Compile Data Set for Download or QSAR
Found 55 Enz. Inhib. hit(s) with all data for entry = 50014825
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580195(CHEMBL5071286)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(-c5ccoc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C26H30N2O5/c1-4-16-13-28-10-9-26(30)23-18(17-8-11-33-14-17)6-5-7-21(23)27-24(26)22(28)12-19(16)20(15-31-2)25(29)32-3/h5-8,11,14-16,19,22,30H,4,9-10,12-13H2,1-3H3/b20-15+/t16-,19+,22+,26+/m1/s1
Affinity DataKi:  6nMAssay Description:Displacement of [3H]-DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells at 10 uMMore data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580194(CHEMBL5074977)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-15-12-25-10-9-23(27)20-14(2)7-6-8-18(20)24-21(23)19(25)11-16(15)17(13-28-3)22(26)29-4/h6-8,13,15-16,19,27H,5,9-12H2,1-4H3/b17-13+/t15-,16+,19+,23+/m1/s1
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells at 10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580193(CHEMBL5086786)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C28H32N2O4/c1-4-18-16-30-14-13-28(32)25-20(19-9-6-5-7-10-19)11-8-12-23(25)29-26(28)24(30)15-21(18)22(17-33-2)27(31)34-3/h5-12,17-18,21,24,32H,4,13-16H2,1-3H3/b22-17+/t18-,21+,24+,28+/m1/s1
Affinity DataKi:  15nMAssay Description:Displacement of [3H]-DAMGO from mu opioid receptor (unknown origin) expressed in CHO cells at 10 uMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580197(CHEMBL5084960)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(-c5ccccc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  83nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580198(CHEMBL5075424)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  83nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580199(CHEMBL5088382)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(-c5ccccc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  3.76E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580200(CHEMBL5094492)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  86nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580201(CHEMBL5075806)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(C)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  370nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580202(CHEMBL5075279)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccccc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C29H34N2O5/c1-5-18-16-31-14-13-29(33)25-23(12-11-20(26(25)35-3)19-9-7-6-8-10-19)30-27(29)24(31)15-21(18)22(17-34-2)28(32)36-4/h6-12,17-18,21,24,33H,5,13-16H2,1-4H3/b22-17+/t18-,21+,24+,29+/m1/s1
Affinity DataEC50:  104nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580203(CHEMBL5089366)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-21(7-6-18(24(23)33-3)17-8-11-35-14-17)28-25(27)22(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,22,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,22+,27+/m1/s1
Affinity DataEC50:  535nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580204(CHEMBL5086376)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(C)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C24H32N2O5/c1-6-15-12-26-10-9-24(28)20-18(8-7-14(2)21(20)30-4)25-22(24)19(26)11-16(15)17(13-29-3)23(27)31-5/h7-8,13,15-16,19,28H,6,9-12H2,1-5H3/b17-13+/t15-,16+,19+,24+/m1/s1
Affinity DataEC50:  30nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580205(CHEMBL5093143)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(ccc(OC)c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  1.11E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580206(CHEMBL5079202)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(ccc(OC)c34)-c3ccoc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  186nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580207(CHEMBL5093673)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(C)ccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  71nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580208(CHEMBL5079626)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C29H34N2O5/c1-5-18-16-31-14-13-29(33)25-24(35-3)12-11-20(19-9-7-6-8-10-19)26(25)30-27(29)23(31)15-21(18)22(17-34-2)28(32)36-4/h6-12,17-18,21,23,33H,5,13-16H2,1-4H3/b22-17+/t18-,21+,23+,29+/m1/s1
Affinity DataEC50:  1.75E+4nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580209(CHEMBL5091971)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4-c3ccoc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-22(33-3)7-6-18(17-8-11-35-14-17)24(23)28-25(27)21(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,21,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,21+,27+/m1/s1
Affinity DataEC50:  1.56E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580210(CHEMBL5081106)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4C)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C24H32N2O5/c1-6-15-12-26-10-9-24(28)20-19(30-4)8-7-14(2)21(20)25-22(24)18(26)11-16(15)17(13-29-3)23(27)31-5/h7-8,13,15-16,18,28H,6,9-12H2,1-5H3/b17-13+/t15-,16+,18+,24+/m1/s1
Affinity DataEC50:  11nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50474152(CHEBI:6956 | CHEMBL299031)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
Affinity DataEC50:  241nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O5/c1-5-14-12-25-10-9-23(27)20-17(7-6-8-19(20)29-3)24-21(23)18(25)11-15(14)16(13-28-2)22(26)30-4/h6-8,13-15,18,27H,5,9-12H2,1-4H3/b16-13+/t14-,15+,18+,23+/m1/s1
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580193(CHEMBL5086786)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C28H32N2O4/c1-4-18-16-30-14-13-28(32)25-20(19-9-6-5-7-10-19)11-8-12-23(25)29-26(28)24(30)15-21(18)22(17-33-2)27(31)34-3/h5-12,17-18,21,24,32H,4,13-16H2,1-3H3/b22-17+/t18-,21+,24+,28+/m1/s1
Affinity DataEC50:  36nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580194(CHEMBL5074977)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-15-12-25-10-9-23(27)20-14(2)7-6-8-18(20)24-21(23)19(25)11-16(15)17(13-28-3)22(26)29-4/h6-8,13,15-16,19,27H,5,9-12H2,1-4H3/b17-13+/t15-,16+,19+,23+/m1/s1
Affinity DataEC50:  5.20nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580196(CHEMBL5091787)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(-c5ccoc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  93nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580197(CHEMBL5084960)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(-c5ccccc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  83nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580198(CHEMBL5075424)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  83nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580199(CHEMBL5088382)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(-c5ccccc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  3.80E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580200(CHEMBL5094492)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  85nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580201(CHEMBL5075806)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4ccc(C)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  372nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580202(CHEMBL5075279)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccccc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C29H34N2O5/c1-5-18-16-31-14-13-29(33)25-23(12-11-20(26(25)35-3)19-9-7-6-8-10-19)30-27(29)24(31)15-21(18)22(17-34-2)28(32)36-4/h6-12,17-18,21,24,33H,5,13-16H2,1-4H3/b22-17+/t18-,21+,24+,29+/m1/s1
Affinity DataEC50:  105nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580203(CHEMBL5089366)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-21(7-6-18(24(23)33-3)17-8-11-35-14-17)28-25(27)22(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,22,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,22+,27+/m1/s1
Affinity DataEC50:  537nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580204(CHEMBL5086376)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(C)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C24H32N2O5/c1-6-15-12-26-10-9-24(28)20-18(8-7-14(2)21(20)30-4)25-22(24)19(26)11-16(15)17(13-29-3)23(27)31-5/h7-8,13,15-16,19,28H,6,9-12H2,1-5H3/b17-13+/t15-,16+,19+,24+/m1/s1
Affinity DataEC50:  30nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580205(CHEMBL5093143)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(ccc(OC)c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  1.12E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580206(CHEMBL5079202)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(ccc(OC)c34)-c3ccoc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  186nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580207(CHEMBL5093673)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4c(C)ccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Affinity DataEC50:  71nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580208(CHEMBL5079626)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C29H34N2O5/c1-5-18-16-31-14-13-29(33)25-24(35-3)12-11-20(19-9-7-6-8-10-19)26(25)30-27(29)23(31)15-21(18)22(17-34-2)28(32)36-4/h6-12,17-18,21,23,33H,5,13-16H2,1-4H3/b22-17+/t18-,21+,23+,29+/m1/s1
Affinity DataEC50:  1.74E+4nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580209(CHEMBL5091971)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4-c3ccoc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-22(33-3)7-6-18(17-8-11-35-14-17)24(23)28-25(27)21(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,21,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,21+,27+/m1/s1
Affinity DataEC50:  1.55E+3nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580210(CHEMBL5081106)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4c3c(OC)ccc4C)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C24H32N2O5/c1-6-15-12-26-10-9-24(28)20-19(30-4)8-7-14(2)21(20)25-22(24)18(26)11-16(15)17(13-29-3)23(27)31-5/h7-8,13,15-16,18,28H,6,9-12H2,1-5H3/b17-13+/t15-,16+,18+,24+/m1/s1
Affinity DataEC50:  11nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580195(CHEMBL5071286)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(-c5ccoc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C26H30N2O5/c1-4-16-13-28-10-9-26(30)23-18(17-8-11-33-14-17)6-5-7-21(23)27-24(26)22(28)12-19(16)20(15-31-2)25(29)32-3/h5-8,11,14-16,19,22,30H,4,9-10,12-13H2,1-3H3/b20-15+/t16-,19+,22+,26+/m1/s1
Affinity DataEC50:  7.20nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50474153(CHEMBL61630)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O5/c1-5-14-12-25-10-9-23(27)20-17(7-6-8-19(20)29-3)24-21(23)18(25)11-15(14)16(13-28-2)22(26)30-4/h6-8,13-15,18,27H,5,9-12H2,1-4H3/b16-13+/t14-,15+,18+,23+/m1/s1
Affinity DataEC50:  240nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
Affinity DataEC50:  5.90nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50474152(CHEBI:6956 | CHEMBL299031)
Show SMILES CC[C@@H]1CN2CCc3c([nH]c4cccc(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-14-12-25-10-9-15-21-18(7-6-8-20(21)28-3)24-22(15)19(25)11-16(14)17(13-27-2)23(26)29-4/h6-8,13-14,16,19,24H,5,9-12H2,1-4H3/b17-13+/t14-,16+,19+/m1/s1
Affinity DataEC50:  0.490nMAssay Description:Agonist activity at human MOR expressed in HEK293T cells assessed as inhibition of forskolin-stimulated cAMP accumulation incubated for 30 mins by Gl...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580193(CHEMBL5086786)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C28H32N2O4/c1-4-18-16-30-14-13-28(32)25-20(19-9-6-5-7-10-19)11-8-12-23(25)29-26(28)24(30)15-21(18)22(17-33-2)27(31)34-3/h5-12,17-18,21,24,32H,4,13-16H2,1-3H3/b22-17+/t18-,21+,24+,28+/m1/s1
Affinity DataEC50:  1.92E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580194(CHEMBL5074977)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-15-12-25-10-9-23(27)20-14(2)7-6-8-18(20)24-21(23)19(25)11-16(15)17(13-28-3)22(26)29-4/h6-8,13,15-16,19,27H,5,9-12H2,1-4H3/b17-13+/t15-,16+,19+,23+/m1/s1
Affinity DataEC50:  1.04E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580195(CHEMBL5071286)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(-c5ccoc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C26H30N2O5/c1-4-16-13-28-10-9-26(30)23-18(17-8-11-33-14-17)6-5-7-21(23)27-24(26)22(28)12-19(16)20(15-31-2)25(29)32-3/h5-8,11,14-16,19,22,30H,4,9-10,12-13H2,1-3H3/b20-15+/t16-,19+,22+,26+/m1/s1
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580203(CHEMBL5089366)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-21(7-6-18(24(23)33-3)17-8-11-35-14-17)28-25(27)22(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,22,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,22+,27+/m1/s1
Affinity DataEC50:  8.04E+3nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM21015((2S)-2-{2-[(2R)-2-[(2S)-2-amino-3-(4-hydroxyphenyl...)
Show SMILES C[C@@H](NC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)NCC(=O)N(C)[C@@H](Cc1ccccc1)C(=O)NCCO
Show InChI InChI=1S/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1
Affinity DataEC50:  182nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580193(CHEMBL5086786)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(c34)-c3ccccc3)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C28H32N2O4/c1-4-18-16-30-14-13-28(32)25-20(19-9-6-5-7-10-19)11-8-12-23(25)29-26(28)24(30)15-21(18)22(17-33-2)27(31)34-3/h5-12,17-18,21,24,32H,4,13-16H2,1-3H3/b22-17+/t18-,21+,24+,28+/m1/s1
Affinity DataEC50:  1.91E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580194(CHEMBL5074977)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(C)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C23H30N2O4/c1-5-15-12-25-10-9-23(27)20-14(2)7-6-8-18(20)24-21(23)19(25)11-16(15)17(13-28-3)22(26)29-4/h6-8,13,15-16,19,27H,5,9-12H2,1-4H3/b17-13+/t15-,16+,19+,23+/m1/s1
Affinity DataEC50:  1.05E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580203(CHEMBL5089366)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4ccc(-c5ccoc5)c(OC)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C27H32N2O6/c1-5-16-13-29-10-9-27(31)23-21(7-6-18(24(23)33-3)17-8-11-35-14-17)28-25(27)22(29)12-19(16)20(15-32-2)26(30)34-4/h6-8,11,14-16,19,22,31H,5,9-10,12-13H2,1-4H3/b20-15+/t16-,19+,22+,27+/m1/s1
Affinity DataEC50:  8.13E+3nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMu-type opioid receptor(Homo sapiens (Human))
University of Health Sciences & Pharmacy at St. Louis

Curated by ChEMBL
LigandPNGBDBM50580195(CHEMBL5071286)
Show SMILES CC[C@@H]1CN2CC[C@@]3(O)C(=Nc4cccc(-c5ccoc5)c34)[C@@H]2C[C@@H]1\C(=C/OC)C(=O)OC
Show InChI InChI=1S/C26H30N2O5/c1-4-16-13-28-10-9-26(30)23-18(17-8-11-33-14-17)6-5-7-21(23)27-24(26)22(28)12-19(16)20(15-31-2)25(29)32-3/h5-8,11,14-16,19,22,30H,4,9-10,12-13H2,1-3H3/b20-15+/t16-,19+,22+,26+/m1/s1
Affinity DataEC50:  1.10E+4nMAssay Description:Agonist activity at human MOR receptor expressed in HTLA cells co-expressing TEV-fused-beta-arrestin2 assessed as induction of beta-arrestin2 recruit...More data for this Ligand-Target Pair
Displayed 1 to 50 (of 55 total ) | Next | Last >>
Jump to: