Compile Data Set for Download or QSAR
Found 73 Enz. Inhib. hit(s) with all data for entry = 50042407
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425599(CHEMBL2314291)
Show SMILES CCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O3/c1-2-28-18-10-12-19(13-11-18)29-22-21(24)14-25-26(23(22)27)15-17-8-5-7-16-6-3-4-9-20(16)17/h3-14H,2,15H2,1H3
Affinity DataIC50: 100nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425598(CHEMBL1972527)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H17ClN2O3/c1-29-15-10-12-16(13-11-15)30-23-21(25)14-26-27(24(23)28)22-19-8-4-2-6-17(19)18-7-3-5-9-20(18)22/h2-14,22H,1H3
Affinity DataIC50: 120nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425597(CHEMBL2314320)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C22H17ClN2O3/c1-27-17-9-11-18(12-10-17)28-21-20(23)13-24-25(22(21)26)14-16-7-4-6-15-5-2-3-8-19(15)16/h2-13H,14H2,1H3
Affinity DataIC50: 140nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425596(CHEMBL1981304)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3-n3cccn3)c2=O)cc1
Show InChI InChI=1S/C21H17ClN4O3/c1-28-16-7-9-17(10-8-16)29-20-18(22)13-24-26(21(20)27)14-15-5-2-3-6-19(15)25-12-4-11-23-25/h2-13H,14H2,1H3
Affinity DataIC50: 220nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425595(CHEMBL2314323)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c(C)ccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O3/c1-15-7-8-16-5-3-4-6-19(16)20(15)14-26-23(27)22(21(24)13-25-26)29-18-11-9-17(28-2)10-12-18/h3-13H,14H2,1-2H3
Affinity DataIC50: 220nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425593(CHEMBL2314301)
Show SMILES CCc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C25H19ClN2O2/c1-2-16-11-13-17(14-12-16)30-24-22(26)15-27-28(25(24)29)23-20-9-5-3-7-18(20)19-8-4-6-10-21(19)23/h3-15,23H,2H2,1H3
Affinity DataIC50: 240nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425594(CHEMBL1987422)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c(C)cccc3C)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13-5-4-6-14(2)17(13)12-23-20(24)19(18(21)11-22-23)26-16-9-7-15(25-3)8-10-16/h4-11H,12H2,1-3H3
Affinity DataIC50: 240nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425592(CHEMBL2314293)
Show SMILES CCc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O2/c1-2-16-10-12-19(13-11-16)28-22-21(24)14-25-26(23(22)27)15-18-8-5-7-17-6-3-4-9-20(17)18/h3-14H,2,15H2,1H3
Affinity DataIC50: 250nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425591(CHEMBL2314300)
Show SMILES CCOc1ccc(Oc2c(Cl)cnn(C3c4ccccc4-c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C25H19ClN2O3/c1-2-30-16-11-13-17(14-12-16)31-24-22(26)15-27-28(25(24)29)23-20-9-5-3-7-18(20)19-8-4-6-10-21(19)23/h3-15,23H,2H2,1H3
Affinity DataIC50: 250nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425590(CHEMBL1964671)
Show SMILES CCc1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Show InChI InChI=1S/C20H19ClN2O3/c1-3-14-6-4-5-7-15(14)13-23-20(24)19(18(21)12-22-23)26-17-10-8-16(25-2)9-11-17/h4-12H,3,13H2,1-2H3
Affinity DataIC50: 260nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75901(5-chloranyl-2-(3,5-dimethylphenyl)-4-(4-methoxyphe...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(-c3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-12-8-13(2)10-14(9-12)22-19(23)18(17(20)11-21-22)25-16-6-4-15(24-3)5-7-16/h4-11H,1-3H3
Affinity DataIC50: 270nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425589(CHEMBL1969065)
Show SMILES COc1ccc(Oc2c(Cl)cnn(CC(=O)N(c3ccccc3)c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C25H20ClN3O4/c1-32-20-12-14-21(15-13-20)33-24-22(26)16-27-28(25(24)31)17-23(30)29(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-16H,17H2,1H3
Affinity DataIC50: 280nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425588(CHEMBL1965488)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1OC
Show InChI InChI=1S/C23H19ClN2O4/c1-28-20-11-10-17(12-21(20)29-2)30-22-19(24)13-25-26(23(22)27)14-16-8-5-7-15-6-3-4-9-18(15)16/h3-13H,14H2,1-2H3
Affinity DataIC50: 290nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425587(CHEMBL2314318)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c4ccccc4cc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C26H19ClN2O3/c1-31-19-10-12-20(13-11-19)32-25-24(27)15-28-29(26(25)30)16-23-21-8-4-2-6-17(21)14-18-7-3-5-9-22(18)23/h2-15H,16H2,1H3
Affinity DataIC50: 320nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425586(CHEMBL2314324)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3c(OC)ccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O4/c1-28-16-8-10-17(11-9-16)30-22-20(24)13-25-26(23(22)27)14-19-18-6-4-3-5-15(18)7-12-21(19)29-2/h3-13H,14H2,1-2H3
Affinity DataIC50: 350nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425584(CHEMBL2005648)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1F
Show InChI InChI=1S/C22H16ClFN2O3/c1-28-20-10-9-16(11-19(20)24)29-21-18(23)12-25-26(22(21)27)13-15-7-4-6-14-5-2-3-8-17(14)15/h2-12H,13H2,1H3
Affinity DataIC50: 360nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425585(CHEMBL2314322)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(F)c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C22H16ClFN2O3/c1-28-15-7-9-16(10-8-15)29-21-19(23)12-25-26(22(21)27)13-14-6-11-20(24)18-5-3-2-4-17(14)18/h2-12H,13H2,1H3
Affinity DataIC50: 360nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425583(CHEMBL2314306)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-13-5-3-4-6-14(13)12-22-19(23)18(17(20)11-21-22)25-16-9-7-15(24-2)8-10-16/h3-11H,12H2,1-2H3
Affinity DataIC50: 370nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425582(CHEMBL2314308)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C(F)(F)F)c2=O)cc1
Show InChI InChI=1S/C19H14ClF3N2O3/c1-27-13-6-8-14(9-7-13)28-17-16(20)10-24-25(18(17)26)11-12-4-2-3-5-15(12)19(21,22)23/h2-10H,11H2,1H3
Affinity DataIC50: 370nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425581(CHEMBL2314326)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C)c4ccccc34)c2=O)cc1
Show InChI InChI=1S/C23H19ClN2O3/c1-15-7-8-16(20-6-4-3-5-19(15)20)14-26-23(27)22(21(24)13-25-26)29-18-11-9-17(28-2)10-12-18/h3-13H,14H2,1-2H3
Affinity DataIC50: 370nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425580(CHEMBL2314621)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C3=Nc4cc(Cl)ccc4Oc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H15Cl2N3O4/c1-31-15-7-9-16(10-8-15)32-22-18(26)13-27-29(24(22)30)23-17-4-2-3-5-20(17)33-21-11-6-14(25)12-19(21)28-23/h2-13H,1H3
Affinity DataIC50: 370nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425579(CHEMBL2314311)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cc(C)cc(C)c3)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13-8-14(2)10-15(9-13)12-23-20(24)19(18(21)11-22-23)26-17-6-4-16(25-3)5-7-17/h4-11H,12H2,1-3H3
Affinity DataIC50: 410nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425578(CHEMBL2314288)
Show SMILES COc1ccc(Oc2c(Cl)cnn(CC(=O)C(c3ccccc3)c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C26H21ClN2O4/c1-32-20-12-14-21(15-13-20)33-25-22(27)16-28-29(26(25)31)17-23(30)24(18-8-4-2-5-9-18)19-10-6-3-7-11-19/h2-16,24H,17H2,1H3
Affinity DataIC50: 430nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425577(CHEMBL2000954)
Show SMILES CSc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C22H17ClN2O2S/c1-28-18-11-9-17(10-12-18)27-21-20(23)13-24-25(22(21)26)14-16-7-4-6-15-5-2-3-8-19(15)16/h2-13H,14H2,1H3
Affinity DataIC50: 430nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425576(CHEMBL2314299)
Show SMILES Clc1cnn(Cc2cccc3ccccc23)c(=O)c1Oc1ccc2OCCc2c1
Show InChI InChI=1S/C23H17ClN2O3/c24-20-13-25-26(14-17-6-3-5-15-4-1-2-7-19(15)17)23(27)22(20)29-18-8-9-21-16(12-18)10-11-28-21/h1-9,12-13H,10-11,14H2
Affinity DataIC50: 430nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425575(CHEMBL2314328)
Show SMILES CCOC(=O)C(c1cccc2ccccc12)n1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Show InChI InChI=1S/C25H21ClN2O5/c1-3-32-25(30)22(20-10-6-8-16-7-4-5-9-19(16)20)28-24(29)23(21(26)15-27-28)33-18-13-11-17(31-2)12-14-18/h4-15,22H,3H2,1-2H3
Affinity DataIC50: 450nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425574(CHEMBL2314622)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C3=Nc4ccccc4Oc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H16ClN3O4/c1-30-15-10-12-16(13-11-15)31-22-18(25)14-26-28(24(22)29)23-17-6-2-4-8-20(17)32-21-9-5-3-7-19(21)27-23/h2-14H,1H3
Affinity DataIC50: 490nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425573(CHEMBL2002956)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C3=Nc4cc(Cl)ccc4Oc4ncccc34)c2=O)cc1
Show InChI InChI=1S/C23H14Cl2N4O4/c1-31-14-5-7-15(8-6-14)32-20-17(25)12-27-29(23(20)30)21-16-3-2-10-26-22(16)33-19-9-4-13(24)11-18(19)28-21/h2-12H,1H3
Affinity DataIC50: 530nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425572(CHEMBL2314295)
Show SMILES CC(C)Oc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H21ClN2O3/c1-16(2)29-19-10-12-20(13-11-19)30-23-22(25)14-26-27(24(23)28)15-18-8-5-7-17-6-3-4-9-21(17)18/h3-14,16H,15H2,1-2H3
Affinity DataIC50: 530nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425571(CHEMBL2314317)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3-c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C24H19ClN2O3/c1-29-19-11-13-20(14-12-19)30-23-22(25)15-26-27(24(23)28)16-18-9-5-6-10-21(18)17-7-3-2-4-8-17/h2-15H,16H2,1H3
Affinity DataIC50: 540nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425570(CHEMBL2314620)
Show SMILES COc1ccc(Oc2c(Cl)cnn(C(C(=O)c3ccccc3)c3ccccc3)c2=O)cc1
Show InChI InChI=1S/C25H19ClN2O4/c1-31-19-12-14-20(15-13-19)32-24-21(26)16-27-28(25(24)30)22(17-8-4-2-5-9-17)23(29)18-10-6-3-7-11-18/h2-16,22H,1H3
Affinity DataIC50: 580nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425569(CHEMBL2314316)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(Cl)cc3)c2=O)cc1
Show InChI InChI=1S/C18H14Cl2N2O3/c1-24-14-6-8-15(9-7-14)25-17-16(20)10-21-22(18(17)23)11-12-2-4-13(19)5-3-12/h2-10H,11H2,1H3
Affinity DataIC50: 590nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425638(CHEMBL2314297)
Show SMILES COc1cccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)c1
Show InChI InChI=1S/C22H17ClN2O3/c1-27-17-9-5-10-18(12-17)28-21-20(23)13-24-25(22(21)26)14-16-8-4-7-15-6-2-3-11-19(15)16/h2-13H,14H2,1H3
Affinity DataIC50: 610nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425639(CHEMBL2314312)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C)c(C)c3)c2=O)cc1
Show InChI InChI=1S/C20H19ClN2O3/c1-13-4-5-15(10-14(13)2)12-23-20(24)19(18(21)11-22-23)26-17-8-6-16(25-3)7-9-17/h4-11H,12H2,1-3H3
Affinity DataIC50: 610nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425637(CHEMBL1980609)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C(C)C)c2=O)cc1
Show InChI InChI=1S/C21H21ClN2O3/c1-14(2)18-7-5-4-6-15(18)13-24-21(25)20(19(22)12-23-24)27-17-10-8-16(26-3)9-11-17/h4-12,14H,13H2,1-3H3
Affinity DataIC50: 640nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425636(CHEMBL1977515)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)c(F)c1
Show InChI InChI=1S/C22H16ClFN2O3/c1-28-16-9-10-20(19(24)11-16)29-21-18(23)12-25-26(22(21)27)13-15-7-4-6-14-5-2-3-8-17(14)15/h2-12H,13H2,1H3
Affinity DataIC50: 640nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425635(CHEMBL1995776)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3OC)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O4/c1-24-14-7-9-15(10-8-14)26-18-16(20)11-21-22(19(18)23)12-13-5-3-4-6-17(13)25-2/h3-11H,12H2,1-2H3
Affinity DataIC50: 670nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425634(CHEMBL2314289)
Show SMILES Cc1ccccc1-n1ncc(Cl)c(Oc2ccc(CO)cc2)c1=O
Show InChI InChI=1S/C18H15ClN2O3/c1-12-4-2-3-5-16(12)21-18(23)17(15(19)10-20-21)24-14-8-6-13(11-22)7-9-14/h2-10,22H,11H2,1H3
Affinity DataIC50: 730nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425632(CHEMBL1968640)
Show SMILES COc1ccc(Oc2c(Cl)cnn(CC(=O)N3C(C)Cc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C22H20ClN3O4/c1-14-11-15-5-3-4-6-19(15)26(14)20(27)13-25-22(28)21(18(23)12-24-25)30-17-9-7-16(29-2)8-10-17/h3-10,12,14H,11,13H2,1-2H3
Affinity DataIC50: 780nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425633(CHEMBL2314305)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3)c2=O)cc1
Show InChI InChI=1S/C18H15ClN2O3/c1-23-14-7-9-15(10-8-14)24-17-16(19)11-20-21(18(17)22)12-13-5-3-2-4-6-13/h2-11H,12H2,1H3
Affinity DataIC50: 780nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425631(CHEMBL2314298)
Show SMILES Clc1cnn(Cc2cccc3ccccc23)c(=O)c1Oc1ccc2occc2c1
Show InChI InChI=1S/C23H15ClN2O3/c24-20-13-25-26(14-17-6-3-5-15-4-1-2-7-19(15)17)23(27)22(20)29-18-8-9-21-16(12-18)10-11-28-21/h1-13H,14H2
Affinity DataIC50: 820nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425630(CHEMBL2001553)
Show SMILES Clc1cnn(Cc2cccc3ccccc23)c(=O)c1Oc1ccc2CCCc2c1
Show InChI InChI=1S/C24H19ClN2O2/c25-22-14-26-27(15-19-9-4-7-17-5-1-2-10-21(17)19)24(28)23(22)29-20-12-11-16-6-3-8-18(16)13-20/h1-2,4-5,7,9-14H,3,6,8,15H2
Affinity DataIC50: 830nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425629(CHEMBL1979763)
Show SMILES CCOc1cccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)c1
Show InChI InChI=1S/C23H19ClN2O3/c1-2-28-18-10-6-11-19(13-18)29-22-21(24)14-25-26(23(22)27)15-17-9-5-8-16-7-3-4-12-20(16)17/h3-14H,2,15H2,1H3
Affinity DataIC50: 980nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425628(CHEMBL2314310)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(cc3)C(F)(F)F)c2=O)cc1
Show InChI InChI=1S/C19H14ClF3N2O3/c1-27-14-6-8-15(9-7-14)28-17-16(20)10-24-25(18(17)26)11-12-2-4-13(5-3-12)19(21,22)23/h2-10H,11H2,1H3
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425627(CHEMBL2314292)
Show SMILES CCCOc1ccc(Oc2c(Cl)cnn(Cc3cccc4ccccc34)c2=O)cc1
Show InChI InChI=1S/C24H21ClN2O3/c1-2-14-29-19-10-12-20(13-11-19)30-23-22(25)15-26-27(24(23)28)16-18-8-5-7-17-6-3-4-9-21(17)18/h3-13,15H,2,14,16H2,1H3
Affinity DataIC50: 1.10E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425626(CHEMBL1977658)
Show SMILES COC(=O)c1ccccc1Cn1ncc(Cl)c(Oc2ccc(OC)cc2)c1=O
Show InChI InChI=1S/C20H17ClN2O5/c1-26-14-7-9-15(10-8-14)28-18-17(21)11-22-23(19(18)24)12-13-5-3-4-6-16(13)20(25)27-2/h3-11H,12H2,1-2H3
Affinity DataIC50: 1.20E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425625(CHEMBL2314307)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3cccc(C)c3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-13-4-3-5-14(10-13)12-22-19(23)18(17(20)11-21-22)25-16-8-6-15(24-2)7-9-16/h3-11H,12H2,1-2H3
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425624(CHEMBL1985845)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccccc3C#N)c2=O)cc1
Show InChI InChI=1S/C19H14ClN3O3/c1-25-15-6-8-16(9-7-15)26-18-17(20)11-22-23(19(18)24)12-14-5-3-2-4-13(14)10-21/h2-9,11H,12H2,1H3
Affinity DataIC50: 1.40E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM50425623(CHEMBL2314319)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc4ccccc4c3)c2=O)cc1
Show InChI InChI=1S/C22H17ClN2O3/c1-27-18-8-10-19(11-9-18)28-21-20(23)13-24-25(22(21)26)14-15-6-7-16-4-2-3-5-17(16)12-15/h2-13H,14H2,1H3
Affinity DataIC50: 1.50E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
TargetNeuropeptides B/W receptor type 1(Homo sapiens (Human))
The Scripps Research Institute

Curated by ChEMBL
LigandPNGBDBM75916(5-chloranyl-4-(4-methoxyphenoxy)-2-[(4-methylpheny...)
Show SMILES COc1ccc(Oc2c(Cl)cnn(Cc3ccc(C)cc3)c2=O)cc1
Show InChI InChI=1S/C19H17ClN2O3/c1-13-3-5-14(6-4-13)12-22-19(23)18(17(20)11-21-22)25-16-9-7-15(24-2)8-10-16/h3-11H,12H2,1-2H3
Affinity DataIC50: 1.70E+3nMAssay Description:Antagonist activity against human NPBWR1 expressed in HEK293 cells co-expressing Gqi3 assessed as inhibition of agonist-induced response by FLIPR ass...More data for this Ligand-Target Pair
Displayed 1 to 50 (of 73 total ) | Next | Last >>
Jump to: