Compile Data Set for Download or QSAR
Found 60 Enz. Inhib. hit(s) with all data for entry = 50014036
LigandPNGBDBM50571993(CHEMBL4871213)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-n3ccnc3)c2c1
Show InChI InChI=1S/C22H15ClN6O2S/c23-22-20(28-32(30,31)17-4-2-1-3-5-17)11-16(12-25-22)15-6-7-19-18(10-15)21(13-26-27-19)29-9-8-24-14-29/h1-14,28H
Affinity DataIC50: 0.210nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571998(CHEMBL4872728)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C28H23ClN6O3S/c29-28-26(34-39(36,37)22-4-2-1-3-5-22)15-21(17-31-28)19-6-8-25-23(14-19)24(18-32-33-25)20-7-9-27(30-16-20)35-10-12-38-13-11-35/h1-9,14-18,34H,10-13H2
Affinity DataIC50: 0.280nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571987(CHEMBL4878126)
Show SMILES CC1CCN(CC1)c1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H24ClN5O2S/c1-17-9-11-31(12-10-17)24-16-28-29-22-8-7-18(13-21(22)24)19-14-23(25(26)27-15-19)30-34(32,33)20-5-3-2-4-6-20/h2-8,13-17,30H,9-12H2,1H3
Affinity DataIC50: 0.320nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571994(CHEMBL4864419)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H16ClN5O2S/c25-24-23(30-33(31,32)19-4-2-1-3-5-19)13-18(14-27-24)17-6-7-22-20(12-17)21(15-28-29-22)16-8-10-26-11-9-16/h1-15,30H
Affinity DataIC50: 0.360nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571996(CHEMBL4853440)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C29H24ClN5O3S/c30-29-28(34-39(36,37)24-4-2-1-3-5-24)17-22(18-31-29)21-8-11-27-25(16-21)26(19-32-33-27)20-6-9-23(10-7-20)35-12-14-38-15-13-35/h1-11,16-19,34H,12-15H2
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571990(CHEMBL4860613)
Show SMILES CCOc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H17ClN4O3S/c1-2-29-20-13-24-25-18-9-8-14(10-17(18)20)15-11-19(21(22)23-12-15)26-30(27,28)16-6-4-3-5-7-16/h3-13,26H,2H2,1H3
Affinity DataIC50: 0.400nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571979(CHEMBL4861043)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(Cl)c2c1
Show InChI InChI=1S/C19H12Cl2N4O2S/c20-16-11-23-24-17-7-6-12(8-15(16)17)13-9-18(19(21)22-10-13)25-28(26,27)14-4-2-1-3-5-14/h1-11,25H
Affinity DataIC50: 0.550nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571997(CHEMBL4871838)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3cnc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H22ClN7O3S/c28-26-25(34-39(36,37)21-4-2-1-3-5-21)13-19(14-29-26)18-6-7-24-22(12-18)23(17-32-33-24)20-15-30-27(31-16-20)35-8-10-38-11-9-35/h1-7,12-17,34H,8-11H2
Affinity DataIC50: 0.650nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50571986(CHEMBL4876806)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCCC3)c2c1
Show InChI InChI=1S/C24H22ClN5O2S/c25-24-22(29-33(31,32)19-7-3-1-4-8-19)14-18(15-26-24)17-9-10-21-20(13-17)23(16-27-28-21)30-11-5-2-6-12-30/h1,3-4,7-10,13-16,29H,2,5-6,11-12H2
Affinity DataIC50: 0.670nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571998(CHEMBL4872728)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C28H23ClN6O3S/c29-28-26(34-39(36,37)22-4-2-1-3-5-22)15-21(17-31-28)19-6-8-25-23(14-19)24(18-32-33-25)20-7-9-27(30-16-20)35-10-12-38-13-11-35/h1-9,14-18,34H,10-13H2
Affinity DataIC50: 0.709nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571994(CHEMBL4864419)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H16ClN5O2S/c25-24-23(30-33(31,32)19-4-2-1-3-5-19)13-18(14-27-24)17-6-7-22-20(12-17)21(15-28-29-22)16-8-10-26-11-9-16/h1-15,30H
Affinity DataIC50: 0.710nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571996(CHEMBL4853440)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C29H24ClN5O3S/c30-29-28(34-39(36,37)24-4-2-1-3-5-24)17-22(18-31-29)21-8-11-27-25(16-21)26(19-32-33-27)20-6-9-23(10-7-20)35-12-14-38-15-13-35/h1-11,16-19,34H,12-15H2
Affinity DataIC50: 0.711nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571973(CHEMBL4850400)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O3S/c24-23-21(28-33(30,31)18-4-2-1-3-5-18)13-17(14-25-23)16-6-7-20-19(12-16)22(15-26-27-20)29-8-10-32-11-9-29/h1-7,12-15,28H,8-11H2
Affinity DataIC50: 0.850nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571985(CHEMBL4845684)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O2S/c24-23-21(28-32(30,31)18-6-2-1-3-7-18)13-17(14-25-23)16-8-9-20-19(12-16)22(15-26-27-20)29-10-4-5-11-29/h1-3,6-9,12-15,28H,4-5,10-11H2
Affinity DataIC50: 0.870nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571997(CHEMBL4871838)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3cnc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H22ClN7O3S/c28-26-25(34-39(36,37)21-4-2-1-3-5-21)13-19(14-29-26)18-6-7-24-22(12-18)23(17-32-33-24)20-15-30-27(31-16-20)35-8-10-38-11-9-35/h1-7,12-17,34H,8-11H2
Affinity DataIC50: 0.936nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50571982(CHEMBL4865798)
Show SMILES COc1ccc(CNc2cnnc3ccc(cc23)-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)cc1
Show InChI InChI=1S/C27H22ClN5O3S/c1-36-21-10-7-18(8-11-21)15-29-26-17-31-32-24-12-9-19(13-23(24)26)20-14-25(27(28)30-16-20)33-37(34,35)22-5-3-2-4-6-22/h2-14,16-17,33H,15H2,1H3,(H,29,32)
Affinity DataIC50: 1nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571989(CHEMBL4846935)
Show SMILES COc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C20H15ClN4O3S/c1-28-19-12-23-24-17-8-7-13(9-16(17)19)14-10-18(20(21)22-11-14)25-29(26,27)15-5-3-2-4-6-15/h2-12,25H,1H3
Affinity DataIC50: 1.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571986(CHEMBL4876806)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCCC3)c2c1
Show InChI InChI=1S/C24H22ClN5O2S/c25-24-22(29-33(31,32)19-7-3-1-4-8-19)14-18(15-26-24)17-9-10-21-20(13-17)23(16-27-28-21)30-11-5-2-6-12-30/h1,3-4,7-10,13-16,29H,2,5-6,11-12H2
Affinity DataIC50: 1.30nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571993(CHEMBL4871213)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-n3ccnc3)c2c1
Show InChI InChI=1S/C22H15ClN6O2S/c23-22-20(28-32(30,31)17-4-2-1-3-5-17)11-16(12-25-22)15-6-7-19-18(10-15)21(13-26-27-19)29-9-8-24-14-29/h1-14,28H
Affinity DataIC50: 1.40nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571998(CHEMBL4872728)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C28H23ClN6O3S/c29-28-26(34-39(36,37)22-4-2-1-3-5-22)15-21(17-31-28)19-6-8-25-23(14-19)24(18-32-33-25)20-7-9-27(30-16-20)35-10-12-38-13-11-35/h1-9,14-18,34H,10-13H2
Affinity DataIC50: 1.5nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571973(CHEMBL4850400)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O3S/c24-23-21(28-33(30,31)18-4-2-1-3-5-18)13-17(14-25-23)16-6-7-20-19(12-16)22(15-26-27-20)29-8-10-32-11-9-29/h1-7,12-15,28H,8-11H2
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571988(CHEMBL4865341)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCNCC3)c2c1
Show InChI InChI=1S/C23H21ClN6O2S/c24-23-21(29-33(31,32)18-4-2-1-3-5-18)13-17(14-26-23)16-6-7-20-19(12-16)22(15-27-28-20)30-10-8-25-9-11-30/h1-7,12-15,25,29H,8-11H2
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571987(CHEMBL4878126)
Show SMILES CC1CCN(CC1)c1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H24ClN5O2S/c1-17-9-11-31(12-10-17)24-16-28-29-22-8-7-18(13-21(22)24)19-14-23(25(26)27-15-19)30-34(32,33)20-5-3-2-4-6-20/h2-8,13-17,30H,9-12H2,1H3
Affinity DataIC50: 1.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571994(CHEMBL4864419)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H16ClN5O2S/c25-24-23(30-33(31,32)19-4-2-1-3-5-19)13-18(14-27-24)17-6-7-22-20(12-17)21(15-28-29-22)16-8-10-26-11-9-16/h1-15,30H
Affinity DataIC50: 1.70nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571990(CHEMBL4860613)
Show SMILES CCOc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H17ClN4O3S/c1-2-29-20-13-24-25-18-9-8-14(10-17(18)20)15-11-19(21(22)23-12-15)26-30(27,28)16-6-4-3-5-7-16/h3-13,26H,2H2,1H3
Affinity DataIC50: 1.80nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571998(CHEMBL4872728)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C28H23ClN6O3S/c29-28-26(34-39(36,37)22-4-2-1-3-5-22)15-21(17-31-28)19-6-8-25-23(14-19)24(18-32-33-25)20-7-9-27(30-16-20)35-10-12-38-13-11-35/h1-9,14-18,34H,10-13H2
Affinity DataIC50: 1.90nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571994(CHEMBL4864419)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccncc3)c2c1
Show InChI InChI=1S/C24H16ClN5O2S/c25-24-23(30-33(31,32)19-4-2-1-3-5-19)13-18(14-27-24)17-6-7-22-20(12-17)21(15-28-29-22)16-8-10-26-11-9-16/h1-15,30H
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571996(CHEMBL4853440)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C29H24ClN5O3S/c30-29-28(34-39(36,37)24-4-2-1-3-5-24)17-22(18-31-29)21-8-11-27-25(16-21)26(19-32-33-27)20-6-9-23(10-7-20)35-12-14-38-15-13-35/h1-11,16-19,34H,12-15H2
Affinity DataIC50: 2.30nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571993(CHEMBL4871213)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-n3ccnc3)c2c1
Show InChI InChI=1S/C22H15ClN6O2S/c23-22-20(28-32(30,31)17-4-2-1-3-5-17)11-16(12-25-22)15-6-7-19-18(10-15)21(13-26-27-19)29-9-8-24-14-29/h1-14,28H
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571985(CHEMBL4845684)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O2S/c24-23-21(28-32(30,31)18-6-2-1-3-7-18)13-17(14-25-23)16-8-9-20-19(12-16)22(15-26-27-20)29-10-4-5-11-29/h1-3,6-9,12-15,28H,4-5,10-11H2
Affinity DataIC50: 2.60nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571995(CHEMBL4872806)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccccc3)c2c1
Show InChI InChI=1S/C25H17ClN4O2S/c26-25-24(30-33(31,32)20-9-5-2-6-10-20)14-19(15-27-25)18-11-12-23-21(13-18)22(16-28-29-23)17-7-3-1-4-8-17/h1-16,30H
Affinity DataIC50: 2.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571996(CHEMBL4853440)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3ccc(cc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C29H24ClN5O3S/c30-29-28(34-39(36,37)24-4-2-1-3-5-24)17-22(18-31-29)21-8-11-27-25(16-21)26(19-32-33-27)20-6-9-23(10-7-20)35-12-14-38-15-13-35/h1-11,16-19,34H,12-15H2
Affinity DataIC50: 3nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM25045(3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin...)
Show SMILES Oc1cccc(c1)-c1nc(N2CCOCC2)c2oc3ncccc3c2n1
Show InChI InChI=1S/C19H16N4O3/c24-13-4-1-3-12(11-13)17-21-15-14-5-2-6-20-19(14)26-16(15)18(22-17)23-7-9-25-10-8-23/h1-6,11,24H,7-10H2
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kalpha (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50571986(CHEMBL4876806)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCCC3)c2c1
Show InChI InChI=1S/C24H22ClN5O2S/c25-24-22(29-33(31,32)19-7-3-1-4-8-19)14-18(15-26-24)17-9-10-21-20(13-17)23(16-27-28-21)30-11-5-2-6-12-30/h1,3-4,7-10,13-16,29H,2,5-6,11-12H2
Affinity DataIC50: 3.20nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571977(CHEMBL4852849)
Show SMILES CC(=O)Nc1ccc(Nc2cnnc3ccc(cc23)-c2cnc(Cl)c(NS(=O)(=O)c3ccccc3)c2)cc1
Show InChI InChI=1S/C27H21ClN6O3S/c1-17(35)31-20-8-10-21(11-9-20)32-26-16-30-33-24-12-7-18(13-23(24)26)19-14-25(27(28)29-15-19)34-38(36,37)22-5-3-2-4-6-22/h2-16,34H,1H3,(H,31,35)(H,32,33)
Affinity DataIC50: 3.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571987(CHEMBL4878126)
Show SMILES CC1CCN(CC1)c1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H24ClN5O2S/c1-17-9-11-31(12-10-17)24-16-28-29-22-8-7-18(13-21(22)24)19-14-23(25(26)27-15-19)30-34(32,33)20-5-3-2-4-6-20/h2-8,13-17,30H,9-12H2,1H3
Affinity DataIC50: 3.70nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571993(CHEMBL4871213)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-n3ccnc3)c2c1
Show InChI InChI=1S/C22H15ClN6O2S/c23-22-20(28-32(30,31)17-4-2-1-3-5-17)11-16(12-25-22)15-6-7-19-18(10-15)21(13-26-27-19)29-9-8-24-14-29/h1-14,28H
Affinity DataIC50: 4nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571974(CHEMBL4867375)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCOCC3)c2c1
Show InChI InChI=1S/C24H23N5O4S/c1-32-24-22(28-34(30,31)19-5-3-2-4-6-19)14-18(15-25-24)17-7-8-21-20(13-17)23(16-26-27-21)29-9-11-33-12-10-29/h2-8,13-16,28H,9-12H2,1H3
Affinity DataIC50: 4.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571997(CHEMBL4871838)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3cnc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H22ClN7O3S/c28-26-25(34-39(36,37)21-4-2-1-3-5-21)13-19(14-29-26)18-6-7-24-22(12-18)23(17-32-33-24)20-15-30-27(31-16-20)35-8-10-38-11-9-35/h1-7,12-17,34H,8-11H2
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50571973(CHEMBL4850400)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCOCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O3S/c24-23-21(28-33(30,31)18-4-2-1-3-5-18)13-17(14-25-23)16-6-7-20-19(12-16)22(15-26-27-20)29-8-10-32-11-9-29/h1-7,12-15,28H,8-11H2
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571980(CHEMBL4846081)
Show SMILES COc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(Cl)c2c1
Show InChI InChI=1S/C20H15ClN4O3S/c1-28-20-19(25-29(26,27)15-5-3-2-4-6-15)10-14(11-22-20)13-7-8-18-16(9-13)17(21)12-23-24-18/h2-12,25H,1H3
Affinity DataIC50: 4.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571975(CHEMBL4867433)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(Nc3ccccc3)c2c1
Show InChI InChI=1S/C25H18ClN5O2S/c26-25-23(31-34(32,33)20-9-5-2-6-10-20)14-18(15-27-25)17-11-12-22-21(13-17)24(16-28-30-22)29-19-7-3-1-4-8-19/h1-16,31H,(H,29,30)
Affinity DataIC50: 4.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571986(CHEMBL4876806)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCCC3)c2c1
Show InChI InChI=1S/C24H22ClN5O2S/c25-24-22(29-33(31,32)19-7-3-1-4-8-19)14-18(15-26-24)17-9-10-21-20(13-17)23(16-27-28-21)30-11-5-2-6-12-30/h1,3-4,7-10,13-16,29H,2,5-6,11-12H2
Affinity DataIC50: 4.60nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571990(CHEMBL4860613)
Show SMILES CCOc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H17ClN4O3S/c1-2-29-20-13-24-25-18-9-8-14(10-17(18)20)15-11-19(21(22)23-12-15)26-30(27,28)16-6-4-3-5-7-16/h3-13,26H,2H2,1H3
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571997(CHEMBL4871838)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(-c3cnc(nc3)N3CCOCC3)c2c1
Show InChI InChI=1S/C27H22ClN7O3S/c28-26-25(34-39(36,37)21-4-2-1-3-5-21)13-19(14-29-26)18-6-7-24-22(12-18)23(17-32-33-24)20-15-30-27(31-16-20)35-8-10-38-11-9-35/h1-7,12-17,34H,8-11H2
Affinity DataIC50: 4.70nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
LigandPNGBDBM50571987(CHEMBL4878126)
Show SMILES CC1CCN(CC1)c1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C25H24ClN5O2S/c1-17-9-11-31(12-10-17)24-16-28-29-22-8-7-18(13-21(22)24)19-14-23(25(26)27-15-19)30-34(32,33)20-5-3-2-4-6-20/h2-8,13-17,30H,9-12H2,1H3
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571985(CHEMBL4845684)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O2S/c24-23-21(28-32(30,31)18-6-2-1-3-7-18)13-17(14-25-23)16-8-9-20-19(12-16)22(15-26-27-20)29-10-4-5-11-29/h1-3,6-9,12-15,28H,4-5,10-11H2
Affinity DataIC50: 5.40nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571983(CHEMBL4851945)
Show SMILES C[C@@H](Nc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1)c1ccccc1
Show InChI InChI=1S/C27H22ClN5O2S/c1-18(19-8-4-2-5-9-19)31-26-17-30-32-24-13-12-20(14-23(24)26)21-15-25(27(28)29-16-21)33-36(34,35)22-10-6-3-7-11-22/h2-18,33H,1H3,(H,31,32)/t18-/m1/s1
Affinity DataIC50: 5.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571990(CHEMBL4860613)
Show SMILES CCOc1cnnc2ccc(cc12)-c1cnc(Cl)c(NS(=O)(=O)c2ccccc2)c1
Show InChI InChI=1S/C21H17ClN4O3S/c1-2-29-20-13-24-25-18-9-8-14(10-17(18)20)15-11-19(21(22)23-12-15)26-30(27,28)16-6-4-3-5-7-16/h3-13,26H,2H2,1H3
Affinity DataIC50: 5.60nMAssay Description:Inhibition of PI3Kbeta (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
LigandPNGBDBM50571985(CHEMBL4845684)
Show SMILES Clc1ncc(cc1NS(=O)(=O)c1ccccc1)-c1ccc2nncc(N3CCCC3)c2c1
Show InChI InChI=1S/C23H20ClN5O2S/c24-23-21(28-32(30,31)18-6-2-1-3-7-18)13-17(14-25-23)16-8-9-20-19(12-16)22(15-26-27-20)29-10-4-5-11-29/h1-3,6-9,12-15,28H,4-5,10-11H2
Affinity DataIC50: 6nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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