Compile Data Set for Download or QSAR
Found 70 Enz. Inhib. hit(s) with all data for entry = 50030409
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295759(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H18ClN7O2S2/c21-18-19(26-7-8-31-20(26)25-18)32(29,30)28-6-3-16-17(28)9-13(10-23-16)14-11-24-27(12-14)15-1-4-22-5-2-15/h3,6-12,15,22H,1-2,4-5H2
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295752(4-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrro...)
Show SMILES O=S(=O)(c1cccc2nonc12)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H19N7O3S/c29-32(30,20-3-1-2-18-21(20)26-31-25-18)28-9-6-17-19(28)10-14(11-23-17)15-12-24-27(13-15)16-4-7-22-8-5-16/h1-3,6,9-13,16,22H,4-5,7-8H2
Affinity DataIC50: 9nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Show SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C12H8ClN5O2S2/c13-10-11(17-3-4-21-12(17)16-10)22(19,20)18-2-1-8-9(18)5-7(14)6-15-8/h1-6H,14H2
Affinity DataIC50: 10nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295754((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
Affinity DataIC50: 11nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295755(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C19H18N6O4S/c1-13(26)23-7-9-24(10-8-23)14-11-17-15(20-12-14)5-6-25(17)30(27,28)18-4-2-3-16-19(18)22-29-21-16/h2-6,11-12H,7-10H2,1H3
Affinity DataIC50: 12nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295756(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CNCC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C20H21N7O4S/c1-21-13-19(28)26-9-7-25(8-10-26)14-11-17-15(22-12-14)5-6-27(17)32(29,30)18-4-2-3-16-20(18)24-31-23-16/h2-6,11-12,21H,7-10,13H2,1H3
Affinity DataIC50: 14nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295750(4-(6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-p...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C23H21N7O3S/c1-28-9-11-29(12-10-28)22-6-5-16(14-25-22)17-13-20-18(24-15-17)7-8-30(20)34(31,32)21-4-2-3-19-23(21)27-33-26-19/h2-8,13-15H,9-12H2,1H3
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295762(CHEMBL550158 | tert-butyl 4-(1-(6-chloroimidazo[2,...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C21H23ClN6O4S2/c1-21(2,3)32-20(29)26-8-6-25(7-9-26)14-12-16-15(23-13-14)4-5-28(16)34(30,31)18-17(22)24-19-27(18)10-11-33-19/h4-5,10-13H,6-9H2,1-3H3
Affinity DataIC50: 15nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295753(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrro...)
Show SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C13H9N5O3S/c14-8-6-11-9(15-7-8)4-5-18(11)22(19,20)12-3-1-2-10-13(12)17-21-16-10/h1-7H,14H2
Affinity DataIC50: 16nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295764(1-benzyl-1H-pyrrolo[3,2-b]pyridine | CHEMBL561256)
Show SMILES C(c1ccccc1)n1ccc2ncccc12
Show InChI InChI=1S/C14H12N2/c1-2-5-12(6-3-1)11-16-10-8-13-14(16)7-4-9-15-13/h1-10H,11H2
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295767(4-((6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrr...)
Show SMILES C(c1cccc2nonc12)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C22H21N7O/c1-2-15(22-20(3-1)26-30-27-22)13-28-9-6-19-21(28)10-16(11-24-19)17-12-25-29(14-17)18-4-7-23-8-5-18/h1-3,6,9-12,14,18,23H,4-5,7-8,13H2
Affinity DataIC50: 19nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295735(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)12-4-1-2-6-13(12)21(19,20)15-9-7-10-11(15)5-3-8-14-10/h1-9H
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295747(CHEMBL556627 | tert-butyl 4-(1-(2-nitrophenylsulfo...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C22H25N5O6S/c1-22(2,3)33-21(28)25-12-10-24(11-13-25)16-14-19-17(23-15-16)8-9-26(19)34(31,32)20-7-5-4-6-18(20)27(29)30/h4-9,14-15H,10-13H2,1-3H3
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295748(1-(2-nitrophenylsulfonyl)-6-(piperazin-1-yl)-1H-py...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C17H17N5O4S/c23-22(24)15-3-1-2-4-17(15)27(25,26)21-8-5-14-16(21)11-13(12-19-14)20-9-6-18-7-10-20/h1-5,8,11-12,18H,6-7,9-10H2
Affinity DataIC50: 20nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295749(4-(1H-pyrrolo[3,2-b]pyridin-1-ylsulfonyl)benzo[c][...)
Show SMILES O=S(=O)(c1cccc2nonc12)n1ccc2ncccc12
Show InChI InChI=1S/C13H8N4O3S/c18-21(19,12-5-1-3-10-13(12)16-20-15-10)17-8-6-9-11(17)4-2-7-14-9/h1-8H
Affinity DataIC50: 22nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295751(4-(6-(piperazin-1-yl)-1H-pyrrolo[3,2-b]pyridin-1-y...)
Show SMILES O=S(=O)(c1cccc2nonc12)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C17H16N6O3S/c24-27(25,16-3-1-2-14-17(16)21-26-20-14)23-7-4-13-15(23)10-12(11-19-13)22-8-5-18-6-9-22/h1-4,7,10-11,18H,5-6,8-9H2
Affinity DataIC50: 23nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295758(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C16H15ClN6O2S2/c17-14-15(22-7-8-26-16(22)20-14)27(24,25)23-4-1-12-13(23)9-11(10-19-12)21-5-2-18-3-6-21/h1,4,7-10,18H,2-3,5-6H2
Affinity DataIC50: 24nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295763(CHEMBL564440 | tert-butyl 4-(4-(1-(6-chloroimidazo...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C25H26ClN7O4S2/c1-25(2,3)37-24(34)30-7-4-18(5-8-30)32-15-17(14-28-32)16-12-20-19(27-13-16)6-9-33(20)39(35,36)22-21(26)29-23-31(22)10-11-38-23/h6,9-15,18H,4-5,7-8H2,1-3H3
Affinity DataIC50: 27nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295769(CHEMBL564827 | tert-butyl 4-(4-(1-(benzo[c][1,2,5]...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc2ccn(Cc3cccc4nonc34)c2c1
Show InChI InChI=1S/C27H29N7O3/c1-27(2,3)36-26(35)32-10-7-21(8-11-32)34-17-20(15-29-34)19-13-24-22(28-14-19)9-12-33(24)16-18-5-4-6-23-25(18)31-37-30-23/h4-6,9,12-15,17,21H,7-8,10-11,16H2,1-3H3
Affinity DataIC50: 33nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295761(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Show SMILES Oc1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C12H7ClN4O3S2/c13-10-11(16-3-4-21-12(16)15-10)22(19,20)17-2-1-8-9(17)5-7(18)6-14-8/h1-6,18H
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295757(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C12H7ClN4O2S2/c13-10-11(16-6-7-20-12(16)15-10)21(18,19)17-5-3-8-9(17)2-1-4-14-8/h1-7H
Affinity DataIC50: 35nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295734(1-(3-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)10-3-1-4-11(9-10)21(19,20)15-8-6-12-13(15)5-2-7-14-12/h1-9H
Affinity DataIC50: 70nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295742(3-(2-nitrophenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin...)
Show SMILES [O-][N+](=O)c1ccccc1S(=O)(=O)c1c[nH]c2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)10-5-1-2-6-11(10)21(19,20)12-8-15-13-9(12)4-3-7-14-13/h1-8H,(H,14,15)
Affinity DataIC50: 75nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295745(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES NC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H10N4O5S/c15-14(19)9-7-12-10(16-8-9)5-6-17(12)24(22,23)13-4-2-1-3-11(13)18(20)21/h1-8H,(H2,15,19)
Affinity DataIC50: 82nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295759(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H18ClN7O2S2/c21-18-19(26-7-8-31-20(26)25-18)32(29,30)28-6-3-16-17(28)9-13(10-23-16)14-11-24-27(12-14)15-1-4-22-5-2-15/h3,6-12,15,22H,1-2,4-5H2
Affinity DataIC50: 90nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295731(1-(2,3-dichlorophenylsulfonyl)-1H-pyrrolo[3,2-b]py...)
Show SMILES Clc1cccc(c1Cl)S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H8Cl2N2O2S/c14-9-3-1-5-12(13(9)15)20(18,19)17-8-6-10-11(17)4-2-7-16-10/h1-8H
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295759(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-6-(...)
Show SMILES Clc1nc2sccn2c1S(=O)(=O)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C20H18ClN7O2S2/c21-18-19(26-7-8-31-20(26)25-18)32(29,30)28-6-3-16-17(28)9-13(10-23-16)14-11-24-27(12-14)15-1-4-22-5-2-15/h3,6-12,15,22H,1-2,4-5H2
Affinity DataIC50: 110nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295762(CHEMBL550158 | tert-butyl 4-(1-(6-chloroimidazo[2,...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C21H23ClN6O4S2/c1-21(2,3)32-20(29)26-8-6-25(7-9-26)14-12-16-15(23-13-14)4-5-28(16)34(30,31)18-17(22)24-19-27(18)10-11-33-19/h4-5,10-13H,6-9H2,1-3H3
Affinity DataIC50: 110nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295752(4-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrro...)
Show SMILES O=S(=O)(c1cccc2nonc12)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H19N7O3S/c29-32(30,20-3-1-2-18-21(20)26-31-25-18)28-9-6-17-19(28)10-14(11-23-17)15-12-24-27(13-15)16-4-7-22-8-5-16/h1-3,6,9-13,16,22H,4-5,7-8H2
Affinity DataIC50: 130nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295763(CHEMBL564440 | tert-butyl 4-(4-(1-(6-chloroimidazo...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C25H26ClN7O4S2/c1-25(2,3)37-24(34)30-7-4-18(5-8-30)32-15-17(14-28-32)16-12-20-19(27-13-16)6-9-33(20)39(35,36)22-21(26)29-23-31(22)10-11-38-23/h6,9-15,18H,4-5,7-8H2,1-3H3
Affinity DataIC50: 147nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295741(3-(3-nitrophenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin...)
Show SMILES [O-][N+](=O)c1cccc(c1)S(=O)(=O)c1c[nH]c2ncccc12
Show InChI InChI=1S/C13H9N3O4S/c17-16(18)9-3-1-4-10(7-9)21(19,20)12-8-15-13-11(12)5-2-6-14-13/h1-8H,(H,14,15)
Affinity DataIC50: 200nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295752(4-(6-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)-1H-pyrro...)
Show SMILES O=S(=O)(c1cccc2nonc12)n1ccc2ncc(cc12)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C21H19N7O3S/c29-32(30,20-3-1-2-18-21(20)26-31-25-18)28-9-6-17-19(28)10-14(11-23-17)15-12-24-27(13-15)16-4-7-22-8-5-16/h1-3,6,9-13,16,22H,4-5,7-8H2
Affinity DataIC50: 200nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295766(1-(2-nitrophenethyl)-1H-pyrrolo[3,2-b]pyridine | C...)
Show SMILES [O-][N+](=O)c1ccccc1CCn1ccc2ncccc12
Show InChI InChI=1S/C15H13N3O2/c19-18(20)14-5-2-1-4-12(14)7-10-17-11-8-13-15(17)6-3-9-16-13/h1-6,8-9,11H,7,10H2
Affinity DataIC50: 250nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295746((4-methylpiperazin-1-yl)(1-(2-nitrophenylsulfonyl)...)
Show SMILES CN1CCN(CC1)C(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C19H19N5O5S/c1-21-8-10-22(11-9-21)19(25)14-12-17-15(20-13-14)6-7-23(17)30(28,29)18-5-3-2-4-16(18)24(26)27/h2-7,12-13H,8-11H2,1H3
Affinity DataIC50: 300nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295744(1-(2-nitrophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridin...)
Show SMILES OC(=O)c1cnc2ccn(c2c1)S(=O)(=O)c1ccccc1[N+]([O-])=O
Show InChI InChI=1S/C14H9N3O6S/c18-14(19)9-7-12-10(15-8-9)5-6-16(12)24(22,23)13-4-2-1-3-11(13)17(20)21/h1-8H,(H,18,19)
Affinity DataIC50: 310nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295755(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C19H18N6O4S/c1-13(26)23-7-9-24(10-8-23)14-11-17-15(20-12-14)5-6-25(17)30(27,28)18-4-2-3-16-19(18)22-29-21-16/h2-6,11-12H,7-10H2,1H3
Affinity DataIC50: 370nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295754((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
Affinity DataIC50: 430nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295763(CHEMBL564440 | tert-butyl 4-(4-(1-(6-chloroimidazo...)
Show SMILES CC(C)(C)OC(=O)N1CCC(CC1)n1cc(cn1)-c1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C25H26ClN7O4S2/c1-25(2,3)37-24(34)30-7-4-18(5-8-30)32-15-17(14-28-32)16-12-20-19(27-13-16)6-9-33(20)39(35,36)22-21(26)29-23-31(22)10-11-38-23/h6,9-15,18H,4-5,7-8H2,1-3H3
Affinity DataIC50: 450nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295754((4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-p...)
Show SMILES O=C(N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12)c1cccnc1
Show InChI InChI=1S/C23H19N7O4S/c31-23(16-3-2-7-24-14-16)29-11-9-28(10-12-29)17-13-20-18(25-15-17)6-8-30(20)35(32,33)21-5-1-4-19-22(21)27-34-26-19/h1-8,13-15H,9-12H2
Affinity DataIC50: 480nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295733(1-(2,6-dichlorophenylsulfonyl)-1H-pyrrolo[3,2-b]py...)
Show SMILES Clc1cccc(Cl)c1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H8Cl2N2O2S/c14-9-3-1-4-10(15)13(9)20(18,19)17-8-6-11-12(17)5-2-7-16-11/h1-8H
Affinity DataIC50: 480nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Show SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C12H8ClN5O2S2/c13-10-11(17-3-4-21-12(17)16-10)22(19,20)18-2-1-8-9(18)5-7(14)6-15-8/h1-6H,14H2
Affinity DataIC50: 490nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295755(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C19H18N6O4S/c1-13(26)23-7-9-24(10-8-23)14-11-17-15(20-12-14)5-6-25(17)30(27,28)18-4-2-3-16-19(18)22-29-21-16/h2-6,11-12H,7-10H2,1H3
Affinity DataIC50: 500nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295756(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CNCC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C20H21N7O4S/c1-21-13-19(28)26-9-7-25(8-10-26)14-11-17-15(22-12-14)5-6-27(17)32(29,30)18-4-2-3-16-20(18)24-31-23-16/h2-6,11-12,21H,7-10,13H2,1H3
Affinity DataIC50: 570nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295756(1-(4-(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H...)
Show SMILES CNCC(=O)N1CCN(CC1)c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C20H21N7O4S/c1-21-13-19(28)26-9-7-25(8-10-26)14-11-17-15(22-12-14)5-6-27(17)32(29,30)18-4-2-3-16-20(18)24-31-23-16/h2-6,11-12,21H,7-10,13H2,1H3
Affinity DataIC50: 570nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295760(1-(6-chloroimidazo[2,1-b]thiazol-5-ylsulfonyl)-1H-...)
Show SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1c(Cl)nc2sccn12
Show InChI InChI=1S/C12H8ClN5O2S2/c13-10-11(17-3-4-21-12(17)16-10)22(19,20)18-2-1-8-9(18)5-7(14)6-15-8/h1-6H,14H2
Affinity DataIC50: 580nMAssay Description:Inhibition of c-Met phosphorylation in human A549 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295750(4-(6-(6-(4-methylpiperazin-1-yl)pyridin-3-yl)-1H-p...)
Show SMILES CN1CCN(CC1)c1ccc(cn1)-c1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C23H21N7O3S/c1-28-9-11-29(12-10-28)22-6-5-16(14-25-22)17-13-20-18(24-15-17)7-8-30(20)34(31,32)21-4-2-3-19-23(21)27-33-26-19/h2-8,13-15H,9-12H2,1H3
Affinity DataIC50: 820nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295730(1-(2-chlorophenylsulfonyl)-1H-pyrrolo[3,2-b]pyridi...)
Show SMILES Clc1ccccc1S(=O)(=O)n1ccc2ncccc12
Show InChI InChI=1S/C13H9ClN2O2S/c14-10-4-1-2-6-13(10)19(17,18)16-9-7-11-12(16)5-3-8-15-11/h1-9H
Affinity DataIC50: 900nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295768(4-((6-(piperazin-1-yl)-1H-pyrrolo[3,2-b]pyridin-1-...)
Show SMILES C(c1cccc2nonc12)n1ccc2ncc(cc12)N1CCNCC1
Show InChI InChI=1S/C18H18N6O/c1-2-13(18-16(3-1)21-25-22-18)12-24-7-4-15-17(24)10-14(11-20-15)23-8-5-19-6-9-23/h1-4,7,10-11,19H,5-6,8-9,12H2
Affinity DataIC50: 1.04E+3nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295740(3-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine | CHE...)
Show SMILES O=S(=O)(c1c[nH]c2ncccc12)c1ccccc1
Show InChI InChI=1S/C13H10N2O2S/c16-18(17,10-5-2-1-3-6-10)12-9-15-13-11(12)7-4-8-14-13/h1-9H,(H,14,15)
Affinity DataIC50: 1.18E+3nMAssay Description:Inhibition of human recombinant His-tagged c-Met by TR-FRET assayMore data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
UCB Pharma SA

Curated by ChEMBL
LigandPNGBDBM50295753(1-(benzo[c][1,2,5]oxadiazol-4-ylsulfonyl)-1H-pyrro...)
Show SMILES Nc1cnc2ccn(c2c1)S(=O)(=O)c1cccc2nonc12
Show InChI InChI=1S/C13H9N5O3S/c14-8-6-11-9(15-7-8)4-5-18(11)22(19,20)12-3-1-2-10-13(12)17-21-16-10/h1-7H,14H2
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of c-Met phosphorylation in human MKN45 cells after 1 hrMore data for this Ligand-Target Pair
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