity DataIC50: 830nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510410(CHEMBL4450446)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(CCc3c12)S(=O)(=O)c1ccc(F)cc1F
Show InChI InChI=1S/C22H17F3N4O3S2/c1-32-17-9-13(24)2-4-16(17)28-21-20-14-6-7-29(10-18(14)33-22(20)27-11-26-21)34(30,31)19-5-3-12(23)8-15(19)25/h2-5,8-9,11H,6-7,10H2,1H3,(H,26,27,28)
Affinity DataIC50: 930nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510403(CHEMBL4521686)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(C)CCc3c12
Show InChI InChI=1S/C17H17FN4OS/c1-22-6-5-11-14(8-22)24-17-15(11)16(19-9-20-17)21-12-4-3-10(18)7-13(12)23-2/h3-4,7,9H,5-6,8H2,1-2H3,(H,19,20,21)
Affinity DataIC50: 930nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510374(CHEMBL4450194)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(CCc3c12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C20H17FN4O3S3/c1-28-15-9-12(21)4-5-14(15)24-19-18-13-6-7-25(31(26,27)17-3-2-8-29-17)10-16(13)30-20(18)23-11-22-19/h2-5,8-9,11H,6-7,10H2,1H3,(H,22,23,24)
Affinity DataIC50: 940nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510364(CHEMBL4554398)
Show SMILES Fc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)c(Br)c1
Show InChI InChI=1S/C19H14BrFN4O2S3/c20-13-8-11(21)3-4-14(13)24-18-17-12-5-6-25(30(26,27)16-2-1-7-28-16)9-15(12)29-19(17)23-10-22-18/h1-4,7-8,10H,5-6,9H2,(H,22,23,24)
Affinity DataIC50: 970nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510429(CHEMBL4447000)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(Cc4ccccc4)CCc3c12
Show InChI InChI=1S/C23H21FN4OS/c1-29-19-11-16(24)7-8-18(19)27-22-21-17-9-10-28(12-15-5-3-2-4-6-15)13-20(17)30-23(21)26-14-25-22/h2-8,11,14H,9-10,12-13H2,1H3,(H,25,26,27)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510421(CHEMBL4537838)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3Br)c21
Show InChI InChI=1S/C22H18BrFN4O3S2/c1-31-14-3-5-15(6-4-14)33(29,30)28-9-8-16-19(11-28)32-22-20(16)21(25-12-26-22)27-18-7-2-13(24)10-17(18)23/h2-7,10,12H,8-9,11H2,1H3,(H,25,26,27)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510386(CHEMBL4569877)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Br)cc3)c21
Show InChI InChI=1S/C22H19BrN4O3S2/c1-30-16-6-8-17(9-7-16)32(28,29)27-11-10-18-19(12-27)31-22-20(18)21(24-13-25-22)26-15-4-2-14(23)3-5-15/h2-9,13H,10-12H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.07E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510370(CHEMBL4443233)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3F)c21
Show InChI InChI=1S/C21H15F2N5O4S2/c22-12-5-6-15(14(23)9-12)26-20-19-13-7-8-27(10-17(13)33-21(19)25-11-24-20)34(31,32)18-4-2-1-3-16(18)28(29)30/h1-6,9,11H,7-8,10H2,(H,24,25,26)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510426(CHEMBL4540853)
Show SMILES CN1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3F)c21
Show InChI InChI=1S/C16H14F2N4S/c1-22-5-4-10-13(7-22)23-16-14(10)15(19-8-20-16)21-12-3-2-9(17)6-11(12)18/h2-3,6,8H,4-5,7H2,1H3,(H,19,20,21)
Affinity DataIC50: 1.09E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510419(CHEMBL4466788)
Show SMILES Fc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2ccc(F)cc2F)c(F)c1
Show InChI InChI=1S/C21H14F4N4O2S2/c22-11-1-3-16(14(24)7-11)28-20-19-13-5-6-29(9-17(13)32-21(19)27-10-26-20)33(30,31)18-4-2-12(23)8-15(18)25/h1-4,7-8,10H,5-6,9H2,(H,26,27,28)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510432(CHEMBL4593296)
Show SMILES Fc1ccc(Nc2ncnc3sc4CN(Cc5ccccc5)CCc4c23)c(F)c1
Show InChI InChI=1S/C22H18F2N4S/c23-15-6-7-18(17(24)10-15)27-21-20-16-8-9-28(11-14-4-2-1-3-5-14)12-19(16)29-22(20)26-13-25-21/h1-7,10,13H,8-9,11-12H2,(H,25,26,27)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510442(CHEMBL4467722)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(CCc3c12)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H18FN5O5S2/c1-33-17-10-13(23)6-7-15(17)26-21-20-14-8-9-27(11-18(14)34-22(20)25-12-24-21)35(31,32)19-5-3-2-4-16(19)28(29)30/h2-7,10,12H,8-9,11H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510407(CHEMBL4472464)
Show SMILES Fc1ccc(Nc2ncnc3sc4CN(Cc5ccccc5)CCc4c23)c(Br)c1
Show InChI InChI=1S/C22H18BrFN4S/c23-17-10-15(24)6-7-18(17)27-21-20-16-8-9-28(11-14-4-2-1-3-5-14)12-19(16)29-22(20)26-13-25-21/h1-7,10,13H,8-9,11-12H2,(H,25,26,27)
Affinity DataIC50: 1.12E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510366(CHEMBL4459257)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3F)c21
Show InChI InChI=1S/C22H18ClFN4O3S2/c1-31-14-3-5-15(6-4-14)33(29,30)28-9-8-16-19(11-28)32-22-20(16)21(25-12-26-22)27-18-7-2-13(23)10-17(18)24/h2-7,10,12H,8-9,11H2,1H3,(H,25,26,27)
Affinity DataIC50: 1.15E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510367(CHEMBL4590109)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3Br)c21
Show InChI InChI=1S/C21H15BrFN5O4S2/c22-14-9-12(23)5-6-15(14)26-20-19-13-7-8-27(10-17(13)33-21(19)25-11-24-20)34(31,32)18-4-2-1-3-16(18)28(29)30/h1-6,9,11H,7-8,10H2,(H,24,25,26)
Affinity DataIC50: 1.16E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510422(CHEMBL4448106)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3)c21
Show InChI InChI=1S/C22H19ClN4O3S2/c1-30-16-6-8-17(9-7-16)32(28,29)27-11-10-18-19(12-27)31-22-20(18)21(24-13-25-22)26-15-4-2-14(23)3-5-15/h2-9,13H,10-12H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.22E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510369(CHEMBL4516825)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Br)cc3)c21
Show InChI InChI=1S/C21H16BrN5O4S2/c22-13-5-7-14(8-6-13)25-20-19-15-9-10-26(11-17(15)32-21(19)24-12-23-20)33(30,31)18-4-2-1-3-16(18)27(28)29/h1-8,12H,9-11H2,(H,23,24,25)
Affinity DataIC50: 1.25E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510363(CHEMBL4449174)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3F)c21
Show InChI InChI=1S/C21H15ClFN5O4S2/c22-12-5-6-15(14(23)9-12)26-20-19-13-7-8-27(10-17(13)33-21(19)25-11-24-20)34(31,32)18-4-2-1-3-16(18)28(29)30/h1-6,9,11H,7-8,10H2,(H,24,25,26)
Affinity DataIC50: 1.26E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510365(CHEMBL4536609)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3Br)c21
Show InChI InChI=1S/C21H14BrF3N4O2S2/c22-14-7-11(23)1-3-16(14)28-20-19-13-5-6-29(9-17(13)32-21(19)27-10-26-20)33(30,31)18-4-2-12(24)8-15(18)25/h1-4,7-8,10H,5-6,9H2,(H,26,27,28)
Affinity DataIC50: 1.28E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510416(CHEMBL4589352)
Show SMILES Fc1cc(Cl)ccc1Nc1ncnc2sc3CN(Cc4ccccc4)CCc3c12
Show InChI InChI=1S/C22H18ClFN4S/c23-15-6-7-18(17(24)10-15)27-21-20-16-8-9-28(11-14-4-2-1-3-5-14)12-19(16)29-22(20)26-13-25-21/h1-7,10,13H,8-9,11-12H2,(H,25,26,27)
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510399(CHEMBL4531356)
Show SMILES COc1cc(F)ccc1Nc1ncnc2sc3CN(CCc3c12)C(=O)OC(C)(C)C
Show InChI InChI=1S/C21H23FN4O3S/c1-21(2,3)29-20(27)26-8-7-13-16(10-26)30-19-17(13)18(23-11-24-19)25-14-6-5-12(22)9-15(14)28-4/h5-6,9,11H,7-8,10H2,1-4H3,(H,23,24,25)
Affinity DataIC50: 1.34E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510375(CHEMBL4561883)
Show SMILES Fc1cc(Cl)ccc1Nc1ncnc2sc3CN(CCc3c12)S(=O)(=O)c1cccs1
Show InChI InChI=1S/C19H14ClFN4O2S3/c20-11-3-4-14(13(21)8-11)24-18-17-12-5-6-25(30(26,27)16-2-1-7-28-16)9-15(12)29-19(17)23-10-22-18/h1-4,7-8,10H,5-6,9H2,(H,22,23,24)
Affinity DataIC50: 1.36E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510378(CHEMBL4575025)
Show SMILES Clc1cccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)c1
Show InChI InChI=1S/C19H15ClN4O2S3/c20-12-3-1-4-13(9-12)23-18-17-14-6-7-24(29(25,26)16-5-2-8-27-16)10-15(14)28-19(17)22-11-21-18/h1-5,8-9,11H,6-7,10H2,(H,21,22,23)
Affinity DataIC50: 1.38E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510435(CHEMBL4446384)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3cccc(F)c3)c21
Show InChI InChI=1S/C22H19FN4O3S2/c1-30-16-5-7-17(8-6-16)32(28,29)27-10-9-18-19(12-27)31-22-20(18)21(24-13-25-22)26-15-4-2-3-14(23)11-15/h2-8,11,13H,9-10,12H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510441(CHEMBL4563436)
Show SMILES Brc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C19H15BrN4O2S3/c20-12-3-5-13(6-4-12)23-18-17-14-7-8-24(29(25,26)16-2-1-9-27-16)10-15(14)28-19(17)22-11-21-18/h1-6,9,11H,7-8,10H2,(H,21,22,23)
Affinity DataIC50: 1.39E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510389(CHEMBL4470343)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3cccc(Cl)c3)c21
Show InChI InChI=1S/C22H19ClN4O3S2/c1-30-16-5-7-17(8-6-16)32(28,29)27-10-9-18-19(12-27)31-22-20(18)21(24-13-25-22)26-15-4-2-3-14(23)11-15/h2-8,11,13H,9-10,12H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510387(CHEMBL4581903)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3cccc(C)c3)c21
Show InChI InChI=1S/C23H22N4O3S2/c1-15-4-3-5-16(12-15)26-22-21-19-10-11-27(13-20(19)31-23(21)25-14-24-22)32(28,29)18-8-6-17(30-2)7-9-18/h3-9,12,14H,10-11,13H2,1-2H3,(H,24,25,26)
Affinity DataIC50: 1.41E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510433(CHEMBL4584574)
Show SMILES Fc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)c(F)c1
Show InChI InChI=1S/C19H14F2N4O2S3/c20-11-3-4-14(13(21)8-11)24-18-17-12-5-6-25(30(26,27)16-2-1-7-28-16)9-15(12)29-19(17)23-10-22-18/h1-4,7-8,10H,5-6,9H2,(H,22,23,24)
Affinity DataIC50: 1.46E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510402(CHEMBL4456947)
Show SMILES CN1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3Br)c21
Show InChI InChI=1S/C16H14BrFN4S/c1-22-5-4-10-13(7-22)23-16-14(10)15(19-8-20-16)21-12-3-2-9(18)6-11(12)17/h2-3,6,8H,4-5,7H2,1H3,(H,19,20,21)
Affinity DataIC50: 1.47E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510418(CHEMBL4475709)
Show SMILES Fc1cccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)c1
Show InChI InChI=1S/C19H15FN4O2S3/c20-12-3-1-4-13(9-12)23-18-17-14-6-7-24(29(25,26)16-5-2-8-27-16)10-15(14)28-19(17)22-11-21-18/h1-5,8-9,11H,6-7,10H2,(H,21,22,23)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510411(CHEMBL4463661)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3)c21
Show InChI InChI=1S/C21H15ClF2N4O2S2/c22-12-1-4-14(5-2-12)27-20-19-15-7-8-28(10-17(15)31-21(19)26-11-25-20)32(29,30)18-6-3-13(23)9-16(18)24/h1-6,9,11H,7-8,10H2,(H,25,26,27)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510394(CHEMBL4567764)
Show SMILES Brc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1
Show InChI InChI=1S/C16H14BrN3S/c17-10-5-7-11(8-6-10)20-15-14-12-3-1-2-4-13(12)21-16(14)19-9-18-15/h5-9H,1-4H2,(H,18,19,20)
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510380(CHEMBL4474103)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3F)c21
Show InChI InChI=1S/C21H14ClF3N4O2S2/c22-11-1-3-16(14(24)7-11)28-20-19-13-5-6-29(9-17(13)32-21(19)27-10-26-20)33(30,31)18-4-2-12(23)8-15(18)25/h1-4,7-8,10H,5-6,9H2,(H,26,27,28)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510405(CHEMBL4582192)
Show SMILES Clc1ccc(Nc2ncnc3sc4CN(Cc5ccccc5)CCc4c23)cc1
Show InChI InChI=1S/C22H19ClN4S/c23-16-6-8-17(9-7-16)26-21-20-18-10-11-27(12-15-4-2-1-3-5-15)13-19(18)28-22(20)25-14-24-21/h1-9,14H,10-13H2,(H,24,25,26)
Affinity DataIC50: 1.54E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510373(CHEMBL4533038)
Show SMILES Cc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)c(Br)c1
Show InChI InChI=1S/C20H17BrN4O2S3/c1-12-4-5-15(14(21)9-12)24-19-18-13-6-7-25(30(26,27)17-3-2-8-28-17)10-16(13)29-20(18)23-11-22-19/h2-5,8-9,11H,6-7,10H2,1H3,(H,22,23,24)
Affinity DataIC50: 1.56E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510408(CHEMBL4552830)
Show SMILES Cc1ccc(Nc2ncnc3sc4CN(Cc5ccccc5)CCc4c23)c(Br)c1
Show InChI InChI=1S/C23H21BrN4S/c1-15-7-8-19(18(24)11-15)27-22-21-17-9-10-28(12-16-5-3-2-4-6-16)13-20(17)29-23(21)26-14-25-22/h2-8,11,14H,9-10,12-13H2,1H3,(H,25,26,27)
Affinity DataIC50: 1.57E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510391(CHEMBL4544794)
Show SMILES Clc1ccc(Nc2ncnc3sc4CCCCc4c23)cc1
Show InChI InChI=1S/C16H14ClN3S/c17-10-5-7-11(8-6-10)20-15-14-12-3-1-2-4-13(12)21-16(14)19-9-18-15/h5-9H,1-4H2,(H,18,19,20)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510397(CHEMBL4560334)
Show SMILES CC(C)(C)OC(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(F)cc3F)c21
Show InChI InChI=1S/C20H20F2N4O2S/c1-20(2,3)28-19(27)26-7-6-12-15(9-26)29-18-16(12)17(23-10-24-18)25-14-5-4-11(21)8-13(14)22/h4-5,8,10H,6-7,9H2,1-3H3,(H,23,24,25)
Affinity DataIC50: 1.62E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510377(CHEMBL4588895)
Show SMILES Clc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2cccs2)cc1
Show InChI InChI=1S/C19H15ClN4O2S3/c20-12-3-5-13(6-4-12)23-18-17-14-7-8-24(29(25,26)16-2-1-9-27-16)10-15(14)28-19(17)22-11-21-18/h1-6,9,11H,7-8,10H2,(H,21,22,23)
Affinity DataIC50: 1.63E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510409(CHEMBL4583540)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3cccc(Cl)c3)c21
Show InChI InChI=1S/C21H16ClN5O4S2/c22-13-4-3-5-14(10-13)25-20-19-15-8-9-26(11-17(15)32-21(19)24-12-23-20)33(30,31)18-7-2-1-6-16(18)27(28)29/h1-7,10,12H,8-9,11H2,(H,23,24,25)
Affinity DataIC50: 1.64E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510427(CHEMBL4563521)
Show SMILES CN1CCc2c(C1)sc1ncnc(Nc3ccc(C)cc3Br)c21
Show InChI InChI=1S/C17H17BrN4S/c1-10-3-4-13(12(18)7-10)21-16-15-11-5-6-22(2)8-14(11)23-17(15)20-9-19-16/h3-4,7,9H,5-6,8H2,1-2H3,(H,19,20,21)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510390(CHEMBL4439152)
Show SMILES Cc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2ccccc2[N+]([O-])=O)c(Br)c1
Show InChI InChI=1S/C22H18BrN5O4S2/c1-13-6-7-16(15(23)10-13)26-21-20-14-8-9-27(11-18(14)33-22(20)25-12-24-21)34(31,32)19-5-3-2-4-17(19)28(29)30/h2-7,10,12H,8-9,11H2,1H3,(H,24,25,26)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510439(CHEMBL4552946)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)N1CCc2c(C1)sc1ncnc(Nc3ccc(Cl)cc3)c21
Show InChI InChI=1S/C21H16ClN5O4S2/c22-13-5-7-14(8-6-13)25-20-19-15-9-10-26(11-17(15)32-21(19)24-12-23-20)33(30,31)18-4-2-1-3-16(18)27(28)29/h1-8,12H,9-11H2,(H,23,24,25)
Affinity DataIC50: 1.65E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510379(CHEMBL4452969)
Show SMILES Cc1ccc(Nc2ncnc3sc4CN(CCc4c23)S(=O)(=O)c2ccc(F)cc2F)c(Br)c1
Show InChI InChI=1S/C22H17BrF2N4O2S2/c1-12-2-4-17(15(23)8-12)28-21-20-14-6-7-29(10-18(14)32-22(20)27-11-26-21)33(30,31)19-5-3-13(24)9-16(19)25/h2-5,8-9,11H,6-7,10H2,1H3,(H,26,27,28)
Affinity DataIC50: 1.68E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510361(CHEMBL4460480)
Show SMILES CN1CCc2c(C1)sc1ncnc(Nc3ccc(Br)cc3)c21
Show InChI InChI=1S/C16H15BrN4S/c1-21-7-6-12-13(8-21)22-16-14(12)15(18-9-19-16)20-11-4-2-10(17)3-5-11/h2-5,9H,6-8H2,1H3,(H,18,19,20)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510428(CHEMBL4513266)
Show SMILES Brc1ccc(Nc2ncnc3sc4CN(Cc5ccccc5)CCc4c23)cc1
Show InChI InChI=1S/C22H19BrN4S/c23-16-6-8-17(9-7-16)26-21-20-18-10-11-27(12-15-4-2-1-3-5-15)13-19(18)28-22(20)25-14-24-21/h1-9,14H,10-13H2,(H,24,25,26)
Affinity DataIC50: 1.69E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510400(CHEMBL4447312)
Show SMILES Cc1ccc(Nc2ncnc3sc4CN(CCc4c23)C(=O)OC(C)(C)C)c(Br)c1
Show InChI InChI=1S/C21H23BrN4O2S/c1-12-5-6-15(14(22)9-12)25-18-17-13-7-8-26(20(27)28-21(2,3)4)10-16(13)29-19(17)24-11-23-18/h5-6,9,11H,7-8,10H2,1-4H3,(H,23,24,25)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMAP kinase-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Chengdu Medical College

Curated by ChEMBL
LigandPNGBDBM50510423(CHEMBL4577910)
Show SMILES COc1cccc(Nc2ncnc3sc4CCCCc4c23)c1
Show InChI InChI=1S/C17H17N3OS/c1-21-12-6-4-5-11(9-12)20-16-15-13-7-2-3-8-14(13)22-17(15)19-10-18-16/h4-6,9-10H,2-3,7-8H2,1H3,(H,18,19,20)
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of human MNK1 using CREBtide substrate by gamma-[32P]-ATP competitive inhibition assayMore data for this Ligand-Target Pair
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