Compile Data Set for Download or QSAR
Found 78 Enz. Inhib. hit(s) with all data for entry = 50012558
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558348(CHEMBL4743158)
Show SMILES Cc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C26H28N2O/c1-18-6-8-19(9-7-18)17-28-24-12-13-25(28)16-23(15-24)27-26(29)22-11-10-20-4-2-3-5-21(20)14-22/h2-11,14,23-25H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558342(CHEMBL4754231)
Show SMILES Clc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25ClN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  0.400nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558345(CHEMBL4788843)
Show SMILES COc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-12-6-18(7-13-25)17-28-23-10-11-24(28)16-22(15-23)27-26(29)21-9-8-19-4-2-3-5-20(19)14-21/h2-9,12-14,22-24H,10-11,15-17H2,1H3,(H,27,29)
Affinity DataKi:  0.600nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM10755(14C-5-hydroxy tryptamine creatinine disulfate | 2-...)
Show SMILES NCCc1c[nH]c2ccc(O)cc12
Show InChI InChI=1S/C10H12N2O/c11-4-3-7-6-12-10-2-1-8(13)5-9(7)10/h1-2,5-6,12-13H,3-4,11H2
Affinity DataKi:  2.30nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558349(CHEMBL4764971)
Show SMILES Cc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H28N2O/c1-18-5-4-6-19(13-18)17-28-24-11-12-25(28)16-23(15-24)27-26(29)22-10-9-20-7-2-3-8-21(20)14-22/h2-10,13-14,23-25H,11-12,15-17H2,1H3,(H,27,29)
Affinity DataKi:  3.30nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558343(CHEMBL4748723)
Show SMILES Clc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25ClN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  3.60nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558339(CHEMBL4744722)
Show SMILES Brc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25BrN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  4.5nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
Affinity DataKi:  8.90nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Show SMILES CCCN(CCC)C1CCc2cccc(O)c2C1
Show InChI InChI=1S/C16H25NO/c1-3-10-17(11-4-2)14-9-8-13-6-5-7-16(18)15(13)12-14/h5-7,14,18H,3-4,8-12H2,1-2H3
Affinity DataKi:  9.40nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558340(CHEMBL4752931)
Show SMILES Brc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25BrN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  12nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50222218(CHEBI:51137 | Mianserin)
Show SMILES CN1CCN2C(C1)c1ccccc1Cc1ccccc21
Show InChI InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3
Affinity DataKi:  18nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558341(CHEMBL4786672)
Show SMILES Brc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25BrN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  23nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558346(CHEMBL4746049)
Show SMILES COc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-8-4-5-18(13-25)17-28-23-11-12-24(28)16-22(15-23)27-26(29)21-10-9-19-6-2-3-7-20(19)14-21/h2-10,13-14,22-24H,11-12,15-17H2,1H3,(H,27,29)
Affinity DataKi:  26nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558351(CHEMBL4793624)
Show SMILES COc1cc(nc2ccccc12)C(=O)NC1CC2CCC(C1)N2Cc1ccccc1
Show InChI InChI=1S/C25H27N3O2/c1-30-24-15-23(27-22-10-6-5-9-21(22)24)25(29)26-18-13-19-11-12-20(14-18)28(19)16-17-7-3-2-4-8-17/h2-10,15,18-20H,11-14,16H2,1H3,(H,26,29)
Affinity DataKi:  31nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558344(CHEMBL4788272)
Show SMILES Clc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25ClN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  35nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558352(CHEMBL4748538)
Show SMILES O=C(NC1CC2CCC(C1)N2Cc1ccccc1)c1ccc2ccccc2n1
Show InChI InChI=1S/C24H25N3O/c28-24(23-13-10-18-8-4-5-9-22(18)26-23)25-19-14-20-11-12-21(15-19)27(20)16-17-6-2-1-3-7-17/h1-10,13,19-21H,11-12,14-16H2,(H,25,28)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558347(CHEMBL4785742)
Show SMILES COc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-9-5-4-8-21(25)17-28-23-12-13-24(28)16-22(15-23)27-26(29)20-11-10-18-6-2-3-7-19(18)14-20/h2-11,14,22-24H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  77nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558347(CHEMBL4785742)
Show SMILES COc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-9-5-4-8-21(25)17-28-23-12-13-24(28)16-22(15-23)27-26(29)20-11-10-18-6-2-3-7-19(18)14-20/h2-11,14,22-24H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  83nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558335(CHEMBL4792888)
Show SMILES FC(F)(F)c1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H25F3N2O/c27-26(28,29)24-8-4-3-7-20(24)16-31-22-11-12-23(31)15-21(14-22)30-25(32)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,30,32)
Affinity DataKi:  102nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558338(CHEMBL4757614)
Show SMILES Fc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25FN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  106nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558350(CHEMBL4760235)
Show SMILES Cc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N2O/c1-18-6-2-3-9-22(18)17-28-24-12-13-25(28)16-23(15-24)27-26(29)21-11-10-19-7-4-5-8-20(19)14-21/h2-11,14,23-25H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  118nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558334(CHEMBL4789287)
Show SMILES FC(F)(F)c1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H25F3N2O/c27-26(28,29)21-7-3-4-17(12-21)16-31-23-10-11-24(31)15-22(14-23)30-25(32)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,30,32)
Affinity DataKi:  130nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
Affinity DataKi:  130nMAssay Description:Binding affinity to human dopamine D2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558341(CHEMBL4786672)
Show SMILES Brc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25BrN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  136nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558336(CHEMBL4794055)
Show SMILES Fc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25FN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  137nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
Show InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
Affinity DataKi:  140nMAssay Description:Binding affinity to human dopamine D2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558336(CHEMBL4794055)
Show SMILES Fc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25FN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  141nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558344(CHEMBL4788272)
Show SMILES Clc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25ClN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  158nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
Show InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
Affinity DataKi:  180nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558349(CHEMBL4764971)
Show SMILES Cc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H28N2O/c1-18-5-4-6-19(13-18)17-28-24-11-12-25(28)16-23(15-24)27-26(29)22-10-9-20-7-2-3-8-21(20)14-22/h2-10,13-14,23-25H,11-12,15-17H2,1H3,(H,27,29)
Affinity DataKi:  182nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558350(CHEMBL4760235)
Show SMILES Cc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N2O/c1-18-6-2-3-9-22(18)17-28-24-12-13-25(28)16-23(15-24)27-26(29)21-11-10-19-7-4-5-8-20(19)14-21/h2-11,14,23-25H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  193nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558341(CHEMBL4786672)
Show SMILES Brc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25BrN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  196nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558340(CHEMBL4752931)
Show SMILES Brc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25BrN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558334(CHEMBL4789287)
Show SMILES FC(F)(F)c1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H25F3N2O/c27-26(28,29)21-7-3-4-17(12-21)16-31-23-10-11-24(31)15-22(14-23)30-25(32)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,30,32)
Affinity DataKi:  209nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558337(CHEMBL4787037)
Show SMILES Fc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25FN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  211nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558346(CHEMBL4746049)
Show SMILES COc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-8-4-5-18(13-25)17-28-23-11-12-24(28)16-22(15-23)27-26(29)21-10-9-19-6-2-3-7-20(19)14-21/h2-10,13-14,22-24H,11-12,15-17H2,1H3,(H,27,29)
Affinity DataKi:  213nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558337(CHEMBL4787037)
Show SMILES Fc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25FN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  214nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558334(CHEMBL4789287)
Show SMILES FC(F)(F)c1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C26H25F3N2O/c27-26(28,29)21-7-3-4-17(12-21)16-31-23-10-11-24(31)15-22(14-23)30-25(32)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,30,32)
Affinity DataKi:  217nMAssay Description:Displacement of [3H] Spiperone from rat striatum dopamine D2 receptor measured after 30 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558336(CHEMBL4794055)
Show SMILES Fc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25FN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  218nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50095890(2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperaz...)
Show SMILES OCCOCCN1CCN(CC1)C1=Nc2ccccc2Sc2ccccc12
Show InChI InChI=1S/C21H25N3O2S/c25-14-16-26-15-13-23-9-11-24(12-10-23)21-17-5-1-3-7-19(17)27-20-8-4-2-6-18(20)22-21/h1-8,25H,9-16H2
Affinity DataKi:  220nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558339(CHEMBL4744722)
Show SMILES Brc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25BrN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
Affinity DataKi:  230nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558347(CHEMBL4785742)
Show SMILES COc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H28N2O2/c1-30-25-9-5-4-8-21(25)17-28-23-12-13-24(28)16-22(15-23)27-26(29)20-11-10-18-6-2-3-7-19(18)14-20/h2-11,14,22-24H,12-13,15-17H2,1H3,(H,27,29)
Affinity DataKi:  231nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558343(CHEMBL4748723)
Show SMILES Clc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25ClN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  298nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558337(CHEMBL4787037)
Show SMILES Fc1cccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)c1
Show InChI InChI=1S/C25H25FN2O/c26-21-7-3-4-17(12-21)16-28-23-10-11-24(28)15-22(14-23)27-25(29)20-9-8-18-5-1-2-6-19(18)13-20/h1-9,12-13,22-24H,10-11,14-16H2,(H,27,29)
Affinity DataKi:  299nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558332(CHEMBL4751499)
Show SMILES O=C(NC1CC2CCC(C1)N2Cc1ccccn1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H25N3O/c28-24(19-9-8-17-5-1-2-6-18(17)13-19)26-21-14-22-10-11-23(15-21)27(22)16-20-7-3-4-12-25-20/h1-9,12-13,21-23H,10-11,14-16H2,(H,26,28)
Affinity DataKi:  315nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558339(CHEMBL4744722)
Show SMILES Brc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25BrN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  327nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558338(CHEMBL4757614)
Show SMILES Fc1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C25H25FN2O/c26-24-8-4-3-7-20(24)16-28-22-11-12-23(28)15-21(14-22)27-25(29)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  366nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 2A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558342(CHEMBL4754231)
Show SMILES Clc1ccc(CN2C3CCC2CC(C3)NC(=O)c2ccc3ccccc3c2)cc1
Show InChI InChI=1S/C25H25ClN2O/c26-21-9-5-17(6-10-21)16-28-23-11-12-24(28)15-22(14-23)27-25(29)20-8-7-18-3-1-2-4-19(18)13-20/h1-10,13,22-24H,11-12,14-16H2,(H,27,29)
Affinity DataKi:  397nMAssay Description:Displacement of [3H]-ketanserin from rat cerebral cortex 5HT2A receptor measured after 20 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
Medical University of Warsaw

Curated by ChEMBL
LigandPNGBDBM50558335(CHEMBL4792888)
Show SMILES FC(F)(F)c1ccccc1CN1C2CCC1CC(C2)NC(=O)c1ccc2ccccc2c1
Show InChI InChI=1S/C26H25F3N2O/c27-26(28,29)24-8-4-3-7-20(24)16-31-22-11-12-23(31)15-21(14-22)30-25(32)19-10-9-17-5-1-2-6-18(17)13-19/h1-10,13,21-23H,11-12,14-16H2,(H,30,32)
Affinity DataKi:  476nMAssay Description:Displacement of [3H]-8-OH-DPAT from rat cerebral cortex 5HT1A receptor measured after 15 mins by liquid scintillation counter methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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