Compile Data Set for Download or QSAR
Found 131 Enz. Inhib. hit(s) with all data for entry = 50015202
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583757(CHEMBL5073869)
Show SMILES Cc1oc2ccc(cc2c1C)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C15H15N3O/c1-8-9(2)19-13-4-3-10(5-12(8)13)11-6-14(16)18-15(17)7-11/h3-7H,1-2H3,(H4,16,17,18)
Affinity DataIC50: 1nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583753(CHEMBL5088511)
Show SMILES Cc1nc2ccc(nc2n1CCOc1ccccc1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C20H20N6O/c1-13-23-17-8-7-16(14-11-18(21)25-19(22)12-14)24-20(17)26(13)9-10-27-15-5-3-2-4-6-15/h2-8,11-12H,9-10H2,1H3,(H4,21,22,25)
Affinity DataIC50: 1nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583748(CHEMBL5084504)
Show SMILES Cc1nc2ccc(nc2n1C1CCCC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C17H20N6/c1-10-20-14-7-6-13(11-8-15(18)22-16(19)9-11)21-17(14)23(10)12-4-2-3-5-12/h6-9,12H,2-5H2,1H3,(H4,18,19,22)
Affinity DataIC50: 1nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583723(CHEMBL5092882)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2ncsc2c1
Show InChI InChI=1S/C12H10N4S/c13-11-4-8(5-12(14)16-11)7-1-2-9-10(3-7)17-6-15-9/h1-6H,(H4,13,14,16)
Affinity DataIC50: 1nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583744(CHEMBL5082456)
Show SMILES CCCCn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H20N6/c1-3-4-7-22-10(2)19-13-6-5-12(20-16(13)22)11-8-14(17)21-15(18)9-11/h5-6,8-9H,3-4,7H2,1-2H3,(H4,17,18,21)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583755(CHEMBL5070553)
Show SMILES Cc1nc2ccc(nc2n1CC(F)(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C14H13F3N6/c1-7-20-10-3-2-9(8-4-11(18)22-12(19)5-8)21-13(10)23(7)6-14(15,16)17/h2-5H,6H2,1H3,(H4,18,19,22)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583762(CHEMBL5089171)
Show SMILES Cc1nc2ccc(nc2n1CCOc1cccc(Br)n1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C19H18BrN7O/c1-11-23-14-6-5-13(12-9-16(21)26-17(22)10-12)24-19(14)27(11)7-8-28-18-4-2-3-15(20)25-18/h2-6,9-10H,7-8H2,1H3,(H4,21,22,26)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583728(CHEMBL5081583)
Show SMILES Nc1cc(cc(N)n1)-c1ccn2nccc2n1
Show InChI InChI=1S/C11H10N6/c12-9-5-7(6-10(13)16-9)8-2-4-17-11(15-8)1-3-14-17/h1-6H,(H4,12,13,16)
Affinity DataIC50: 2nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583763(CHEMBL5093661)
Show SMILES Cc1nc2ccc(nc2n1CCOc1cccc(Cl)n1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C19H18ClN7O/c1-11-23-14-6-5-13(12-9-16(21)26-17(22)10-12)24-19(14)27(11)7-8-28-18-4-2-3-15(20)25-18/h2-6,9-10H,7-8H2,1H3,(H4,21,22,26)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583754(CHEMBL5077927)
Show SMILES Cc1nc2ccc(nc2n1CC(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C14H14F2N6/c1-7-19-10-3-2-9(8-4-12(17)21-13(18)5-8)20-14(10)22(7)6-11(15)16/h2-5,11H,6H2,1H3,(H4,17,18,21)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50530430(CHEMBL4460561)
Show SMILES Cc1nc2ccc(nc2n1C1CC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C15H16N6/c1-8-18-12-5-4-11(9-6-13(16)20-14(17)7-9)19-15(12)21(8)10-2-3-10/h4-7,10H,2-3H2,1H3,(H4,16,17,20)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583752(CHEMBL5073976)
Show SMILES Cc1nc2ccc(nc2n1CCc1ccco1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C18H18N6O/c1-11-21-15-5-4-14(12-9-16(19)23-17(20)10-12)22-18(15)24(11)7-6-13-3-2-8-25-13/h2-5,8-10H,6-7H2,1H3,(H4,19,20,23)
Affinity DataIC50: 3nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583754(CHEMBL5077927)
Show SMILES Cc1nc2ccc(nc2n1CC(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C14H14F2N6/c1-7-19-10-3-2-9(8-4-12(17)21-13(18)5-8)20-14(10)22(7)6-11(15)16/h2-5,11H,6H2,1H3,(H4,17,18,21)
Affinity DataIC50: 4nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583750(CHEMBL5072926)
Show SMILES Cc1nc2ccc(nc2n1CCC1CCCCC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C20H26N6/c1-13-23-17-8-7-16(15-11-18(21)25-19(22)12-15)24-20(17)26(13)10-9-14-5-3-2-4-6-14/h7-8,11-12,14H,2-6,9-10H2,1H3,(H4,21,22,25)
Affinity DataIC50: 4nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583764(CHEMBL5084166)
Show SMILES C[C@H](Cn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1)Oc1cccc(Br)n1
Show InChI InChI=1S/C20H20BrN7O/c1-11(29-19-5-3-4-16(21)26-19)10-28-12(2)24-15-7-6-14(25-20(15)28)13-8-17(22)27-18(23)9-13/h3-9,11H,10H2,1-2H3,(H4,22,23,27)/t11-/m1/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583749(CHEMBL5089294)
Show SMILES COCCCn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H20N6O/c1-10-19-13-5-4-12(11-8-14(17)21-15(18)9-11)20-16(13)22(10)6-3-7-23-2/h4-5,8-9H,3,6-7H2,1-2H3,(H4,17,18,21)
Affinity DataIC50: 5nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583749(CHEMBL5089294)
Show SMILES COCCCn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H20N6O/c1-10-19-13-5-4-12(11-8-14(17)21-15(18)9-11)20-16(13)22(10)6-3-7-23-2/h4-5,8-9H,3,6-7H2,1-2H3,(H4,17,18,21)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583756(CHEMBL5080497)
Show SMILES Cc1nc2ccc(nc2n1CCCC(F)(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H17F3N6/c1-9-22-12-4-3-11(10-7-13(20)24-14(21)8-10)23-15(12)25(9)6-2-5-16(17,18)19/h3-4,7-8H,2,5-6H2,1H3,(H4,20,21,24)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583755(CHEMBL5070553)
Show SMILES Cc1nc2ccc(nc2n1CC(F)(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C14H13F3N6/c1-7-20-10-3-2-9(8-4-11(18)22-12(19)5-8)21-13(10)23(7)6-14(15,16)17/h2-5H,6H2,1H3,(H4,18,19,22)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583752(CHEMBL5073976)
Show SMILES Cc1nc2ccc(nc2n1CCc1ccco1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C18H18N6O/c1-11-21-15-5-4-14(12-9-16(19)23-17(20)10-12)22-18(15)24(11)7-6-13-3-2-8-25-13/h2-5,8-10H,6-7H2,1H3,(H4,19,20,23)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583747(CHEMBL5094409)
Show SMILES Cc1nc2ccc(nc2n1C(C)(C)C)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H20N6/c1-9-19-12-6-5-11(10-7-13(17)21-14(18)8-10)20-15(12)22(9)16(2,3)4/h5-8H,1-4H3,(H4,17,18,21)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583759(CHEMBL5077422)
Show SMILES Cc1nc2ccc(nc2n1CCOc1ccccn1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C19H19N7O/c1-12-23-15-6-5-14(13-10-16(20)25-17(21)11-13)24-19(15)26(12)8-9-27-18-4-2-3-7-22-18/h2-7,10-11H,8-9H2,1H3,(H4,20,21,25)
Affinity DataIC50: 6nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583760(CHEMBL5092833)
Show SMILES C[C@H](Cn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1)Oc1ccccn1
Show InChI InChI=1S/C20H21N7O/c1-12(28-19-5-3-4-8-23-19)11-27-13(2)24-16-7-6-15(25-20(16)27)14-9-17(21)26-18(22)10-14/h3-10,12H,11H2,1-2H3,(H4,21,22,26)/t12-/m1/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583747(CHEMBL5094409)
Show SMILES Cc1nc2ccc(nc2n1C(C)(C)C)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H20N6/c1-9-19-12-6-5-11(10-7-13(17)21-14(18)8-10)20-15(12)22(9)16(2,3)4/h5-8H,1-4H3,(H4,17,18,21)
Affinity DataIC50: 7nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583758(CHEMBL5071425)
Show SMILES C[C@@H](Cn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1)Oc1ccccc1
Show InChI InChI=1S/C21H22N6O/c1-13(28-16-6-4-3-5-7-16)12-27-14(2)24-18-9-8-17(25-21(18)27)15-10-19(22)26-20(23)11-15/h3-11,13H,12H2,1-2H3,(H4,22,23,26)/t13-/m0/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583746(CHEMBL5091644)
Show SMILES CCCCc1nc2ccc(nc2n1CCCC)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C19H26N6/c1-3-5-7-18-22-15-9-8-14(13-11-16(20)24-17(21)12-13)23-19(15)25(18)10-6-4-2/h8-9,11-12H,3-7,10H2,1-2H3,(H4,20,21,24)
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50530429(CHEMBL4575900)
Show SMILES C[C@H](Cn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1)Oc1ccccc1
Show InChI InChI=1S/C21H22N6O/c1-13(28-16-6-4-3-5-7-16)12-27-14(2)24-18-9-8-17(25-21(18)27)15-10-19(22)26-20(23)11-15/h3-11,13H,12H2,1-2H3,(H4,22,23,26)/t13-/m1/s1
Affinity DataIC50: 8nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583750(CHEMBL5072926)
Show SMILES Cc1nc2ccc(nc2n1CCC1CCCCC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C20H26N6/c1-13-23-17-8-7-16(15-11-18(21)25-19(22)12-15)24-20(17)26(13)10-9-14-5-3-2-4-6-14/h7-8,11-12,14H,2-6,9-10H2,1H3,(H4,21,22,25)
Affinity DataIC50: 9nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583753(CHEMBL5088511)
Show SMILES Cc1nc2ccc(nc2n1CCOc1ccccc1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C20H20N6O/c1-13-23-17-8-7-16(14-11-18(21)25-19(22)12-14)24-20(17)26(13)9-10-27-15-5-3-2-4-6-15/h2-8,11-12H,9-10H2,1H3,(H4,21,22,25)
Affinity DataIC50: 9nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583756(CHEMBL5080497)
Show SMILES Cc1nc2ccc(nc2n1CCCC(F)(F)F)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C16H17F3N6/c1-9-22-12-4-3-11(10-7-13(20)24-14(21)8-10)23-15(12)25(9)6-2-5-16(17,18)19/h3-4,7-8H,2,5-6H2,1H3,(H4,20,21,24)
Affinity DataIC50: 10nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583721(CHEMBL5081861)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2occc2n1
Show InChI InChI=1S/C12H10N4O/c13-11-5-7(6-12(14)16-11)8-1-2-10-9(15-8)3-4-17-10/h1-6H,(H4,13,14,16)
Affinity DataIC50: 10nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583732(CHEMBL5089304)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2ncccc2c1
Show InChI InChI=1S/C14H12N4/c15-13-7-11(8-14(16)18-13)9-3-4-12-10(6-9)2-1-5-17-12/h1-8H,(H4,15,16,18)
Affinity DataIC50: 10nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583722(CHEMBL5089741)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2ncoc2c1
Show InChI InChI=1S/C12H10N4O/c13-11-4-8(5-12(14)16-11)7-1-2-9-10(3-7)17-6-15-9/h1-6H,(H4,13,14,16)
Affinity DataIC50: 10nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583745(CHEMBL5092736)
Show SMILES CCCCn1c(CC)nc2ccc(nc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C17H22N6/c1-3-5-8-23-16(4-2)20-13-7-6-12(21-17(13)23)11-9-14(18)22-15(19)10-11/h6-7,9-10H,3-5,8H2,1-2H3,(H4,18,19,22)
Affinity DataIC50: 11nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50530430(CHEMBL4460561)
Show SMILES Cc1nc2ccc(nc2n1C1CC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C15H16N6/c1-8-18-12-5-4-11(9-6-13(16)20-14(17)7-9)19-15(12)21(8)10-2-3-10/h4-7,10H,2-3H2,1H3,(H4,16,17,20)
Affinity DataIC50: 11nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583730(CHEMBL5094016)
Show SMILES Nc1cc(cc(N)n1)C1=CC2OCCOC2C=C1
Show InChI InChI=1S/C13H15N3O2/c14-12-6-9(7-13(15)16-12)8-1-2-10-11(5-8)18-4-3-17-10/h1-2,5-7,10-11H,3-4H2,(H4,14,15,16)
Affinity DataIC50: 11nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583748(CHEMBL5084504)
Show SMILES Cc1nc2ccc(nc2n1C1CCCC1)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C17H20N6/c1-10-20-14-7-6-13(11-8-15(18)22-16(19)9-11)21-17(14)23(10)12-4-2-3-5-12/h6-9,12H,2-5H2,1H3,(H4,18,19,22)
Affinity DataIC50: 13nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583725(CHEMBL5080876)
Show SMILES Cn1cnc2ccc(nc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C12H12N6/c1-18-6-15-9-3-2-8(16-12(9)18)7-4-10(13)17-11(14)5-7/h2-6H,1H3,(H4,13,14,17)
Affinity DataIC50: 13nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583724(CHEMBL5083489)
Show SMILES Cn1cnc2ccc(cc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C13H13N5/c1-18-7-16-10-3-2-8(4-11(10)18)9-5-12(14)17-13(15)6-9/h2-7H,1H3,(H4,14,15,17)
Affinity DataIC50: 14nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583718(CHEMBL5092362)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2occc2c1
Show InChI InChI=1S/C13H11N3O/c14-12-6-10(7-13(15)16-12)8-1-2-11-9(5-8)3-4-17-11/h1-7H,(H4,14,15,16)
Affinity DataIC50: 14nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583743(CHEMBL5088553)
Show SMILES Cc1nc2ccc(nc2n1C)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C13H14N6/c1-7-16-10-4-3-9(17-13(10)19(7)2)8-5-11(14)18-12(15)6-8/h3-6H,1-2H3,(H4,14,15,18)
Affinity DataIC50: 15nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583727(CHEMBL5087683)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2ncnn2c1
Show InChI InChI=1S/C11H10N6/c12-9-3-8(4-10(13)16-9)7-1-2-11-14-6-15-17(11)5-7/h1-6H,(H4,12,13,16)
Affinity DataIC50: 15nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583717(CHEMBL5094043)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C13H13N3O/c14-12-6-10(7-13(15)16-12)8-1-2-11-9(5-8)3-4-17-11/h1-2,5-7H,3-4H2,(H4,14,15,16)
Affinity DataIC50: 16nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583761(CHEMBL5079873)
Show SMILES C[C@@H](Cn1c(C)nc2ccc(nc12)-c1cc(N)nc(N)c1)Oc1ccccn1
Show InChI InChI=1S/C20H21N7O/c1-12(28-19-5-3-4-8-23-19)11-27-13(2)24-16-7-6-15(25-20(16)27)14-9-17(21)26-18(22)10-14/h3-10,12H,11H2,1-2H3,(H4,21,22,26)/t12-/m0/s1
Affinity DataIC50: 16nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583737(CHEMBL5083033)
Show SMILES CNc1cc(cc(N)n1)-c1ccc2occc2c1
Show InChI InChI=1S/C14H13N3O/c1-16-14-8-11(7-13(15)17-14)9-2-3-12-10(6-9)4-5-18-12/h2-8H,1H3,(H3,15,16,17)
Affinity DataIC50: 17nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583726(CHEMBL5092022)
Show SMILES Nc1cc(cc(N)n1)-c1ccc2nccn2c1
Show InChI InChI=1S/C12H11N5/c13-10-5-9(6-11(14)16-10)8-1-2-12-15-3-4-17(12)7-8/h1-7H,(H4,13,14,16)
Affinity DataIC50: 17nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583733(CHEMBL5083053)
Show SMILES Nc1cc(ccn1)-c1ccc2occc2c1
Show InChI InChI=1S/C13H10N2O/c14-13-8-10(3-5-15-13)9-1-2-12-11(7-9)4-6-16-12/h1-8H,(H2,14,15)
Affinity DataIC50: 19nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583729(CHEMBL5071564)
Show SMILES Cc1onc2ccc(cc12)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C13H12N4O/c1-7-10-4-8(2-3-11(10)17-18-7)9-5-12(14)16-13(15)6-9/h2-6H,1H3,(H4,14,15,16)
Affinity DataIC50: 19nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetDual specificity tyrosine-phosphorylation-regulated kinase 2(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583757(CHEMBL5073869)
Show SMILES Cc1oc2ccc(cc2c1C)-c1cc(N)nc(N)c1
Show InChI InChI=1S/C15H15N3O/c1-8-9(2)19-13-4-3-10(5-12(8)13)11-6-14(16)18-15(17)7-11/h3-7H,1-2H3,(H4,16,17,18)
Affinity DataIC50: 21nMAssay Description:Inhibition of DYRK2 (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Servier Research Institute of Medicinal Chemistry

Curated by ChEMBL
LigandPNGBDBM50583715(CHEMBL5084991)
Show SMILES Nc1cc(nc(N)n1)-c1ccc2OCCc2c1
Show InChI InChI=1S/C12H12N4O/c13-11-6-9(15-12(14)16-11)7-1-2-10-8(5-7)3-4-17-10/h1-2,5-6H,3-4H2,(H4,13,14,15,16)
Affinity DataIC50: 22nMAssay Description:Inhibition of DYRK1A (unknown origin) using Ulight-MBP as substrate and ATP as co-substrate incubated for 40 mins and measured after 1 hr by TR-FRET ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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