Compile Data Set for Download or QSAR
Found 41 Enz. Inhib. hit(s) with all data for entry = 50014101
Target1,3-beta-glucan synthase component GSC2(Saccharomyces cerevisiae)
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572670(CHEMBL4872371)
Show SMILES FC(F)(F)c1ccc(OCC2CN(C2)C(=O)NCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C21H20F3N3O2/c22-21(23,24)17-2-4-18(5-3-17)29-13-15-11-27(12-15)20(28)26-10-14-1-6-19-16(9-14)7-8-25-19/h1-9,15,25H,10-13H2,(H,26,28)
Affinity DataIC50: 4.60E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells measured after 7 to 10 mins at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
Target1,3-beta-glucan synthase component GSC2(Saccharomyces cerevisiae)
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572638(CHEMBL4873077)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H26N4O2/c1-17-3-5-18(6-4-17)16-26-11-13-27(14-12-26)23(29)22(28)24-20-7-8-21-19(15-20)9-10-25(21)2/h3-10,15H,11-14,16H2,1-2H3,(H,24,28)
Affinity DataIC50: 7.50E+3nMAssay Description:Inhibition of human ERG channel expressed in CHO cells measured after 7 to 10 mins at -80 mV holding potential by whole cell patch clamp assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572636(CHEMBL4846787)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H25N3O3/c1-16-3-6-19(7-4-16)29-20-10-13-26(14-11-20)23(28)22(27)24-18-5-8-21-17(15-18)9-12-25(21)2/h3-9,12,15,20H,10-11,13-14H2,1-2H3,(H,24,27)
Affinity DataEC50:  120nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572637(CHEMBL4875161)
Show SMILES Cc1ccc(OCC2CN(C2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H23N3O3/c1-15-3-6-19(7-4-15)28-14-16-12-25(13-16)22(27)21(26)23-18-5-8-20-17(11-18)9-10-24(20)2/h3-11,16H,12-14H2,1-2H3,(H,23,26)
Affinity DataEC50:  3.00E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572638(CHEMBL4873077)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H26N4O2/c1-17-3-5-18(6-4-17)16-26-11-13-27(14-12-26)23(29)22(28)24-20-7-8-21-19(15-20)9-10-25(21)2/h3-10,15H,11-14,16H2,1-2H3,(H,24,28)
Affinity DataEC50:  90nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572639(CHEMBL4868738)
Show SMILES Cc1ccc(CN2CCC(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C24H27N3O2/c1-17-3-5-18(6-4-17)16-27-13-10-19(11-14-27)23(28)24(29)25-21-7-8-22-20(15-21)9-12-26(22)2/h3-9,12,15,19H,10-11,13-14,16H2,1-2H3,(H,25,29)
Affinity DataEC50:  600nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572640(CHEMBL4848669)
Show SMILES Cc1ccc(O[C@H]2CC[C@@H](CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cn1
Show InChI InChI=1S/C23H25N3O3/c1-15-3-7-20(14-24-15)29-19-8-4-16(5-9-19)22(27)23(28)25-18-6-10-21-17(13-18)11-12-26(21)2/h3,6-7,10-14,16,19H,4-5,8-9H2,1-2H3,(H,25,28)/t16-,19-
Affinity DataEC50:  670nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572641(CHEMBL4854435)
Show SMILES Cc1ccc(Oc2ccc(cc2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C24H20N2O3/c1-16-3-8-20(9-4-16)29-21-10-5-17(6-11-21)23(27)24(28)25-19-7-12-22-18(15-19)13-14-26(22)2/h3-15H,1-2H3,(H,25,28)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572642(CHEMBL4871951)
Show SMILES Cc1ccc(Oc2ccc(cn2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H19N3O3/c1-15-3-7-19(8-4-15)29-21-10-5-17(14-24-21)22(27)23(28)25-18-6-9-20-16(13-18)11-12-26(20)2/h3-14H,1-2H3,(H,25,28)
Affinity DataEC50:  130nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572643(CHEMBL4877754)
Show SMILES Cc1ccc(Oc2cnc(cn2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H18N4O3/c1-14-3-6-17(7-4-14)29-20-13-23-18(12-24-20)21(27)22(28)25-16-5-8-19-15(11-16)9-10-26(19)2/h3-13H,1-2H3,(H,25,28)
Affinity DataEC50:  650nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572644(CHEMBL4865579)
Show SMILES Cc1cn(C)c2ccc(NC(=O)C(=O)N3CCN(Cc4ccc(C)cc4)CC3)cc12
Show InChI InChI=1S/C24H28N4O2/c1-17-4-6-19(7-5-17)16-27-10-12-28(13-11-27)24(30)23(29)25-20-8-9-22-21(14-20)18(2)15-26(22)3/h4-9,14-15H,10-13,16H2,1-3H3,(H,25,29)
Affinity DataEC50:  920nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572645(CHEMBL4846975)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3c(F)cn(C)c3c2)cc1
Show InChI InChI=1S/C23H25FN4O2/c1-16-3-5-17(6-4-16)14-27-9-11-28(12-10-27)23(30)22(29)25-18-7-8-19-20(24)15-26(2)21(19)13-18/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,29)
Affinity DataEC50:  1.40E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572646(CHEMBL4859273)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2cc3ccn(C)c3cc2F)cc1
Show InChI InChI=1S/C23H25FN4O2/c1-16-3-5-17(6-4-16)15-27-9-11-28(12-10-27)23(30)22(29)25-20-13-18-7-8-26(2)21(18)14-19(20)24/h3-8,13-14H,9-12,15H2,1-2H3,(H,25,29)
Affinity DataEC50:  900nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572647(CHEMBL4855001)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)cc(F)c3c2)cc1
Show InChI InChI=1S/C23H25FN4O2/c1-16-3-5-17(6-4-16)14-27-9-11-28(12-10-27)23(30)22(29)25-18-7-8-21-19(13-18)20(24)15-26(21)2/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,29)
Affinity DataEC50:  85nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572648(CHEMBL4863064)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)cc(Cl)c3c2)cc1
Show InChI InChI=1S/C23H25ClN4O2/c1-16-3-5-17(6-4-16)14-27-9-11-28(12-10-27)23(30)22(29)25-18-7-8-21-19(13-18)20(24)15-26(21)2/h3-8,13,15H,9-12,14H2,1-2H3,(H,25,29)
Affinity DataEC50:  420nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572649(CHEMBL4847388)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2cc(F)c3[nH]ccc3c2)cc1
Show InChI InChI=1S/C22H23FN4O2/c1-15-2-4-16(5-3-15)14-26-8-10-27(11-9-26)22(29)21(28)25-18-12-17-6-7-24-20(17)19(23)13-18/h2-7,12-13,24H,8-11,14H2,1H3,(H,25,28)
Affinity DataEC50:  110nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572650(CHEMBL4868623)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2cnc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H25N5O2/c1-16-3-5-17(6-4-16)15-26-9-11-27(12-10-26)22(29)21(28)24-19-13-18-7-8-25(2)20(18)23-14-19/h3-8,13-14H,9-12,15H2,1-2H3,(H,24,28)
Affinity DataEC50:  400nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572651(CHEMBL4862421)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2cnc3n(C)cc(F)c3c2)cc1
Show InChI InChI=1S/C22H24FN5O2/c1-15-3-5-16(6-4-15)13-27-7-9-28(10-8-27)22(30)21(29)25-17-11-18-19(23)14-26(2)20(18)24-12-17/h3-6,11-12,14H,7-10,13H2,1-2H3,(H,25,29)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572652(CHEMBL4864942)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccn3cccc3c2)cc1
Show InChI InChI=1S/C22H24N4O2/c1-17-4-6-18(7-5-17)16-24-11-13-26(14-12-24)22(28)21(27)23-19-8-10-25-9-2-3-20(25)15-19/h2-10,15H,11-14,16H2,1H3,(H,23,27)
Affinity DataEC50:  3.30E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572653(CHEMBL4877509)
Show SMILES CN1CCc2cc(NC(=O)C(=O)N3CCN(Cc4ccc(C)cc4)CC3)ccc12
Show InChI InChI=1S/C23H28N4O2/c1-17-3-5-18(6-4-17)16-26-11-13-27(14-12-26)23(29)22(28)24-20-7-8-21-19(15-20)9-10-25(21)2/h3-8,15H,9-14,16H2,1-2H3,(H,24,28)
Affinity DataEC50:  820nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572654(CHEMBL4866453)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)c2nnc(o2)-c2cccc3n(C)ccc23)cc1
Show InChI InChI=1S/C24H25N5O2/c1-17-6-8-18(9-7-17)16-28-12-14-29(15-13-28)24(30)23-26-25-22(31-23)20-4-3-5-21-19(20)10-11-27(21)2/h3-11H,12-16H2,1-2H3
Affinity DataEC50:  660nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572655(CHEMBL4867172)
Show SMILES Cn1ccc2cc(ccc12)-c1cc(C(=O)N2CCN(Cc3ccc(Cl)cc3)CC2)n(C)n1
Show InChI InChI=1S/C25H26ClN5O/c1-28-10-9-20-15-19(5-8-23(20)28)22-16-24(29(2)27-22)25(32)31-13-11-30(12-14-31)17-18-3-6-21(26)7-4-18/h3-10,15-16H,11-14,17H2,1-2H3
Affinity DataEC50:  2.50E+3nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572656(CHEMBL4859529)
Show SMILES Cc1ccc(Oc2ccc(cc2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C24H22N2O2/c1-17-3-8-21(9-4-17)28-22-10-6-19(7-11-22)24(27)25-16-18-5-12-23-20(15-18)13-14-26(23)2/h3-15H,16H2,1-2H3,(H,25,27)
Affinity DataEC50:  40nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572657(CHEMBL4859122)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H27N3O2/c1-17-3-6-20(7-4-17)28-21-10-13-26(14-11-21)23(27)24-16-18-5-8-22-19(15-18)9-12-25(22)2/h3-9,12,15,21H,10-11,13-14,16H2,1-2H3,(H,24,27)
Affinity DataEC50:  210nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572658(CHEMBL4845808)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H28N4O/c1-18-3-5-19(6-4-18)17-26-11-13-27(14-12-26)23(28)24-16-20-7-8-22-21(15-20)9-10-25(22)2/h3-10,15H,11-14,16-17H2,1-2H3,(H,24,28)
Affinity DataEC50:  490nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572659(CHEMBL4854890)
Show SMILES Cc1ccc(OC2CN(C2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C21H23N3O2/c1-15-3-6-18(7-4-15)26-19-13-24(14-19)21(25)22-12-16-5-8-20-17(11-16)9-10-23(20)2/h3-11,19H,12-14H2,1-2H3,(H,22,25)
Affinity DataEC50:  620nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572660(CHEMBL4859390)
Show SMILES Cc1ccc(OC2CCN(C2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H25N3O2/c1-16-3-6-19(7-4-16)27-20-10-12-25(15-20)22(26)23-14-17-5-8-21-18(13-17)9-11-24(21)2/h3-9,11,13,20H,10,12,14-15H2,1-2H3,(H,23,26)
Affinity DataEC50:  170nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572661(CHEMBL4877102)
Show SMILES Cc1ccc(OCC2CCN(C2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H27N3O2/c1-17-3-6-21(7-4-17)28-16-19-9-12-26(15-19)23(27)24-14-18-5-8-22-20(13-18)10-11-25(22)2/h3-8,10-11,13,19H,9,12,14-16H2,1-2H3,(H,24,27)
Affinity DataEC50:  280nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572662(CHEMBL4876566)
Show SMILES Cc1ccc(OCC2CN(C2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H25N3O2/c1-16-3-6-20(7-4-16)27-15-18-13-25(14-18)22(26)23-12-17-5-8-21-19(11-17)9-10-24(21)2/h3-11,18H,12-15H2,1-2H3,(H,23,26)
Affinity DataEC50:  40nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572663(CHEMBL4857578)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(F)cc4)C3)ccc12
Show InChI InChI=1S/C21H22FN3O2/c1-24-9-8-17-10-15(2-7-20(17)24)11-23-21(26)25-12-16(13-25)14-27-19-5-3-18(22)4-6-19/h2-10,16H,11-14H2,1H3,(H,23,26)
Affinity DataEC50:  220nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572664(CHEMBL4857691)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(Cl)cc4)C3)ccc12
Show InChI InChI=1S/C21H22ClN3O2/c1-24-9-8-17-10-15(2-7-20(17)24)11-23-21(26)25-12-16(13-25)14-27-19-5-3-18(22)4-6-19/h2-10,16H,11-14H2,1H3,(H,23,26)
Affinity DataEC50:  55nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572665(CHEMBL4848402)
Show SMILES COc1ccc(OCC2CN(C2)C(=O)NCc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C22H25N3O3/c1-24-10-9-18-11-16(3-8-21(18)24)12-23-22(26)25-13-17(14-25)15-28-20-6-4-19(27-2)5-7-20/h3-11,17H,12-15H2,1-2H3,(H,23,26)
Affinity DataEC50:  60nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572666(CHEMBL4870678)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(OC(F)(F)F)cc4)C3)ccc12
Show InChI InChI=1S/C22H22F3N3O3/c1-27-9-8-17-10-15(2-7-20(17)27)11-26-21(29)28-12-16(13-28)14-30-18-3-5-19(6-4-18)31-22(23,24)25/h2-10,16H,11-14H2,1H3,(H,26,29)
Affinity DataEC50:  25nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572667(CHEMBL4867462)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccccc4)C3)ccc12
Show InChI InChI=1S/C21H23N3O2/c1-23-10-9-18-11-16(7-8-20(18)23)12-22-21(25)24-13-17(14-24)15-26-19-5-3-2-4-6-19/h2-11,17H,12-15H2,1H3,(H,22,25)
Affinity DataEC50:  180nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572668(CHEMBL4856543)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(cc4)C#N)C3)ccc12
Show InChI InChI=1S/C22H22N4O2/c1-25-9-8-19-10-17(4-7-21(19)25)12-24-22(27)26-13-18(14-26)15-28-20-5-2-16(11-23)3-6-20/h2-10,18H,12-15H2,1H3,(H,24,27)
Affinity DataEC50:  350nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572669(CHEMBL4859758)
Show SMILES Cn1ccc2cc(CNC(=O)N3CC(COc4ccc(cc4)C(F)(F)F)C3)ccc12
Show InChI InChI=1S/C22H22F3N3O2/c1-27-9-8-17-10-15(2-7-20(17)27)11-26-21(29)28-12-16(13-28)14-30-19-5-3-18(4-6-19)22(23,24)25/h2-10,16H,11-14H2,1H3,(H,26,29)
Affinity DataEC50:  80nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572670(CHEMBL4872371)
Show SMILES FC(F)(F)c1ccc(OCC2CN(C2)C(=O)NCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C21H20F3N3O2/c22-21(23,24)17-2-4-18(5-3-17)29-13-15-11-27(12-15)20(28)26-10-14-1-6-19-16(9-14)7-8-25-19/h1-9,15,25H,10-13H2,(H,26,28)
Affinity DataEC50:  160nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572638(CHEMBL4873077)
Show SMILES Cc1ccc(CN2CCN(CC2)C(=O)C(=O)Nc2ccc3n(C)ccc3c2)cc1
Show InChI InChI=1S/C23H26N4O2/c1-17-3-5-18(6-4-17)16-26-11-13-27(14-12-26)23(29)22(28)24-20-7-8-21-19(15-20)9-10-25(21)2/h3-10,15H,11-14,16H2,1-2H3,(H,24,28)
Affinity DataEC50:  710nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in HEK293 cells assessed as increase in peak current amplitude measured after 6 to 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572670(CHEMBL4872371)
Show SMILES FC(F)(F)c1ccc(OCC2CN(C2)C(=O)NCc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C21H20F3N3O2/c22-21(23,24)17-2-4-18(5-3-17)29-13-15-11-27(12-15)20(28)26-10-14-1-6-19-16(9-14)7-8-25-19/h1-9,15,25H,10-13H2,(H,26,28)
Affinity DataEC50:  590nMAssay Description:Positive allosteric modulation of human alpha7 nAChR expressed in HEK293 cells assessed as increase in peak current amplitude measured after 6 to 10 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572634(CHEMBL4864764)
Show SMILES Cc1ccc(CC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C23H25N3O2/c1-16-2-4-17(5-3-16)14-18-9-12-26(13-10-18)23(28)22(27)25-20-6-7-21-19(15-20)8-11-24-21/h2-8,11,15,18,24H,9-10,12-14H2,1H3,(H,25,27)
Affinity DataEC50:  910nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNeuronal acetylcholine receptor subunit alpha-7(Homo sapiens (Human))
Gedeon Richter Plc.

Curated by ChEMBL
LigandPNGBDBM50572635(CHEMBL4855193)
Show SMILES Cc1ccc(OC2CCN(CC2)C(=O)C(=O)Nc2ccc3[nH]ccc3c2)cc1
Show InChI InChI=1S/C22H23N3O3/c1-15-2-5-18(6-3-15)28-19-9-12-25(13-10-19)22(27)21(26)24-17-4-7-20-16(14-17)8-11-23-20/h2-8,11,14,19,23H,9-10,12-13H2,1H3,(H,24,26)
Affinity DataEC50:  260nMAssay Description:Positive allosteric modulator activity at human alpha7 nAChR expressed in Flp-In-HEK293 cells co-expressing RIC-3 assessed as potentiation of PNU2829...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid