Compile Data Set for Download or QSAR
Found 289 Enz. Inhib. hit(s) with all data for entry = 50025288
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270243(CHEMBL525961 | TPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C58H112N28O14/c1-30(77-44(90)35(16-8-24-72-54(62)63)84-51(97)40-21-13-29-86(40)52(98)41(61)31(2)87)43(89)78-36(17-9-25-73-55(64)65)47(93)81-38(19-11-27-75-57(68)69)49(95)82-37(18-10-26-74-56(66)67)48(94)80-33(14-4-6-22-59)45(91)79-34(15-5-7-23-60)46(92)83-39(20-12-28-76-58(70)71)50(96)85-42(32(3)88)53(99)100/h30-42,87-88H,4-29,59-61H2,1-3H3,(H,77,90)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,95)(H,83,92)(H,84,97)(H,85,96)(H,99,100)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270054(CHEMBL502642 | TPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(N)=O
Show InChI InChI=1S/C58H113N29O13/c1-30(78-45(92)35(16-8-24-73-54(63)64)85-52(99)40-21-13-29-87(40)53(100)41(61)31(2)88)44(91)79-36(17-9-25-74-55(65)66)48(95)82-38(19-11-27-76-57(69)70)50(97)83-37(18-10-26-75-56(67)68)49(96)81-33(14-4-6-22-59)46(93)80-34(15-5-7-23-60)47(94)84-39(20-12-28-77-58(71)72)51(98)86-42(32(3)89)43(62)90/h30-42,88-89H,4-29,59-61H2,1-3H3,(H2,62,90)(H,78,92)(H,79,91)(H,80,93)(H,81,96)(H,82,95)(H,83,97)(H,84,94)(H,85,99)(H,86,98)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t30-,31+,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270237(CHEMBL504578 | TPRARRRKKRI)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C60H116N28O13/c1-5-32(2)44(55(100)101)87-52(97)41(22-14-30-78-60(72)73)85-48(93)36(17-7-9-25-62)81-47(92)35(16-6-8-24-61)82-50(95)39(20-12-28-76-58(68)69)84-51(96)40(21-13-29-77-59(70)71)83-49(94)38(19-11-27-75-57(66)67)80-45(90)33(3)79-46(91)37(18-10-26-74-56(64)65)86-53(98)42-23-15-31-88(42)54(99)43(63)34(4)89/h32-44,89H,5-31,61-63H2,1-4H3,(H,79,91)(H,80,90)(H,81,92)(H,82,95)(H,83,94)(H,84,96)(H,85,93)(H,86,98)(H,87,97)(H,100,101)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269901(CHEMBL525748 | TPRARRRKKRI)
Show SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C60H117N29O12/c1-5-32(2)44(45(64)91)88-53(99)41(22-14-30-79-60(73)74)86-49(95)36(17-7-9-25-62)82-48(94)35(16-6-8-24-61)83-51(97)39(20-12-28-77-58(69)70)85-52(98)40(21-13-29-78-59(71)72)84-50(96)38(19-11-27-76-57(67)68)81-46(92)33(3)80-47(93)37(18-10-26-75-56(65)66)87-54(100)42-23-15-31-89(42)55(101)43(63)34(4)90/h32-44,90H,5-31,61-63H2,1-4H3,(H2,64,91)(H,80,93)(H,81,92)(H,82,94)(H,83,97)(H,84,96)(H,85,98)(H,86,95)(H,87,100)(H,88,99)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t32-,33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
Affinity DataKi:  30nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270060(CHEMBL455792 | TPQRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H]([C@@H](C)O)C(O)=O
Show InChI InChI=1S/C63H120N30O16/c1-32(83-48(98)37(16-8-26-78-59(68)69)87-54(104)42(22-23-44(66)96)91-56(106)43-21-13-31-93(43)57(107)45(67)33(2)94)47(97)84-38(17-9-27-79-60(70)71)51(101)88-40(19-11-29-81-62(74)75)53(103)89-39(18-10-28-80-61(72)73)52(102)86-35(14-4-6-24-64)49(99)85-36(15-5-7-25-65)50(100)90-41(20-12-30-82-63(76)77)55(105)92-46(34(3)95)58(108)109/h32-43,45-46,94-95H,4-31,64-65,67H2,1-3H3,(H2,66,96)(H,83,98)(H,84,97)(H,85,99)(H,86,102)(H,87,104)(H,88,101)(H,89,103)(H,90,100)(H,91,106)(H,92,105)(H,108,109)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,45-,46-/m0/s1
Affinity DataKi:  33nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270067(CHEMBL503520 | TPQRARRRKKRW)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C70H123N31O15/c1-37(91-55(105)44(19-9-29-85-66(75)76)95-62(112)49(25-26-52(73)103)99-63(113)51-24-14-34-101(51)64(114)53(74)38(2)102)54(104)92-45(20-10-30-86-67(77)78)58(108)96-47(22-12-32-88-69(81)82)60(110)97-46(21-11-31-87-68(79)80)59(109)94-42(17-5-7-27-71)56(106)93-43(18-6-8-28-72)57(107)98-48(23-13-33-89-70(83)84)61(111)100-50(65(115)116)35-39-36-90-41-16-4-3-15-40(39)41/h3-4,15-16,36-38,42-51,53,90,102H,5-14,17-35,71-72,74H2,1-2H3,(H2,73,103)(H,91,105)(H,92,104)(H,93,106)(H,94,109)(H,95,112)(H,96,108)(H,97,110)(H,98,107)(H,99,113)(H,100,111)(H,115,116)(H4,75,76,85)(H4,77,78,86)(H4,79,80,87)(H4,81,82,88)(H4,83,84,89)/t37-,38+,42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,53-/m0/s1
Affinity DataKi:  34nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270238(CHEMBL451290 | TPRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C63H114N28O13/c1-35(82-49(94)40(20-10-28-77-59(67)68)89-56(101)46-25-15-33-91(46)57(102)47(66)36(2)92)48(93)83-41(21-11-29-78-60(69)70)52(97)86-43(23-13-31-80-62(73)74)54(99)87-42(22-12-30-79-61(71)72)53(98)85-38(18-6-8-26-64)50(95)84-39(19-7-9-27-65)51(96)88-44(24-14-32-81-63(75)76)55(100)90-45(58(103)104)34-37-16-4-3-5-17-37/h3-5,16-17,35-36,38-47,92H,6-15,18-34,64-66H2,1-2H3,(H,82,94)(H,83,93)(H,84,95)(H,85,98)(H,86,97)(H,87,99)(H,88,96)(H,89,101)(H,90,100)(H,103,104)(H4,67,68,77)(H4,69,70,78)(H4,71,72,79)(H4,73,74,80)(H4,75,76,81)/t35-,36+,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269903(CHEMBL524695 | TPRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Show InChI InChI=1S/C63H115N29O12/c1-35(83-50(96)40(20-10-28-78-59(68)69)90-57(103)46-25-15-33-92(46)58(104)47(66)36(2)93)49(95)84-41(21-11-29-79-60(70)71)53(99)87-43(23-13-31-81-62(74)75)55(101)88-42(22-12-30-80-61(72)73)54(100)86-38(18-6-8-26-64)51(97)85-39(19-7-9-27-65)52(98)89-44(24-14-32-82-63(76)77)56(102)91-45(48(67)94)34-37-16-4-3-5-17-37/h3-5,16-17,35-36,38-47,93H,6-15,18-34,64-66H2,1-2H3,(H2,67,94)(H,83,96)(H,84,95)(H,85,97)(H,86,100)(H,87,99)(H,88,101)(H,89,98)(H,90,103)(H,91,102)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t35-,36+,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270068(CHEMBL500184 | TPQRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C68H122N30O15/c1-37(88-53(102)42(20-10-30-83-64(73)74)92-60(109)47(26-27-50(71)100)96-61(110)49-25-15-35-98(49)62(111)51(72)38(2)99)52(101)89-43(21-11-31-84-65(75)76)56(105)93-45(23-13-33-86-67(79)80)58(107)94-44(22-12-32-85-66(77)78)57(106)91-40(18-6-8-28-69)54(103)90-41(19-7-9-29-70)55(104)95-46(24-14-34-87-68(81)82)59(108)97-48(63(112)113)36-39-16-4-3-5-17-39/h3-5,16-17,37-38,40-49,51,99H,6-15,18-36,69-70,72H2,1-2H3,(H2,71,100)(H,88,102)(H,89,101)(H,90,103)(H,91,106)(H,92,109)(H,93,105)(H,94,107)(H,95,104)(H,96,110)(H,97,108)(H,112,113)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t37-,38+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,51-/m0/s1
Affinity DataKi:  38nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270210(CHEMBL526518 | GGGTPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CN)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C64H121N31O17/c1-33(85-50(102)38(16-8-24-78-60(68)69)92-57(109)43-21-13-29-95(43)58(110)47(34(2)96)93-46(100)32-84-45(99)31-83-44(98)30-67)49(101)86-39(17-9-25-79-61(70)71)53(105)89-41(19-11-27-81-63(74)75)55(107)90-40(18-10-26-80-62(72)73)54(106)88-36(14-4-6-22-65)51(103)87-37(15-5-7-23-66)52(104)91-42(20-12-28-82-64(76)77)56(108)94-48(35(3)97)59(111)112/h33-43,47-48,96-97H,4-32,65-67H2,1-3H3,(H,83,98)(H,84,99)(H,85,102)(H,86,101)(H,87,103)(H,88,106)(H,89,105)(H,90,107)(H,91,104)(H,92,109)(H,93,100)(H,94,108)(H,111,112)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t33-,34+,35+,36-,37-,38-,39-,40-,41-,42-,43-,47-,48-/m0/s1
Affinity DataKi:  39nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270215(CHEMBL504271 | GGGTPRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C69H123N31O17/c1-37(90-55(107)43(15-7-27-83-65(73)74)97-62(114)49-20-12-32-100(49)63(115)53(38(2)101)99-52(105)36-89-51(104)35-88-50(103)34-72)54(106)91-44(16-8-28-84-66(75)76)58(110)94-46(18-10-30-86-68(79)80)60(112)95-45(17-9-29-85-67(77)78)59(111)93-41(13-3-5-25-70)56(108)92-42(14-4-6-26-71)57(109)96-47(19-11-31-87-69(81)82)61(113)98-48(64(116)117)33-39-21-23-40(102)24-22-39/h21-24,37-38,41-49,53,101-102H,3-20,25-36,70-72H2,1-2H3,(H,88,103)(H,89,104)(H,90,107)(H,91,106)(H,92,108)(H,93,111)(H,94,110)(H,95,112)(H,96,109)(H,97,114)(H,98,113)(H,99,105)(H,116,117)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t37-,38+,41-,42-,43-,44-,45-,46-,47-,48-,49-,53-/m0/s1
Affinity DataKi:  42nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270213(CHEMBL501270 | GGGGGGTPRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C75H132N34O19/c1-41(99-61(118)46(20-10-28-89-71(79)80)106-68(125)52-25-15-33-109(52)69(126)59(42(2)110)108-58(116)40-98-57(115)39-97-56(114)38-96-55(113)37-95-54(112)36-94-53(111)35-78)60(117)100-47(21-11-29-90-72(81)82)64(121)103-49(23-13-31-92-74(85)86)66(123)104-48(22-12-30-91-73(83)84)65(122)102-44(18-6-8-26-76)62(119)101-45(19-7-9-27-77)63(120)105-50(24-14-32-93-75(87)88)67(124)107-51(70(127)128)34-43-16-4-3-5-17-43/h3-5,16-17,41-42,44-52,59,110H,6-15,18-40,76-78H2,1-2H3,(H,94,111)(H,95,112)(H,96,113)(H,97,114)(H,98,115)(H,99,118)(H,100,117)(H,101,119)(H,102,122)(H,103,121)(H,104,123)(H,105,120)(H,106,125)(H,107,124)(H,108,116)(H,127,128)(H4,79,80,89)(H4,81,82,90)(H4,83,84,91)(H4,85,86,92)(H4,87,88,93)/t41-,42+,44-,45-,46-,47-,48-,49-,50-,51-,52-,59-/m0/s1
Affinity DataKi:  45nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270057(CHEMBL526181 | TPRARRRKKRN)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(N)=O
Show InChI InChI=1S/C58H112N30O13/c1-30(79-45(93)34(15-7-23-74-54(64)65)86-52(100)40-20-12-28-88(40)53(101)42(62)31(2)89)44(92)80-35(16-8-24-75-55(66)67)48(96)83-37(18-10-26-77-57(70)71)50(98)84-36(17-9-25-76-56(68)69)49(97)82-32(13-3-5-21-59)46(94)81-33(14-4-6-22-60)47(95)85-38(19-11-27-78-58(72)73)51(99)87-39(43(63)91)29-41(61)90/h30-40,42,89H,3-29,59-60,62H2,1-2H3,(H2,61,90)(H2,63,91)(H,79,93)(H,80,92)(H,81,94)(H,82,97)(H,83,96)(H,84,98)(H,85,95)(H,86,100)(H,87,99)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1
Affinity DataKi:  45nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270246(CHEMBL506161 | TPRARRRKKRN)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(N)=O)C(O)=O
Show InChI InChI=1S/C58H111N29O14/c1-30(78-44(91)34(15-7-23-73-54(63)64)85-51(98)40-20-12-28-87(40)52(99)42(62)31(2)88)43(90)79-35(16-8-24-74-55(65)66)47(94)82-37(18-10-26-76-57(69)70)49(96)83-36(17-9-25-75-56(67)68)48(95)81-32(13-3-5-21-59)45(92)80-33(14-4-6-22-60)46(93)84-38(19-11-27-77-58(71)72)50(97)86-39(53(100)101)29-41(61)89/h30-40,42,88H,3-29,59-60,62H2,1-2H3,(H2,61,89)(H,78,91)(H,79,90)(H,80,92)(H,81,95)(H,82,94)(H,83,96)(H,84,93)(H,85,98)(H,86,97)(H,100,101)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1
Affinity DataKi:  45nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270069(CHEMBL499438 | TPQRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C68H122N30O16/c1-36(88-53(103)42(15-7-29-83-64(73)74)92-60(110)47(25-26-50(71)101)96-61(111)49-20-12-34-98(49)62(112)51(72)37(2)99)52(102)89-43(16-8-30-84-65(75)76)56(106)93-45(18-10-32-86-67(79)80)58(108)94-44(17-9-31-85-66(77)78)57(107)91-40(13-3-5-27-69)54(104)90-41(14-4-6-28-70)55(105)95-46(19-11-33-87-68(81)82)59(109)97-48(63(113)114)35-38-21-23-39(100)24-22-38/h21-24,36-37,40-49,51,99-100H,3-20,25-35,69-70,72H2,1-2H3,(H2,71,101)(H,88,103)(H,89,102)(H,90,104)(H,91,107)(H,92,110)(H,93,106)(H,94,108)(H,95,105)(H,96,111)(H,97,109)(H,113,114)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t36-,37+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,51-/m0/s1
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270212(CHEMBL509337 | GAGAGATPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CN)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C73H136N34O20/c1-36(94-50(110)33-76)55(113)92-34-51(111)95-37(2)56(114)93-35-52(112)96-38(3)58(116)105-53(40(5)108)67(125)107-32-16-24-49(107)66(124)104-44(19-11-27-87-69(77)78)59(117)97-39(4)57(115)98-45(20-12-28-88-70(79)80)62(120)101-47(22-14-30-90-72(83)84)64(122)102-46(21-13-29-89-71(81)82)63(121)100-42(17-7-9-25-74)60(118)99-43(18-8-10-26-75)61(119)103-48(23-15-31-91-73(85)86)65(123)106-54(41(6)109)68(126)127/h36-49,53-54,108-109H,7-35,74-76H2,1-6H3,(H,92,113)(H,93,114)(H,94,110)(H,95,111)(H,96,112)(H,97,117)(H,98,115)(H,99,118)(H,100,121)(H,101,120)(H,102,122)(H,103,119)(H,104,124)(H,105,116)(H,106,123)(H,126,127)(H4,77,78,87)(H4,79,80,88)(H4,81,82,89)(H4,83,84,90)(H4,85,86,91)/t36-,37-,38-,39-,40+,41+,42-,43-,44-,45-,46-,47-,48-,49-,53-,54-/m0/s1
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270247(CHEMBL501011 | TPRARRRKKRQ)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(O)=O
Show InChI InChI=1S/C59H113N29O14/c1-31(79-45(92)35(15-7-25-74-55(64)65)86-52(99)41-20-12-30-88(41)53(100)43(63)32(2)89)44(91)80-36(16-8-26-75-56(66)67)48(95)83-38(18-10-28-77-58(70)71)50(97)84-37(17-9-27-76-57(68)69)49(96)82-33(13-3-5-23-60)46(93)81-34(14-4-6-24-61)47(94)85-39(19-11-29-78-59(72)73)51(98)87-40(54(101)102)21-22-42(62)90/h31-41,43,89H,3-30,60-61,63H2,1-2H3,(H2,62,90)(H,79,92)(H,80,91)(H,81,93)(H,82,96)(H,83,95)(H,84,97)(H,85,94)(H,86,99)(H,87,98)(H,101,102)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270058(CHEMBL505833 | TPRARRRKKRQ)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(N)=O)C(N)=O
Show InChI InChI=1S/C59H114N30O13/c1-31(80-46(94)36(15-7-25-75-55(65)66)88-53(101)41-20-12-30-89(41)54(102)43(63)32(2)90)45(93)82-37(16-8-26-76-56(67)68)50(98)86-40(19-11-29-79-59(73)74)52(100)87-39(18-10-28-78-58(71)72)51(99)84-34(13-3-5-23-60)48(96)83-35(14-4-6-24-61)49(97)85-38(17-9-27-77-57(69)70)47(95)81-33(44(64)92)21-22-42(62)91/h31-41,43,90H,3-30,60-61,63H2,1-2H3,(H2,62,91)(H2,64,92)(H,80,94)(H,81,95)(H,82,93)(H,83,96)(H,84,99)(H,85,97)(H,86,98)(H,87,100)(H,88,101)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1
Affinity DataKi:  47nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270153(CHEMBL525632 | TPQRARRRKKRV)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C64H122N30O15/c1-33(2)47(59(108)109)93-56(105)42(21-13-31-83-64(77)78)91-51(100)37(16-6-8-26-66)86-50(99)36(15-5-7-25-65)87-53(102)40(19-11-29-81-62(73)74)90-54(103)41(20-12-30-82-63(75)76)89-52(101)39(18-10-28-80-61(71)72)85-48(97)34(3)84-49(98)38(17-9-27-79-60(69)70)88-55(104)43(23-24-45(67)96)92-57(106)44-22-14-32-94(44)58(107)46(68)35(4)95/h33-44,46-47,95H,5-32,65-66,68H2,1-4H3,(H2,67,96)(H,84,98)(H,85,97)(H,86,99)(H,87,102)(H,88,104)(H,89,101)(H,90,103)(H,91,100)(H,92,106)(H,93,105)(H,108,109)(H4,69,70,79)(H4,71,72,80)(H4,73,74,81)(H4,75,76,82)(H4,77,78,83)/t34-,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,46-,47-/m0/s1
Affinity DataKi:  48nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270164(CHEMBL500506 | TPQRARRRKKRD)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C63H118N30O17/c1-32(83-48(99)36(15-7-25-78-59(68)69)87-55(106)41(21-22-44(66)95)91-56(107)43-20-12-30-93(43)57(108)46(67)33(2)94)47(98)84-37(16-8-26-79-60(70)71)51(102)88-39(18-10-28-81-62(74)75)53(104)89-38(17-9-27-80-61(72)73)52(103)86-34(13-3-5-23-64)49(100)85-35(14-4-6-24-65)50(101)90-40(19-11-29-82-63(76)77)54(105)92-42(58(109)110)31-45(96)97/h32-43,46,94H,3-31,64-65,67H2,1-2H3,(H2,66,95)(H,83,99)(H,84,98)(H,85,100)(H,86,103)(H,87,106)(H,88,102)(H,89,104)(H,90,101)(H,91,107)(H,92,105)(H,96,97)(H,109,110)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-,46-/m0/s1
Affinity DataKi:  50nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270245(CHEMBL448278 | TPRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C63H114N28O14/c1-34(82-49(95)40(15-7-27-77-59(67)68)89-56(102)46-20-12-32-91(46)57(103)47(66)35(2)92)48(94)83-41(16-8-28-78-60(69)70)52(98)86-43(18-10-30-80-62(73)74)54(100)87-42(17-9-29-79-61(71)72)53(99)85-38(13-3-5-25-64)50(96)84-39(14-4-6-26-65)51(97)88-44(19-11-31-81-63(75)76)55(101)90-45(58(104)105)33-36-21-23-37(93)24-22-36/h21-24,34-35,38-47,92-93H,3-20,25-33,64-66H2,1-2H3,(H,82,95)(H,83,94)(H,84,96)(H,85,99)(H,86,98)(H,87,100)(H,88,97)(H,89,102)(H,90,101)(H,104,105)(H4,67,68,77)(H4,69,70,78)(H4,71,72,79)(H4,73,74,80)(H4,75,76,81)/t34-,35+,38-,39-,40-,41-,42-,43-,44-,45-,46-,47-/m0/s1
Affinity DataKi:  53nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270056(CHEMBL2372270 | TPRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(N)=O
Show InChI InChI=1S/C63H115N29O13/c1-34(83-50(97)40(15-7-27-78-59(68)69)90-57(104)46-20-12-32-92(46)58(105)47(66)35(2)93)49(96)84-41(16-8-28-79-60(70)71)53(100)87-43(18-10-30-81-62(74)75)55(102)88-42(17-9-29-80-61(72)73)54(101)86-38(13-3-5-25-64)51(98)85-39(14-4-6-26-65)52(99)89-44(19-11-31-82-63(76)77)56(103)91-45(48(67)95)33-36-21-23-37(94)24-22-36/h21-24,34-35,38-47,93-94H,3-20,25-33,64-66H2,1-2H3,(H2,67,95)(H,83,97)(H,84,96)(H,85,98)(H,86,101)(H,87,100)(H,88,102)(H,89,99)(H,90,104)(H,91,103)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t34-,35+,38-,39-,40-,41-,42-,43-,44-,45?,46-,47-/m0/s1
Affinity DataKi:  53nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270216(CHEMBL524356 | GGGGGGTPRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C75H132N34O20/c1-40(99-61(119)46(15-7-27-89-71(79)80)106-68(126)52-20-12-32-109(52)69(127)59(41(2)110)108-58(117)39-98-57(116)38-97-56(115)37-96-55(114)36-95-54(113)35-94-53(112)34-78)60(118)100-47(16-8-28-90-72(81)82)64(122)103-49(18-10-30-92-74(85)86)66(124)104-48(17-9-29-91-73(83)84)65(123)102-44(13-3-5-25-76)62(120)101-45(14-4-6-26-77)63(121)105-50(19-11-31-93-75(87)88)67(125)107-51(70(128)129)33-42-21-23-43(111)24-22-42/h21-24,40-41,44-52,59,110-111H,3-20,25-39,76-78H2,1-2H3,(H,94,112)(H,95,113)(H,96,114)(H,97,115)(H,98,116)(H,99,119)(H,100,118)(H,101,120)(H,102,123)(H,103,122)(H,104,124)(H,105,121)(H,106,126)(H,107,125)(H,108,117)(H,128,129)(H4,79,80,89)(H4,81,82,90)(H4,83,84,91)(H4,85,86,92)(H4,87,88,93)/t40-,41+,44-,45-,46-,47-,48-,49-,50-,51-,52-,59-/m0/s1
Affinity DataKi:  54nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270248(CHEMBL525574 | TPRARRRKKRD)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(O)=O)C(O)=O
Show InChI InChI=1S/C58H110N28O15/c1-30(77-44(91)34(15-7-23-72-54(62)63)84-51(98)40-20-12-28-86(40)52(99)42(61)31(2)87)43(90)78-35(16-8-24-73-55(64)65)47(94)81-37(18-10-26-75-57(68)69)49(96)82-36(17-9-25-74-56(66)67)48(95)80-32(13-3-5-21-59)45(92)79-33(14-4-6-22-60)46(93)83-38(19-11-27-76-58(70)71)50(97)85-39(53(100)101)29-41(88)89/h30-40,42,87H,3-29,59-61H2,1-2H3,(H,77,91)(H,78,90)(H,79,92)(H,80,95)(H,81,94)(H,82,96)(H,83,93)(H,84,98)(H,85,97)(H,88,89)(H,100,101)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270214(CHEMBL524315 | GAGAGATPRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C78H138N34O19/c1-41(99-56(114)38-81)60(117)97-39-57(115)100-42(2)61(118)98-40-58(116)101-43(3)63(120)111-59(45(5)113)72(129)112-36-18-28-55(112)71(128)109-49(23-13-31-92-74(82)83)64(121)102-44(4)62(119)103-50(24-14-32-93-75(84)85)67(124)106-52(26-16-34-95-77(88)89)69(126)107-51(25-15-33-94-76(86)87)68(125)105-47(21-9-11-29-79)65(122)104-48(22-10-12-30-80)66(123)108-53(27-17-35-96-78(90)91)70(127)110-54(73(130)131)37-46-19-7-6-8-20-46/h6-8,19-20,41-45,47-55,59,113H,9-18,21-40,79-81H2,1-5H3,(H,97,117)(H,98,118)(H,99,114)(H,100,115)(H,101,116)(H,102,121)(H,103,119)(H,104,122)(H,105,125)(H,106,124)(H,107,126)(H,108,123)(H,109,128)(H,110,127)(H,111,120)(H,130,131)(H4,82,83,92)(H4,84,85,93)(H4,86,87,94)(H4,88,89,95)(H4,90,91,96)/t41-,42-,43-,44-,45+,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-/m0/s1
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270059(CHEMBL506175 | TPRARRRKKRD)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC(O)=O)C(N)=O
Show InChI InChI=1S/C58H111N29O14/c1-30(78-45(93)34(15-7-23-73-54(63)64)85-52(100)40-20-12-28-87(40)53(101)42(61)31(2)88)44(92)79-35(16-8-24-74-55(65)66)48(96)82-37(18-10-26-76-57(69)70)50(98)83-36(17-9-25-75-56(67)68)49(97)81-32(13-3-5-21-59)46(94)80-33(14-4-6-22-60)47(95)84-38(19-11-27-77-58(71)72)51(99)86-39(43(62)91)29-41(89)90/h30-40,42,88H,3-29,59-61H2,1-2H3,(H2,62,91)(H,78,93)(H,79,92)(H,80,94)(H,81,97)(H,82,96)(H,83,98)(H,84,95)(H,85,100)(H,86,99)(H,89,90)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,42-/m0/s1
Affinity DataKi:  56nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269867(CHEMBL499187 | TPRARRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C56H109N29O12/c1-30(77-44(90)35(16-8-24-72-53(63)64)84-50(96)39-20-12-28-85(39)51(97)41(60)31(2)86)42(88)78-36(17-9-25-73-54(65)66)47(93)82-38(19-11-27-75-56(69)70)49(95)83-37(18-10-26-74-55(67)68)48(94)81-34(14-4-6-22-58)46(92)80-33(13-3-5-21-57)45(91)79-32(15-7-23-71-52(61)62)43(89)76-29-40(59)87/h30-39,41,86H,3-29,57-58,60H2,1-2H3,(H2,59,87)(H,76,89)(H,77,90)(H,78,88)(H,79,91)(H,80,92)(H,81,94)(H,82,93)(H,83,95)(H,84,96)(H4,61,62,71)(H4,63,64,72)(H4,65,66,73)(H4,67,68,74)(H4,69,70,75)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270227(CHEMBL509645 | TPRARRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(O)=O
Show InChI InChI=1S/C56H108N28O13/c1-30(76-44(90)35(16-8-24-71-53(62)63)83-50(96)39-20-12-28-84(39)51(97)41(59)31(2)85)42(88)77-36(17-9-25-72-54(64)65)47(93)81-38(19-11-27-74-56(68)69)49(95)82-37(18-10-26-73-55(66)67)48(94)80-34(14-4-6-22-58)46(92)79-33(13-3-5-21-57)45(91)78-32(15-7-23-70-52(60)61)43(89)75-29-40(86)87/h30-39,41,85H,3-29,57-59H2,1-2H3,(H,75,89)(H,76,90)(H,77,88)(H,78,91)(H,79,92)(H,80,94)(H,81,93)(H,82,95)(H,83,96)(H,86,87)(H4,60,61,70)(H4,62,63,71)(H4,64,65,72)(H4,66,67,73)(H4,68,69,74)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,41-/m0/s1
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270217(CHEMBL524690 | GAGAGATPRARRRKKRY)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](C)NC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(O)=O
Show InChI InChI=1S/C78H138N34O20/c1-40(99-56(115)37-81)60(118)97-38-57(116)100-41(2)61(119)98-39-58(117)101-42(3)63(121)111-59(44(5)113)72(130)112-35-15-23-55(112)71(129)109-49(18-10-30-92-74(82)83)64(122)102-43(4)62(120)103-50(19-11-31-93-75(84)85)67(125)106-52(21-13-33-95-77(88)89)69(127)107-51(20-12-32-94-76(86)87)68(126)105-47(16-6-8-28-79)65(123)104-48(17-7-9-29-80)66(124)108-53(22-14-34-96-78(90)91)70(128)110-54(73(131)132)36-45-24-26-46(114)27-25-45/h24-27,40-44,47-55,59,113-114H,6-23,28-39,79-81H2,1-5H3,(H,97,118)(H,98,119)(H,99,115)(H,100,116)(H,101,117)(H,102,122)(H,103,120)(H,104,123)(H,105,126)(H,106,125)(H,107,127)(H,108,124)(H,109,129)(H,110,128)(H,111,121)(H,131,132)(H4,82,83,92)(H4,84,85,93)(H4,86,87,94)(H4,88,89,95)(H4,90,91,96)/t40-,41-,42-,43-,44+,47-,48-,49-,50-,51-,52-,53-,54-,55-,59-/m0/s1
Affinity DataKi:  57nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270159(CHEMBL504132 | TPQRARRRKKRM)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C64H122N30O15S/c1-34(84-49(98)38(16-8-27-79-60(69)70)88-56(105)43(22-23-46(67)96)92-57(106)45-21-13-32-94(45)58(107)47(68)35(2)95)48(97)85-39(17-9-28-80-61(71)72)52(101)89-41(19-11-30-82-63(75)76)54(103)90-40(18-10-29-81-62(73)74)53(102)87-36(14-4-6-25-65)50(99)86-37(15-5-7-26-66)51(100)91-42(20-12-31-83-64(77)78)55(104)93-44(59(108)109)24-33-110-3/h34-45,47,95H,4-33,65-66,68H2,1-3H3,(H2,67,96)(H,84,98)(H,85,97)(H,86,99)(H,87,102)(H,88,105)(H,89,101)(H,90,103)(H,91,100)(H,92,106)(H,93,104)(H,108,109)(H4,69,70,79)(H4,71,72,80)(H4,73,74,81)(H4,75,76,82)(H4,77,78,83)/t34-,35+,36-,37-,38-,39-,40-,41-,42-,43-,44-,45-,47-/m0/s1
Affinity DataKi:  58nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270240(CHEMBL506239 | TPRARRRKKRW)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C65H115N29O13/c1-35(85-51(97)42(19-9-27-79-61(69)70)92-58(104)48-24-14-32-94(48)59(105)49(68)36(2)95)50(96)86-43(20-10-28-80-62(71)72)54(100)89-45(22-12-30-82-64(75)76)56(102)90-44(21-11-29-81-63(73)74)55(101)88-40(17-5-7-25-66)52(98)87-41(18-6-8-26-67)53(99)91-46(23-13-31-83-65(77)78)57(103)93-47(60(106)107)33-37-34-84-39-16-4-3-15-38(37)39/h3-4,15-16,34-36,40-49,84,95H,5-14,17-33,66-68H2,1-2H3,(H,85,97)(H,86,96)(H,87,98)(H,88,101)(H,89,100)(H,90,102)(H,91,99)(H,92,104)(H,93,103)(H,106,107)(H4,69,70,79)(H4,71,72,80)(H4,73,74,81)(H4,75,76,82)(H4,77,78,83)/t35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  59nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269904(CHEMBL527041 | TPRARRRKKRW)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(N)=O
Show InChI InChI=1S/C65H116N30O12/c1-35(86-52(99)42(19-9-27-80-61(70)71)93-59(106)48-24-14-32-95(48)60(107)49(68)36(2)96)51(98)87-43(20-10-28-81-62(72)73)55(102)90-45(22-12-30-83-64(76)77)57(104)91-44(21-11-29-82-63(74)75)56(103)89-40(17-5-7-25-66)53(100)88-41(18-6-8-26-67)54(101)92-46(23-13-31-84-65(78)79)58(105)94-47(50(69)97)33-37-34-85-39-16-4-3-15-38(37)39/h3-4,15-16,34-36,40-49,85,96H,5-14,17-33,66-68H2,1-2H3,(H2,69,97)(H,86,99)(H,87,98)(H,88,100)(H,89,103)(H,90,102)(H,91,104)(H,92,101)(H,93,106)(H,94,105)(H4,70,71,80)(H4,72,73,81)(H4,74,75,82)(H4,76,77,83)(H4,78,79,84)/t35-,36+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-/m0/s1
Affinity DataKi:  59nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270253(CHEMBL454768 | TPRARRRKKR5)
Show SMILES CSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C58H112N28O13S/c1-31(77-44(89)35(16-8-24-72-54(62)63)84-51(96)41-21-13-29-86(41)52(97)42(61)32(2)87)43(88)78-36(17-9-25-73-55(64)65)47(92)81-38(19-11-27-75-57(68)69)49(94)82-37(18-10-26-74-56(66)67)48(93)80-33(14-4-6-22-59)45(90)79-34(15-5-7-23-60)46(91)83-39(20-12-28-76-58(70)71)50(95)85-40(30-100-3)53(98)99/h31-42,87H,4-30,59-61H2,1-3H3,(H,77,89)(H,78,88)(H,79,90)(H,80,93)(H,81,92)(H,82,94)(H,83,91)(H,84,96)(H,85,95)(H,98,99)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
Affinity DataKi:  65nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270065(CHEMBL501797 | TPRARRRKKR5)
Show SMILES CSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C58H113N29O12S/c1-31(78-45(91)35(16-8-24-73-54(63)64)85-52(98)41-21-13-29-87(41)53(99)42(61)32(2)88)44(90)79-36(17-9-25-74-55(65)66)48(94)82-38(19-11-27-76-57(69)70)50(96)83-37(18-10-26-75-56(67)68)49(95)81-33(14-4-6-22-59)46(92)80-34(15-5-7-23-60)47(93)84-39(20-12-28-77-58(71)72)51(97)86-40(30-100-3)43(62)89/h31-42,88H,4-30,59-61H2,1-3H3,(H2,62,89)(H,78,91)(H,79,90)(H,80,92)(H,81,95)(H,82,94)(H,83,96)(H,84,93)(H,85,98)(H,86,97)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,42-/m0/s1
Affinity DataKi:  65nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270211(CHEMBL524837 | GGGGGGTPRARRRKKRT)
Show SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C70H130N34O20/c1-36(94-56(114)41(16-8-24-84-66(74)75)101-63(121)46-21-13-29-104(46)64(122)53(37(2)105)102-52(112)35-93-51(111)34-92-50(110)33-91-49(109)32-90-48(108)31-89-47(107)30-73)55(113)95-42(17-9-25-85-67(76)77)59(117)98-44(19-11-27-87-69(80)81)61(119)99-43(18-10-26-86-68(78)79)60(118)97-39(14-4-6-22-71)57(115)96-40(15-5-7-23-72)58(116)100-45(20-12-28-88-70(82)83)62(120)103-54(38(3)106)65(123)124/h36-46,53-54,105-106H,4-35,71-73H2,1-3H3,(H,89,107)(H,90,108)(H,91,109)(H,92,110)(H,93,111)(H,94,114)(H,95,113)(H,96,115)(H,97,118)(H,98,117)(H,99,119)(H,100,116)(H,101,121)(H,102,112)(H,103,120)(H,123,124)(H4,74,75,84)(H4,76,77,85)(H4,78,79,86)(H4,80,81,87)(H4,82,83,88)/t36-,37+,38+,39-,40-,41-,42-,43-,44-,45-,46-,53-,54-/m0/s1
Affinity DataKi:  66nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269861(CHEMBL505375 | GGGTPRARRRKKRF)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Show InChI InChI=1S/C69H123N31O16/c1-38(90-55(106)43(20-10-28-83-65(73)74)97-62(113)49-25-15-33-100(49)63(114)53(39(2)101)99-52(104)37-89-51(103)36-88-50(102)35-72)54(105)91-44(21-11-29-84-66(75)76)58(109)94-46(23-13-31-86-68(79)80)60(111)95-45(22-12-30-85-67(77)78)59(110)93-41(18-6-8-26-70)56(107)92-42(19-7-9-27-71)57(108)96-47(24-14-32-87-69(81)82)61(112)98-48(64(115)116)34-40-16-4-3-5-17-40/h3-5,16-17,38-39,41-49,53,101H,6-15,18-37,70-72H2,1-2H3,(H,88,102)(H,89,103)(H,90,106)(H,91,105)(H,92,107)(H,93,110)(H,94,109)(H,95,111)(H,96,108)(H,97,113)(H,98,112)(H,99,104)(H,115,116)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t38-,39+,41-,42-,43-,44-,45-,46-,47-,48-,49-,53-/m0/s1
Affinity DataKi:  67nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270218(CHEMBL504445 | GGGTPQRARRRKKRW)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C76H132N34O18/c1-40(99-61(117)47(19-9-29-91-72(81)82)103-68(124)52(25-26-55(80)112)107-69(125)54-24-14-34-110(54)70(126)59(41(2)111)109-58(115)39-98-57(114)38-97-56(113)36-79)60(116)100-48(20-10-30-92-73(83)84)64(120)104-50(22-12-32-94-75(87)88)66(122)105-49(21-11-31-93-74(85)86)65(121)102-45(17-5-7-27-77)62(118)101-46(18-6-8-28-78)63(119)106-51(23-13-33-95-76(89)90)67(123)108-53(71(127)128)35-42-37-96-44-16-4-3-15-43(42)44/h3-4,15-16,37,40-41,45-54,59,96,111H,5-14,17-36,38-39,77-79H2,1-2H3,(H2,80,112)(H,97,113)(H,98,114)(H,99,117)(H,100,116)(H,101,118)(H,102,121)(H,103,124)(H,104,120)(H,105,122)(H,106,119)(H,107,125)(H,108,123)(H,109,115)(H,127,128)(H4,81,82,91)(H4,83,84,92)(H4,85,86,93)(H4,87,88,94)(H4,89,90,95)/t40-,41+,45-,46-,47-,48-,49-,50-,51-,52-,53-,54-,59-/m0/s1
Affinity DataKi:  67nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270235(CHEMBL526675 | TPRARRRKKRV)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C59H114N28O13/c1-31(2)43(54(99)100)86-51(96)40(21-13-29-77-59(71)72)84-47(92)35(16-6-8-24-61)80-46(91)34(15-5-7-23-60)81-49(94)38(19-11-27-75-57(67)68)83-50(95)39(20-12-28-76-58(69)70)82-48(93)37(18-10-26-74-56(65)66)79-44(89)32(3)78-45(90)36(17-9-25-73-55(63)64)85-52(97)41-22-14-30-87(41)53(98)42(62)33(4)88/h31-43,88H,5-30,60-62H2,1-4H3,(H,78,90)(H,79,89)(H,80,91)(H,81,94)(H,82,93)(H,83,95)(H,84,92)(H,85,97)(H,86,96)(H,99,100)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)(H4,71,72,77)/t32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269899(CHEMBL503500 | TPRARRRKKRV)
Show SMILES CC(C)[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C59H115N29O12/c1-31(2)43(44(63)90)87-52(98)40(21-13-29-78-59(72)73)85-48(94)35(16-6-8-24-61)81-47(93)34(15-5-7-23-60)82-50(96)38(19-11-27-76-57(68)69)84-51(97)39(20-12-28-77-58(70)71)83-49(95)37(18-10-26-75-56(66)67)80-45(91)32(3)79-46(92)36(17-9-25-74-55(64)65)86-53(99)41-22-14-30-88(41)54(100)42(62)33(4)89/h31-43,89H,5-30,60-62H2,1-4H3,(H2,63,90)(H,79,92)(H,80,91)(H,81,93)(H,82,96)(H,83,95)(H,84,97)(H,85,94)(H,86,99)(H,87,98)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
Affinity DataKi:  80nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270066(CHEMBL526506 | TPRARRRKKR6)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C60H117N29O12/c1-4-5-16-35(45(64)91)81-48(94)40(21-12-29-77-58(69)70)85-50(96)37(18-7-9-26-62)83-49(95)36(17-6-8-25-61)84-52(98)41(22-13-30-78-59(71)72)87-53(99)42(23-14-31-79-60(73)74)86-51(97)39(20-11-28-76-57(67)68)82-46(92)33(2)80-47(93)38(19-10-27-75-56(65)66)88-54(100)43-24-15-32-89(43)55(101)44(63)34(3)90/h33-44,90H,4-32,61-63H2,1-3H3,(H2,64,91)(H,80,93)(H,81,94)(H,82,92)(H,83,95)(H,84,98)(H,85,96)(H,86,97)(H,87,99)(H,88,100)(H4,65,66,75)(H4,67,68,76)(H4,69,70,77)(H4,71,72,78)(H4,73,74,79)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
Affinity DataKi:  81nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270254(CHEMBL503035 | TPRARRRKKR6)
Show SMILES CCCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C60H116N28O13/c1-4-5-16-42(55(100)101)87-52(97)41(23-14-31-78-60(72)73)85-48(93)36(18-7-9-26-62)81-47(92)35(17-6-8-25-61)82-50(95)39(21-12-29-76-58(68)69)84-51(96)40(22-13-30-77-59(70)71)83-49(94)38(20-11-28-75-57(66)67)80-45(90)33(2)79-46(91)37(19-10-27-74-56(64)65)86-53(98)43-24-15-32-88(43)54(99)44(63)34(3)89/h33-44,89H,4-32,61-63H2,1-3H3,(H,79,91)(H,80,90)(H,81,92)(H,82,95)(H,83,94)(H,84,96)(H,85,93)(H,86,98)(H,87,97)(H,100,101)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-/m0/s1
Affinity DataKi:  81nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270219(CHEMBL510847 | GGGGGGTPQRARRRKKRW)
Show SMILES C[C@@H](O)[C@H](NC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CNC(=O)CN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(O)=O
Show InChI InChI=1S/C82H141N37O21/c1-43(108-67(129)50(19-9-29-97-78(87)88)112-74(136)55(25-26-58(86)121)116-75(137)57-24-14-34-119(57)76(138)65(44(2)120)118-64(127)42-107-63(126)41-106-62(125)40-105-61(124)39-104-60(123)38-103-59(122)36-85)66(128)109-51(20-10-30-98-79(89)90)70(132)113-53(22-12-32-100-81(93)94)72(134)114-52(21-11-31-99-80(91)92)71(133)111-48(17-5-7-27-83)68(130)110-49(18-6-8-28-84)69(131)115-54(23-13-33-101-82(95)96)73(135)117-56(77(139)140)35-45-37-102-47-16-4-3-15-46(45)47/h3-4,15-16,37,43-44,48-57,65,102,120H,5-14,17-36,38-42,83-85H2,1-2H3,(H2,86,121)(H,103,122)(H,104,123)(H,105,124)(H,106,125)(H,107,126)(H,108,129)(H,109,128)(H,110,130)(H,111,133)(H,112,136)(H,113,132)(H,114,134)(H,115,131)(H,116,137)(H,117,135)(H,118,127)(H,139,140)(H4,87,88,97)(H4,89,90,98)(H4,91,92,99)(H4,93,94,100)(H4,95,96,101)/t43-,44+,48-,49-,50-,51-,52-,53-,54-,55-,56-,57-,65-/m0/s1
Affinity DataKi:  88nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270170(CHEMBL446203 | TPQRARRRKKR5)
Show SMILES CSC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(O)=O
Show InChI InChI=1S/C63H120N30O15S/c1-33(83-48(97)37(16-8-26-78-59(68)69)87-55(104)42(22-23-45(66)95)91-56(105)44-21-13-31-93(44)57(106)46(67)34(2)94)47(96)84-38(17-9-27-79-60(70)71)51(100)88-40(19-11-29-81-62(74)75)53(102)89-39(18-10-28-80-61(72)73)52(101)86-35(14-4-6-24-64)49(98)85-36(15-5-7-25-65)50(99)90-41(20-12-30-82-63(76)77)54(103)92-43(32-109-3)58(107)108/h33-44,46,94H,4-32,64-65,67H2,1-3H3,(H2,66,95)(H,83,97)(H,84,96)(H,85,98)(H,86,101)(H,87,104)(H,88,100)(H,89,102)(H,90,99)(H,91,105)(H,92,103)(H,107,108)(H4,68,69,78)(H4,70,71,79)(H4,72,73,80)(H4,74,75,81)(H4,76,77,82)/t33-,34+,35-,36-,37-,38-,39-,40-,41-,42-,43-,44-,46-/m0/s1
Affinity DataKi:  93nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270061(CHEMBL508133 | TPRARRRKKRE)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCC(O)=O)C(N)=O
Show InChI InChI=1S/C59H113N29O14/c1-31(79-46(94)36(15-7-25-74-55(64)65)87-53(101)41-20-12-30-88(41)54(102)43(62)32(2)89)45(93)81-37(16-8-26-75-56(66)67)50(98)85-40(19-11-29-78-59(72)73)52(100)86-39(18-10-28-77-58(70)71)51(99)83-34(13-3-5-23-60)48(96)82-35(14-4-6-24-61)49(97)84-38(17-9-27-76-57(68)69)47(95)80-33(44(63)92)21-22-42(90)91/h31-41,43,89H,3-30,60-62H2,1-2H3,(H2,63,92)(H,79,94)(H,80,95)(H,81,93)(H,82,96)(H,83,99)(H,84,97)(H,85,98)(H,86,100)(H,87,101)(H,90,91)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t31-,32+,33-,34-,35-,36-,37-,38-,39-,40-,41-,43-/m0/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50270055(CHEMBL504115 | TPRARRRKKRC)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CS)C(N)=O
Show InChI InChI=1S/C57H111N29O12S/c1-30(77-44(90)34(15-7-23-72-53(62)63)84-51(97)40-20-12-28-86(40)52(98)41(60)31(2)87)43(89)78-35(16-8-24-73-54(64)65)47(93)81-37(18-10-26-75-56(68)69)49(95)82-36(17-9-25-74-55(66)67)48(94)80-32(13-3-5-21-58)45(91)79-33(14-4-6-22-59)46(92)83-38(19-11-27-76-57(70)71)50(96)85-39(29-99)42(61)88/h30-41,87,99H,3-29,58-60H2,1-2H3,(H2,61,88)(H,77,90)(H,78,89)(H,79,91)(H,80,94)(H,81,93)(H,82,95)(H,83,92)(H,84,97)(H,85,96)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269913(CHEMBL525570 | TPRARRRKKRS)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CO)C(N)=O
Show InChI InChI=1S/C57H111N29O13/c1-30(77-44(91)34(15-7-23-72-53(62)63)84-51(98)40-20-12-28-86(40)52(99)41(60)31(2)88)43(90)78-35(16-8-24-73-54(64)65)47(94)81-37(18-10-26-75-56(68)69)49(96)82-36(17-9-25-74-55(66)67)48(95)80-32(13-3-5-21-58)45(92)79-33(14-4-6-22-59)46(93)83-38(19-11-27-76-57(70)71)50(97)85-39(29-87)42(61)89/h30-41,87-88H,3-29,58-60H2,1-2H3,(H2,61,89)(H,77,91)(H,78,90)(H,79,92)(H,80,95)(H,81,94)(H,82,96)(H,83,93)(H,84,98)(H,85,97)(H4,62,63,72)(H4,64,65,73)(H4,66,67,74)(H4,68,69,75)(H4,70,71,76)/t30-,31+,32-,33-,34-,35-,36-,37-,38-,39-,40-,41-/m0/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269905(CHEMBL477091 | TPRARRRKKRM)
Show SMILES CSCC[C@H](NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)[C@@H](C)O)C(N)=O
Show InChI InChI=1S/C59H115N29O12S/c1-32(79-46(92)37(16-8-25-74-55(64)65)87-53(99)42-21-13-30-88(42)54(100)43(62)33(2)89)45(91)81-38(17-9-26-75-56(66)67)50(96)85-41(20-12-29-78-59(72)73)52(98)86-40(19-11-28-77-58(70)71)51(97)83-35(14-4-6-23-60)48(94)82-36(15-5-7-24-61)49(95)84-39(18-10-27-76-57(68)69)47(93)80-34(44(63)90)22-31-101-3/h32-43,89H,4-31,60-62H2,1-3H3,(H2,63,90)(H,79,92)(H,80,93)(H,81,91)(H,82,94)(H,83,97)(H,84,95)(H,85,96)(H,86,98)(H,87,99)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269902(CHEMBL526711 | TPRARRRKKRP)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N1CCC[C@H]1C(N)=O
Show InChI InChI=1S/C59H113N29O12/c1-32(79-46(92)36(16-7-25-74-55(64)65)85-52(98)42-22-13-31-88(42)54(100)43(62)33(2)89)45(91)80-37(17-8-26-75-56(66)67)48(94)83-39(19-10-28-77-58(70)71)50(96)84-38(18-9-27-76-57(68)69)49(95)81-34(14-3-5-23-60)47(93)82-35(15-4-6-24-61)51(97)86-40(20-11-29-78-59(72)73)53(99)87-30-12-21-41(87)44(63)90/h32-43,89H,3-31,60-62H2,1-2H3,(H2,63,90)(H,79,92)(H,80,91)(H,81,95)(H,82,93)(H,83,94)(H,84,96)(H,85,98)(H,86,97)(H4,64,65,74)(H4,66,67,75)(H4,68,69,76)(H4,70,71,77)(H4,72,73,78)/t32-,33+,34-,35-,36-,37-,38-,39-,40-,41-,42-,43-/m0/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269893(CHEMBL524725 | TPR2RRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCCCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C59H115N29O12/c1-34(89)45(63)54(100)88-32-14-22-42(88)53(99)87-35(17-9-27-75-55(64)65)46(92)74-26-8-2-3-23-44(91)81-37(19-11-29-77-57(68)69)48(94)85-40(20-12-30-78-58(70)71)52(98)86-41(21-13-31-79-59(72)73)51(97)84-39(16-5-7-25-61)50(96)83-38(15-4-6-24-60)49(95)82-36(18-10-28-76-56(66)67)47(93)80-33-43(62)90/h34-42,45,89H,2-33,60-61,63H2,1H3,(H2,62,90)(H,74,92)(H,80,93)(H,81,91)(H,82,95)(H,83,96)(H,84,97)(H,85,94)(H,86,98)(H,87,99)(H4,64,65,75)(H4,66,67,76)(H4,68,69,77)(H4,70,71,78)(H4,72,73,79)/t34-,35+,36+,37+,38+,39+,40+,41+,42+,45+/m1/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
TargetFurin(Homo sapiens (Human))
Institute for Medical Research

Curated by ChEMBL
LigandPNGBDBM50269892(CHEMBL508995 | TPR1RRRKKRG)
Show SMILES C[C@@H](O)[C@H](N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCCC(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C(N)N)C(=O)NCC(N)=O
Show InChI InChI=1S/C56H109N29O12/c1-31(86)42(60)51(97)85-29-11-19-39(85)50(96)84-32(14-6-23-72-52(61)62)43(89)71-28-20-41(88)78-34(16-8-25-74-54(65)66)45(91)82-37(17-9-26-75-55(67)68)49(95)83-38(18-10-27-76-56(69)70)48(94)81-36(13-3-5-22-58)47(93)80-35(12-2-4-21-57)46(92)79-33(15-7-24-73-53(63)64)44(90)77-30-40(59)87/h31-39,42,86H,2-30,57-58,60H2,1H3,(H2,59,87)(H,71,89)(H,77,90)(H,78,88)(H,79,92)(H,80,93)(H,81,94)(H,82,91)(H,83,95)(H,84,96)(H4,61,62,72)(H4,63,64,73)(H4,65,66,74)(H4,67,68,75)(H4,69,70,76)/t31-,32+,33+,34+,35+,36+,37+,38+,39+,42+/m1/s1
Affinity DataKi: >100nMAssay Description:Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavageMore data for this Ligand-Target Pair
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