Compile Data Set for Download or QSAR
Found 47 Enz. Inhib. hit(s) with all data for entry = 50014166
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573200(CHEMBL4861491)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Br)c1=O
Show InChI InChI=1S/C13H15BrN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataIC50: 36nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573201(CHEMBL4848701)
Show SMILES CN(C)CCCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C16H21ClN4O/c1-20(2)10-4-5-12-6-8-13(9-7-12)19-14-11-18-21(3)16(22)15(14)17/h6-9,11,19H,4-5,10H2,1-3H3
Affinity DataIC50: 56nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataIC50: 67nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573198(CHEMBL4848138)
Show SMILES CN(C)CCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C15H19ClN4O/c1-19(2)9-8-11-4-6-12(7-5-11)18-13-10-17-20(3)15(21)14(13)16/h4-7,10,18H,8-9H2,1-3H3
Affinity DataIC50: 170nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50234940(CHEMBL4101756)
Show SMILES Cn1ncc(Nc2ccccc2CN)c(Cl)c1=O
Show InChI InChI=1S/C12H13ClN4O/c1-17-12(18)11(13)10(7-15-17)16-9-5-3-2-4-8(9)6-14/h2-5,7,16H,6,14H2,1H3
Affinity DataIC50: 220nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573192(CHEMBL4850516)
Show SMILES Cn1ncc(Nc2ccc3CNCCc3c2)c(Cl)c1=O
Show InChI InChI=1S/C14H15ClN4O/c1-19-14(20)13(15)12(8-17-19)18-11-3-2-10-7-16-5-4-9(10)6-11/h2-3,6,8,16,18H,4-5,7H2,1H3
Affinity DataIC50: 250nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573190(CHEMBL4866748)
Show SMILES Cn1ncc(Nc2ccc(CN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C12H13ClN4O/c1-17-12(18)11(13)10(7-15-17)16-9-4-2-8(6-14)3-5-9/h2-5,7,16H,6,14H2,1H3
Affinity DataIC50: 290nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573191(CHEMBL4870218)
Show SMILES CN(C)Cc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C14H17ClN4O/c1-18(2)9-10-4-6-11(7-5-10)17-12-8-16-19(3)14(20)13(12)15/h4-8,17H,9H2,1-3H3
Affinity DataIC50: 310nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573193(CHEMBL4848082)
Show SMILES Cn1ncc(Nc2ccc3CCNCc3c2)c(Cl)c1=O
Show InChI InChI=1S/C14H15ClN4O/c1-19-14(20)13(15)12(8-17-19)18-11-3-2-9-4-5-16-7-10(9)6-11/h2-3,6,8,16,18H,4-5,7H2,1H3
Affinity DataIC50: 370nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573203(CHEMBL4863631)
Show SMILES NCc1ccc(Nc2cnn(CC#N)c(=O)c2Cl)cc1
Show InChI InChI=1S/C13H12ClN5O/c14-12-11(8-17-19(6-5-15)13(12)20)18-10-3-1-9(7-16)2-4-10/h1-4,8,18H,6-7,16H2
Affinity DataIC50: 380nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573202(CHEMBL4877696)
Show SMILES CCn1ncc(Nc2ccc(CN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-2-18-13(19)12(14)11(8-16-18)17-10-5-3-9(7-15)4-6-10/h3-6,8,17H,2,7,15H2,1H3
Affinity DataIC50: 550nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573188(CHEMBL4850913)
Show SMILES Cn1ncc(Nc2ccc(F)cc2)c(Cl)c1=O
Show InChI InChI=1S/C11H9ClFN3O/c1-16-11(17)10(12)9(6-14-16)15-8-4-2-7(13)3-5-8/h2-6,15H,1H3
Affinity DataIC50: 700nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573204(CHEMBL4863529)
Show SMILES CC(C)n1ncc(Nc2ccc(CN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C14H17ClN4O/c1-9(2)19-14(20)13(15)12(8-17-19)18-11-5-3-10(7-16)4-6-11/h3-6,8-9,18H,7,16H2,1-2H3
Affinity DataIC50: 790nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573195(CHEMBL4855881)
Show SMILES Cn1ncc(Nc2cccc(CN)c2)c(Cl)c1=O
Show InChI InChI=1S/C12H13ClN4O/c1-17-12(18)11(13)10(7-15-17)16-9-4-2-3-8(5-9)6-14/h2-5,7,16H,6,14H2,1H3
Affinity DataIC50: 800nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50234924(CHEMBL4065579)
Show SMILES Cn1ncc(Nc2ccccc2)c(Cl)c1=O
Show InChI InChI=1S/C11H10ClN3O/c1-15-11(16)10(12)9(7-13-15)14-8-5-3-2-4-6-8/h2-7,14H,1H3
Affinity DataIC50: 950nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573196(CHEMBL4877118)
Show SMILES CC(=O)NCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C14H15ClN4O2/c1-9(20)16-7-10-3-5-11(6-4-10)18-12-8-17-19(2)14(21)13(12)15/h3-6,8,18H,7H2,1-2H3,(H,16,20)
Affinity DataIC50: 970nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50234923(CHEMBL4069412)
Show SMILES CN1C[C@@H](C[C@@H](C1)c1ccccc1)Nc1cnn(C)c(=O)c1Br
Show InChI InChI=1S/C17H21BrN4O/c1-21-10-13(12-6-4-3-5-7-12)8-14(11-21)20-15-9-19-22(2)17(23)16(15)18/h3-7,9,13-14,20H,8,10-11H2,1-2H3/t13-,14+/m0/s1
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573187(CHEMBL4861822)
Show SMILES Cn1ncc(Nc2ccc(N)cc2)c(Cl)c1=O
Show InChI InChI=1S/C11H11ClN4O/c1-16-11(17)10(12)9(6-14-16)15-8-4-2-7(13)3-5-8/h2-6,15H,13H2,1H3
Affinity DataIC50: 3.20E+3nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573194(CHEMBL4858548)
Show SMILES Cn1ncc(Nc2ccc3CCCCc3c2)c(Cl)c1=O
Show InChI InChI=1S/C15H16ClN3O/c1-19-15(20)14(16)13(9-17-19)18-12-7-6-10-4-2-3-5-11(10)8-12/h6-9,18H,2-5H2,1H3
Affinity DataIC50: 3.90E+3nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573186(CHEMBL4872107)
Show SMILES Cn1ncc(NC2CCCCNC2)c(Cl)c1=O
Show InChI InChI=1S/C11H17ClN4O/c1-16-11(17)10(12)9(7-14-16)15-8-4-2-3-5-13-6-8/h7-8,13,15H,2-6H2,1H3
Affinity DataIC50: 7.70E+3nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573185(CHEMBL4853420)
Show SMILES Cn1ncc(NC2CNC2)c(Cl)c1=O
Show InChI InChI=1S/C8H11ClN4O/c1-13-8(14)7(9)6(4-11-13)12-5-2-10-3-5/h4-5,10,12H,2-3H2,1H3
Affinity DataIC50: 8.70E+3nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573199(CHEMBL4849136)
Show SMILES CN(C)CCNc1c(Cl)cnn(C)c1=O
Show InChI InChI=1S/C9H15ClN4O/c1-13(2)5-4-11-8-7(10)6-12-14(3)9(8)15/h6,11H,4-5H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573183(CHEMBL4867912)
Show SMILES Cn1ncc(N[C@@H]2CCNC2)c(Cl)c1=O
Show InChI InChI=1S/C9H13ClN4O/c1-14-9(15)8(10)7(5-12-14)13-6-2-3-11-4-6/h5-6,11,13H,2-4H2,1H3/t6-/m1/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573189(CHEMBL4857332)
Show SMILES Cn1ncc(NCc2cccc(N)c2)c(Cl)c1=O
Show InChI InChI=1S/C12H13ClN4O/c1-17-12(18)11(13)10(7-16-17)15-6-8-3-2-4-9(14)5-8/h2-5,7,15H,6,14H2,1H3
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50234944(CHEMBL4072538 | US10239861, Example 60)
Show SMILES CN1CCC[C@H](C1)Nc1cnn(C)c(=O)c1Cl
Show InChI InChI=1S/C11H17ClN4O/c1-15-5-3-4-8(7-15)14-9-6-13-16(2)11(17)10(9)12/h6,8,14H,3-5,7H2,1-2H3/t8-/m1/s1
Affinity DataIC50: 1.90E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of HIS9-tagged BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573184(CHEMBL4871852)
Show SMILES Cn1ncc(N[C@H]2CCNC2)c(Cl)c1=O
Show InChI InChI=1S/C9H13ClN4O/c1-14-9(15)8(10)7(5-12-14)13-6-2-3-11-4-6/h5-6,11,13H,2-4H2,1H3/t6-/m0/s1
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of HIS9-tagged BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573202(CHEMBL4877696)
Show SMILES CCn1ncc(Nc2ccc(CN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-2-18-13(19)12(14)11(8-16-18)17-10-5-3-9(7-15)4-6-10/h3-6,8,17H,2,7,15H2,1H3
Affinity DataIC50: 3.50E+4nMAssay Description:Inhibition of HIS9-tagged BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573190(CHEMBL4866748)
Show SMILES Cn1ncc(Nc2ccc(CN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C12H13ClN4O/c1-17-12(18)11(13)10(7-15-17)16-9-4-2-8(6-14)3-5-9/h2-5,7,16H,6,14H2,1H3
Affinity DataIC50: 4.20E+4nMAssay Description:Inhibition of HIS9-tagged BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573203(CHEMBL4863631)
Show SMILES NCc1ccc(Nc2cnn(CC#N)c(=O)c2Cl)cc1
Show InChI InChI=1S/C13H12ClN5O/c14-12-11(8-17-19(6-5-15)13(12)20)18-10-3-1-9(7-16)2-4-10/h1-4,8,18H,6-7,16H2
Affinity DataIC50: 7.10E+4nMAssay Description:Inhibition of HIS9-tagged BRD4 (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by AlphaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573201(CHEMBL4848701)
Show SMILES CN(C)CCCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C16H21ClN4O/c1-20(2)10-4-5-12-6-8-13(9-7-12)19-14-11-18-21(3)16(22)15(14)17/h6-9,11,19H,4-5,10H2,1-3H3
Affinity DataKd:  230nMAssay Description:Binding affinity to BRD9 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573200(CHEMBL4861491)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Br)c1=O
Show InChI InChI=1S/C13H15BrN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  0.240nMAssay Description:Binding affinity to BRD9 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetBromodomain-containing protein 9(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  0.470nMAssay Description:Binding affinity to BRD9 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 7(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  0.760nMAssay Description:Binding affinity to BRD7 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetChromatin remodeling regulator CECR2(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  11nMAssay Description:Binding affinity to CECR2 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2A(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  44nMAssay Description:Binding affinity to GCN5L2 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573203(CHEMBL4863631)
Show SMILES NCc1ccc(Nc2cnn(CC#N)c(=O)c2Cl)cc1
Show InChI InChI=1S/C13H12ClN5O/c14-12-11(8-17-19(6-5-15)13(12)20)18-10-3-1-9(7-16)2-4-10/h1-4,8,18H,6-7,16H2
Affinity DataKd:  300nMAssay Description:Binding affinity to PCAF (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573201(CHEMBL4848701)
Show SMILES CN(C)CCCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C16H21ClN4O/c1-20(2)10-4-5-12-6-8-13(9-7-12)19-14-11-18-21(3)16(22)15(14)17/h6-9,11,19H,4-5,10H2,1-3H3
Affinity DataKd:  370nMAssay Description:Binding affinity to PCAF (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573200(CHEMBL4861491)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Br)c1=O
Show InChI InChI=1S/C13H15BrN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  14nMAssay Description:Binding affinity to PCAF (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHistone acetyltransferase KAT2B(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  12nMAssay Description:Binding affinity to PCAF (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573203(CHEMBL4863631)
Show SMILES NCc1ccc(Nc2cnn(CC#N)c(=O)c2Cl)cc1
Show InChI InChI=1S/C13H12ClN5O/c14-12-11(8-17-19(6-5-15)13(12)20)18-10-3-1-9(7-16)2-4-10/h1-4,8,18H,6-7,16H2
Affinity DataKd:  200nMAssay Description:Binding affinity to BPTF (unknown origin) by by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573201(CHEMBL4848701)
Show SMILES CN(C)CCCc1ccc(Nc2cnn(C)c(=O)c2Cl)cc1
Show InChI InChI=1S/C16H21ClN4O/c1-20(2)10-4-5-12-6-8-13(9-7-12)19-14-11-18-21(3)16(22)15(14)17/h6-9,11,19H,4-5,10H2,1-3H3
Affinity DataKd:  70nMAssay Description:Binding affinity to BPTF (unknown origin) by by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573200(CHEMBL4861491)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Br)c1=O
Show InChI InChI=1S/C13H15BrN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  9.30nMAssay Description:Binding affinity to BPTF (unknown origin) by by BROMOscan methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  6.30nMAssay Description:Binding affinity to BPTF (unknown origin) by by BROMOscan methodMore data for this Ligand-Target Pair
TargetBromodomain-containing protein 4(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50573197(CHEMBL4872300)
Show SMILES Cn1ncc(Nc2ccc(CCN)cc2)c(Cl)c1=O
Show InChI InChI=1S/C13H15ClN4O/c1-18-13(19)12(14)11(8-16-18)17-10-4-2-9(3-5-10)6-7-15/h2-5,8,17H,6-7,15H2,1H3
Affinity DataKd:  2.20E+3nMAssay Description:Binding affinity to BRD4 BD1 (unknown origin) by BROMOscan methodMore data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50157526(CHEMBL586426 | D3RKN_107 | TCMDC-133606)
Show SMILES COC(=O)c1cccc(NC(=O)NC2CCN(C2)c2ccnc(Nc3ccc(F)cc3)n2)c1
Show InChI InChI=1S/C23H23FN6O3/c1-33-21(31)15-3-2-4-18(13-15)27-23(32)28-19-10-12-30(14-19)20-9-11-25-22(29-20)26-17-7-5-16(24)6-8-17/h2-9,11,13,19H,10,12,14H2,1H3,(H,25,26,29)(H2,27,28,32)
Affinity DataKd:  2.80E+3nMAssay Description:Binding affinity to 5FW-labeled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by BODIPY-BI2536 tracer ba...More data for this Ligand-Target Pair
TargetNucleosome-remodeling factor subunit BPTF(Homo sapiens (Human))
University of Minnesota

Curated by ChEMBL
LigandPNGBDBM50514899(CHEMBL4461619)
Show SMILES CN(C)CCCOc1ccc(cc1)-c1cc(NCCCn2cccn2)nc(n1)S(C)(=O)=O
Show InChI InChI=1S/C22H30N6O3S/c1-27(2)13-6-16-31-19-9-7-18(8-10-19)20-17-21(26-22(25-20)32(3,29)30)23-11-4-14-28-15-5-12-24-28/h5,7-10,12,15,17H,4,6,11,13-14,16H2,1-3H3,(H,23,25,26)
Affinity DataKd:  1.20E+5nMAssay Description:Binding affinity to 5FW-labeled BPTF (unknown origin) expressed in Escherichia coli BL21 (DE3) cells incubated for 30 mins by BODIPY-BI2536 tracer ba...More data for this Ligand-Target Pair