Compile Data Set for Download or QSAR
Found 126 Enz. Inhib. hit(s) with all data for entry = 50015277
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 6.30nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 7nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584944(CHEMBL5087319)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCCC2)c2nnc(C)n2n1
Show InChI InChI=1S/C28H36N8O2/c1-17(2)24-25-20-10-5-4-9-19(20)15-23(27(37)30-24)35(25)28(38)22-16-21(26-32-31-18(3)36(26)33-22)29-11-8-14-34-12-6-7-13-34/h4-5,9-10,16-17,23-25,29H,6-8,11-15H2,1-3H3,(H,30,37)/t23-,24+,25+/m0/s1
Affinity DataIC50: 14nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584944(CHEMBL5087319)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCCC2)c2nnc(C)n2n1
Show InChI InChI=1S/C28H36N8O2/c1-17(2)24-25-20-10-5-4-9-19(20)15-23(27(37)30-24)35(25)28(38)22-16-21(26-32-31-18(3)36(26)33-22)29-11-8-14-34-12-6-7-13-34/h4-5,9-10,16-17,23-25,29H,6-8,11-15H2,1-3H3,(H,30,37)/t23-,24+,25+/m0/s1
Affinity DataIC50: 16nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584945(CHEMBL5093862)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCC(F)(F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-17(2)24-25-20-8-5-4-7-19(20)15-23(27(40)33-24)38(25)28(41)22-16-21(26-35-34-18(3)39(26)36-22)32-11-6-12-37-13-9-29(30,31)10-14-37/h4-5,7-8,16-17,23-25,32H,6,9-15H2,1-3H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584945(CHEMBL5093862)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCC(F)(F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-17(2)24-25-20-8-5-4-7-19(20)15-23(27(40)33-24)38(25)28(41)22-16-21(26-35-34-18(3)39(26)36-22)32-11-6-12-37-13-9-29(30,31)10-14-37/h4-5,7-8,16-17,23-25,32H,6,9-15H2,1-3H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 20nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 22nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C24H28N8O2/c1-14-27-28-22-18(26-16-7-9-30(2)10-8-16)12-19(29-32(14)22)24(34)31-20-11-15-5-3-4-6-17(15)21(31)13-25-23(20)33/h3-6,12,16,20-21,26H,7-11,13H2,1-2H3,(H,25,33)/t20-,21-/m0/s1
Affinity DataIC50: 32nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584943(CHEMBL5086059)
Show SMILES Cc1nnc2c(NCCCN3CCCC3)cc(nn12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C25H30N8O2/c1-16-28-29-23-19(26-9-6-12-31-10-4-5-11-31)14-20(30-33(16)23)25(35)32-21-13-17-7-2-3-8-18(17)22(32)15-27-24(21)34/h2-3,7-8,14,21-22,26H,4-6,9-13,15H2,1H3,(H,27,34)/t21-,22-/m0/s1
Affinity DataIC50: 40nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584943(CHEMBL5086059)
Show SMILES Cc1nnc2c(NCCCN3CCCC3)cc(nn12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C25H30N8O2/c1-16-28-29-23-19(26-9-6-12-31-10-4-5-11-31)14-20(30-33(16)23)25(35)32-21-13-17-7-2-3-8-18(17)22(32)15-27-24(21)34/h2-3,7-8,14,21-22,26H,4-6,9-13,15H2,1H3,(H,27,34)/t21-,22-/m0/s1
Affinity DataIC50: 41nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 50nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 78nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 79nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 79nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 100nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584925(CHEMBL5079885)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(C)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C30H39FN8O2/c1-17(2)25-26-21-9-7-6-8-19(21)14-24(28(40)33-25)38(26)29(41)23-15-22(27-35-34-18(3)39(27)36-23)32-20-10-12-37(13-11-20)16-30(4,5)31/h6-9,15,17,20,24-26,32H,10-14,16H2,1-5H3,(H,33,40)/t24-,25+,26+/m0/s1
Affinity DataIC50: 126nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50464128(CHEMBL4206758)
Show SMILES CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12
Show InChI InChI=1S/C28H35F2N5O3/c1-16-8-19(11-31-10-16)21-12-33-26(24-20(21)9-17(2)27(36)35-24)34-25-22(37-3)13-32-14-23(25)38-15-18-4-6-28(29,30)7-5-18/h8-12,18,22-23,25,32H,4-7,13-15H2,1-3H3,(H,33,34)(H,35,36)/t22-,23+,25+/m0/s1
Affinity DataIC50: 158nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50464128(CHEMBL4206758)
Show SMILES CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12
Show InChI InChI=1S/C28H35F2N5O3/c1-16-8-19(11-31-10-16)21-12-33-26(24-20(21)9-17(2)27(36)35-24)34-25-22(37-3)13-32-14-23(25)38-15-18-4-6-28(29,30)7-5-18/h8-12,18,22-23,25,32H,4-7,13-15H2,1-3H3,(H,33,34)(H,35,36)/t22-,23+,25+/m0/s1
Affinity DataIC50: 200nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584936(CHEMBL5074983)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12
Affinity DataIC50: 200nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584936(CHEMBL5074983)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12
Affinity DataIC50: 210nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50464128(CHEMBL4206758)
Show SMILES CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12
Show InChI InChI=1S/C28H35F2N5O3/c1-16-8-19(11-31-10-16)21-12-33-26(24-20(21)9-17(2)27(36)35-24)34-25-22(37-3)13-32-14-23(25)38-15-18-4-6-28(29,30)7-5-18/h8-12,18,22-23,25,32H,4-7,13-15H2,1-3H3,(H,33,34)(H,35,36)/t22-,23+,25+/m0/s1
Affinity DataIC50: 251nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584939(CHEMBL5084768)
Show SMILES Cc1nnc2c(N)cc(nn12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C18H17N7O2/c1-9-21-22-16-12(19)7-13(23-25(9)16)18(27)24-14-6-10-4-2-3-5-11(10)15(24)8-20-17(14)26/h2-5,7,14-15H,6,8,19H2,1H3,(H,20,26)/t14-,15-/m0/s1
Affinity DataIC50: 251nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584939(CHEMBL5084768)
Show SMILES Cc1nnc2c(N)cc(nn12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C18H17N7O2/c1-9-21-22-16-12(19)7-13(23-25(9)16)18(27)24-14-6-10-4-2-3-5-11(10)15(24)8-20-17(14)26/h2-5,7,14-15H,6,8,19H2,1H3,(H,20,26)/t14-,15-/m0/s1
Affinity DataIC50: 280nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C24H28N8O2/c1-14-27-28-22-18(26-16-7-9-30(2)10-8-16)12-19(29-32(14)22)24(34)31-20-11-15-5-3-4-6-17(15)21(31)13-25-23(20)33/h3-6,12,16,20-21,26H,7-11,13H2,1-2H3,(H,25,33)/t20-,21-/m0/s1
Affinity DataIC50: 300nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584940(CHEMBL5092181)
Show SMILES CN1CCC(CC1)Nc1cc(cn2c(C)nnc12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C25H29N7O2/c1-15-28-29-23-20(27-18-7-9-30(2)10-8-18)11-17(14-31(15)23)25(34)32-21-12-16-5-3-4-6-19(16)22(32)13-26-24(21)33/h3-6,11,14,18,21-22,27H,7-10,12-13H2,1-2H3,(H,26,33)/t21-,22-/m0/s1
Affinity DataIC50: 370nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584940(CHEMBL5092181)
Show SMILES CN1CCC(CC1)Nc1cc(cn2c(C)nnc12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C25H29N7O2/c1-15-28-29-23-20(27-18-7-9-30(2)10-8-18)11-17(14-31(15)23)25(34)32-21-12-16-5-3-4-6-19(16)22(32)13-26-24(21)33/h3-6,11,14,18,21-22,27H,7-10,12-13H2,1-2H3,(H,26,33)/t21-,22-/m0/s1
Affinity DataIC50: 398nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584935(CHEMBL5083025)
Show SMILES Cn1cc(C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O)c2c3ccccc3[nH]c2c1=O
Affinity DataIC50: 398nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584937(CHEMBL5093167)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12
Affinity DataIC50: 398nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584935(CHEMBL5083025)
Show SMILES Cn1cc(C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O)c2c3ccccc3[nH]c2c1=O
Affinity DataIC50: 420nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584937(CHEMBL5093167)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccccc3c12
Affinity DataIC50: 440nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 501nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 501nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 501nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 501nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584946(CHEMBL5090369)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NC2CCN(CC(C)(F)F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-16(2)24-25-20-8-6-5-7-18(20)13-23(27(40)33-24)38(25)28(41)22-14-21(26-35-34-17(3)39(26)36-22)32-19-9-11-37(12-10-19)15-29(4,30)31/h5-8,14,16,19,23-25,32H,9-13,15H2,1-4H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 501nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50464128(CHEMBL4206758)
Show SMILES CO[C@H]1CNC[C@@H](OCC2CCC(F)(F)CC2)[C@@H]1Nc1ncc(-c2cncc(C)c2)c2cc(C)c(=O)[nH]c12
Show InChI InChI=1S/C28H35F2N5O3/c1-16-8-19(11-31-10-16)21-12-33-26(24-20(21)9-17(2)27(36)35-24)34-25-22(37-3)13-32-14-23(25)38-15-18-4-6-28(29,30)7-5-18/h8-12,18,22-23,25,32H,4-7,13-15H2,1-3H3,(H,33,34)(H,35,36)/t22-,23+,25+/m0/s1
Affinity DataIC50: 631nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 794nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 794nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2 BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated fo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584938(CHEMBL5086260)
Show SMILES C[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cn(C)c(=O)c2[nH]c3ccc(OC(F)(F)F)cc3c12
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584945(CHEMBL5093862)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCC(F)(F)CC2)c2nnc(C)n2n1
Show InChI InChI=1S/C29H36F2N8O2/c1-17(2)24-25-20-8-5-4-7-19(20)15-23(27(40)33-24)38(25)28(41)22-16-21(26-35-34-18(3)39(26)36-22)32-11-6-12-37-13-9-29(30,31)10-14-37/h4-5,7-8,16-17,23-25,32H,6,9-15H2,1-3H3,(H,33,40)/t23-,24+,25+/m0/s1
Affinity DataIC50: 1.26E+3nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584931(CHEMBL5083653)
Show SMILES Cn1cc(C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O)c2cc[nH]c2c1=O
Affinity DataIC50: 1.48E+3nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584931(CHEMBL5083653)
Show SMILES Cn1cc(C(=O)N2[C@H]3Cc4ccccc4[C@@H]2CNC3=O)c2cc[nH]c2c1=O
Affinity DataIC50: 1.59E+3nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584944(CHEMBL5087319)
Show SMILES CC(C)[C@H]1NC(=O)[C@@H]2Cc3ccccc3[C@H]1N2C(=O)c1cc(NCCCN2CCCC2)c2nnc(C)n2n1
Show InChI InChI=1S/C28H36N8O2/c1-17(2)24-25-20-10-5-4-9-19(20)15-23(27(37)30-24)35(25)28(38)22-16-21(26-32-31-18(3)36(26)33-22)29-11-8-14-34-12-6-7-13-34/h4-5,9-10,16-17,23-25,29H,6-8,11-15H2,1-3H3,(H,30,37)/t23-,24+,25+/m0/s1
Affinity DataIC50: 2.00E+3nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584941(CHEMBL5077167)
Show SMILES CN1CCC(CC1)Nc1cc(nn2c(C)nnc12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Show InChI InChI=1S/C24H28N8O2/c1-14-27-28-22-18(26-16-7-9-30(2)10-8-16)12-19(29-32(14)22)24(34)31-20-11-15-5-3-4-6-17(15)21(31)13-25-23(20)33/h3-6,12,16,20-21,26H,7-11,13H2,1-2H3,(H,25,33)/t20-,21-/m0/s1
Affinity DataIC50: 2.51E+3nMAssay Description:Displacement of Halo-tagged Histone H3.3 from Nanoluc-ATAD2A BD (962 to 1119 residues) (unknown origin) transfected in human HCT116 cells incubated f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584947(CHEMBL5074478)
Show SMILES CC1=C(C#N)c2nc(N)c(C#N)c(C)c2\C1=C/c1ccc(o1)-c1cc(ccc1Cl)C(O)=O
Show InChI InChI=1S/C24H15ClN4O3/c1-11-15(21-12(2)18(10-27)23(28)29-22(21)17(11)9-26)8-14-4-6-20(32-14)16-7-13(24(30)31)3-5-19(16)25/h3-8H,1-2H3,(H2,28,29)(H,30,31)/b15-8-
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584934(CHEMBL5090538)
Show SMILES CN1C[C@@H]2N([C@@H](Cc3ccccc23)C1=O)C(=O)c1cn(C)c(=O)c2[nH]ccc12
Affinity DataIC50: 3.16E+3nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584934(CHEMBL5090538)
Show SMILES CN1C[C@@H]2N([C@@H](Cc3ccccc23)C1=O)C(=O)c1cn(C)c(=O)c2[nH]ccc12
Affinity DataIC50: 3.56E+3nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584932(CHEMBL5087156)
Show SMILES COc1cc(cc2c(C)n[nH]c12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Affinity DataIC50: 4.88E+3nMAssay Description:Inhibition of GST-ATAD2 BD (951 to 1132 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetATPase family AAA domain-containing protein 2(Homo sapiens (Human))
AstraZeneca

Curated by ChEMBL
LigandPNGBDBM50584932(CHEMBL5087156)
Show SMILES COc1cc(cc2c(C)n[nH]c12)C(=O)N1[C@H]2Cc3ccccc3[C@@H]1CNC2=O
Affinity DataIC50: 5.01E+3nMAssay Description:Inhibition of GST-ATAD2 BD (981 to 1108 residues) (unknown origin) expressed in Escherichia coli BL21 (DE3) and biotinylated tetra-acetylated histone...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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