Compile Data Set for Download or QSAR
Found 13 Enz. Inhib. hit(s) with all data for entry = 50010882
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543060(CHEMBL4642843)
Show SMILES C[C@@H](c1ccc(Cl)c(Cl)c1)n1ncc2nc([nH]c(=O)c12)-n1cc(cn1)C(O)=O
Affinity DataIC50: 9nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543056(CHEMBL4647424)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cnn(Cc3ccc(cc3)-c3ccccc3)c2c(=O)[nH]1
Show InChI InChI=1S/C22H16N6O3/c29-20-19-18(25-22(26-20)28-13-17(10-23-28)21(30)31)11-24-27(19)12-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-11,13H,12H2,(H,30,31)(H,25,26,29)
Affinity DataIC50: 9nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543057(CHEMBL4645985)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cn(Cc3ccc(cc3)-c3ccccc3)nc2c(=O)[nH]1
Show InChI InChI=1S/C22H16N6O3/c29-20-19-18(24-22(25-20)28-12-17(10-23-28)21(30)31)13-27(26-19)11-14-6-8-16(9-7-14)15-4-2-1-3-5-15/h1-10,12-13H,11H2,(H,30,31)(H,24,25,29)
Affinity DataIC50: 12nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543054(CHEMBL4648388)
Show SMILES OC(=O)c1cnn(c1)-c1nc2scc(Cc3ccc(cc3)-c3ccccc3)c2c(=O)[nH]1
Show InChI InChI=1S/C23H16N4O3S/c28-20-19-17(10-14-6-8-16(9-7-14)15-4-2-1-3-5-15)13-31-21(19)26-23(25-20)27-12-18(11-24-27)22(29)30/h1-9,11-13H,10H2,(H,29,30)(H,25,26,28)
Affinity DataIC50: 23nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543059(CHEMBL4643092)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cnn(Cc3ccc(Cl)c(Cl)c3)c2c(=O)[nH]1
Show InChI InChI=1S/C16H10Cl2N6O3/c17-10-2-1-8(3-11(10)18)6-23-13-12(5-20-23)21-16(22-14(13)25)24-7-9(4-19-24)15(26)27/h1-5,7H,6H2,(H,26,27)(H,21,22,25)
Affinity DataIC50: 24nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543058(CHEMBL4648359)
Show SMILES OC(=O)c1cnn(c1)-c1nc2cnn(Cc3ccc(c(F)c3)-c3ccccc3F)c2c(=O)[nH]1
Show InChI InChI=1S/C22H14F2N6O3/c23-16-4-2-1-3-14(16)15-6-5-12(7-17(15)24)10-29-19-18(9-26-29)27-22(28-20(19)31)30-11-13(8-25-30)21(32)33/h1-9,11H,10H2,(H,32,33)(H,27,28,31)
Affinity DataIC50: 25nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543055(CHEMBL4647772)
Show SMILES OC(=O)c1cnn(c1)-c1nc2ccn(Cc3ccc(cc3)-c3ccccc3)c2c(=O)[nH]1
Show InChI InChI=1S/C23H17N5O3/c29-21-20-19(25-23(26-21)28-14-18(12-24-28)22(30)31)10-11-27(20)13-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-12,14H,13H2,(H,30,31)(H,25,26,29)
Affinity DataIC50: 51nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543062(CHEMBL4646935)
Show SMILES C[C@@H](c1cc(Cl)ccc1Cl)n1ncc2nc([nH]c(=O)c12)-n1cc(cn1)C(O)=O
Affinity DataIC50: 54nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543061(CHEMBL4638332)
Show SMILES C[C@H](c1ccc(Cl)c(Cl)c1)n1ncc2nc([nH]c(=O)c12)-n1cc(cn1)C(O)=O
Affinity DataIC50: 60nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543053(CHEMBL4649343)
Show SMILES OC(=O)c1cnn(c1)-c1nc2scc(Cc3ccccc3)c2c(=O)[nH]1
Show InChI InChI=1S/C17H12N4O3S/c22-14-13-11(6-10-4-2-1-3-5-10)9-25-15(13)20-17(19-14)21-8-12(7-18-21)16(23)24/h1-5,7-9H,6H2,(H,23,24)(H,19,20,22)
Affinity DataIC50: 78nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543051(CHEMBL4638096)
Show SMILES OC(=O)c1cnn(c1)-c1nc2scc(CC3CCCCC3)c2c(=O)[nH]1
Show InChI InChI=1S/C17H18N4O3S/c22-14-13-11(6-10-4-2-1-3-5-10)9-25-15(13)20-17(19-14)21-8-12(7-18-21)16(23)24/h7-10H,1-6H2,(H,23,24)(H,19,20,22)
Affinity DataIC50: 140nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50543052(CHEMBL4644023)
Show SMILES Cc1csc2nc([nH]c(=O)c12)-n1cc(cn1)C(O)=O
Show InChI InChI=1S/C11H8N4O3S/c1-5-4-19-9-7(5)8(16)13-11(14-9)15-3-6(2-12-15)10(17)18/h2-4H,1H3,(H,17,18)(H,13,14,16)
Affinity DataIC50: 290nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetEgl nine homolog 1(Homo sapiens (Human))
Mitsubishi Tanabe Pharma Corporation

Curated by ChEMBL
LigandPNGBDBM50193145(2-(1-chloro-4-hydroxyisoquinoline-3-carboxamido)ac...)
Show SMILES OC(=O)CNC(=O)c1nc(Cl)c2ccccc2c1O
Show InChI InChI=1S/C12H9ClN2O4/c13-11-7-4-2-1-3-6(7)10(18)9(15-11)12(19)14-5-8(16)17/h1-4,18H,5H2,(H,14,19)(H,16,17)
Affinity DataIC50: 640nMAssay Description:Inhibition of HIF-PHD2 (unknown origin) using FAM-HIF2alpha peptide incubated for 20 to 40 mins by fluorescence polarization assayMore data for this Ligand-Target Pair