Compile Data Set for Download or QSAR
Found 24 Enz. Inhib. hit(s) with all data for entry = 50014801
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50223647(CHEMBL112366)
Show SMILES Nc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O2/c24-17-12-16-8-11-28-20(16)18(13-17)19(14-4-2-1-3-5-14)26-21(23(28)30)27-22(29)15-6-9-25-10-7-15/h1-7,9-10,12-13,21H,8,11,24H2,(H,27,29)/t21-/m0/s1
Affinity DataIC50: 270nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50217550(CHEMBL111925 | CI-1018)
Show SMILES Cc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1
Show InChI InChI=1S/C24H20N4O2/c1-15-13-18-9-12-28-21(18)19(14-15)20(16-5-3-2-4-6-16)26-22(24(28)30)27-23(29)17-7-10-25-11-8-17/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50223646(CHEMBL418848)
Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50451952(CHEMBL2111730)
Show SMILES COc1cc2CCN3c2c(n1)C(=N[C@@H](NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)/t21-/m0/s1
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50451952(CHEMBL2111730)
Show SMILES COc1cc2CCN3c2c(n1)C(=N[C@@H](NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)/t21-/m0/s1
Affinity DataIC50: 1.20E+4nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair
LigandPNGBDBM50451952(CHEMBL2111730)
Show SMILES COc1cc2CCN3c2c(n1)C(=N[C@@H](NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)/t21-/m0/s1
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
LigandPNGBDBM50223646(CHEMBL418848)
Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147632(4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-be...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-9-12-7-8-20-14(21)10-18-15(16(19-13)17(12)20)11-5-3-2-4-6-11/h2-6,9H,7-8,10H2,1H3
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 2.80E+4nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 3.10E+4nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50223645(CHEMBL109754)
Show SMILES COc1cc2CCN3c2c(c1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-22-14-9-13-7-8-20-16(21)11-19-17(15(10-14)18(13)20)12-5-3-2-4-6-12/h2-6,9-10H,7-8,11H2,1H3
Affinity DataIC50: 4.00E+4nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50223646(CHEMBL418848)
Show SMILES COc1cc2CCN3c2c(c1)C(=N[C@@H](NC(=O)c1ccncc1)C3=O)c1ccccc1
Show InChI InChI=1S/C24H20N4O3/c1-31-18-13-17-9-12-28-21(17)19(14-18)20(15-5-3-2-4-6-15)26-22(24(28)30)27-23(29)16-7-10-25-11-8-16/h2-8,10-11,13-14,22H,9,12H2,1H3,(H,27,29)/t22-/m0/s1
Affinity DataIC50: 4.10E+4nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair
LigandPNGBDBM50223645(CHEMBL109754)
Show SMILES COc1cc2CCN3c2c(c1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-22-14-9-13-7-8-20-16(21)11-19-17(15(10-14)18(13)20)12-5-3-2-4-6-12/h2-6,9-10H,7-8,11H2,1H3
Affinity DataIC50: 5.20E+4nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 7.30E+4nMAssay Description:Inhibition of phosphodiesterase 4More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50223645(CHEMBL109754)
Show SMILES COc1cc2CCN3c2c(c1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C18H16N2O2/c1-22-14-9-13-7-8-20-16(21)11-19-17(15(10-14)18(13)20)12-5-3-2-4-6-12/h2-6,9-10H,7-8,11H2,1H3
Affinity DataIC50: 7.70E+4nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147632(4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-be...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-9-12-7-8-20-14(21)10-18-15(16(19-13)17(12)20)11-5-3-2-4-6-11/h2-6,9H,7-8,10H2,1H3
Affinity DataIC50: 9.10E+4nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 9.50E+4nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair
LigandPNGBDBM50147632(4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-be...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-9-12-7-8-20-14(21)10-18-15(16(19-13)17(12)20)11-5-3-2-4-6-11/h2-6,9H,7-8,10H2,1H3
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Phosphodiesterase 1More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147630(CHEMBL112996 | N-(4-Methoxy-9-oxo-6-phenyl-1,2,8,9...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NC(NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50451952(CHEMBL2111730)
Show SMILES COc1cc2CCN3c2c(n1)C(=N[C@@H](NC(=O)c1cccnc1)C3=O)c1ccccc1
Show InChI InChI=1S/C23H19N5O3/c1-31-17-12-15-9-11-28-20(15)19(25-17)18(14-6-3-2-4-7-14)26-21(23(28)30)27-22(29)16-8-5-10-24-13-16/h2-8,10,12-13,21H,9,11H2,1H3,(H,27,29)/t21-/m0/s1
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of Phosphodiesterase 5More data for this Ligand-Target Pair
TargetcGMP-inhibited 3',5'-cyclic phosphodiesterase 3A/3B(Homo sapiens (Human))
Pfizer Inc

Curated by ChEMBL
LigandPNGBDBM50147632(4-Methoxy-6-phenyl-1,2-dihydro-8H-5,7,9a-triaza-be...)
Show SMILES COc1cc2CCN3c2c(n1)C(=NCC3=O)c1ccccc1
Show InChI InChI=1S/C17H15N3O2/c1-22-13-9-12-7-8-20-14(21)10-18-15(16(19-13)17(12)20)11-5-3-2-4-6-11/h2-6,9H,7-8,10H2,1H3
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of phosphodiesterase 3More data for this Ligand-Target Pair