Compile Data Set for Download or QSAR
maximum 50k data
Found 37 Enz. Inhib. hit(s) with all data for entry = 50011276
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  4nMAssay Description:Inhibition of SPPL2a in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  5nMAssay Description:Inhibition of mouse SPPL2a cotransfected with EGFP-NLP-fused TNFalpha (1 to 77 residues)-NTF incubated for 24 hrs by Hoechst staining based Cellomics...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546130(CHEMBL4762492)
Affinity DataIC50:  7nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  9nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546128(CHEMBL4753654)
Affinity DataIC50:  13nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546125(CHEMBL4792187)
Affinity DataIC50:  15nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546131(CHEMBL4759943)
Affinity DataIC50:  25nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546124(CHEMBL4740837)
Affinity DataIC50:  88nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Mus musculus)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  150nMAssay Description:Inhibition of SPPL2a in Balb/c mouse A20 cells assessed as reduction in CD74/p8 NTF accumulation incubated for overnight by Western blot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50:  200nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2B(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  270nMAssay Description:Inhibition of SPPL2b in human U2OS cells cotransfected with EGFP-labeled TNFalpha (1 to 76 residues)-NTF incubated for 24 hrs by Hoechst staining bas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546122(CHEMBL4747630)
Affinity DataIC50:  350nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546123(CHEMBL4789381)
Affinity DataIC50:  620nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546129(CHEMBL4785324)
Affinity DataIC50:  840nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546120(CHEMBL4743609)
Affinity DataIC50:  860nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546127(CHEMBL4753079)
Affinity DataIC50:  900nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546121(CHEMBL4798232)
Affinity DataIC50:  910nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546132(CHEMBL4759048)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546126(CHEMBL4741014)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546128(CHEMBL4753654)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546125(CHEMBL4792187)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546123(CHEMBL4789381)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546130(CHEMBL4762492)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546131(CHEMBL4759943)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSignal peptide peptidase-like 2A(Homo sapiens)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546119(CHEMBL4762488)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luciferase reporter plasmid and VP16-TNFalpha(1-76)-NTF incubated for 24...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50:  4.80E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546124(CHEMBL4740837)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546122(CHEMBL4747630)
Affinity DataIC50:  5.90E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546127(CHEMBL4753079)
Affinity DataIC50:  6.40E+3nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546121(CHEMBL4798232)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546126(CHEMBL4741014)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPresenilin-1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546129(CHEMBL4785324)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of gamma-secretase (unknown origin) expressed in HEK293 cells cotransfected with Notch1-VP16-GAL4 fusion and Gal4 luciferase reporter plas...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human BACE1 (46 to 435 residues) expressed in baculovirus infected insect cells using Ac-C(PT14)EVNLDAEWK-NH2 as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human BACE2 (63 to 466 residues) expressed in baculovirus infected insect cells using Ac-C(PT14)EVNLDAEWK-NH2 as substrate preincubated...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRenin(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human renin (67 to 406 residues) expressed in CHO cells using KHPWHLVIHT-C(PT14)-K as substrate preincubated for 1 hr followed by subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin E(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human cathepsin E isoform 1 (19 to 401 residues) expressed in Escherichia coli using R-C(PT14)KPILFFRLGWR-OH as substrate preincubated ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50546118(CHEMBL4762370)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of human cathepsin D (1 to 412 residues) expressed in baculovirus infected insect cells using R-C(PT14)-KPILFFRLGWR-OH as substrate preinc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed