Compile Data Set for Download or QSAR
Found 36 Enz. Inhib. hit(s) with all data for entry = 50013775
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569506(CHEMBL1520901 | US11452717, Compound TableB-2.28)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C16H17N3O3/c1-2-22-15(20)13-3-5-14(6-4-13)19-16(21)18-11-12-7-9-17-10-8-12/h3-10H,2,11H2,1H3,(H2,18,19,21)
Affinity DataEC50:  3.25E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569541(CHEMBL4859855 | US11452717, Compound TableB-5.29)
Show SMILES FC(F)(F)Oc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)NCc2cnco2)cc1
Show InChI InChI=1S/C18H14F3N3O5S/c19-18(20,21)29-13-2-1-3-16(8-13)30(26,27)15-6-4-12(5-7-15)24-17(25)23-10-14-9-22-11-28-14/h1-9,11H,10H2,(H2,23,24,25)
Affinity DataEC50:  70nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569508(CHEMBL4876305)
Show SMILES CCOC(=O)c1ccc(NC(=O)CCc2ccncc2)cc1
Show InChI InChI=1S/C17H18N2O3/c1-2-22-17(21)14-4-6-15(7-5-14)19-16(20)8-3-13-9-11-18-12-10-13/h4-7,9-12H,2-3,8H2,1H3,(H,19,20)
Affinity DataEC50:  1.59E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569509(CHEMBL4849439)
Show SMILES CCOC(=O)c1ccc(NC(=O)OCc2ccncc2)cc1
Show InChI InChI=1S/C16H16N2O4/c1-2-21-15(19)13-3-5-14(6-4-13)18-16(20)22-11-12-7-9-17-10-8-12/h3-10H,2,11H2,1H3,(H,18,20)
Affinity DataEC50:  1.08E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569510(CHEMBL4873588)
Show SMILES CCOC(=O)c1ccc(NC(=O)N(C)Cc2ccncc2)cc1
Show InChI InChI=1S/C17H19N3O3/c1-3-23-16(21)14-4-6-15(7-5-14)19-17(22)20(2)12-13-8-10-18-11-9-13/h4-11H,3,12H2,1-2H3,(H,19,22)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569511(CHEMBL4856058)
Show SMILES CCOC(=O)c1ccc(cc1)N(C)C(=O)NCc1ccncc1
Show InChI InChI=1S/C17H19N3O3/c1-3-23-16(21)14-4-6-15(7-5-14)20(2)17(22)19-12-13-8-10-18-11-9-13/h4-11H,3,12H2,1-2H3,(H,19,22)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569512(CHEMBL4864044 | US11452717, Compound TableB-3.15)
Show SMILES CCOC(=O)c1ccc(NC(=S)NCc2ccncc2)cc1
Show InChI InChI=1S/C16H17N3O2S/c1-2-21-15(20)13-3-5-14(6-4-13)19-16(22)18-11-12-7-9-17-10-8-12/h3-10H,2,11H2,1H3,(H2,18,19,22)
Affinity DataEC50:  9.77E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569513(CHEMBL4858899)
Show SMILES CCOC(=O)c1ccc(N\C(NCc2ccncc2)=N/C#N)cc1
Show InChI InChI=1S/C17H17N5O2/c1-2-24-16(23)14-3-5-15(6-4-14)22-17(21-12-18)20-11-13-7-9-19-10-8-13/h3-10H,2,11H2,1H3,(H2,20,21,22)
Affinity DataEC50:  4.14E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569514(CHEMBL1460701 | US11452717, Compound TableB-3.16)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2ccccc2)cc1
Show InChI InChI=1S/C17H18N2O3/c1-2-22-16(20)14-8-10-15(11-9-14)19-17(21)18-12-13-6-4-3-5-7-13/h3-11H,2,12H2,1H3,(H2,18,19,21)
Affinity DataEC50:  1.37E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569515(CHEMBL4847790 | US11452717, Compound TableB-3.21)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2ccnnc2)cc1
Show InChI InChI=1S/C15H16N4O3/c1-2-22-14(20)12-3-5-13(6-4-12)19-15(21)16-9-11-7-8-17-18-10-11/h3-8,10H,2,9H2,1H3,(H2,16,19,21)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569516(CHEMBL4868902)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2ccncn2)cc1
Show InChI InChI=1S/C15H16N4O3/c1-2-22-14(20)11-3-5-12(6-4-11)19-15(21)17-9-13-7-8-16-10-18-13/h3-8,10H,2,9H2,1H3,(H2,17,19,21)
Affinity DataEC50:  1.36E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569517(CHEMBL4879262)
Show SMILES CCOC(=O)c1ccc(NC(=O)NC(C)c2ccncc2)cc1
Show InChI InChI=1S/C17H19N3O3/c1-3-23-16(21)14-4-6-15(7-5-14)20-17(22)19-12(2)13-8-10-18-11-9-13/h4-12H,3H2,1-2H3,(H2,19,20,22)
Affinity DataEC50:  2.28E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569518(CHEMBL4873308 | US11452717, Compound TableB-1.1)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2cn[nH]c2)cc1
Show InChI InChI=1S/C14H16N4O3/c1-2-21-13(19)11-3-5-12(6-4-11)18-14(20)15-7-10-8-16-17-9-10/h3-6,8-9H,2,7H2,1H3,(H,16,17)(H2,15,18,20)
Affinity DataEC50:  1.85E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569519(CHEMBL4850097 | US11452717, Compound TableB-1.16)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2cc[nH]n2)cc1
Show InChI InChI=1S/C14H16N4O3/c1-2-21-13(19)10-3-5-11(6-4-10)17-14(20)15-9-12-7-8-16-18-12/h3-8H,2,9H2,1H3,(H,16,18)(H2,15,17,20)
Affinity DataEC50:  6.90E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569520(CHEMBL4860765 | US11452717, Compound TableB-1.11)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2cnco2)cc1
Show InChI InChI=1S/C14H15N3O4/c1-2-20-13(18)10-3-5-11(6-4-10)17-14(19)16-8-12-7-15-9-21-12/h3-7,9H,2,8H2,1H3,(H2,16,17,19)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569521(CHEMBL4848681 | US11452717, Compound TableB-1.2)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2cocn2)cc1
Show InChI InChI=1S/C14H15N3O4/c1-2-21-13(18)10-3-5-11(6-4-10)17-14(19)15-7-12-8-20-9-16-12/h3-6,8-9H,2,7H2,1H3,(H2,15,17,19)
Affinity DataEC50:  2.76E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569522(CHEMBL4867843 | US11452717, Compound TableB-1.19)
Show SMILES CCOC(=O)c1ccc(NC(=O)NCc2c[nH]nn2)cc1
Show InChI InChI=1S/C13H15N5O3/c1-2-21-12(19)9-3-5-10(6-4-9)16-13(20)14-7-11-8-15-18-17-11/h3-6,8H,2,7H2,1H3,(H2,14,16,20)(H,15,17,18)
Affinity DataEC50:  7.75E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569523(CHEMBL4846686 | US11452717, Compound TableB-2.190)
Show SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)N1CC2CCC(C1)O2
Show InChI InChI=1S/C19H22N4O4S/c24-19(21-11-14-7-9-20-10-8-14)22-15-1-5-18(6-2-15)28(25,26)23-12-16-3-4-17(13-23)27-16/h1-2,5-10,16-17H,3-4,11-13H2,(H2,21,22,24)
Affinity DataEC50:  279nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569524(CHEMBL4870791 | US11452717, Compound TableB-2.103)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C13H14N4O3S/c14-21(19,20)12-3-1-11(2-4-12)17-13(18)16-9-10-5-7-15-8-6-10/h1-8H,9H2,(H2,14,19,20)(H2,16,17,18)
Affinity DataEC50:  1.43E+4nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569525(CHEMBL4855512 | US11452717, Compound TableB-2.104)
Show SMILES CNS(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C14H16N4O3S/c1-15-22(20,21)13-4-2-12(3-5-13)18-14(19)17-10-11-6-8-16-9-7-11/h2-9,15H,10H2,1H3,(H2,17,18,19)
Affinity DataEC50:  3.23E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569526(CHEMBL4876062 | US11452717, Compound TableB-2.162)
Show SMILES CN(C)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C15H18N4O3S/c1-19(2)23(21,22)14-5-3-13(4-6-14)18-15(20)17-11-12-7-9-16-10-8-12/h3-10H,11H2,1-2H3,(H2,17,18,20)
Affinity DataEC50:  3.11E+3nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569527(CHEMBL4865311 | US11452717, Compound TableB-2.163)
Show SMILES CCN(CC)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C17H22N4O3S/c1-3-21(4-2)25(23,24)16-7-5-15(6-8-16)20-17(22)19-13-14-9-11-18-12-10-14/h5-12H,3-4,13H2,1-2H3,(H2,19,20,22)
Affinity DataEC50:  384nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569528(CHEMBL4873259 | US11452717, Compound TableB-2.165)
Show SMILES CN(C1CCCC1)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C19H24N4O3S/c1-23(17-4-2-3-5-17)27(25,26)18-8-6-16(7-9-18)22-19(24)21-14-15-10-12-20-13-11-15/h6-13,17H,2-5,14H2,1H3,(H2,21,22,24)
Affinity DataEC50:  123nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569529(CHEMBL4867743 | US11452717, Compound TableB-2.173)
Show SMILES CCN(C1CCCC1)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C20H26N4O3S/c1-2-24(18-5-3-4-6-18)28(26,27)19-9-7-17(8-10-19)23-20(25)22-15-16-11-13-21-14-12-16/h7-14,18H,2-6,15H2,1H3,(H2,22,23,25)
Affinity DataEC50:  60nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569530(CHEMBL4860473 | US11452717, Compound TableB-2.198)
Show SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)Nc1ccccc1
Show InChI InChI=1S/C19H18N4O3S/c24-19(21-14-15-10-12-20-13-11-15)22-16-6-8-18(9-7-16)27(25,26)23-17-4-2-1-3-5-17/h1-13,23H,14H2,(H2,21,22,24)
Affinity DataEC50:  410nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569531(CHEMBL4877035 | US11452717, Compound TableB-2.127)
Show SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)NCc1ccccc1
Show InChI InChI=1S/C20H20N4O3S/c25-20(22-14-17-10-12-21-13-11-17)24-18-6-8-19(9-7-18)28(26,27)23-15-16-4-2-1-3-5-16/h1-13,23H,14-15H2,(H2,22,24,25)
Affinity DataEC50:  102nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569532(CHEMBL4848112 | US11452717, Compound TableB-2.191)
Show SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)N1CCc2ccccc2C1
Show InChI InChI=1S/C22H22N4O3S/c27-22(24-15-17-9-12-23-13-10-17)25-20-5-7-21(8-6-20)30(28,29)26-14-11-18-3-1-2-4-19(18)16-26/h1-10,12-13H,11,14-16H2,(H2,24,25,27)
Affinity DataEC50:  142nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569533(CHEMBL4858231 | US11452717, Compound TableB-2.166)
Show SMILES CN(Cc1ccccc1)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C21H22N4O3S/c1-25(16-18-5-3-2-4-6-18)29(27,28)20-9-7-19(8-10-20)24-21(26)23-15-17-11-13-22-14-12-17/h2-14H,15-16H2,1H3,(H2,23,24,26)
Affinity DataEC50:  23nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569534(CHEMBL4868692 | US11452717, Compound TableB-2.224)
Show SMILES O=C(NCc1ccncc1)Nc1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C19H17N3O3S/c23-19(21-14-15-10-12-20-13-11-15)22-16-6-8-18(9-7-16)26(24,25)17-4-2-1-3-5-17/h1-13H,14H2,(H2,21,22,23)
Affinity DataEC50:  85nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569535(CHEMBL4856434 | US11452717, Compound TableB-2.221)
Show SMILES Clc1ccccc1S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C19H16ClN3O3S/c20-17-3-1-2-4-18(17)27(25,26)16-7-5-15(6-8-16)23-19(24)22-13-14-9-11-21-12-10-14/h1-12H,13H2,(H2,22,23,24)
Affinity DataEC50:  79nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569536(CHEMBL4852773 | US11452717, Compound TableB-2.219)
Show SMILES Clc1cccc(c1)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C19H16ClN3O3S/c20-15-2-1-3-18(12-15)27(25,26)17-6-4-16(5-7-17)23-19(24)22-13-14-8-10-21-11-9-14/h1-12H,13H2,(H2,22,23,24)
Affinity DataEC50:  69nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569537(CHEMBL4871017 | US11452717, Compound TableB-2.220)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C19H16ClN3O3S/c20-15-1-5-17(6-2-15)27(25,26)18-7-3-16(4-8-18)23-19(24)22-13-14-9-11-21-12-10-14/h1-12H,13H2,(H2,22,23,24)
Affinity DataEC50:  126nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569538(CHEMBL4859010 | US11452717, Compound TableB-1.48)
Show SMILES O=C(NCc1cn[nH]c1)Nc1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H16N4O3S/c22-17(18-10-13-11-19-20-12-13)21-14-6-8-16(9-7-14)25(23,24)15-4-2-1-3-5-15/h1-9,11-12H,10H2,(H,19,20)(H2,18,21,22)
Affinity DataEC50:  28nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM572570(1-[4-(4-Chloro-benzenesulfonyl)-phenyl]-3-(1H-pyra...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)c1ccc(NC(=O)NCC2=CN[H]=C2)cc1
Show InChI InChI=1S/C17H16ClN3O3S/c18-13-1-5-15(6-2-13)25(23,24)16-7-3-14(4-8-16)21-17(22)19-9-12-10-20-26-11-12/h1-8,10-11,20H,9H2,(H2,19,21,22)
Affinity DataEC50:  23nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPurchase
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569540(CHEMBL4868976 | US11452717, Compound TableB-1.47)
Show SMILES O=C(NCc1cnco1)Nc1ccc(cc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O4S/c21-17(19-11-14-10-18-12-24-14)20-13-6-8-16(9-7-13)25(22,23)15-4-2-1-3-5-15/h1-10,12H,11H2,(H2,19,20,21)
Affinity DataEC50:  77nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNicotinamide phosphoribosyltransferase(Homo sapiens (Human))
Sanford Burnham Prebys Medical Discovery Institute

Curated by ChEMBL
LigandPNGBDBM50569507(CHEMBL4879143)
Show SMILES CCOC(=O)c1ccc(CC(=O)NCc2ccncc2)cc1
Show InChI InChI=1S/C17H18N2O3/c1-2-22-17(21)15-5-3-13(4-6-15)11-16(20)19-12-14-7-9-18-10-8-14/h3-10H,2,11-12H2,1H3,(H,19,20)
Affinity DataEC50: >1.00E+5nMAssay Description:Activation of human NAMPTMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid