Compile Data Set for Download or QSAR
Found 96 Enz. Inhib. hit(s) with all data for entry = 50033433
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
Affinity DataKi:  0.900nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  2.5nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Show SMILES CCCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-5-6-11(4-2)14(17)16-12-7-9-13(10-8-12)20(15,18)19/h7-11H,3-6H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  5nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Show SMILES CCCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-5-6-11(4-2)14(17)16-12-7-9-13(10-8-12)20(15,18)19/h7-11H,3-6H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  5.5nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345225(2,2-Dimethyl-N-(4-sulfamoylbenzyl)propionamide | C...)
Show SMILES CC(C)(C)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-12(2,3)11(15)14-8-9-4-6-10(7-5-9)18(13,16)17/h4-7H,8H2,1-3H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  5.80nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Show SMILES CCCC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C15H24N2O3S/c1-5-6-13(15(2,3)4)14(18)17-11-7-9-12(10-8-11)21(16,19)20/h7-10,13H,5-6H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345222(2-ethyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL1...)
Show SMILES CCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H20N2O3S/c1-3-5-10(4-2)13(16)15-11-6-8-12(9-7-11)19(14,17)18/h6-10H,3-5H2,1-2H3,(H,15,16)(H2,14,17,18)
Affinity DataKi:  6.5nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(C)C(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-10(3)13(5-2)14(17)16-11-6-8-12(9-7-11)20(15,18)19/h6-10,13H,4-5H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  6.90nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345220(2-Isopropyl-3,3-dimethyl-N-(4-sulfamoylphenyl)buty...)
Show SMILES CC(C)C(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C15H24N2O3S/c1-10(2)13(15(3,4)5)14(18)17-11-6-8-12(9-7-11)21(16,19)20/h6-10,13H,1-5H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  7.30nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
Affinity DataKi:  7.60nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
Affinity DataKi:  9nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Show SMILES CCC(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-3-9(2)8-12(15)14-10-4-6-11(7-5-10)18(13,16)17/h4-7,9H,3,8H2,1-2H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  9.40nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345219(2-Ethyl-3,3-dimethyl-N-(4-sulfamoylphenyl)butyrami...)
Show SMILES CCC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C14H22N2O3S/c1-5-12(14(2,3)4)13(17)16-10-6-8-11(9-7-10)20(15,18)19/h6-9,12H,5H2,1-4H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  9.60nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Show SMILES CCCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-5-6-11(4-2)14(17)16-12-7-9-13(10-8-12)20(15,18)19/h7-11H,3-6H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  9.70nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10887(Sulfamate 7 | Topiramate (TPM) | US11535599, Examp...)
Show SMILES CC1(C)O[C@@H]2CO[C@@]3(COS(N)(=O)=O)OC(C)(C)O[C@H]3[C@@H]2O1
Show InChI InChI=1S/C12H21NO8S/c1-10(2)18-7-5-16-12(6-17-22(13,14)15)9(8(7)19-10)20-11(3,4)21-12/h7-9H,5-6H2,1-4H3,(H2,13,14,15)/t7-,8-,9+,12+/m1/s1
Affinity DataKi:  10nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Show SMILES CCCC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C15H24N2O3S/c1-5-6-13(15(2,3)4)14(18)17-11-7-9-12(10-8-11)21(16,19)20/h7-10,13H,5-6H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  10.1nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345216(2-ethyl-N-(4-sulfamoylphenyl)hexanamide | CHEMBL10...)
Show SMILES CCCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-5-6-11(4-2)14(17)16-12-7-9-13(10-8-12)20(15,18)19/h7-11H,3-6H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  10.2nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Show SMILES CCC(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-3-9(2)8-12(15)14-10-4-6-11(7-5-10)18(13,16)17/h4-7,9H,3,8H2,1-2H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  10.3nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  12nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345225(2,2-Dimethyl-N-(4-sulfamoylbenzyl)propionamide | C...)
Show SMILES CC(C)(C)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-12(2,3)11(15)14-8-9-4-6-10(7-5-9)18(13,16)17/h4-7H,8H2,1-3H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  28.6nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345226(2-Ethyl-N-[2-(4-sulfamoylphenyl)ethyl]butyramide |...)
Show SMILES CCC(CC)C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-12(4-2)14(17)16-10-9-11-5-7-13(8-6-11)20(15,18)19/h5-8,12H,3-4,9-10H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  33.8nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)
Show SMILES NS(=O)(=O)Cc1noc2ccccc12
Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
Affinity DataKi:  35nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10880(AZA | AZA2 | AZM acetazolamide | Acerazolamide, AA...)
Show SMILES CC(=O)Nc1nnc(s1)S(N)(=O)=O
Show InChI InChI=1S/C4H6N4O3S2/c1-2(9)6-3-7-8-4(12-3)13(5,10)11/h1H3,(H2,5,10,11)(H,6,7,9)
Affinity DataKi:  41nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
Affinity DataKi:  46nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345219(2-Ethyl-3,3-dimethyl-N-(4-sulfamoylphenyl)butyrami...)
Show SMILES CCC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C14H22N2O3S/c1-5-12(14(2,3)4)13(17)16-10-6-8-11(9-7-10)20(15,18)19/h6-9,12H,5H2,1-4H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  49nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345226(2-Ethyl-N-[2-(4-sulfamoylphenyl)ethyl]butyramide |...)
Show SMILES CCC(CC)C(=O)NCCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-3-12(4-2)14(17)16-10-9-11-5-7-13(8-6-11)20(15,18)19/h5-8,12H,3-4,9-10H2,1-2H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  51nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM35733(sulfonamide deriv., 7a)
Show SMILES NS(=O)(=O)c1ccc(NC(=O)Cc2ccccc2)cc1
Show InChI InChI=1S/C14H14N2O3S/c15-20(18,19)13-8-6-12(7-9-13)16-14(17)10-11-4-2-1-3-5-11/h1-9H,10H2,(H,16,17)(H2,15,18,19)
Affinity DataKi:  52nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Show SMILES CCC(C)C(C(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H24N2O3S/c1-5-11(4)14(10(2)3)15(18)17-12-6-8-13(9-7-12)21(16,19)20/h6-11,14H,5H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  53nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(C)C(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-10(3)13(5-2)14(17)16-11-6-8-12(9-7-11)20(15,18)19/h6-10,13H,4-5H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  54nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Show SMILES CCC(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-3-9(2)8-12(15)14-10-4-6-11(7-5-10)18(13,16)17/h4-7,9H,3,8H2,1-2H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  54nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)
Show SMILES NS(=O)(=O)Cc1noc2ccccc12
Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
Affinity DataKi:  56nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345222(2-ethyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL1...)
Show SMILES CCCC(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H20N2O3S/c1-3-5-10(4-2)13(16)15-11-6-8-12(9-7-11)19(14,17)18/h6-10H,3-5H2,1-2H3,(H,15,16)(H2,14,17,18)
Affinity DataKi:  60nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345221(3,3-Dimethyl-N-(4-sulfamoylphenyl)butyramide | 3,3...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-12(2,3)8-11(15)14-9-4-6-10(7-5-9)18(13,16)17/h4-7H,8H2,1-3H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  62nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345214(2-ethyl-4-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(CC(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-11(9-10(2)3)14(17)16-12-5-7-13(8-6-12)20(15,18)19/h5-8,10-11H,4,9H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  62nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345214(2-ethyl-4-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(CC(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-11(9-10(2)3)14(17)16-12-5-7-13(8-6-12)20(15,18)19/h5-8,10-11H,4,9H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  64nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345218(2-Methyl-N-(4-sulfamoylphenyl)butyramide | 2-methy...)
Show SMILES CCC(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C11H16N2O3S/c1-3-8(2)11(14)13-9-4-6-10(7-5-9)17(12,15)16/h4-8H,3H2,1-2H3,(H,13,14)(H2,12,15,16)
Affinity DataKi:  65nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345225(2,2-Dimethyl-N-(4-sulfamoylbenzyl)propionamide | C...)
Show SMILES CC(C)(C)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-12(2,3)11(15)14-8-9-4-6-10(7-5-9)18(13,16)17/h4-7H,8H2,1-3H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  65nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Show SMILES CCC(C)C(C(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H24N2O3S/c1-5-11(4)14(10(2)3)15(18)17-12-6-8-13(9-7-12)21(16,19)20/h6-11,14H,5H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  66nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345224(2-tert-butyl-N-(4-sulfamoylphenyl)pentanamide | CH...)
Show SMILES CCCC(C(=O)Nc1ccc(cc1)S(N)(=O)=O)C(C)(C)C
Show InChI InChI=1S/C15H24N2O3S/c1-5-6-13(15(2,3)4)14(18)17-11-7-9-12(10-8-11)21(16,19)20/h7-10,13H,5-6H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  70nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345221(3,3-Dimethyl-N-(4-sulfamoylphenyl)butyramide | 3,3...)
Show SMILES CC(C)(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-12(2,3)8-11(15)14-9-4-6-10(7-5-9)18(13,16)17/h4-7H,8H2,1-3H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  71nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345217(2-Ethyl-N-(4-sulfamoyl-benzyl)-butyramide | 2-Ethy...)
Show SMILES CCC(CC)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H20N2O3S/c1-3-11(4-2)13(16)15-9-10-5-7-12(8-6-10)19(14,17)18/h5-8,11H,3-4,9H2,1-2H3,(H,15,16)(H2,14,17,18)
Affinity DataKi:  71nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345218(2-Methyl-N-(4-sulfamoylphenyl)butyramide | 2-methy...)
Show SMILES CCC(C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C11H16N2O3S/c1-3-8(2)11(14)13-9-4-6-10(7-5-9)17(12,15)16/h4-8H,3H2,1-2H3,(H,13,14)(H2,12,15,16)
Affinity DataKi:  78nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345215(3-methyl-N-(4-sulfamoylphenyl)pentanamide | CHEMBL...)
Show SMILES CCC(C)CC(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C12H18N2O3S/c1-3-9(2)8-12(15)14-10-4-6-11(7-5-10)18(13,16)17/h4-7,9H,3,8H2,1-2H3,(H,14,15)(H2,13,16,17)
Affinity DataKi:  78nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345217(2-Ethyl-N-(4-sulfamoyl-benzyl)-butyramide | 2-Ethy...)
Show SMILES CCC(CC)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H20N2O3S/c1-3-11(4-2)13(16)15-9-10-5-7-12(8-6-10)19(14,17)18/h5-8,11H,3-4,9H2,1-2H3,(H,15,16)(H2,14,17,18)
Affinity DataKi:  82nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 14(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345217(2-Ethyl-N-(4-sulfamoyl-benzyl)-butyramide | 2-Ethy...)
Show SMILES CCC(CC)C(=O)NCc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C13H20N2O3S/c1-3-11(4-2)13(16)15-9-10-5-7-12(8-6-10)19(14,17)18/h5-8,11H,3-4,9H2,1-2H3,(H,15,16)(H2,14,17,18)
Affinity DataKi:  82nMAssay Description:Inhibition of human carbonic anhydrase 14 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 1(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Show SMILES CCC(C)C(C(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H24N2O3S/c1-5-11(4)14(10(2)3)15(18)17-12-6-8-13(9-7-12)21(16,19)20/h6-11,14H,5H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  101nMAssay Description:Inhibition of human carbonic anhydrase 1 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345214(2-ethyl-4-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(CC(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-11(9-10(2)3)14(17)16-12-5-7-13(8-6-12)20(15,18)19/h5-8,10-11H,4,9H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  104nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345212(2-isopropyl-3-methyl-N-(4-sulfamoylphenyl)pentanam...)
Show SMILES CCC(C)C(C(C)C)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C15H24N2O3S/c1-5-11(4)14(10(2)3)15(18)17-12-6-8-13(9-7-12)21(16,19)20/h6-11,14H,5H2,1-4H3,(H,17,18)(H2,16,19,20)
Affinity DataKi:  106nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 7(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM10888(1,2-benzoxazol-3-ylmethanesulfonamide | CHEMBL750 ...)
Show SMILES NS(=O)(=O)Cc1noc2ccccc12
Show InChI InChI=1S/C8H8N2O3S/c9-14(11,12)5-7-6-3-1-2-4-8(6)13-10-7/h1-4H,5H2,(H2,9,11,12)
Affinity DataKi:  117nMAssay Description:Inhibition of human carbonic anhydrase 7 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
TargetCarbonic anhydrase 2(Homo sapiens (Human))
The Hebrew University of Jerusalem

Curated by ChEMBL
LigandPNGBDBM50345223(2-ethyl-3-methyl-N-(4-sulfamoylphenyl)pentanamide ...)
Show SMILES CCC(C)C(CC)C(=O)Nc1ccc(cc1)S(N)(=O)=O
Show InChI InChI=1S/C14H22N2O3S/c1-4-10(3)13(5-2)14(17)16-11-6-8-12(9-7-11)20(15,18)19/h6-10,13H,4-5H2,1-3H3,(H,16,17)(H2,15,18,19)
Affinity DataKi:  142nMAssay Description:Inhibition of human carbonic anhydrase 2 preincubated with compound for 15 mins by carbon dioxide hydration assayMore data for this Ligand-Target Pair
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