Compile Data Set for Download or QSAR
Found 39 Enz. Inhib. hit(s) with all data for entry = 50038026
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212534(1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
Show SMILES COc1cccc(c1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O4S/c1-19-13-7-5-6-12(10-13)15(16)11-20(17,18)14-8-3-2-4-9-14/h2-10H,11H2,1H3
Affinity DataIC50: 60nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212535(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
Show SMILES COc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O4S/c1-19-13-9-7-12(8-10-13)15(16)11-20(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3
Affinity DataIC50: 75nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212525(1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
Show SMILES Fc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H11FO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 90nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212532(1-(3,4-dichlorophenyl)-2-(phenylsulfonyl)ethanone ...)
Show SMILES Clc1ccc(cc1Cl)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H10Cl2O3S/c15-12-7-6-10(8-13(12)16)14(17)9-20(18,19)11-4-2-1-3-5-11/h1-8H,9H2
Affinity DataIC50: 101nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212530(2-(phenylsulfonyl)-1-p-tolylethanone | CHEMBL39280...)
Show SMILES Cc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O3S/c1-12-7-9-13(10-8-12)15(16)11-19(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3
Affinity DataIC50: 102nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212529(2-(phenylsulfonyl)-1-(5-phenylthiophen-2-yl)ethano...)
Show SMILES O=C(CS(=O)(=O)c1ccccc1)c1ccc(s1)-c1ccccc1
Show InChI InChI=1S/C18H14O3S2/c19-16(13-23(20,21)15-9-5-2-6-10-15)18-12-11-17(22-18)14-7-3-1-4-8-14/h1-12H,13H2
Affinity DataIC50: 134nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212543(1-(5-(2,4-dichlorophenyl)furan-2-yl)-2-(phenylsulf...)
Show SMILES Clc1ccc(-c2ccc(o2)C(=O)CS(=O)(=O)c2ccccc2)c(Cl)c1
Show InChI InChI=1S/C18H12Cl2O4S/c19-12-6-7-14(15(20)10-12)17-8-9-18(24-17)16(21)11-25(22,23)13-4-2-1-3-5-13/h1-10H,11H2
Affinity DataIC50: 169nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50167718(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H11F3O3S/c16-15(17,18)12-8-6-11(7-9-12)14(19)10-22(20,21)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 187nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212531(1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
Show SMILES Clc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H11ClO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 200nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212533(2-(phenylsulfonyl)-1-(thiophen-3-yl)ethanone | CHE...)
Show SMILES O=C(CS(=O)(=O)c1ccccc1)c1ccsc1
Show InChI InChI=1S/C12H10O3S2/c13-12(10-6-7-16-8-10)9-17(14,15)11-4-2-1-3-5-11/h1-8H,9H2
Affinity DataIC50: 345nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212548(1-(3-methylbenzo[b]thiophen-2-yl)-2-(phenylsulfony...)
Show SMILES Cc1c(sc2ccccc12)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C17H14O3S2/c1-12-14-9-5-6-10-16(14)21-17(12)15(18)11-22(19,20)13-7-3-2-4-8-13/h2-10H,11H2,1H3
Affinity DataIC50: 525nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212547(1-(3,5-dimethylphenyl)-2-(phenylsulfonyl)ethanone ...)
Show SMILES Cc1ccc(C(=O)CS(=O)(=O)c2ccccc2)c(C)c1
Show InChI InChI=1S/C16H16O3S/c1-12-8-9-15(13(2)10-12)16(17)11-20(18,19)14-6-4-3-5-7-14/h3-10H,11H2,1-2H3
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212551(1-(4-nitrophenyl)-2-(phenylsulfonyl)ethanone | CHE...)
Show SMILES [O-][N+](=O)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H11NO5S/c16-14(11-6-8-12(9-7-11)15(17)18)10-21(19,20)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 1.31E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
Show SMILES CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1
Show InChI InChI=1S/C16H20ClN3O3S2/c1-4-20(5-2)15(21)9-12-10-24-16(18-12)19-25(22,23)14-8-6-7-13(17)11(14)3/h6-8,10H,4-5,9H2,1-3H3,(H,18,19)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212538(1,1-diphenyl-3-(phenylsulfonyl)propan-2-one | CHEM...)
Show SMILES O=C(CS(=O)(=O)c1ccccc1)C(c1ccccc1)c1ccccc1
Show InChI InChI=1S/C21H18O3S/c22-20(16-25(23,24)19-14-8-3-9-15-19)21(17-10-4-1-5-11-17)18-12-6-2-7-13-18/h1-15,21H,16H2
Affinity DataIC50: 2.90E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212544(1-(4-(diethylamino)phenyl)-2-(phenylsulfonyl)ethan...)
Show SMILES CCN(CC)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C18H21NO3S/c1-3-19(4-2)16-12-10-15(11-13-16)18(20)14-23(21,22)17-8-6-5-7-9-17/h5-13H,3-4,14H2,1-2H3
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212522(CHEMBL393285 | ethyl 3,3-dimethyl-4-oxo-5-(phenyls...)
Show SMILES CCOC(=O)CC(C)(C)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H20O5S/c1-4-20-14(17)10-15(2,3)13(16)11-21(18,19)12-8-6-5-7-9-12/h5-9H,4,10-11H2,1-3H3
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212524(CHEMBL241160 | N-benzyl-N-(phenylsulfonyl)benzamid...)
Show SMILES O=C(N(Cc1ccccc1)S(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C20H17NO3S/c22-20(18-12-6-2-7-13-18)21(16-17-10-4-1-5-11-17)25(23,24)19-14-8-3-9-15-19/h1-15H,16H2
Affinity DataIC50: 5.70E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212526(1-(2,5-dimethoxyphenyl)-2-(phenylsulfonyl)ethanone...)
Show SMILES COc1ccc(OC)c(c1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C16H16O5S/c1-20-12-8-9-16(21-2)14(10-12)15(17)11-22(18,19)13-6-4-3-5-7-13/h3-10H,11H2,1-2H3
Affinity DataIC50: 9.30E+3nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212545(1-(phenylsulfonyl)butan-2-one | CHEMBL240761)
Show SMILES CCC(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C10H12O3S/c1-2-9(11)8-14(12,13)10-6-4-3-5-7-10/h3-7H,2,8H2,1H3
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212536(1-phenyl-3-(phenylsulfonyl)propan-1-one | CHEMBL24...)
Show SMILES O=C(CCS(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C15H14O3S/c16-15(13-7-3-1-4-8-13)11-12-19(17,18)14-9-5-2-6-10-14/h1-10H,11-12H2
Affinity DataIC50: 1.74E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212549(1-(4-fluorophenyl)-3-(phenylsulfonyl)propan-1-one ...)
Show SMILES Fc1ccc(cc1)C(=O)CCS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H13FO3S/c16-13-8-6-12(7-9-13)15(17)10-11-20(18,19)14-4-2-1-3-5-14/h1-9H,10-11H2
Affinity DataIC50: 1.96E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212550(1-(4-chlorophenyl)-3-(phenylsulfonyl)propan-1-one ...)
Show SMILES Clc1ccc(cc1)C(=O)CCS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H13ClO3S/c16-13-8-6-12(7-9-13)15(17)10-11-20(18,19)14-4-2-1-3-5-14/h1-9H,10-11H2
Affinity DataIC50: 2.40E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212527(1-(4-bromophenyl)-3-(phenylsulfonyl)propan-1-one |...)
Show SMILES Brc1ccc(cc1)C(=O)CCS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H13BrO3S/c16-13-8-6-12(7-9-13)15(17)10-11-20(18,19)14-4-2-1-3-5-14/h1-9H,10-11H2
Affinity DataIC50: 2.50E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212540(CHEMBL392809 | N-methyl-N-(phenylsulfonyl)benzamid...)
Show SMILES CN(C(=O)c1ccccc1)S(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H13NO3S/c1-15(14(16)12-8-4-2-5-9-12)19(17,18)13-10-6-3-7-11-13/h2-11H,1H3
Affinity DataIC50: 3.55E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212523(3,3-dimethyl-1-(phenylsulfonyl)butan-2-one | CHEMB...)
Show SMILES CC(C)(C)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C12H16O3S/c1-12(2,3)11(13)9-16(14,15)10-7-5-4-6-8-10/h4-8H,9H2,1-3H3
Affinity DataIC50: 9.00E+4nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212528(CHEMBL241150 | N-[(4-methylphenyl)sulfonyl]benzami...)
Show SMILES Cc1ccc(cc1)S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C14H13NO3S/c1-11-7-9-13(10-8-11)19(17,18)15-14(16)12-5-3-2-4-6-12/h2-10H,1H3,(H,15,16)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212546(CHEMBL391616 | N-(phenylsulfonyl)-4-(trifluorometh...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H10F3NO3S/c15-14(16,17)11-8-6-10(7-9-11)13(19)18-22(20,21)12-4-2-1-3-5-12/h1-9H,(H,18,19)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212539(CHEMBL241149 | N-(phenylsulfonyl)benzamide)
Show SMILES O=C(NS(=O)(=O)c1ccccc1)c1ccccc1
Show InChI InChI=1S/C13H11NO3S/c15-13(11-7-3-1-4-8-11)14-18(16,17)12-9-5-2-6-10-12/h1-10H,(H,14,15)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212537(3-chloro-N-(phenylsulfonyl)benzamide | CHEMBL39197...)
Show SMILES Clc1cccc(c1)C(=O)NS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C13H10ClNO3S/c14-11-6-4-5-10(9-11)13(16)15-19(17,18)12-7-2-1-3-8-12/h1-9H,(H,15,16)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212542(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)
Show SMILES OC(CS(=O)(=O)c1ccccc1)c1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C15H13F3O3S/c16-15(17,18)12-8-6-11(7-9-12)14(19)10-22(20,21)13-4-2-1-3-5-13/h1-9,14,19H,10H2
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50154511(CHEMBL189770 | N-(4-chlorophenylsulfonyl)benzamide...)
Show SMILES Clc1ccc(cc1)S(=O)(=O)NC(=O)c1ccccc1
Show InChI InChI=1S/C13H10ClNO3S/c14-11-6-8-12(9-7-11)19(17,18)15-13(16)10-4-2-1-3-5-10/h1-9H,(H,15,16)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human 11beta-HSD1 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50167718(2-(phenylsulfonyl)-1-(4-(trifluoromethyl)phenyl)et...)
Show SMILES FC(F)(F)c1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H11F3O3S/c16-15(17,18)12-8-6-11(7-9-12)14(19)10-22(20,21)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212535(1-(4-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
Show SMILES COc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O4S/c1-19-13-9-7-12(8-10-13)15(16)11-20(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212525(1-(4-fluorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
Show SMILES Fc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H11FO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212530(2-(phenylsulfonyl)-1-p-tolylethanone | CHEMBL39280...)
Show SMILES Cc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O3S/c1-12-7-9-13(10-8-12)15(16)11-19(17,18)14-5-3-2-4-6-14/h2-10H,11H2,1H3
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212531(1-(4-chlorophenyl)-2-(phenylsulfonyl)ethanone | CH...)
Show SMILES Clc1ccc(cc1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C14H11ClO3S/c15-12-8-6-11(7-9-12)14(16)10-19(17,18)13-4-2-1-3-5-13/h1-9H,10H2
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50117901(2-(2-(3-chloro-2-methylphenylsulfonamido)thiazol-4...)
Show SMILES CCN(CC)C(=O)Cc1csc(NS(=O)(=O)c2cccc(Cl)c2C)n1
Show InChI InChI=1S/C16H20ClN3O3S2/c1-4-20(5-2)15(21)9-12-10-24-16(18-12)19-25(22,23)14-8-6-7-13(17)11(14)3/h6-8,10H,4-5,9H2,1-3H3,(H,18,19)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase type 2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50212534(1-(3-methoxyphenyl)-2-(phenylsulfonyl)ethanone | C...)
Show SMILES COc1cccc(c1)C(=O)CS(=O)(=O)c1ccccc1
Show InChI InChI=1S/C15H14O4S/c1-19-13-7-5-6-12(10-13)15(16)11-20(17,18)14-8-3-2-4-9-14/h2-10H,11H2,1H3
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of human 11beta-HSD2 expressed in CHO cellsMore data for this Ligand-Target Pair