Compile Data Set for Download or QSAR
Found 77 Enz. Inhib. hit(s) with all data for entry = 50033435
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+
Affinity DataIC50: 1nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345259(CHEMBL1782530 | cis-7-(4-aminocyclohexylamino)-5-b...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11+
Affinity DataIC50: 4nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345260(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11-
Affinity DataIC50: 19nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NCC3CCNCC3)c2o1
Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20)
Affinity DataIC50: 20nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345245(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
Affinity DataIC50: 21nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345253(5-bromo-7-(2-(piperidin-4-yl)ethylamino)benzofuran...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NCCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H19BrN2O3/c17-12-7-11-8-14(16(20)21)22-15(11)13(9-12)19-6-3-10-1-4-18-5-2-10/h7-10,18-19H,1-6H2,(H,20,21)
Affinity DataIC50: 40nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345251(5-bromo-7-(2-(piperidin-4-yl)ethoxy)benzofuran-2-c...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H18BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h7-10,18H,1-6H2,(H,19,20)
Affinity DataIC50: 51nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345245(CHEMBL1782516 | trans-5-(6-(4-(aminomethyl)cyclohe...)
Show SMILES NC[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C20H22N4O3/c21-9-12-1-4-15(5-2-12)23-19-11-22-10-16(24-19)13-3-6-17-14(7-13)8-18(27-17)20(25)26/h3,6-8,10-12,15H,1-2,4-5,9,21H2,(H,23,24)(H,25,26)/t12-,15-
Affinity DataIC50: 53nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345242(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
Affinity DataIC50: 54nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345255(5-bromo-7-(2-(piperidin-4-yl)acetamido)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NC(=O)CC3CCNCC3)c2o1
Show InChI InChI=1S/C16H17BrN2O4/c17-11-6-10-7-13(16(21)22)23-15(10)12(8-11)19-14(20)5-9-1-3-18-4-2-9/h6-9,18H,1-5H2,(H,19,20)(H,21,22)
Affinity DataIC50: 55nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345247(5-bromo-7-(piperidin-4-ylmethoxy)benzofuran-2-carb...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC3CCNCC3)c2o1
Show InChI InChI=1S/C15H16BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h5-7,9,17H,1-4,8H2,(H,18,19)
Affinity DataIC50: 60nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345260(CHEMBL1782531 | trans-7-(4-aminocyclohexylamino)-5...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H17BrN2O3/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)18-11-3-1-10(17)2-4-11/h5-7,10-11,18H,1-4,17H2,(H,19,20)/t10-,11-
Affinity DataIC50: 66nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345249(5-bromo-7-(piperidin-3-ylmethoxy)benzofuran-2-carb...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC3CCCNC3)c2o1
Show InChI InChI=1S/C15H16BrNO4/c16-11-4-10-5-13(15(18)19)21-14(10)12(6-11)20-8-9-2-1-3-17-7-9/h4-6,9,17H,1-3,7-8H2,(H,18,19)
Affinity DataIC50: 71nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345246(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CNC2)n1
Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22)
Affinity DataIC50: 100nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345243(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
Affinity DataIC50: 110nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345242(CHEMBL1782513 | trans-5-(6-(4-aminocyclohexylamino...)
Show SMILES N[C@H]1CC[C@@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14-
Affinity DataIC50: 120nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345254(5-bromo-7-(piperidine-4-carboxamido)benzofuran-2-c...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NC(=O)C3CCNCC3)c2o1
Show InChI InChI=1S/C15H15BrN2O4/c16-10-5-9-6-12(15(20)21)22-13(9)11(7-10)18-14(19)8-1-3-17-4-2-8/h5-8,17H,1-4H2,(H,18,19)(H,20,21)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345244(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CCNCC2)n1
Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345238(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NCC2CCNCC2)n1
Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25)
Affinity DataIC50: 160nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345250(5-bromo-7-(piperidin-4-ylmethylamino)benzofuran-2-...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NCC3CCNCC3)c2o1
Show InChI InChI=1S/C15H17BrN2O3/c16-11-5-10-6-13(15(19)20)21-14(10)12(7-11)18-8-9-1-3-17-4-2-9/h5-7,9,17-18H,1-4,8H2,(H,19,20)
Affinity DataIC50: 190nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345243(CHEMBL1782514 | cis-5-(6-(4-aminocyclohexylamino)p...)
Show SMILES N[C@H]1CC[C@H](CC1)Nc1cncc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C19H20N4O3/c20-13-2-4-14(5-3-13)22-18-10-21-9-15(23-18)11-1-6-16-12(7-11)8-17(26-16)19(24)25/h1,6-10,13-14H,2-5,20H2,(H,22,23)(H,24,25)/t13-,14+
Affinity DataIC50: 200nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345244(5-(6-(piperidin-4-ylamino)pyrazin-2-yl)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CCNCC2)n1
Show InChI InChI=1S/C18H18N4O3/c23-18(24)16-8-12-7-11(1-2-15(12)25-16)14-9-20-10-17(22-14)21-13-3-5-19-6-4-13/h1-2,7-10,13,19H,3-6H2,(H,21,22)(H,23,24)
Affinity DataIC50: 210nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345256(5-bromo-7-(2-oxo-2-(piperazin-1-yl)ethoxy)benzofur...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC(=O)N3CCNCC3)c2o1
Show InChI InChI=1S/C15H15BrN2O5/c16-10-5-9-6-12(15(20)21)23-14(9)11(7-10)22-8-13(19)18-3-1-17-2-4-18/h5-7,17H,1-4,8H2,(H,20,21)
Affinity DataIC50: 220nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345247(5-bromo-7-(piperidin-4-ylmethoxy)benzofuran-2-carb...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC3CCNCC3)c2o1
Show InChI InChI=1S/C15H16BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h5-7,9,17H,1-4,8H2,(H,18,19)
Affinity DataIC50: 250nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345254(5-bromo-7-(piperidine-4-carboxamido)benzofuran-2-c...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NC(=O)C3CCNCC3)c2o1
Show InChI InChI=1S/C15H15BrN2O4/c16-10-5-9-6-12(15(20)21)22-13(9)11(7-10)18-14(19)8-1-3-17-4-2-8/h5-8,17H,1-4H2,(H,18,19)(H,20,21)
Affinity DataIC50: 260nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345249(5-bromo-7-(piperidin-3-ylmethoxy)benzofuran-2-carb...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC3CCCNC3)c2o1
Show InChI InChI=1S/C15H16BrNO4/c16-11-4-10-5-13(15(18)19)21-14(10)12(6-11)20-8-9-2-1-3-17-7-9/h4-6,9,17H,1-3,7-8H2,(H,18,19)
Affinity DataIC50: 330nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345255(5-bromo-7-(2-(piperidin-4-yl)acetamido)benzofuran-...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NC(=O)CC3CCNCC3)c2o1
Show InChI InChI=1S/C16H17BrN2O4/c17-11-6-10-7-13(16(21)22)23-15(10)12(8-11)19-14(20)5-9-1-3-18-4-2-9/h6-9,18H,1-5H2,(H,19,20)(H,21,22)
Affinity DataIC50: 340nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345251(5-bromo-7-(2-(piperidin-4-yl)ethoxy)benzofuran-2-c...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H18BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h7-10,18H,1-6H2,(H,19,20)
Affinity DataIC50: 350nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345238(5-(6-(piperidin-4-ylmethylamino)pyrazin-2-yl)benzo...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NCC2CCNCC2)n1
Show InChI InChI=1S/C19H20N4O3/c24-19(25)17-8-14-7-13(1-2-16(14)26-17)15-10-21-11-18(23-15)22-9-12-3-5-20-6-4-12/h1-2,7-8,10-12,20H,3-6,9H2,(H,22,23)(H,24,25)
Affinity DataIC50: 380nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345246(5-(6-(azetidin-3-ylamino)pyrazin-2-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cncc(NC2CNC2)n1
Show InChI InChI=1S/C16H14N4O3/c21-16(22)14-4-10-3-9(1-2-13(10)23-14)12-7-18-8-15(20-12)19-11-5-17-6-11/h1-4,7-8,11,17H,5-6H2,(H,19,20)(H,21,22)
Affinity DataIC50: 450nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345241(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)
Show SMILES NCCCCNc1nccc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
Affinity DataIC50: 460nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345253(5-bromo-7-(2-(piperidin-4-yl)ethylamino)benzofuran...)
Show SMILES OC(=O)c1cc2cc(Br)cc(NCCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H19BrN2O3/c17-12-7-11-8-14(16(20)21)22-15(11)13(9-12)19-6-3-10-1-4-18-5-2-10/h7-10,18-19H,1-6H2,(H,20,21)
Affinity DataIC50: 540nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345241(5-(2-(4-aminobutylamino)pyrimidin-4-yl)benzofuran-...)
Show SMILES NCCCCNc1nccc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-17-20-8-5-13(21-17)11-3-4-14-12(9-11)10-15(24-14)16(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
Affinity DataIC50: 590nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345257(5-bromo-7-(piperidin-4-ylcarbamoyl)benzofuran-2-ca...)
Show SMILES OC(=O)c1cc2cc(Br)cc(C(=O)NC3CCNCC3)c2o1
Show InChI InChI=1S/C15H15BrN2O4/c16-9-5-8-6-12(15(20)21)22-13(8)11(7-9)14(19)18-10-1-3-17-4-2-10/h5-7,10,17H,1-4H2,(H,18,19)(H,20,21)
Affinity DataIC50: 980nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345240(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)
Show SMILES NCCCCNc1ccnc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345258(5-bromo-7-(piperidin-4-ylmethylcarbamoyl)benzofura...)
Show SMILES OC(=O)c1cc2cc(Br)cc(C(=O)NCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H17BrN2O4/c17-11-5-10-6-13(16(21)22)23-14(10)12(7-11)15(20)19-8-9-1-3-18-4-2-9/h5-7,9,18H,1-4,8H2,(H,19,20)(H,21,22)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345256(5-bromo-7-(2-oxo-2-(piperazin-1-yl)ethoxy)benzofur...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCC(=O)N3CCNCC3)c2o1
Show InChI InChI=1S/C15H15BrN2O5/c16-10-5-9-6-12(15(20)21)23-14(9)11(7-10)22-8-13(19)18-3-1-17-2-4-18/h5-7,17H,1-4,8H2,(H,20,21)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345240(5-(4-(4-aminobutylamino)pyrimidin-2-yl)benzofuran-...)
Show SMILES NCCCCNc1ccnc(n1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C17H18N4O3/c18-6-1-2-7-19-15-5-8-20-16(21-15)11-3-4-13-12(9-11)10-14(24-13)17(22)23/h3-5,8-10H,1-2,6-7,18H2,(H,22,23)(H,19,20,21)
Affinity DataIC50: 1.90E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345261(CHEMBL1782532 | cis-5-bromo-7-(4-hydroxycyclohexyl...)
Show SMILES O[C@H]1CC[C@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11+
Affinity DataIC50: 2.30E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345262(CHEMBL1782533 | trans-5-bromo-7-(4-hydroxycyclohex...)
Show SMILES O[C@H]1CC[C@@H](CC1)Nc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C15H16BrNO4/c16-9-5-8-6-13(15(19)20)21-14(8)12(7-9)17-10-1-3-11(18)4-2-10/h5-7,10-11,17-18H,1-4H2,(H,19,20)/t10-,11-
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345258(5-bromo-7-(piperidin-4-ylmethylcarbamoyl)benzofura...)
Show SMILES OC(=O)c1cc2cc(Br)cc(C(=O)NCC3CCNCC3)c2o1
Show InChI InChI=1S/C16H17BrN2O4/c17-11-5-10-6-13(16(21)22)23-14(10)12(7-11)15(20)19-8-9-1-3-18-4-2-9/h5-7,9,18H,1-4,8H2,(H,19,20)(H,21,22)
Affinity DataIC50: 2.70E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345237(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)
Show SMILES Cn1cc(cn1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17)
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345252(5-bromo-7-(2-(pyridin-4-yl)ethoxy)benzofuran-2-car...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCCc3ccncc3)c2o1
Show InChI InChI=1S/C16H12BrNO4/c17-12-7-11-8-14(16(19)20)22-15(11)13(9-12)21-6-3-10-1-4-18-5-2-10/h1-2,4-5,7-9H,3,6H2,(H,19,20)
Affinity DataIC50: 4.50E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345248(5-bromo-7-(pyridin-4-ylmethoxy)benzofuran-2-carbox...)
Show SMILES OC(=O)c1cc2cc(Br)cc(OCc3ccncc3)c2o1
Show InChI InChI=1S/C15H10BrNO4/c16-11-5-10-6-13(15(18)19)21-14(10)12(7-11)20-8-9-1-3-17-4-2-9/h1-7H,8H2,(H,18,19)
Affinity DataIC50: 4.90E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345233(5-(trifluoromethyl)benzofuran-2-carboxylic acid | ...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)C(F)(F)F
Show InChI InChI=1S/C10H5F3O3/c11-10(12,13)6-1-2-7-5(3-6)4-8(16-7)9(14)15/h1-4H,(H,14,15)
Affinity DataIC50: 5.30E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345237(5-(1-methyl-1H-pyrazol-4-yl)benzofuran-2-carboxyli...)
Show SMILES Cn1cc(cn1)-c1ccc2oc(cc2c1)C(O)=O
Show InChI InChI=1S/C13H10N2O3/c1-15-7-10(6-14-15)8-2-3-11-9(4-8)5-12(18-11)13(16)17/h2-7H,1H3,(H,16,17)
Affinity DataIC50: 5.40E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-2(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345239(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human Pim2 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 90 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345232(5-bromo-7-methoxy-1-benzofuran-2-carboxylic acid |...)
Show SMILES COc1cc(Br)cc2cc(oc12)C(O)=O
Show InChI InChI=1S/C10H7BrO4/c1-14-7-4-6(11)2-5-3-8(10(12)13)15-9(5)7/h2-4H,1H3,(H,12,13)
Affinity DataIC50: 5.80E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345239(5-(1-(piperidin-4-yl)-1H-pyrazol-4-yl)benzofuran-2...)
Show SMILES OC(=O)c1cc2cc(ccc2o1)-c1cnn(c1)C1CCNCC1
Show InChI InChI=1S/C17H17N3O3/c21-17(22)16-8-12-7-11(1-2-15(12)23-16)13-9-19-20(10-13)14-3-5-18-6-4-14/h1-2,7-10,14,18H,3-6H2,(H,21,22)
Affinity DataIC50: 6.00E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase pim-1(Homo sapiens (Human))
Genzyme Corp.

Curated by ChEMBL
LigandPNGBDBM50345234(5-(trifluoromethoxy)benzofuran-2-carboxylic acid |...)
Show SMILES OC(=O)c1cc2cc(OC(F)(F)F)ccc2o1
Show InChI InChI=1S/C10H5F3O4/c11-10(12,13)17-6-1-2-7-5(3-6)4-8(16-7)9(14)15/h1-4H,(H,14,15)
Affinity DataIC50: 6.10E+3nMAssay Description:Inhibition of human Pim1 using 5-FAM-RSRHSSYPAGT-CONH2 as substrate after 45 mins by off-chip mobility shift methodMore data for this Ligand-Target Pair
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