Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with all data for entry = 50018441
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195804(1-[1-(3,4-dimethylphenyl)cyclopropyl]-2-[2-(4-meth...)
Show SMILES COc1ccc(CCn2nnn[n+]2C2(CC2)c2ccc(C)c(C)c2)cc1
Show InChI InChI=1S/C20H24N5O/c1-15-4-7-18(14-16(15)2)20(11-12-20)25-23-21-22-24(25)13-10-17-5-8-19(26-3)9-6-17/h4-9,14H,10-13H2,1-3H3/q+1
Affinity DataIC50: 180nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195800(2-[2-(4-methoxyphenyl)ethyl]-1-[1-(4-methylphenyl)...)
Show SMILES COc1ccc(CCn2nnn[n+]2C2(CC2)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C19H22N5O/c1-15-3-7-17(8-4-15)19(12-13-19)24-22-20-21-23(24)14-11-16-5-9-18(25-2)10-6-16/h3-10H,11-14H2,1-2H3/q+1
Affinity DataIC50: 330nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195802(1-(2,3-dimethylphenyl)-2-[2-(4-methoxyphenyl)ethyl...)
Show SMILES COc1ccc(CCn2nnn[n+]2-c2cccc(C)c2C)cc1
Show InChI InChI=1S/C17H20N5O/c1-13-5-4-6-17(14(13)2)22-20-18-19-21(22)12-11-15-7-9-16(23-3)10-8-15/h4-10H,11-12H2,1-3H3/q+1
Affinity DataIC50: 330nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195801(2-[2-(4-methoxyphenyl)ethyl]-1-[1-(4-methylphenyl)...)
Show SMILES COc1ccc(CCn2nnn[n+]2C2(CCCC2)c2ccc(C)cc2)cc1
Show InChI InChI=1S/C21H26N5O/c1-17-5-9-19(10-6-17)21(14-3-4-15-21)26-24-22-23-25(26)16-13-18-7-11-20(27-2)12-8-18/h5-12H,3-4,13-16H2,1-2H3/q+1
Affinity DataIC50: 400nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195805(1-[1-(4-methylphenyl)cyclopropyl]-2-(3-phenylpropy...)
Show SMILES Cc1ccc(cc1)C1(CC1)[n+]1nnnn1CCCc1ccccc1
Show InChI InChI=1S/C19H22N5/c1-16-9-11-18(12-10-16)19(13-14-19)24-22-20-21-23(24)15-5-8-17-6-3-2-4-7-17/h2-4,6-7,9-12H,5,8,13-15H2,1H3/q+1
Affinity DataIC50: 480nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily A member 5(Homo sapiens (Human))
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50195803(1-(3,4-dichlorophenyl)-2-[2-(4-methoxyphenyl)ethyl...)
Show SMILES COc1ccc(CCn2nnn[n+]2-c2ccc(Cl)c(Cl)c2)cc1
Show InChI InChI=1S/C15H14Cl2N5O/c1-23-13-5-2-11(3-6-13)8-9-21-19-18-20-22(21)12-4-7-14(16)15(17)10-12/h2-7,10H,8-9H2,1H3/q+1
Affinity DataIC50: 550nMAssay Description:Inhibition of Kv1.5 expressed in LTK- cells by whole cell patch clamp assayMore data for this Ligand-Target Pair