Compile Data Set for Download or QSAR
Found 159 Enz. Inhib. hit(s) with all data for entry = 50014160
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C#N
Show InChI InChI=1S/C24H22N8O/c1-15-11-18(22-16(2)29-31(4)20(22)12-25)6-7-19(15)23-27-28-24(33-23)30(3)13-17-5-8-21-26-9-10-32(21)14-17/h5-11,14H,13H2,1-4H3
Affinity DataIC50: 1.60nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573135(CHEMBL4873217)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1cnn(C)c1C
Show InChI InChI=1S/C23H23N7O/c1-15-11-18(20-12-25-29(4)16(20)2)6-7-19(15)22-26-27-23(31-22)28(3)13-17-5-8-21-24-9-10-30(21)14-17/h5-12,14H,13H2,1-4H3
Affinity DataIC50: 2nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573128(CHEMBL4865752)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1Cl)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H22ClN7O/c1-14-21(15(2)30(4)28-14)17-6-7-18(19(24)11-17)22-26-27-23(32-22)29(3)12-16-5-8-20-25-9-10-31(20)13-16/h5-11,13H,12H2,1-4H3
Affinity DataIC50: 2.5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573130(CHEMBL4855381)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C24H25N7O/c1-15-12-19(22-16(2)28-30(5)17(22)3)7-8-20(15)23-26-27-24(32-23)29(4)13-18-6-9-21-25-10-11-31(21)14-18/h6-12,14H,13H2,1-5H3
Affinity DataIC50: 3.20nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50563643(CHEMBL4754609)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H18ClN5O/c1-28(14-16-6-11-21-25-12-13-29(21)15-16)23-27-26-22(30-23)18-9-7-17(8-10-18)19-4-2-3-5-20(19)24/h2-13,15H,14H2,1H3
Affinity DataIC50: 5nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM298766(2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C34H41N7O2/c1-39-14-16-41(17-15-39)21-24-6-10-26(11-7-24)27-12-8-25(9-13-27)23-43-32-5-3-4-31(32)38-34(42)30-18-28(19-36-33(30)35)29-20-37-40(2)22-29/h6-13,18-20,22,31-32H,3-5,14-17,21,23H2,1-2H3,(H2,35,36)(H,38,42)/t31-,32-/m0/s1
Affinity DataIC50: 7.90nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573123(CHEMBL4863682)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1C
Show InChI InChI=1S/C24H21N5O/c1-17-5-3-4-6-21(17)19-8-10-20(11-9-19)23-26-27-24(30-23)28(2)15-18-7-12-22-25-13-14-29(22)16-18/h3-14,16H,15H2,1-2H3
Affinity DataIC50: 13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573127(CHEMBL4849757)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1F)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H22FN7O/c1-14-21(15(2)30(4)28-14)17-6-7-18(19(24)11-17)22-26-27-23(32-22)29(3)12-16-5-8-20-25-9-10-31(20)13-16/h5-11,13H,12H2,1-4H3
Affinity DataIC50: 13nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573142(CHEMBL4852375)
Show SMILES CN(Cc1ccc2ncc(-c3cnn(C)c3)n2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C28H29N9O/c1-17-11-21(26-18(2)33-36(6)19(26)3)8-9-23(17)27-31-32-28(38-27)34(4)14-20-7-10-25-29-13-24(37(25)15-20)22-12-30-35(5)16-22/h7-13,15-16H,14H2,1-6H3
Affinity DataIC50: 13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573149(CHEMBL4879167)
Show SMILES CN(C)Cc1ccc(nc1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C31H34N10O/c1-19-12-24(28-20(2)37-40(7)21(28)3)14-34-29(19)30-35-36-31(42-30)39(6)17-23-9-11-27-33-15-26(41(27)18-23)25-10-8-22(13-32-25)16-38(4)5/h8-15,18H,16-17H2,1-7H3
Affinity DataIC50: 13nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573129(CHEMBL4872116)
Show SMILES COc1cc(ccc1-c1nnc(o1)N(C)Cc1ccc2nccn2c1)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C24H25N7O2/c1-15-22(16(2)30(4)28-15)18-7-8-19(20(12-18)32-5)23-26-27-24(33-23)29(3)13-17-6-9-21-25-10-11-31(21)14-17/h6-12,14H,13H2,1-5H3
Affinity DataIC50: 16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573146(CHEMBL4879190)
Show SMILES CN(C)Cc1ccc(cc1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C32H35N9O/c1-20-14-26(29-21(2)37-40(7)22(29)3)15-34-30(20)31-35-36-32(42-31)39(6)18-24-10-13-28-33-16-27(41(28)19-24)25-11-8-23(9-12-25)17-38(4)5/h8-16,19H,17-18H2,1-7H3
Affinity DataIC50: 16nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573120(CHEMBL4869181)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1F
Show InChI InChI=1S/C23H18FN5O/c1-28(14-16-6-11-21-25-12-13-29(21)15-16)23-27-26-22(30-23)18-9-7-17(8-10-18)19-4-2-3-5-20(19)24/h2-13,15H,14H2,1H3
Affinity DataIC50: 16nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573144(CHEMBL4846456)
Show SMILES CN(C)CCn1cc(cn1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ccc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C31H36N10O/c1-20-14-24(29-21(2)36-39(7)22(29)3)9-10-26(20)30-34-35-31(42-30)38(6)17-23-8-11-28-32-16-27(41(28)18-23)25-15-33-40(19-25)13-12-37(4)5/h8-11,14-16,18-19H,12-13,17H2,1-7H3
Affinity DataIC50: 20nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573122(CHEMBL4869862)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1C#N
Show InChI InChI=1S/C24H18N6O/c1-29(15-17-6-11-22-26-12-13-30(22)16-17)24-28-27-23(31-24)19-9-7-18(8-10-19)21-5-3-2-4-20(21)14-25/h2-13,16H,15H2,1H3
Affinity DataIC50: 25nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573130(CHEMBL4855381)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C24H25N7O/c1-15-12-19(22-16(2)28-30(5)17(22)3)7-8-20(15)23-26-27-24(32-23)29(4)13-18-6-9-21-25-10-11-31(21)14-18/h6-12,14H,13H2,1-5H3
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573137(CHEMBL4870528)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)n(C)nc1C#N
Show InChI InChI=1S/C24H22N8O/c1-15-11-18(22-16(2)31(4)29-20(22)12-25)6-7-19(15)23-27-28-24(33-23)30(3)13-17-5-8-21-26-9-10-32(21)14-17/h5-11,14H,13H2,1-4H3
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573140(CHEMBL4862672)
Show SMILES CN(C)C(=O)c1cnc2ccc(CN(C)c3nnc(o3)-c3ccc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C27H30N8O2/c1-16-12-20(24-17(2)31-34(7)18(24)3)9-10-21(16)25-29-30-27(37-25)33(6)14-19-8-11-23-28-13-22(35(23)15-19)26(36)32(4)5/h8-13,15H,14H2,1-7H3
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM298766(2-amino-5-(1-methyl-1H-pyrazol-4-yl)-N-((1S,2S)-2-...)
Show SMILES CN1CCN(Cc2ccc(cc2)-c2ccc(CO[C@H]3CCC[C@@H]3NC(=O)c3cc(cnc3N)-c3cnn(C)c3)cc2)CC1
Show InChI InChI=1S/C34H41N7O2/c1-39-14-16-41(17-15-39)21-24-6-10-26(11-7-24)27-12-8-25(9-13-27)23-43-32-5-3-4-31(32)38-34(42)30-18-28(19-36-33(30)35)29-20-37-40(2)22-29/h6-13,18-20,22,31-32H,3-5,14-17,21,23H2,1-2H3,(H2,35,36)(H,38,42)/t31-,32-/m0/s1
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573125(CHEMBL4866573)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H23N7O/c1-15-21(16(2)29(4)27-15)18-6-8-19(9-7-18)22-25-26-23(31-22)28(3)13-17-5-10-20-24-11-12-30(20)14-17/h5-12,14H,13H2,1-4H3
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573141(CHEMBL4853066)
Show SMILES CN(Cc1ccc2ncc(-c3ccccc3)n2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C30H29N7O/c1-19-15-24(28-20(2)34-36(5)21(28)3)12-13-25(19)29-32-33-30(38-29)35(4)17-22-11-14-27-31-16-26(37(27)18-22)23-9-7-6-8-10-23/h6-16,18H,17H2,1-5H3
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573121(CHEMBL4859554)
Show SMILES COc1ccccc1-c1ccc(cc1)-c1nnc(o1)N(C)Cc1ccc2nccn2c1
Show InChI InChI=1S/C24H21N5O2/c1-28(15-17-7-12-22-25-13-14-29(22)16-17)24-27-26-23(31-24)19-10-8-18(9-11-19)20-5-3-4-6-21(20)30-2/h3-14,16H,15H2,1-2H3
Affinity DataIC50: 32nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573147(CHEMBL4873714)
Show SMILES CN(C)Cc1cccc(c1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C32H35N9O/c1-20-13-26(29-21(2)37-40(7)22(29)3)15-34-30(20)31-35-36-32(42-31)39(6)18-24-11-12-28-33-16-27(41(28)19-24)25-10-8-9-23(14-25)17-38(4)5/h8-16,19H,17-18H2,1-7H3
Affinity DataIC50: 32nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573139(CHEMBL4856195)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nc(C)n1C
Show InChI InChI=1S/C24H25N7O/c1-15-12-19(22-16(2)26-17(3)30(22)5)7-8-20(15)23-27-28-24(32-23)29(4)13-18-6-9-21-25-10-11-31(21)14-18/h6-12,14H,13H2,1-5H3
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573134(CHEMBL4852533)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)n[nH]c1C
Show InChI InChI=1S/C23H23N7O/c1-14-11-18(21-15(2)25-26-16(21)3)6-7-19(14)22-27-28-23(31-22)29(4)12-17-5-8-20-24-9-10-30(20)13-17/h5-11,13H,12H2,1-4H3,(H,25,26)
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573119(CHEMBL4850040)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C23H19N5O/c1-27(15-17-7-12-21-24-13-14-28(21)16-17)23-26-25-22(29-23)20-10-8-19(9-11-20)18-5-3-2-4-6-18/h2-14,16H,15H2,1H3
Affinity DataIC50: 40nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C#N
Show InChI InChI=1S/C24H22N8O/c1-15-11-18(22-16(2)29-31(4)20(22)12-25)6-7-19(15)23-27-28-24(33-23)30(3)13-17-5-8-21-26-9-10-32(21)14-17/h5-11,14H,13H2,1-4H3
Affinity DataIC50: 40nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573136(CHEMBL4875486)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C#N
Show InChI InChI=1S/C24H22N8O/c1-15-11-18(22-16(2)29-31(4)20(22)12-25)6-7-19(15)23-27-28-24(33-23)30(3)13-17-5-8-21-26-9-10-32(21)14-17/h5-11,14H,13H2,1-4H3
Affinity DataIC50: 40nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573124(CHEMBL4851329)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1cccnc1C
Show InChI InChI=1S/C23H20N6O/c1-16-20(4-3-11-24-16)18-6-8-19(9-7-18)22-26-27-23(30-22)28(2)14-17-5-10-21-25-12-13-29(21)15-17/h3-13,15H,14H2,1-2H3
Affinity DataIC50: 50nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573142(CHEMBL4852375)
Show SMILES CN(Cc1ccc2ncc(-c3cnn(C)c3)n2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C28H29N9O/c1-17-11-21(26-18(2)33-36(6)19(26)3)8-9-23(17)27-31-32-28(38-27)34(4)14-20-7-10-25-29-13-24(37(25)15-20)22-12-30-35(5)16-22/h7-13,15-16H,14H2,1-6H3
Affinity DataIC50: 63nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573133(CHEMBL4865034)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(nc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H24N8O/c1-14-18(7-8-19(25-14)21-15(2)28-30(5)16(21)3)22-26-27-23(32-22)29(4)12-17-6-9-20-24-10-11-31(20)13-17/h6-11,13H,12H2,1-5H3
Affinity DataIC50: 63nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573130(CHEMBL4855381)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C24H25N7O/c1-15-12-19(22-16(2)28-30(5)17(22)3)7-8-20(15)23-26-27-24(32-23)29(4)13-18-6-9-21-25-10-11-31(21)14-18/h6-12,14H,13H2,1-5H3
Affinity DataIC50: 79nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573135(CHEMBL4873217)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1cnn(C)c1C
Show InChI InChI=1S/C23H23N7O/c1-15-11-18(20-12-25-29(4)16(20)2)6-7-19(15)22-26-27-23(31-22)28(3)13-17-5-8-21-24-9-10-30(21)14-17/h5-12,14H,13H2,1-4H3
Affinity DataIC50: 79nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573128(CHEMBL4865752)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1Cl)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H22ClN7O/c1-14-21(15(2)30(4)28-14)17-6-7-18(19(24)11-17)22-26-27-23(32-22)29(3)12-16-5-8-20-25-9-10-31(20)13-16/h5-11,13H,12H2,1-4H3
Affinity DataIC50: 79nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573128(CHEMBL4865752)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1Cl)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H22ClN7O/c1-14-21(15(2)30(4)28-14)17-6-7-18(19(24)11-17)22-26-27-23(32-22)29(3)12-16-5-8-20-25-9-10-31(20)13-16/h5-11,13H,12H2,1-4H3
Affinity DataIC50: 79nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573132(CHEMBL4852284)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ncc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H24N8O/c1-14-10-18(20-15(2)28-30(5)16(20)3)11-25-21(14)22-26-27-23(32-22)29(4)12-17-6-7-19-24-8-9-31(19)13-17/h6-11,13H,12H2,1-5H3
Affinity DataIC50: 100nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573146(CHEMBL4879190)
Show SMILES CN(C)Cc1ccc(cc1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C32H35N9O/c1-20-14-26(29-21(2)37-40(7)22(29)3)15-34-30(20)31-35-36-32(42-31)39(6)18-24-10-13-28-33-16-27(41(28)19-24)25-11-8-23(9-12-25)17-38(4)5/h8-16,19H,17-18H2,1-7H3
Affinity DataIC50: 100nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573148(CHEMBL4854327)
Show SMILES CN(C)Cc1ccc(cn1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C31H34N10O/c1-19-12-24(28-20(2)37-40(7)21(28)3)14-34-29(19)30-35-36-31(42-30)39(6)16-22-8-11-27-33-15-26(41(27)17-22)23-9-10-25(32-13-23)18-38(4)5/h8-15,17H,16,18H2,1-7H3
Affinity DataIC50: 100nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573135(CHEMBL4873217)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1cnn(C)c1C
Show InChI InChI=1S/C23H23N7O/c1-15-11-18(20-12-25-29(4)16(20)2)6-7-19(15)22-26-27-23(31-22)28(3)13-17-5-8-21-24-9-10-30(21)14-17/h5-12,14H,13H2,1-4H3
Affinity DataIC50: 100nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573149(CHEMBL4879167)
Show SMILES CN(C)Cc1ccc(nc1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C31H34N10O/c1-19-12-24(28-20(2)37-40(7)21(28)3)14-34-29(19)30-35-36-31(42-30)39(6)17-23-9-11-27-33-15-26(41(27)18-23)25-10-8-22(13-32-25)16-38(4)5/h8-15,18H,16-17H2,1-7H3
Affinity DataIC50: 126nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573144(CHEMBL4846456)
Show SMILES CN(C)CCn1cc(cn1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ccc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C31H36N10O/c1-20-14-24(29-21(2)36-39(7)22(29)3)9-10-26(20)30-34-35-31(42-30)38(6)17-23-8-11-28-32-16-27(41(28)18-23)25-15-33-40(19-25)13-12-37(4)5/h8-11,14-16,18-19H,12-13,17H2,1-7H3
Affinity DataIC50: 126nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573141(CHEMBL4853066)
Show SMILES CN(Cc1ccc2ncc(-c3ccccc3)n2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C30H29N7O/c1-19-15-24(28-20(2)34-36(5)21(28)3)12-13-25(19)29-32-33-30(38-29)35(4)17-22-11-14-27-31-16-26(37(27)18-22)23-9-7-6-8-10-23/h6-16,18H,17H2,1-5H3
Affinity DataIC50: 200nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573125(CHEMBL4866573)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H23N7O/c1-15-21(16(2)29(4)27-15)18-6-8-19(9-7-18)22-25-26-23(31-22)28(3)13-17-5-10-20-24-11-12-30(20)14-17/h5-12,14H,13H2,1-4H3
Affinity DataIC50: 200nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573126(CHEMBL4862829)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1c(C)noc1C
Show InChI InChI=1S/C22H20N6O2/c1-14-20(15(2)30-26-14)17-5-7-18(8-6-17)21-24-25-22(29-21)27(3)12-16-4-9-19-23-10-11-28(19)13-16/h4-11,13H,12H2,1-3H3
Affinity DataIC50: 200nMAssay Description:Inhibition of MER (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573145(CHEMBL4847257)
Show SMILES CN(C)CCn1cc(cn1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C30H35N11O/c1-19-12-23(27-20(2)36-39(7)21(27)3)13-32-28(19)29-34-35-30(42-29)38(6)16-22-8-9-26-31-15-25(41(26)17-22)24-14-33-40(18-24)11-10-37(4)5/h8-9,12-15,17-18H,10-11,16H2,1-7H3
Affinity DataIC50: 200nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573143(CHEMBL4858663)
Show SMILES CN(Cc1ccc2ncc(C3CCN(C)CC3)n2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C30H36N8O/c1-19-15-24(28-20(2)34-37(6)21(28)3)8-9-25(19)29-32-33-30(39-29)36(5)17-22-7-10-27-31-16-26(38(27)18-22)23-11-13-35(4)14-12-23/h7-10,15-16,18,23H,11-14,17H2,1-6H3
Affinity DataIC50: 251nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573147(CHEMBL4873714)
Show SMILES CN(C)Cc1cccc(c1)-c1cnc2ccc(CN(C)c3nnc(o3)-c3ncc(cc3C)-c3c(C)nn(C)c3C)cn12
Show InChI InChI=1S/C32H35N9O/c1-20-13-26(29-21(2)37-40(7)22(29)3)15-34-30(20)31-35-36-32(42-31)39(6)18-24-11-12-28-33-16-27(41(28)19-24)25-10-8-9-23(14-25)17-38(4)5/h8-16,19H,17-18H2,1-7H3
Affinity DataIC50: 316nMAssay Description:Inhibition of FLAG-tagged AXL (unknown origin) transfected in Cos-7 cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573137(CHEMBL4870528)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1C)-c1c(C)n(C)nc1C#N
Show InChI InChI=1S/C24H22N8O/c1-15-11-18(22-16(2)31(4)29-20(22)12-25)6-7-19(15)23-27-28-24(33-23)30(3)13-17-5-8-21-26-9-10-32(21)14-17/h5-11,14H,13H2,1-4H3
Affinity DataIC50: 316nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50573127(CHEMBL4849757)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1F)-c1c(C)nn(C)c1C
Show InChI InChI=1S/C23H22FN7O/c1-14-21(15(2)30(4)28-14)17-6-7-18(19(24)11-17)22-26-27-23(32-22)29(3)12-16-5-8-20-25-9-10-31(20)13-16/h5-11,13H,12H2,1-4H3
Affinity DataIC50: 316nMAssay Description:Inhibition of FLAG-tagged MER (unknown origin) transfected in Cos-7cells assessed as phosphorylation level incubated for 1 hr by ELISAMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTyrosine-protein kinase receptor UFO(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50563643(CHEMBL4754609)
Show SMILES CN(Cc1ccc2nccn2c1)c1nnc(o1)-c1ccc(cc1)-c1ccccc1Cl
Show InChI InChI=1S/C23H18ClN5O/c1-28(14-16-6-11-21-25-12-13-29(21)15-16)23-27-26-22(30-23)18-9-7-17(8-10-18)19-4-2-3-5-20(19)24/h2-13,15H,14H2,1H3
Affinity DataIC50: 398nMAssay Description:Inhibition of AXL (unknown origin) by LC-MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
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