Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with all data for entry = 50008084
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50515526(CHEMBL4452230)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(CO)cc3)c12
Show InChI InChI=1S/C20H18ClN5O/c21-16(14-4-2-1-3-5-14)10-26-20-17(19(22)23-12-24-20)18(25-26)15-8-6-13(11-27)7-9-15/h1-9,12,16,27H,10-11H2,(H2,22,23,24)
Affinity DataKi:  120nMAssay Description:Inhibition of recombinant full length N-terminal His6 tagged human FYN expressed in baculovirus infected sf21 cells using KVEKIGEGTYGVVYK as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Fyn(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50089575(CHEMBL3578214)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C19H15Cl2N5/c20-14-8-6-13(7-9-14)17-16-18(22)23-11-24-19(16)26(25-17)10-15(21)12-4-2-1-3-5-12/h1-9,11,15H,10H2,(H2,22,23,24)
Affinity DataKi:  160nMAssay Description:Inhibition of recombinant full length N-terminal His6 tagged human FYN expressed in baculovirus infected sf21 cells using KVEKIGEGTYGVVYK as substrat...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50515526(CHEMBL4452230)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(CO)cc3)c12
Show InChI InChI=1S/C20H18ClN5O/c21-16(14-4-2-1-3-5-14)10-26-20-17(19(22)23-12-24-20)18(25-26)15-8-6-13(11-27)7-9-15/h1-9,12,16,27H,10-11H2,(H2,22,23,24)
Affinity DataKi:  170nMAssay Description:Inhibition of BLK (unknown origin) using KVEKIGEGTYGVVYK as substrate in presence of [gamma33P]ATP as substrate in presence of [gamma33P]ATP by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50515526(CHEMBL4452230)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(CO)cc3)c12
Show InChI InChI=1S/C20H18ClN5O/c21-16(14-4-2-1-3-5-14)10-26-20-17(19(22)23-12-24-20)18(25-26)15-8-6-13(11-27)7-9-15/h1-9,12,16,27H,10-11H2,(H2,22,23,24)
Affinity DataKi:  190nMAssay Description:Inhibition of LYN (unknown origin) using KVEKIGEGTYGVVYK as substrate in presence of [gamma33P]ATP as substrate in presence of [gamma33P]ATP by scint...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50089575(CHEMBL3578214)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C19H15Cl2N5/c20-14-8-6-13(7-9-14)17-16-18(22)23-11-24-19(16)26(25-17)10-15(21)12-4-2-1-3-5-12/h1-9,11,15H,10H2,(H2,22,23,24)
Affinity DataKi:  190nMAssay Description:Inhibition of BLK (unknown origin) using KVEKIGEGTYGVVYK as substrate in presence of [gamma33P]ATP as substrate in presence of [gamma33P]ATP by scint...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
University of Siena

Curated by ChEMBL
LigandPNGBDBM50089575(CHEMBL3578214)
Show SMILES Nc1ncnc2n(CC(Cl)c3ccccc3)nc(-c3ccc(Cl)cc3)c12
Show InChI InChI=1S/C19H15Cl2N5/c20-14-8-6-13(7-9-14)17-16-18(22)23-11-24-19(16)26(25-17)10-15(21)12-4-2-1-3-5-12/h1-9,11,15H,10H2,(H2,22,23,24)
Affinity DataKi:  190nMAssay Description:Inhibition of LYN (unknown origin) using KVEKIGEGTYGVVYK as substrate in presence of [gamma33P]ATP as substrate in presence of [gamma33P]ATP by scint...More data for this Ligand-Target Pair