Compile Data Set for Download or QSAR
Found 9 Enz. Inhib. hit(s) with all data for entry = 50028674
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50259542(2-(3-Trifluoromethylphenyl)-4(5)-(3-trifluoromethy...)
Show SMILES FC(F)(F)c1cccc(c1)-c1c[nH]c(n1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C17H10F6N2/c18-16(19,20)12-5-1-3-10(7-12)14-9-24-15(25-14)11-4-2-6-13(8-11)17(21,22)23/h1-9H,(H,24,25)
Affinity DataIC50: 200nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50259388(2-(4-Chlorophenyl)-4(5)-phenylimidazole | CHEMBL50...)
Show SMILES Clc1ccc(cc1)-c1nc(c[nH]1)-c1ccccc1
Show InChI InChI=1S/C15H11ClN2/c16-13-8-6-12(7-9-13)15-17-10-14(18-15)11-4-2-1-3-5-11/h1-10H,(H,17,18)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50259490(2-Phenyl-4(5)-(4-trifluoromethylphenyl)imidazole |...)
Show SMILES FC(F)(F)c1ccc(cc1)-c1c[nH]c(n1)-c1ccccc1
Show InChI InChI=1S/C16H11F3N2/c17-16(18,19)13-8-6-11(7-9-13)14-10-20-15(21-14)12-4-2-1-3-5-12/h1-10H,(H,20,21)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50259541(2-(4-Nitrophenyl)-4(5)-(3-trifluoromethylphenyl)-i...)
Show SMILES [O-][N+](=O)c1ccc(cc1)-c1nc(c[nH]1)-c1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C16H10F3N3O2/c17-16(18,19)12-3-1-2-11(8-12)14-9-20-15(21-14)10-4-6-13(7-5-10)22(23)24/h1-9H,(H,20,21)
Affinity DataIC50: 2.50E+3nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50145044(2-Phenyl-4(5)-(3-trifluoromethylphenyl)imidazole |...)
Show SMILES FC(F)(F)c1cccc(c1)-c1c[nH]c(n1)-c1ccccc1
Show InChI InChI=1S/C16H11F3N2/c17-16(18,19)13-8-4-7-12(9-13)14-10-20-15(21-14)11-5-2-1-3-6-11/h1-10H,(H,20,21)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50133778(2,4(5)-Diphenylimidazole | 2,4-diphenyl-1H-imidazo...)
Show SMILES c1[nH]c(nc1-c1ccccc1)-c1ccccc1
Show InChI InChI=1S/C15H12N2/c1-3-7-12(8-4-1)14-11-16-15(17-14)13-9-5-2-6-10-13/h1-11H,(H,16,17)
Affinity DataIC50: 4.06E+4nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50259540(2-(4-Chlorophenyl)-4(5)-(3-trifluoromethylphenyl)-...)
Show SMILES FC(F)(F)c1cccc(c1)-c1c[nH]c(n1)-c1ccc(Cl)cc1
Show InChI InChI=1S/C16H10ClF3N2/c17-13-6-4-10(5-7-13)15-21-9-14(22-15)11-2-1-3-12(8-11)16(18,19)20/h1-9H,(H,21,22)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50031299(6-(2,3-Dichloro-phenyl)-[1,2,4]triazine-3,5-diamin...)
Show SMILES Nc1nnc(c(N)n1)-c1cccc(Cl)c1Cl
Show InChI InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Università degli Studi di Parma

Curated by ChEMBL
LigandPNGBDBM50003655(Phenytoin)
Show SMILES O=C1NC(=O)C(N1)(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H12N2O2/c18-13-15(17-14(19)16-13,11-7-3-1-4-8-11)12-9-5-2-6-10-12/h1-10H,(H2,16,17,18,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human Nav1.2 channel expressed in HEK cells by patch-clamp electrophysiology methodMore data for this Ligand-Target Pair