Compile Data Set for Download or QSAR
Found 158 Enz. Inhib. hit(s) with all data for entry = 50031656
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataIC50: 2.90nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataIC50: 6nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataIC50: 142nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 4(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataIC50: 1.96E+3nMAssay Description:Displacement of [33P]S1P from human recombinant S1P4 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataIC50: 2.07E+3nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataIC50: 1.00E+4nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataEC50:  5.70nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 5(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P5 receptor expressed in CHO cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316768((Z,Z)-5-[3-Chloro-4-((2S)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1
Affinity DataEC50:  12nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  0.700nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataEC50:  9.10nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  44nMAssay Description:Agonist activity at human recombinant S1P2 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  25nMAssay Description:Agonist activity at human recombinant S1P1 receptor expressed in HEK cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316768((Z,Z)-5-[3-Chloro-4-((2S)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m1/s1
Affinity DataEC50:  174nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316769((Z,Z)-5-[3-Chloro-4-((2R)-2,3-dihydroxy-propoxy)-b...)
Show SMILES CCC\N=C1/S\C(=C/c2ccc(OC[C@@H](O)CO)c(Cl)c2)C(=O)N1c1ccccc1C
Show InChI InChI=1S/C23H25ClN2O4S/c1-3-10-25-23-26(19-7-5-4-6-15(19)2)22(29)21(31-23)12-16-8-9-20(18(24)11-16)30-14-17(28)13-27/h4-9,11-12,17,27-28H,3,10,13-14H2,1-2H3/b21-12-,25-23-/t17-/m0/s1
Affinity DataEC50:  123nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 1(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  0.100nMAssay Description:Displacement of [33P]S1P from human recombinant S1P1 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  0.200nMAssay Description:Displacement of [33P]S1P from human recombinant S1P3 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50158348((2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihy...)
Show SMILES CCCCCCCCCCCCC\C=C\[C@@H](O)[C@@H](N)COP(O)(O)=O
Show InChI InChI=1S/C18H38NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-18(20)17(19)16-24-25(21,22)23/h14-15,17-18,20H,2-13,16,19H2,1H3,(H2,21,22,23)/b15-14+/t17-,18+/m0/s1
Affinity DataEC50:  0.700nMAssay Description:Displacement of [33P]S1P from human recombinant S1P2 receptor expressed in HEK cells by scintillation countingMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316707(CHEMBL1097182 | rac-(Z,Z)-5-[4-(2,3-Dihydroxy-prop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(OCC(O)CO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C22H24N2O4S/c1-15(2)23-22-24(17-6-4-3-5-7-17)21(27)20(29-22)12-16-8-10-19(11-9-16)28-14-18(26)13-25/h3-12,15,18,25-26H,13-14H2,1-2H3/b20-12-,23-22-
Affinity DataEC50:  240nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316708((Z,Z)-5-[4-(3-Hydroxy-propoxy)-benzylidene]-2-isop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(OCCCO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C22H24N2O3S/c1-16(2)23-22-24(18-7-4-3-5-8-18)21(26)20(28-22)15-17-9-11-19(12-10-17)27-14-6-13-25/h3-5,7-12,15-16,25H,6,13-14H2,1-2H3/b20-15-,23-22-
Affinity DataEC50:  68nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316709((Z,Z)-5-[4-(2-Hydroxy-ethoxy)-benzylidene]-2-isopr...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(OCCO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C21H22N2O3S/c1-15(2)22-21-23(17-6-4-3-5-7-17)20(25)19(27-21)14-16-8-10-18(11-9-16)26-13-12-24/h3-11,14-15,24H,12-13H2,1-2H3/b19-14-,22-21-
Affinity DataEC50:  114nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316710((Z,Z)-5-[4-(3-Hydroxy-propyl)-benzylidene]-2-isopr...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(CCCO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C22H24N2O2S/c1-16(2)23-22-24(19-8-4-3-5-9-19)21(26)20(27-22)15-18-12-10-17(11-13-18)7-6-14-25/h3-5,8-13,15-16,25H,6-7,14H2,1-2H3/b20-15-,23-22-
Affinity DataEC50:  54nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316711((Z,Z)-5-[4-(2-Hydroxy-ethyl)-benzylidene]-2-isopro...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(CCO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C21H22N2O2S/c1-15(2)22-21-23(18-6-4-3-5-7-18)20(25)19(26-21)14-17-10-8-16(9-11-17)12-13-24/h3-11,14-15,24H,12-13H2,1-2H3/b19-14-,22-21-
Affinity DataEC50:  59nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316712((Z,Z)-5-(4-Hydroxymethyl-benzylidene)-2-isopropyli...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(CO)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C20H20N2O2S/c1-14(2)21-20-22(17-6-4-3-5-7-17)19(24)18(25-20)12-15-8-10-16(13-23)11-9-15/h3-12,14,23H,13H2,1-2H3/b18-12-,21-20-
Affinity DataEC50:  86nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316713((Z,Z)-2-Isopropylimino-5-(2-methoxy-benzylidene)-3...)
Show SMILES COc1ccccc1\C=C1/S\C(=N/C(C)C)N(C1=O)c1ccccc1
Show InChI InChI=1S/C20H20N2O2S/c1-14(2)21-20-22(16-10-5-4-6-11-16)19(23)18(25-20)13-15-9-7-8-12-17(15)24-3/h4-14H,1-3H3/b18-13-,21-20-
Affinity DataEC50:  6.69E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316714((Z,Z)-5-(2-Chloro-benzylidene)-2-isopropylimino-3-...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccccc2Cl)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H17ClN2OS/c1-13(2)21-19-22(15-9-4-3-5-10-15)18(23)17(24-19)12-14-8-6-7-11-16(14)20/h3-13H,1-2H3/b17-12-,21-19-
Affinity DataEC50:  2.58E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316715((Z,Z)-2-Isopropylimino-5-(2-methyl-benzylidene)-3-...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccccc2C)C(=O)N1c1ccccc1
Show InChI InChI=1S/C20H20N2OS/c1-14(2)21-20-22(17-11-5-4-6-12-17)19(23)18(24-20)13-16-10-8-7-9-15(16)3/h4-14H,1-3H3/b18-13-,21-20-
Affinity DataEC50:  5.79E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316716((Z,Z)-5-(3,4-Dihydroxy-benzylidene)-2-isopropylimi...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(O)c2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H18N2O3S/c1-12(2)20-19-21(14-6-4-3-5-7-14)18(24)17(25-19)11-13-8-9-15(22)16(23)10-13/h3-12,22-23H,1-2H3/b17-11-,20-19-
Affinity DataEC50: >1.00E+4nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316717((Z,Z)-5-(3-Hydroxy-4-methoxy-benzylidene)-2-isopro...)
Show SMILES COc1ccc(\C=C2/S\C(=N/C(C)C)N(C2=O)c2ccccc2)cc1O
Show InChI InChI=1S/C20H20N2O3S/c1-13(2)21-20-22(15-7-5-4-6-8-15)19(24)18(26-20)12-14-9-10-17(25-3)16(23)11-14/h4-13,23H,1-3H3/b18-12-,21-20-
Affinity DataEC50:  212nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316718((Z,Z)-5-(3-Hydroxy-benzylidene)-2-isopropylimino-3...)
Show SMILES CC(C)\N=C1/S\C(=C/c2cccc(O)c2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H18N2O2S/c1-13(2)20-19-21(15-8-4-3-5-9-15)18(23)17(24-19)12-14-7-6-10-16(22)11-14/h3-13,22H,1-2H3/b17-12-,20-19-
Affinity DataEC50:  103nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316719((Z,Z)-2-Isopropylimino-5-(3-methoxy-benzylidene)-3...)
Show SMILES COc1cccc(\C=C2/S\C(=N/C(C)C)N(C2=O)c2ccccc2)c1
Show InChI InChI=1S/C20H20N2O2S/c1-14(2)21-20-22(16-9-5-4-6-10-16)19(23)18(25-20)13-15-8-7-11-17(12-15)24-3/h4-14H,1-3H3/b18-13-,21-20-
Affinity DataEC50:  35nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316720((Z,Z)-5-(4-Bromo-benzylidene)-2-isopropylimino-3-p...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(Br)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H17BrN2OS/c1-13(2)21-19-22(16-6-4-3-5-7-16)18(23)17(24-19)12-14-8-10-15(20)11-9-14/h3-13H,1-2H3/b17-12-,21-19-
Affinity DataEC50:  136nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316721((Z,Z)-5-(4-Dimethylamino-benzylidene)-2-isopropyli...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(cc2)N(C)C)C(=O)N1c1ccccc1
Show InChI InChI=1S/C21H23N3OS/c1-15(2)22-21-24(18-8-6-5-7-9-18)20(25)19(26-21)14-16-10-12-17(13-11-16)23(3)4/h5-15H,1-4H3/b19-14-,22-21-
Affinity DataEC50:  165nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316722((Z,Z)-5-(3,4-Dimethoxy-benzylidene)-2-isopropylimi...)
Show SMILES COc1ccc(\C=C2/S\C(=N/C(C)C)N(C2=O)c2ccccc2)cc1OC
Show InChI InChI=1S/C21H22N2O3S/c1-14(2)22-21-23(16-8-6-5-7-9-16)20(24)19(27-21)13-15-10-11-17(25-3)18(12-15)26-4/h5-14H,1-4H3/b19-13-,22-21-
Affinity DataEC50:  1.39E+3nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316723((Z,Z)-2-Isopropylimino-5-(4-methoxy-benzylidene)-3...)
Show SMILES COc1ccc(\C=C2/S\C(=N/C(C)C)N(C2=O)c2ccccc2)cc1
Show InChI InChI=1S/C20H20N2O2S/c1-14(2)21-20-22(16-7-5-4-6-8-16)19(23)18(25-20)13-15-9-11-17(24-3)12-10-15/h4-14H,1-3H3/b18-13-,21-20-
Affinity DataEC50:  106nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316724((Z,Z)-5-(4-Hydroxy-3-methoxy-benzylidene)-2-isopro...)
Show SMILES COc1cc(\C=C2/S\C(=N/C(C)C)N(C2=O)c2ccccc2)ccc1O
Show InChI InChI=1S/C20H20N2O3S/c1-13(2)21-20-22(15-7-5-4-6-8-15)19(24)18(26-20)12-14-9-10-16(23)17(11-14)25-3/h4-13,23H,1-3H3/b18-12-,21-20-
Affinity DataEC50:  335nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316725((Z,Z)-5-(4-Hydroxy-3-methyl-benzylidene)-2-isoprop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(C)c2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C20H20N2O2S/c1-13(2)21-20-22(16-7-5-4-6-8-16)19(24)18(25-20)12-15-9-10-17(23)14(3)11-15/h4-13,23H,1-3H3/b18-12-,21-20-
Affinity DataEC50:  50nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316726((Z,Z)-5-(3-Fluoro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(F)c2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H17FN2O2S/c1-12(2)21-19-22(14-6-4-3-5-7-14)18(24)17(25-19)11-13-8-9-16(23)15(20)10-13/h3-12,23H,1-2H3/b17-11-,21-19-
Affinity DataEC50:  99nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316727((Z,Z)-5-(4-Hydroxy-benzylidene)-2-isopropylimino-3...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)cc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H18N2O2S/c1-13(2)20-19-21(15-6-4-3-5-7-15)18(23)17(24-19)12-14-8-10-16(22)11-9-14/h3-13,22H,1-2H3/b17-12-,20-19-
Affinity DataEC50:  95nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316728((Z,Z)-5-Benzylidene-2-isopropylimino-3-phenyl-thia...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccccc2)C(=O)N1c1ccccc1
Show InChI InChI=1S/C19H18N2OS/c1-14(2)20-19-21(16-11-7-4-8-12-16)18(22)17(23-19)13-15-9-5-3-6-10-15/h3-14H,1-2H3/b17-13-,20-19-
Affinity DataEC50:  317nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316729((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1CCCCc1ccccc1
Show InChI InChI=1S/C23H25ClN2O2S/c1-16(2)25-23-26(13-7-6-10-17-8-4-3-5-9-17)22(28)21(29-23)15-18-11-12-20(27)19(24)14-18/h3-5,8-9,11-12,14-16,27H,6-7,10,13H2,1-2H3/b21-15-,25-23-
Affinity DataEC50:  212nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316730((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1CCc1ccccc1
Show InChI InChI=1S/C21H21ClN2O2S/c1-14(2)23-21-24(11-10-15-6-4-3-5-7-15)20(26)19(27-21)13-16-8-9-18(25)17(22)12-16/h3-9,12-14,25H,10-11H2,1-2H3/b19-13-,23-21-
Affinity DataEC50:  183nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316731((Z,Z)-3-Benzyl-5-(3-chloro-4-hydroxy-benzylidene)-...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1Cc1ccccc1
Show InChI InChI=1S/C20H19ClN2O2S/c1-13(2)22-20-23(12-14-6-4-3-5-7-14)19(25)18(26-20)11-15-8-9-17(24)16(21)10-15/h3-11,13,24H,12H2,1-2H3/b18-11-,22-20-
Affinity DataEC50:  674nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316732((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1c1cccnc1
Show InChI InChI=1S/C18H16ClN3O2S/c1-11(2)21-18-22(13-4-3-7-20-10-13)17(24)16(25-18)9-12-5-6-15(23)14(19)8-12/h3-11,23H,1-2H3/b16-9-,21-18-
Affinity DataEC50:  228nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316733((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(2,4-di...)
Show SMILES COc1ccc(N2\C(S\C(=C/c3ccc(O)c(Cl)c3)C2=O)=N\C(C)C)c(OC)c1
Show InChI InChI=1S/C21H21ClN2O4S/c1-12(2)23-21-24(16-7-6-14(27-3)11-18(16)28-4)20(26)19(29-21)10-13-5-8-17(25)15(22)9-13/h5-12,25H,1-4H3/b19-10-,23-21-
Affinity DataEC50:  525nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316734((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES COc1ccc(cc1)N1\C(S\C(=C/c2ccc(O)c(Cl)c2)C1=O)=N\C(C)C
Show InChI InChI=1S/C20H19ClN2O3S/c1-12(2)22-20-23(14-5-7-15(26-3)8-6-14)19(25)18(27-20)11-13-4-9-17(24)16(21)10-13/h4-12,24H,1-3H3/b18-11-,22-20-
Affinity DataEC50:  127nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316735((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES COc1cccc(c1)N1\C(S\C(=C/c2ccc(O)c(Cl)c2)C1=O)=N\C(C)C
Show InChI InChI=1S/C20H19ClN2O3S/c1-12(2)22-20-23(14-5-4-6-15(11-14)26-3)19(25)18(27-20)10-13-7-8-17(24)16(21)9-13/h4-12,24H,1-3H3/b18-10-,22-20-
Affinity DataEC50:  514nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316736((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-2-isoprop...)
Show SMILES COc1ccccc1N1\C(S\C(=C/c2ccc(O)c(Cl)c2)C1=O)=N\C(C)C
Show InChI InChI=1S/C20H19ClN2O3S/c1-12(2)22-20-23(15-6-4-5-7-17(15)26-3)19(25)18(27-20)11-13-8-9-16(24)14(21)10-13/h4-12,24H,1-3H3/b18-11-,22-20-
Affinity DataEC50:  428nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316737((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(3-chlo...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1c1ccc(C)c(Cl)c1
Show InChI InChI=1S/C20H18Cl2N2O2S/c1-11(2)23-20-24(14-6-4-12(3)15(21)10-14)19(26)18(27-20)9-13-5-7-17(25)16(22)8-13/h4-11,25H,1-3H3/b18-9-,23-20-
Affinity DataEC50:  144nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
TargetSphingosine 1-phosphate receptor 3(Homo sapiens (Human))
Actelion Pharmaceuticals Ltd

Curated by ChEMBL
LigandPNGBDBM50316738((Z,Z)-5-(3-Chloro-4-hydroxy-benzylidene)-3-(3-chlo...)
Show SMILES CC(C)\N=C1/S\C(=C/c2ccc(O)c(Cl)c2)C(=O)N1c1cccc(Cl)c1C
Show InChI InChI=1S/C20H18Cl2N2O2S/c1-11(2)23-20-24(16-6-4-5-14(21)12(16)3)19(26)18(27-20)10-13-7-8-17(25)15(22)9-13/h4-11,25H,1-3H3/b18-10-,23-20-
Affinity DataEC50:  246nMAssay Description:Agonist activity at human recombinant S1P3 receptor expressed in CHO cells by GTPgammaS binding assayMore data for this Ligand-Target Pair
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