Compile Data Set for Download or QSAR
Found 28 Enz. Inhib. hit(s) with all data for entry = 50034758
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50005229(2-{[Acetyl-(5-octadecyloxy-tetrahydro-furan-3-ylme...)
Show SMILES CCCCCCCCCCCCCCCCCCOC1CC(COC(=O)N(Cc2cccc[n+]2CC)C(C)=O)CO1
Show InChI InChI=1S/C34H59N2O5/c1-4-6-7-8-9-10-11-12-13-14-15-16-17-18-19-22-25-39-33-26-31(28-40-33)29-41-34(38)36(30(3)37)27-32-23-20-21-24-35(32)5-2/h20-21,23-24,31,33H,4-19,22,25-29H2,1-3H3/q+1
Affinity DataIC50: 12nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM81972((S)-(+)-ALPHA-METHYL-1H-IMIDAZOLE-4-ETHANAMINE DIH...)
Show SMILES C[C@H](N)Cc1cnc[nH]1
Show InChI InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m0/s1
Affinity DataIC50: 13nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50041921(5-{4-[2-(3,4,5-Trimethoxy-phenyl)-ethyl]-phenyl}-2...)
Show SMILES COc1cc(CCc2ccc(cc2)C2=Cc3ccccc3C3=NCCN23)cc(OC)c1OC
Show InChI InChI=1S/C28H28N2O3/c1-31-25-16-20(17-26(32-2)27(25)33-3)9-8-19-10-12-21(13-11-19)24-18-22-6-4-5-7-23(22)28-29-14-15-30(24)28/h4-7,10-13,16-18H,8-9,14-15H2,1-3H3
Affinity DataIC50: 40nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282029((cis)-3-{3-[5-(3,4,5-Trimethoxy-phenyl)-tetrahydro...)
Show SMILES COc1cc(cc(OC)c1OC)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C21H27NO5/c1-23-18-12-16(13-19(24-2)21(18)25-3)17-8-9-20(27-17)26-11-5-7-15-6-4-10-22-14-15/h4,6,10,12-14,17,20H,5,7-9,11H2,1-3H3/t17-,20+/m1/s1
Affinity DataIC50: 100nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282027(3-{3-[(2S,5R)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)
Show SMILES COc1ccc(cc1OC)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C20H25NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3,5,7-8,11,13-14,17,20H,4,6,9-10,12H2,1-2H3/t17-,20+/m1/s1
Affinity DataIC50: 150nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282024((cis)-3-{3-[5-(3,4-Dichloro-phenyl)-tetrahydro-fur...)
Show SMILES Clc1ccc(cc1Cl)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H19Cl2NO2/c19-15-6-5-14(11-16(15)20)17-7-8-18(23-17)22-10-2-4-13-3-1-9-21-12-13/h1,3,5-6,9,11-12,17-18H,2,4,7-8,10H2/t17-,18+/m1/s1
Affinity DataIC50: 200nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282020((cis)-3-{3-[5-(4-Fluoro-phenyl)-tetrahydro-furan-2...)
Show SMILES Fc1ccc(cc1)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20FNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18+/m1/s1
Affinity DataIC50: 230nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282007(3-{3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCCCc2cccnc2)O1
Show InChI InChI=1S/C20H25NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3,5,7-8,11,13-14,17,20H,4,6,9-10,12H2,1-2H3
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282014(3-{(E)-3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-fura...)
Show SMILES COc1ccc(cc1OC)C1CCC(OC\C=C\c2cccnc2)O1
Show InChI InChI=1S/C20H23NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3-8,11,13-14,17,20H,9-10,12H2,1-2H3/b6-4+
Affinity DataIC50: 300nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282028((cis)-3-{3-[5-(4-Bromo-phenyl)-tetrahydro-furan-2-...)
Show SMILES Brc1ccc(cc1)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20BrNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18+/m1/s1
Affinity DataIC50: 800nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282015((cis)-3-{3-[5-(4-Chloro-phenyl)-tetrahydro-furan-2...)
Show SMILES Clc1ccc(cc1)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20ClNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18+/m1/s1
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282031(3-{3-[(2S,5R)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)
Show SMILES COc1ccc(cc1OC)[C@H]1CC[C@@H](OCCCc2ccc[n+](C)c2)O1
Show InChI InChI=1S/C21H28NO4/c1-22-12-4-6-16(15-22)7-5-13-25-21-11-10-18(26-21)17-8-9-19(23-2)20(14-17)24-3/h4,6,8-9,12,14-15,18,21H,5,7,10-11,13H2,1-3H3/q+1/t18-,21+/m1/s1
Affinity DataIC50: 1.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282010((trans)-3-{3-[5-(3,4,5-Trimethoxy-phenyl)-tetrahyd...)
Show SMILES COc1cc(cc(OC)c1OC)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C21H27NO5/c1-23-18-12-16(13-19(24-2)21(18)25-3)17-8-9-20(27-17)26-11-5-7-15-6-4-10-22-14-15/h4,6,10,12-14,17,20H,5,7-9,11H2,1-3H3/t17-,20-/m0/s1
Affinity DataIC50: 1.50E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282021(1-[6-(5-Hexyl-tetrahydro-furan-2-yloxy)-hexyl]-pyr...)
Show SMILES CCCCCCC1CCC(OCCCCCC[n+]2ccccc2)O1
Show InChI InChI=1S/C21H36NO2/c1-2-3-4-8-13-20-14-15-21(24-20)23-19-12-6-5-9-16-22-17-10-7-11-18-22/h7,10-11,17-18,20-21H,2-6,8-9,12-16,19H2,1H3/q+1
Affinity DataIC50: 1.60E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282019((cis)-3-{3-[5-(4-Methoxy-phenyl)-tetrahydro-furan-...)
Show SMILES COc1ccc(cc1)[C@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C19H23NO3/c1-21-17-8-6-16(7-9-17)18-10-11-19(23-18)22-13-3-5-15-4-2-12-20-14-15/h2,4,6-9,12,14,18-19H,3,5,10-11,13H2,1H3/t18-,19+/m1/s1
Affinity DataIC50: 2.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282018((trans)-3-{3-[5-(3,4-Dichloro-phenyl)-tetrahydro-f...)
Show SMILES Clc1ccc(cc1Cl)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H19Cl2NO2/c19-15-6-5-14(11-16(15)20)17-7-8-18(23-17)22-10-2-4-13-3-1-9-21-12-13/h1,3,5-6,9,11-12,17-18H,2,4,7-8,10H2/t17-,18-/m0/s1
Affinity DataIC50: 2.50E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282023(3-{3-[(2S,5S)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)
Show SMILES COc1ccc(cc1OC)[C@@H]1CC[C@@H](OCCCc2ccc[n+](C)c2)O1
Show InChI InChI=1S/C21H28NO4/c1-22-12-4-6-16(15-22)7-5-13-25-21-11-10-18(26-21)17-8-9-19(23-2)20(14-17)24-3/h4,6,8-9,12,14-15,18,21H,5,7,10-11,13H2,1-3H3/q+1/t18-,21-/m0/s1
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282009(3-{5-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCCCCCc2cccnc2)O1
Show InChI InChI=1S/C22H29NO4/c1-24-20-10-9-18(15-21(20)25-2)19-11-12-22(27-19)26-14-5-3-4-7-17-8-6-13-23-16-17/h6,8-10,13,15-16,19,22H,3-5,7,11-12,14H2,1-2H3
Affinity DataIC50: 3.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282017((trans)-3-{3-[5-(4-Fluoro-phenyl)-tetrahydro-furan...)
Show SMILES Fc1ccc(cc1)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20FNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18-/m0/s1
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282026(3-{3-[(2S,5S)-5-(3,4-Dimethoxy-phenyl)-tetrahydro-...)
Show SMILES COc1ccc(cc1OC)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C20H25NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3,5,7-8,11,13-14,17,20H,4,6,9-10,12H2,1-2H3/t17-,20-/m0/s1
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282025((trans)-3-{3-[5-(4-Bromo-phenyl)-tetrahydro-furan-...)
Show SMILES Brc1ccc(cc1)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20BrNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18-/m0/s1
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282022((trans)-3-{3-[5-(4-Methoxy-phenyl)-tetrahydro-fura...)
Show SMILES COc1ccc(cc1)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C19H23NO3/c1-21-17-8-6-16(7-9-17)18-10-11-19(23-18)22-13-3-5-15-4-2-12-20-14-15/h2,4,6-9,12,14,18-19H,3,5,10-11,13H2,1H3/t18-,19-/m0/s1
Affinity DataIC50: 4.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282013((trans)-3-{3-[5-(4-Chloro-phenyl)-tetrahydro-furan...)
Show SMILES Clc1ccc(cc1)[C@@H]1CC[C@@H](OCCCc2cccnc2)O1
Show InChI InChI=1S/C18H20ClNO2/c19-16-7-5-15(6-8-16)17-9-10-18(22-17)21-12-2-4-14-3-1-11-20-13-14/h1,3,5-8,11,13,17-18H,2,4,9-10,12H2/t17-,18-/m0/s1
Affinity DataIC50: 5.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282030((trans)-3-[3-(5-Phenyl-tetrahydro-furan-2-yloxy)-p...)
Show SMILES C(COC1CCC(O1)c1ccccc1)Cc1cccnc1
Show InChI InChI=1S/C18H21NO2/c1-2-8-16(9-3-1)17-10-11-18(21-17)20-13-5-7-15-6-4-12-19-14-15/h1-4,6,8-9,12,14,17-18H,5,7,10-11,13H2
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282012(3-{4-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCCCCc2cccnc2)O1
Show InChI InChI=1S/C21H27NO4/c1-23-19-9-8-17(14-20(19)24-2)18-10-11-21(26-18)25-13-4-3-6-16-7-5-12-22-15-16/h5,7-9,12,14-15,18,21H,3-4,6,10-11,13H2,1-2H3
Affinity DataIC50: 6.00E+3nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282008(3-{2-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCCc2cccnc2)O1
Show InChI InChI=1S/C19H23NO4/c1-21-17-6-5-15(12-18(17)22-2)16-7-8-19(24-16)23-11-9-14-4-3-10-20-13-14/h3-6,10,12-13,16,19H,7-9,11H2,1-2H3
Affinity DataIC50: 1.50E+4nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282011(3-{3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCC#Cc2cccnc2)O1
Show InChI InChI=1S/C20H21NO4/c1-22-18-8-7-16(13-19(18)23-2)17-9-10-20(25-17)24-12-4-6-15-5-3-11-21-14-15/h3,5,7-8,11,13-14,17,20H,9-10,12H2,1-2H3
Affinity DataIC50: 1.80E+4nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair
TargetPlatelet-activating factor receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50282016(3-[5-(3,4-Dimethoxy-phenyl)-tetrahydro-furan-2-ylo...)
Show SMILES COc1ccc(cc1OC)C1CCC(OCc2cccnc2)O1
Show InChI InChI=1S/C18H21NO4/c1-20-16-6-5-14(10-17(16)21-2)15-7-8-18(23-15)22-12-13-4-3-9-19-11-13/h3-6,9-11,15,18H,7-8,12H2,1-2H3
Affinity DataIC50: 2.50E+4nMAssay Description:In vitro inhibition of [3H]PAF receptor binding to washed human platelet membranesMore data for this Ligand-Target Pair