Compile Data Set for Download or QSAR
Found 51 Enz. Inhib. hit(s) with all data for entry = 50040466
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29)
Affinity DataIC50: 1.40nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C24H24ClN3O2/c25-20-9-11-22(12-10-20)30-23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29)
Affinity DataIC50: 6nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394627(CHEMBL2164598 | US9169224, 62)
Show SMILES Cc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O2/c1-20-10-12-23(13-11-20)30-24-9-5-6-21(18-24)19-27-14-16-28(17-15-27)25(29)26-22-7-3-2-4-8-22/h2-13,18H,14-17,19H2,1H3,(H,26,29)
Affinity DataIC50: 11nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394623(CHEMBL2164603)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccn3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-7-9-20(10-8-19)30-21-5-3-4-18(16-21)17-27-12-14-28(15-13-27)23(29)26-22-6-1-2-11-25-22/h1-11,16H,12-15,17H2,(H,25,26,29)
Affinity DataIC50: 12nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394626(CHEMBL2164599 | US9169224, 65)
Show SMILES COc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O3/c1-30-22-10-12-23(13-11-22)31-24-9-5-6-20(18-24)19-27-14-16-28(17-15-27)25(29)26-21-7-3-2-4-8-21/h2-13,18H,14-17,19H2,1H3,(H,26,29)
Affinity DataIC50: 12nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394624(CHEMBL2164601)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccncc3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-4-6-21(7-5-19)30-22-3-1-2-18(16-22)17-27-12-14-28(15-13-27)23(29)26-20-8-10-25-11-9-20/h1-11,16H,12-15,17H2,(H,25,26,29)
Affinity DataIC50: 15nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29)
Affinity DataIC50: 33nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394622(CHEMBL2164604)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccncn3)c2)cc1
Show InChI InChI=1S/C22H22ClN5O2/c23-18-4-6-19(7-5-18)30-20-3-1-2-17(14-20)15-27-10-12-28(13-11-27)22(29)26-21-8-9-24-16-25-21/h1-9,14,16H,10-13,15H2,(H,24,25,26,29)
Affinity DataIC50: 41nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394625(CHEMBL2164600 | US9169224, 63)
Show SMILES CC(C)(C)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C28H33N3O2/c1-28(2,3)23-12-14-25(15-13-23)33-26-11-7-8-22(20-26)21-30-16-18-31(19-17-30)27(32)29-24-9-5-4-6-10-24/h4-15,20H,16-19,21H2,1-3H3,(H,29,32)
Affinity DataIC50: 46nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394634(CHEMBL2164591)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C19H20F3N3O/c20-19(21,22)16-8-6-15(7-9-16)14-24-10-12-25(13-11-24)18(26)23-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,23,26)
Affinity DataIC50: 50nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394628(CHEMBL2164597)
Show SMILES Clc1ccc(Oc2ccc(CN3CCN(CC3)C(=O)Nc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H24ClN3O2/c25-20-8-12-23(13-9-20)30-22-10-6-19(7-11-22)18-27-14-16-28(17-15-27)24(29)26-21-4-2-1-3-5-21/h1-13H,14-18H2,(H,26,29)
Affinity DataIC50: 62nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394631(CHEMBL2164594 | US9169224, 28)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Show InChI InChI=1S/C24H25N3O2/c28-24(25-21-9-3-1-4-10-21)27-16-14-26(15-17-27)19-20-8-7-13-23(18-20)29-22-11-5-2-6-12-22/h1-13,18H,14-17,19H2,(H,25,28)
Affinity DataIC50: 74nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394625(CHEMBL2164600 | US9169224, 63)
Show SMILES CC(C)(C)c1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C28H33N3O2/c1-28(2,3)23-12-14-25(15-13-23)33-26-11-7-8-22(20-26)21-30-16-18-31(19-17-30)27(32)29-24-9-5-4-6-10-24/h4-15,20H,16-19,21H2,1-3H3,(H,29,32)
Affinity DataIC50: 75nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394621(CHEMBL2164605 | US9169224, 26)
Show SMILES COc1cc(Br)cc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1O
Show InChI InChI=1S/C19H22BrN3O3/c1-26-17-12-15(20)11-14(18(17)24)13-22-7-9-23(10-8-22)19(25)21-16-5-3-2-4-6-16/h2-6,11-12,24H,7-10,13H2,1H3,(H,21,25)
Affinity DataIC50: 120nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394640(CHEMBL1895507)
Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 128nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394626(CHEMBL2164599 | US9169224, 65)
Show SMILES COc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O3/c1-30-22-10-12-23(13-11-22)31-24-9-5-6-20(18-24)19-27-14-16-28(17-15-27)25(29)26-21-7-3-2-4-8-21/h2-13,18H,14-17,19H2,1H3,(H,26,29)
Affinity DataIC50: 133nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394621(CHEMBL2164605 | US9169224, 26)
Show SMILES COc1cc(Br)cc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1O
Show InChI InChI=1S/C19H22BrN3O3/c1-26-17-12-15(20)11-14(18(17)24)13-22-7-9-23(10-8-22)19(25)21-16-5-3-2-4-6-16/h2-6,11-12,24H,7-10,13H2,1H3,(H,21,25)
Affinity DataIC50: 243nMAssay Description:Inhibition of rat FAAHMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394634(CHEMBL2164591)
Show SMILES FC(F)(F)c1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C19H20F3N3O/c20-19(21,22)16-8-6-15(7-9-16)14-24-10-12-25(13-11-24)18(26)23-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,23,26)
Affinity DataIC50: 260nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394629(CHEMBL2164596 | US9169224, 60)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C24H24ClN3O2/c25-20-9-11-22(12-10-20)30-23-8-4-5-19(17-23)18-27-13-15-28(16-14-27)24(29)26-21-6-2-1-3-7-21/h1-12,17H,13-16,18H2,(H,26,29)
Affinity DataIC50: 300nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394635(CHEMBL2164590)
Show SMILES FC(F)(F)c1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H20F3N3O/c20-19(21,22)16-6-4-5-15(13-16)14-24-9-11-25(12-10-24)18(26)23-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,23,26)
Affinity DataIC50: 350nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394623(CHEMBL2164603)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccn3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-7-9-20(10-8-19)30-21-5-3-4-18(16-21)17-27-12-14-28(15-13-27)23(29)26-22-6-1-2-11-25-22/h1-11,16H,12-15,17H2,(H,25,26,29)
Affinity DataIC50: 470nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394632(CHEMBL2164593 | US9169224, 36)
Show SMILES COc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C19H23N3O2/c1-24-18-9-7-16(8-10-18)15-21-11-13-22(14-12-21)19(23)20-17-5-3-2-4-6-17/h2-10H,11-15H2,1H3,(H,20,23)
Affinity DataIC50: 490nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394624(CHEMBL2164601)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccncc3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-4-6-21(7-5-19)30-22-3-1-2-18(16-22)17-27-12-14-28(15-13-27)23(29)26-20-8-10-25-11-9-20/h1-11,16H,12-15,17H2,(H,25,26,29)
Affinity DataIC50: 520nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394627(CHEMBL2164598 | US9169224, 62)
Show SMILES Cc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccccc3)c2)cc1
Show InChI InChI=1S/C25H27N3O2/c1-20-10-12-23(13-11-20)30-24-9-5-6-21(18-24)19-27-14-16-28(17-15-27)25(29)26-22-7-3-2-4-8-22/h2-13,18H,14-17,19H2,1H3,(H,26,29)
Affinity DataIC50: 640nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394635(CHEMBL2164590)
Show SMILES FC(F)(F)c1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H20F3N3O/c20-19(21,22)16-6-4-5-15(13-16)14-24-9-11-25(12-10-24)18(26)23-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,23,26)
Affinity DataIC50: 830nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394641(CHEMBL2164585)
Show SMILES Clc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C18H20ClN3O/c19-16-6-4-5-15(13-16)14-21-9-11-22(12-10-21)18(23)20-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,20,23)
Affinity DataIC50: 840nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394622(CHEMBL2164604)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3ccncn3)c2)cc1
Show InChI InChI=1S/C22H22ClN5O2/c23-18-4-6-19(7-5-18)30-20-3-1-2-17(14-20)15-27-10-12-28(13-11-27)22(29)26-21-8-9-24-16-25-21/h1-9,14,16H,10-13,15H2,(H,24,25,26,29)
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394633(CHEMBL2164592 | US9169224, 39)
Show SMILES COc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H23N3O2/c1-24-18-9-5-6-16(14-18)15-21-10-12-22(13-11-21)19(23)20-17-7-3-2-4-8-17/h2-9,14H,10-13,15H2,1H3,(H,20,23)
Affinity DataIC50: 1.53E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394639(CHEMBL2164586)
Show SMILES Fc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C18H20FN3O/c19-16-6-4-5-15(13-16)14-21-9-11-22(12-10-21)18(23)20-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,20,23)
Affinity DataIC50: 2.47E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394640(CHEMBL1895507)
Show SMILES Clc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20ClN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 2.67E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394638(CHEMBL2164587)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20FN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 2.77E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394630(CHEMBL2164595 | US9169224, 74)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C24H25N3O2/c28-24(25-21-7-3-1-4-8-21)27-17-15-26(16-18-27)19-20-11-13-23(14-12-20)29-22-9-5-2-6-10-22/h1-14H,15-19H2,(H,25,28)
Affinity DataIC50: 2.83E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394628(CHEMBL2164597)
Show SMILES Clc1ccc(Oc2ccc(CN3CCN(CC3)C(=O)Nc3ccccc3)cc2)cc1
Show InChI InChI=1S/C24H24ClN3O2/c25-20-8-12-23(13-9-20)30-22-10-6-19(7-11-22)18-27-14-16-28(17-15-27)24(29)26-21-4-2-1-3-5-21/h1-13H,14-18H2,(H,26,29)
Affinity DataIC50: 4.00E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394636(CHEMBL2164589)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C19H20N4O/c20-14-16-6-8-17(9-7-16)15-22-10-12-23(13-11-22)19(24)21-18-4-2-1-3-5-18/h1-9H,10-13,15H2,(H,21,24)
Affinity DataIC50: 4.67E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394642(CHEMBL2164606)
Show SMILES Clc1ccccc1CN1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H20ClN3O/c19-17-9-5-4-6-15(17)14-21-10-12-22(13-11-21)18(23)20-16-7-2-1-3-8-16/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 4.67E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394641(CHEMBL2164585)
Show SMILES Clc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C18H20ClN3O/c19-16-6-4-5-15(13-16)14-21-9-11-22(12-10-21)18(23)20-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,20,23)
Affinity DataIC50: 5.60E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394631(CHEMBL2164594 | US9169224, 28)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(Oc3ccccc3)c2)CC1
Show InChI InChI=1S/C24H25N3O2/c28-24(25-21-9-3-1-4-10-21)27-16-14-26(15-17-27)19-20-8-7-13-23(18-20)29-22-11-5-2-6-12-22/h1-13,18H,14-17,19H2,(H,25,28)
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394637(CHEMBL2164588)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C19H20N4O/c20-14-16-5-4-6-17(13-16)15-22-9-11-23(12-10-22)19(24)21-18-7-2-1-3-8-18/h1-8,13H,9-12,15H2,(H,21,24)
Affinity DataIC50: 6.67E+3nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394636(CHEMBL2164589)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc(cc2)C#N)CC1
Show InChI InChI=1S/C19H20N4O/c20-14-16-6-8-17(9-7-16)15-22-10-12-23(13-11-22)19(24)21-18-4-2-1-3-5-18/h1-9H,10-13,15H2,(H,21,24)
Affinity DataIC50: 7.67E+3nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394643(CHEMBL1619418 | US9169224, J)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C18H21N3O/c22-18(19-17-9-5-2-6-10-17)21-13-11-20(12-14-21)15-16-7-3-1-4-8-16/h1-10H,11-15H2,(H,19,22)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394643(CHEMBL1619418 | US9169224, J)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccccc2)CC1
Show InChI InChI=1S/C18H21N3O/c22-18(19-17-9-5-2-6-10-17)21-13-11-20(12-14-21)15-16-7-3-1-4-8-16/h1-10H,11-15H2,(H,19,22)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394642(CHEMBL2164606)
Show SMILES Clc1ccccc1CN1CCN(CC1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C18H20ClN3O/c19-17-9-5-4-6-15(17)14-21-10-12-22(13-11-21)18(23)20-16-7-2-1-3-8-16/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394639(CHEMBL2164586)
Show SMILES Fc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C18H20FN3O/c19-16-6-4-5-15(13-16)14-21-9-11-22(12-10-21)18(23)20-17-7-2-1-3-8-17/h1-8,13H,9-12,14H2,(H,20,23)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394638(CHEMBL2164587)
Show SMILES Fc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C18H20FN3O/c19-16-8-6-15(7-9-16)14-21-10-12-22(13-11-21)18(23)20-17-4-2-1-3-5-17/h1-9H,10-14H2,(H,20,23)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394637(CHEMBL2164588)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2cccc(c2)C#N)CC1
Show InChI InChI=1S/C19H20N4O/c20-14-16-5-4-6-17(13-16)15-22-9-11-23(12-10-22)19(24)21-18-7-2-1-3-8-18/h1-8,13H,9-12,15H2,(H,21,24)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394633(CHEMBL2164592 | US9169224, 39)
Show SMILES COc1cccc(CN2CCN(CC2)C(=O)Nc2ccccc2)c1
Show InChI InChI=1S/C19H23N3O2/c1-24-18-9-5-6-16(14-18)15-21-10-12-22(13-11-21)19(23)20-17-7-3-2-4-8-17/h2-9,14H,10-13,15H2,1H3,(H,20,23)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394632(CHEMBL2164593 | US9169224, 36)
Show SMILES COc1ccc(CN2CCN(CC2)C(=O)Nc2ccccc2)cc1
Show InChI InChI=1S/C19H23N3O2/c1-24-18-9-7-16(8-10-18)15-21-11-13-22(14-12-21)19(23)20-17-5-3-2-4-6-17/h2-10H,11-15H2,1H3,(H,20,23)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 2(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394620(CHEMBL2164602)
Show SMILES Clc1ccc(Oc2cccc(CN3CCN(CC3)C(=O)Nc3cccnc3)c2)cc1
Show InChI InChI=1S/C23H23ClN4O2/c24-19-6-8-21(9-7-19)30-22-5-1-3-18(15-22)17-27-11-13-28(14-12-27)23(29)26-20-4-2-10-25-16-20/h1-10,15-16H,11-14,17H2,(H,26,29)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of FAAH2More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50394630(CHEMBL2164595 | US9169224, 74)
Show SMILES O=C(Nc1ccccc1)N1CCN(Cc2ccc(Oc3ccccc3)cc2)CC1
Show InChI InChI=1S/C24H25N3O2/c28-24(25-21-7-3-1-4-8-21)27-17-15-26(16-18-27)19-20-11-13-23(14-12-20)29-22-9-5-2-6-10-22/h1-14H,15-19H2,(H,25,28)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat FAAH after 1 hrMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50394619(CHEMBL2164583)
Show SMILES Fc1ccc(NC(=O)NC(Cc2ccccc2)C(=O)N2CCC(Cc3ccccc3)CC2)c(F)c1
Show InChI InChI=1S/C28H29F2N3O2/c29-23-11-12-25(24(30)19-23)31-28(35)32-26(18-21-9-5-2-6-10-21)27(34)33-15-13-22(14-16-33)17-20-7-3-1-4-8-20/h1-12,19,22,26H,13-18H2,(H2,31,32,35)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of human FAAHMore data for this Ligand-Target Pair
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