Compile Data Set for Download or QSAR
Found 85 Enz. Inhib. hit(s) with all data for entry = 50018206
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Show SMILES CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C21H28BrN3O3/c1-20(2,28-17-4-3-15(22)11-24-17)19(27)25-18-13-5-12-6-14(18)9-21(7-12,8-13)10-16(23)26/h3-4,11-14,18H,5-10H2,1-2H3,(H2,23,26)(H,25,27)/t12-,13-,14?,18+,21+/m0/s1
Affinity DataIC50: 4nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192792(CHEMBL219348 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)-n1cccn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C24H31N5O3/c1-23(2,32-20-5-4-18(14-26-20)29-7-3-6-27-29)22(31)28-21-16-8-15-9-17(21)12-24(10-15,11-16)13-19(25)30/h3-7,14-17,21H,8-13H2,1-2H3,(H2,25,30)(H,28,31)/t15-,16-,17?,21+,24+/m0/s1
Affinity DataIC50: 5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Show SMILES CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C21H28BrN3O3/c1-20(2,28-17-4-3-15(22)11-24-17)19(27)25-18-13-5-12-6-14(18)9-21(7-12,8-13)10-16(23)26/h3-4,11-14,18H,5-10H2,1-2H3,(H2,23,26)(H,25,27)/t12-,13-,14?,18+,21+/m0/s1
Affinity DataIC50: 6nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ncc[nH]1
Show InChI InChI=1S/C23H28ClN3O2/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)27-19-15-9-14-10-16(19)13-23(11-14,12-15)20-25-7-8-26-20/h3-8,14-16,19H,9-13H2,1-2H3,(H,25,26)(H,27,28)/t14-,15-,16?,19+,23+/m0/s1
Affinity DataIC50: 10nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192792(CHEMBL219348 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)-n1cccn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C24H31N5O3/c1-23(2,32-20-5-4-18(14-26-20)29-7-3-6-27-29)22(31)28-21-16-8-15-9-17(21)12-24(10-15,11-16)13-19(25)30/h3-7,14-17,21H,8-13H2,1-2H3,(H2,25,30)(H,28,31)/t15-,16-,17?,21+,24+/m0/s1
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ncc[nH]1
Show InChI InChI=1S/C23H28ClN3O2/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)27-19-15-9-14-10-16(19)13-23(11-14,12-15)20-25-7-8-26-20/h3-8,14-16,19H,9-13H2,1-2H3,(H,25,26)(H,27,28)/t14-,15-,16?,19+,23+/m0/s1
Affinity DataIC50: 11nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192798(CHEMBL219349 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H28N4O2/c1-21(2,17-4-3-13(11-23)12-25-17)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-18(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 14nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192791(2-(5-bromo-pyridin-2-yloxy)-N-((1R,2S,5R,7S)-5-car...)
Show SMILES CC(C)(Oc1ccc(Br)cn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C21H28BrN3O3/c1-20(2,28-17-4-3-15(22)11-24-17)19(27)25-18-13-5-12-6-14(18)9-21(7-12,8-13)10-16(23)26/h3-4,11-14,18H,5-10H2,1-2H3,(H2,23,26)(H,25,27)/t12-,13-,14?,18+,21+/m0/s1
Affinity DataIC50: 18nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192790(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxy...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)C(=N)NO
Show InChI InChI=1S/C21H28ClN3O3/c1-20(2,28-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-27/h3-6,12-14,17,27H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13-,14?,17+,21+/m0/s1
Affinity DataIC50: 26nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192785(CHEMBL385176 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H28N4O3/c1-21(2,29-18-4-3-13(11-23)12-25-18)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-17(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 28nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192795(CHEMBL219081 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CNc1ccc(cn1)C(C)(C)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H32N4O2/c1-21(2,16-4-5-18(24-3)25-12-16)20(28)26-19-14-6-13-7-15(19)10-22(8-13,9-14)11-17(23)27/h4-5,12-15,19H,6-11H2,1-3H3,(H2,23,27)(H,24,25)(H,26,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 29nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192800(2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ccno1
Show InChI InChI=1S/C23H27ClN2O3/c1-22(2,28-18-5-3-17(24)4-6-18)21(27)26-20-15-9-14-10-16(20)13-23(11-14,12-15)19-7-8-25-29-19/h3-8,14-16,20H,9-13H2,1-2H3,(H,26,27)/t14-,15-,16?,20+,23+/m0/s1
Affinity DataIC50: 31nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192787(CHEMBL219136 | N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nnc(N)[nH]1
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-16-5-3-15(23)4-6-16)19(29)25-17-13-7-12-8-14(17)11-22(9-12,10-13)18-26-20(24)28-27-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,25,29)(H3,24,26,27,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 35nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192785(CHEMBL385176 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H28N4O3/c1-21(2,29-18-4-3-13(11-23)12-25-18)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-17(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 36nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192792(CHEMBL219348 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)-n1cccn1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C24H31N5O3/c1-23(2,32-20-5-4-18(14-26-20)29-7-3-6-27-29)22(31)28-21-16-8-15-9-17(21)12-24(10-15,11-16)13-19(25)30/h3-7,14-17,21H,8-13H2,1-2H3,(H2,25,30)(H,28,31)/t15-,16-,17?,21+,24+/m0/s1
Affinity DataIC50: 38nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192790(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxy...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)C(=N)NO
Show InChI InChI=1S/C21H28ClN3O3/c1-20(2,28-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-27/h3-6,12-14,17,27H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13-,14?,17+,21+/m0/s1
Affinity DataIC50: 39nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192789(2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](Cc1nnn[nH]1)(C3)C2
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-17-5-3-16(23)4-6-17)20(29)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18-25-27-28-26-18/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,29)(H,25,26,27,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 41nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(CHEMBL216976 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C25H36N4O4/c1-24(2,33-21-4-3-19(15-27-21)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 44nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192801(CHEMBL220414 | {(1R,4S,5R,7S)-4-[2-(4-chloro-pheno...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(O)=O)(C3)C2
Show InChI InChI=1S/C22H28ClNO4/c1-21(2,28-17-5-3-16(23)4-6-17)20(27)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(25)26/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,27)(H,25,26)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 45nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192799(CHEMBL375979 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C25H36N4O3/c1-24(2,19-3-4-21(27-15-19)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 47nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(CHEMBL216976 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C25H36N4O4/c1-24(2,33-21-4-3-19(15-27-21)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 51nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192787(CHEMBL219136 | N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nnc(N)[nH]1
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-16-5-3-15(23)4-6-16)19(29)25-17-13-7-12-8-14(17)11-22(9-12,10-13)18-26-20(24)28-27-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,25,29)(H3,24,26,27,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 53nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192799(CHEMBL375979 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C25H36N4O3/c1-24(2,19-3-4-21(27-15-19)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 59nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192798(CHEMBL219349 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H28N4O2/c1-21(2,17-4-3-13(11-23)12-25-17)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-18(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 65nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192800(2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ccno1
Show InChI InChI=1S/C23H27ClN2O3/c1-22(2,28-18-5-3-17(24)4-6-18)21(27)26-20-15-9-14-10-16(20)13-23(11-14,12-15)19-7-8-25-29-19/h3-8,14-16,20H,9-13H2,1-2H3,(H,26,27)/t14-,15-,16?,20+,23+/m0/s1
Affinity DataIC50: 71nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192793(3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CCC(O)=O)(C3)C2
Show InChI InChI=1S/C23H30ClNO4/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)25-20-15-9-14-10-16(20)13-23(11-14,12-15)8-7-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15-,16?,20+,23-/m0/s1
Affinity DataIC50: 74nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192801(CHEMBL220414 | {(1R,4S,5R,7S)-4-[2-(4-chloro-pheno...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(O)=O)(C3)C2
Show InChI InChI=1S/C22H28ClNO4/c1-21(2,28-17-5-3-16(23)4-6-17)20(27)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(25)26/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,27)(H,25,26)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 82nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192789(2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](Cc1nnn[nH]1)(C3)C2
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-17-5-3-16(23)4-6-17)20(29)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18-25-27-28-26-18/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,29)(H,25,26,27,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 87nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192793(3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CCC(O)=O)(C3)C2
Show InChI InChI=1S/C23H30ClNO4/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)25-20-15-9-14-10-16(20)13-23(11-14,12-15)8-7-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15-,16?,20+,23-/m0/s1
Affinity DataIC50: 89nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192801(CHEMBL220414 | {(1R,4S,5R,7S)-4-[2-(4-chloro-pheno...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(O)=O)(C3)C2
Show InChI InChI=1S/C22H28ClNO4/c1-21(2,28-17-5-3-16(23)4-6-17)20(27)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18(25)26/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,27)(H,25,26)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 92nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192788(2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1
Show InChI InChI=1S/C22H26ClN3O4/c1-21(2,29-16-5-3-15(23)4-6-16)19(27)24-17-13-7-12-8-14(17)11-22(9-12,10-13)18-25-20(28)30-26-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,24,27)(H,25,26,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 101nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192800(2-(4-chloro-phenoxy)-N-((1R,2S,5S,7S)-5-isoxazol-5...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ccno1
Show InChI InChI=1S/C23H27ClN2O3/c1-22(2,28-18-5-3-17(24)4-6-18)21(27)26-20-15-9-14-10-16(20)13-23(11-14,12-15)19-7-8-25-29-19/h3-8,14-16,20H,9-13H2,1-2H3,(H,26,27)/t14-,15-,16?,20+,23+/m0/s1
Affinity DataIC50: 105nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192797(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(1H-imidaz...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1ncc[nH]1
Show InChI InChI=1S/C23H28ClN3O2/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)27-19-15-9-14-10-16(19)13-23(11-14,12-15)20-25-7-8-26-20/h3-8,14-16,19H,9-13H2,1-2H3,(H,25,26)(H,27,28)/t14-,15-,16?,19+,23+/m0/s1
Affinity DataIC50: 110nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192789(2-(4-chloro-phenoxy)-2-methyl-N-[(1S,2S,5R,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](Cc1nnn[nH]1)(C3)C2
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-17-5-3-16(23)4-6-17)20(29)24-19-14-7-13-8-15(19)11-22(9-13,10-14)12-18-25-27-28-26-18/h3-6,13-15,19H,7-12H2,1-2H3,(H,24,29)(H,25,26,27,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 119nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192790(2-(4-chloro-phenoxy)-N-[(1R,2S,5S,7S)-5-(N-hydroxy...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)C(=N)NO
Show InChI InChI=1S/C21H28ClN3O3/c1-20(2,28-16-5-3-15(22)4-6-16)19(26)24-17-13-7-12-8-14(17)11-21(9-12,10-13)18(23)25-27/h3-6,12-14,17,27H,7-11H2,1-2H3,(H2,23,25)(H,24,26)/t12-,13-,14?,17+,21+/m0/s1
Affinity DataIC50: 124nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192796(CHEMBL219575 | N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(C#N)c(N)o1
Show InChI InChI=1S/C24H27ClN4O3/c1-23(2,32-17-5-3-16(25)4-6-17)21(30)29-19-14-7-13-8-15(19)11-24(9-13,10-14)22-28-18(12-26)20(27)31-22/h3-6,13-15,19H,7-11,27H2,1-2H3,(H,29,30)/t13-,14-,15?,19+,24+/m0/s1
Affinity DataIC50: 146nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192798(CHEMBL219349 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(cn1)C#N
Show InChI InChI=1S/C22H28N4O2/c1-21(2,17-4-3-13(11-23)12-25-17)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-18(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 165nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192799(CHEMBL375979 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2)c1ccc(nc1)N1CCOCC1
Show InChI InChI=1S/C25H36N4O3/c1-24(2,19-3-4-21(27-15-19)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 169nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192794(CHEMBL216977 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CN1CCN(CC1)c1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@H]2C[C@](CC(N)=O)(C4)C3)nc1
Show InChI InChI=1S/C26H39N5O3/c1-25(2,34-22-5-4-20(16-28-22)31-8-6-30(3)7-9-31)24(33)29-23-18-10-17-11-19(23)14-26(12-17,13-18)15-21(27)32/h4-5,16-19,23H,6-15H2,1-3H3,(H2,27,32)(H,29,33)/t17-,18-,19?,23+,26+/m0/s1
Affinity DataIC50: 185nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192796(CHEMBL219575 | N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(C#N)c(N)o1
Show InChI InChI=1S/C24H27ClN4O3/c1-23(2,32-17-5-3-16(25)4-6-17)21(30)29-19-14-7-13-8-15(19)11-24(9-13,10-14)22-28-18(12-26)20(27)31-22/h3-6,13-15,19H,7-11,27H2,1-2H3,(H,29,30)/t13-,14-,15?,19+,24+/m0/s1
Affinity DataIC50: 205nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192795(CHEMBL219081 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CNc1ccc(cn1)C(C)(C)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H32N4O2/c1-21(2,16-4-5-18(24-3)25-12-16)20(28)26-19-14-6-13-7-15(19)10-22(8-13,9-14)11-17(23)27/h4-5,12-15,19H,6-11H2,1-3H3,(H2,23,27)(H,24,25)(H,26,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 246nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192796(CHEMBL219575 | N-[(1R,2S,5S,7S)-5-(5-amino-4-cyano...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(C#N)c(N)o1
Show InChI InChI=1S/C24H27ClN4O3/c1-23(2,32-17-5-3-16(25)4-6-17)21(30)29-19-14-7-13-8-15(19)11-24(9-13,10-14)22-28-18(12-26)20(27)31-22/h3-6,13-15,19H,7-11,27H2,1-2H3,(H,29,30)/t13-,14-,15?,19+,24+/m0/s1
Affinity DataIC50: 306nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192795(CHEMBL219081 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CNc1ccc(cn1)C(C)(C)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H32N4O2/c1-21(2,16-4-5-18(24-3)25-12-16)20(28)26-19-14-6-13-7-15(19)10-22(8-13,9-14)11-17(23)27/h4-5,12-15,19H,6-11H2,1-3H3,(H2,23,27)(H,24,25)(H,26,28)/t13-,14-,15?,19+,22+/m0/s1
Affinity DataIC50: 310nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192788(2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1
Show InChI InChI=1S/C22H26ClN3O4/c1-21(2,29-16-5-3-15(23)4-6-16)19(27)24-17-13-7-12-8-14(17)11-22(9-12,10-13)18-25-20(28)30-26-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,24,27)(H,25,26,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 358nMAssay Description:Inhibition of human 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192785(CHEMBL385176 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)C#N)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C22H28N4O3/c1-21(2,29-18-4-3-13(11-23)12-25-18)20(28)26-19-15-5-14-6-16(19)9-22(7-14,8-15)10-17(24)27/h3-4,12,14-16,19H,5-10H2,1-2H3,(H2,24,27)(H,26,28)/t14-,15-,16?,19+,22+/m0/s1
Affinity DataIC50: 373nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192786(CHEMBL216976 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CC(C)(Oc1ccc(cn1)N1CCOCC1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CC(N)=O)(C3)C2
Show InChI InChI=1S/C25H36N4O4/c1-24(2,33-21-4-3-19(15-27-21)29-5-7-32-8-6-29)23(31)28-22-17-9-16-10-18(22)13-25(11-16,12-17)14-20(26)30/h3-4,15-18,22H,5-14H2,1-2H3,(H2,26,30)(H,28,31)/t16-,17-,18?,22+,25+/m0/s1
Affinity DataIC50: 444nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192793(3-{(1R,4S,5R,7S)-4-[2-(4-chloro-phenoxy)-2-methyl-...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](CCC(O)=O)(C3)C2
Show InChI InChI=1S/C23H30ClNO4/c1-22(2,29-18-5-3-17(24)4-6-18)21(28)25-20-15-9-14-10-16(20)13-23(11-14,12-15)8-7-19(26)27/h3-6,14-16,20H,7-13H2,1-2H3,(H,25,28)(H,26,27)/t14-,15-,16?,20+,23-/m0/s1
Affinity DataIC50: 455nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192787(CHEMBL219136 | N-[(1R,2S,5S,7S)-5-(5-amino-4H-[1,2...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nnc(N)[nH]1
Show InChI InChI=1S/C22H28ClN5O2/c1-21(2,30-16-5-3-15(23)4-6-16)19(29)25-17-13-7-12-8-14(17)11-22(9-12,10-13)18-26-20(24)28-27-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,25,29)(H3,24,26,27,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 476nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Mus musculus (mouse))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192794(CHEMBL216977 | N-((1R,2S,5R,7S)-5-carbamoylmethyl-...)
Show SMILES CN1CCN(CC1)c1ccc(OC(C)(C)C(=O)N[C@H]2C3C[C@@H]4C[C@H]2C[C@](CC(N)=O)(C4)C3)nc1
Show InChI InChI=1S/C26H39N5O3/c1-25(2,34-22-5-4-20(16-28-22)31-8-6-30(3)7-9-31)24(33)29-23-18-10-17-11-19(23)14-26(12-17,13-18)15-21(27)32/h4-5,16-19,23H,6-15H2,1-3H3,(H2,27,32)(H,29,33)/t17-,18-,19?,23+,26+/m0/s1
Affinity DataIC50: 519nMAssay Description:Inhibition of mouse 11beta-HSD1 expressed in Escherichia coliMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Abbott Laboratories

Curated by ChEMBL
LigandPNGBDBM50192788(2-(4-chloro-phenoxy)-2-methyl-N-[(1R,2S,5S,7S)-5-(...)
Show SMILES CC(C)(Oc1ccc(Cl)cc1)C(=O)N[C@H]1C2C[C@@H]3C[C@H]1C[C@](C3)(C2)c1nc(=O)o[nH]1
Show InChI InChI=1S/C22H26ClN3O4/c1-21(2,29-16-5-3-15(23)4-6-16)19(27)24-17-13-7-12-8-14(17)11-22(9-12,10-13)18-25-20(28)30-26-18/h3-6,12-14,17H,7-11H2,1-2H3,(H,24,27)(H,25,26,28)/t12-,13-,14?,17+,22+/m0/s1
Affinity DataIC50: 532nMAssay Description:Inhibition of human 11beta-HSD1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
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