Compile Data Set for Download or QSAR
Found 48 Enz. Inhib. hit(s) with all data for entry = 50043869
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447701(CHEMBL3113206)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(=O)[nH]3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H21ClN4O5S/c26-18-6-9-20(10-7-18)36(32,33)30-11-1-2-15-5-8-19(14-21(15)30)34-23-13-17(12-22(31)27-23)25-28-24(29-35-25)16-3-4-16/h5-10,12-14,16H,1-4,11H2,(H,27,31)
Affinity DataEC50: >3.00E+4nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447744(CHEMBL3112990)
Show SMILES Fc1cc2CCCN(c2cc1Oc1cc(cc(Cl)n1)-c1nc(no1)C1CC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H19Cl2FN4O4S/c26-17-5-7-18(8-6-17)37(33,34)32-9-1-2-15-10-19(28)21(13-20(15)32)35-23-12-16(11-22(27)29-23)25-30-24(31-36-25)14-3-4-14/h5-8,10-14H,1-4,9H2
Affinity DataEC50:  40nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447702(CHEMBL3112985)
Show SMILES CC(C)(C)c1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C26H24Cl2N4O4S/c1-26(2,3)25-30-24(36-31-25)17-13-22(28)29-23(14-17)35-19-9-6-16-5-4-12-32(21(16)15-19)37(33,34)20-10-7-18(27)8-11-20/h6-11,13-15H,4-5,12H2,1-3H3
Affinity DataEC50:  50nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50343449(CHEMBL1775171 | isopropyl 4-(1-(4-(methylsulfonyl)...)
Show SMILES CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2n(ncc12)-c1ccc(cc1)S(C)(=O)=O
Show InChI InChI=1S/C21H25N5O5S/c1-14(2)30-21(27)25-10-8-16(9-11-25)31-20-18-12-24-26(19(18)22-13-23-20)15-4-6-17(7-5-15)32(3,28)29/h4-7,12-14,16H,8-11H2,1-3H3
Affinity DataEC50:  40nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50435635(CHEMBL2391601)
Show SMILES CC(C)c1noc(n1)-c1cc(Cl)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1
Show InChI InChI=1S/C22H18Cl2N4O4S/c1-13(2)21-26-22(32-27-21)14-10-19(24)25-20(11-14)31-17-5-3-4-16(12-17)28-33(29,30)18-8-6-15(23)7-9-18/h3-13,28H,1-2H3
Affinity DataEC50:  20nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447703(CHEMBL3113003)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H22Cl2N4O4S/c27-19-7-10-21(11-8-19)37(33,34)32-12-2-1-3-16-6-9-20(15-22(16)32)35-24-14-18(13-23(28)29-24)26-30-25(31-36-26)17-4-5-17/h6-11,13-15,17H,1-5,12H2
Affinity DataEC50:  4.30E+3nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447704(CHEMBL3112989)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(cs3)C3CC3)cc12
Show InChI InChI=1S/C26H21Cl2N3O3S2/c27-19-6-9-21(10-7-19)36(32,33)31-11-1-2-17-5-8-20(14-23(17)31)34-25-13-18(12-24(28)30-25)26-29-22(15-35-26)16-3-4-16/h5-10,12-16H,1-4,11H2
Affinity DataEC50:  1.50E+3nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447705(CHEMBL3113016)
Show SMILES Fc1ccc(c(F)c1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H19ClF2N4O4S/c26-22-10-16(25-30-24(31-36-25)15-3-4-15)11-23(29-22)35-18-7-5-14-2-1-9-32(20(14)13-18)37(33,34)21-8-6-17(27)12-19(21)28/h5-8,10-13,15H,1-4,9H2
Affinity DataEC50:  860nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447706(CHEMBL3113014)
Show SMILES CS(=O)(=O)c1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H23ClN4O6S2/c1-38(32,33)20-8-10-21(11-9-20)39(34,35)31-12-2-3-16-6-7-19(15-22(16)31)36-24-14-18(13-23(27)28-24)26-29-25(30-37-26)17-4-5-17/h6-11,13-15,17H,2-5,12H2,1H3
Affinity DataEC50:  770nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447707(CHEMBL3113009)
Show SMILES COc1cccc(c1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H23ClN4O5S/c1-34-19-5-2-6-21(14-19)37(32,33)31-11-3-4-16-9-10-20(15-22(16)31)35-24-13-18(12-23(27)28-24)26-29-25(30-36-26)17-7-8-17/h2,5-6,9-10,12-15,17H,3-4,7-8,11H2,1H3
Affinity DataEC50:  590nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447708(CHEMBL3113006)
Show SMILES Clc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2cccc(c2)C#N)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C26H20ClN5O4S/c27-23-12-19(26-30-25(31-36-26)18-6-7-18)13-24(29-23)35-20-9-8-17-4-2-10-32(22(17)14-20)37(33,34)21-5-1-3-16(11-21)15-28/h1,3,5,8-9,11-14,18H,2,4,6-7,10H2
Affinity DataEC50:  550nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447709(CHEMBL3113008)
Show SMILES Clc1cccc(c1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H20Cl2N4O4S/c26-18-4-1-5-20(13-18)36(32,33)31-10-2-3-15-8-9-19(14-21(15)31)34-23-12-17(11-22(27)28-23)25-29-24(30-35-25)16-6-7-16/h1,4-5,8-9,11-14,16H,2-3,6-7,10H2
Affinity DataEC50:  540nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447710(CHEMBL3113007)
Show SMILES Fc1cccc(c1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H20ClFN4O4S/c26-22-11-17(25-29-24(30-35-25)16-6-7-16)12-23(28-22)34-19-9-8-15-3-2-10-31(21(15)14-19)36(32,33)20-5-1-4-18(27)13-20/h1,4-5,8-9,11-14,16H,2-3,6-7,10H2
Affinity DataEC50:  320nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447711(CHEMBL3112996)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCS(=O)(=O)c2cc(Cl)c(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C24H17Cl3N4O6S2/c25-15-3-5-16(6-4-15)39(34,35)31-7-8-38(32,33)20-11-17(26)19(12-18(20)31)36-22-10-14(9-21(27)28-22)24-29-23(30-37-24)13-1-2-13/h3-6,9-13H,1-2,7-8H2
Affinity DataEC50:  310nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447712(CHEMBL3113004)
Show SMILES Clc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccccc2)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C25H21ClN4O4S/c26-22-13-18(25-28-24(29-34-25)17-8-9-17)14-23(27-22)33-19-11-10-16-5-4-12-30(21(16)15-19)35(31,32)20-6-2-1-3-7-20/h1-3,6-7,10-11,13-15,17H,4-5,8-9,12H2
Affinity DataEC50:  290nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447713(CHEMBL3113207)
Show SMILES COc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C26H23ClN4O5S/c1-34-23-13-18(26-29-25(30-36-26)17-4-5-17)14-24(28-23)35-20-9-6-16-3-2-12-31(22(16)15-20)37(32,33)21-10-7-19(27)8-11-21/h6-11,13-15,17H,2-5,12H2,1H3
Affinity DataEC50:  270nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447714(CHEMBL3113005)
Show SMILES Clc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccccc2C#N)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C26H20ClN5O4S/c27-23-12-19(26-30-25(31-36-26)17-7-8-17)13-24(29-23)35-20-10-9-16-5-3-11-32(21(16)14-20)37(33,34)22-6-2-1-4-18(22)15-28/h1-2,4,6,9-10,12-14,17H,3,5,7-8,11H2
Affinity DataEC50:  270nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447715(CHEMBL3112983)
Show SMILES FC(F)(F)Cc1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H17Cl2F3N4O4S/c25-16-4-7-18(8-5-16)38(34,35)33-9-1-2-14-3-6-17(12-19(14)33)36-22-11-15(10-20(26)30-22)23-31-21(32-37-23)13-24(27,28)29/h3-8,10-12H,1-2,9,13H2
Affinity DataEC50:  190nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447716(CHEMBL3112980)
Show SMILES Cc1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H18Cl2N4O4S/c1-14-26-23(33-28-14)16-11-21(25)27-22(12-16)32-18-7-4-15-3-2-10-29(20(15)13-18)34(30,31)19-8-5-17(24)6-9-19/h4-9,11-13H,2-3,10H2,1H3
Affinity DataEC50:  180nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447717(CHEMBL3113010)
Show SMILES CS(=O)(=O)c1cccc(c1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H23ClN4O6S2/c1-38(32,33)20-5-2-6-21(15-20)39(34,35)31-11-3-4-16-9-10-19(14-22(16)31)36-24-13-18(12-23(27)28-24)26-29-25(30-37-26)17-7-8-17/h2,5-6,9-10,12-15,17H,3-4,7-8,11H2,1H3
Affinity DataEC50:  180nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447718(CHEMBL3112986)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3noc(n3)C3CC3)cc12
Show InChI InChI=1S/C25H20Cl2N4O4S/c26-18-6-9-20(10-7-18)36(32,33)31-11-1-2-15-5-8-19(14-21(15)31)34-23-13-17(12-22(27)28-23)24-29-25(35-30-24)16-3-4-16/h5-10,12-14,16H,1-4,11H2
Affinity DataEC50:  140nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447719(CHEMBL3112979)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(n3)C3CC3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C28H25ClN4O4S/c29-21-8-11-23(12-9-21)38(34,35)33-13-1-2-18-7-10-22(16-25(18)33)36-26-15-20(14-24(30-26)17-3-4-17)28-31-27(32-37-28)19-5-6-19/h7-12,14-17,19H,1-6,13H2
Affinity DataEC50:  130nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447720(CHEMBL3113205)
Show SMILES Cc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C26H23ClN4O4S/c1-16-13-19(26-29-25(30-35-26)18-4-5-18)14-24(28-16)34-21-9-6-17-3-2-12-31(23(17)15-21)36(32,33)22-10-7-20(27)8-11-22/h6-11,13-15,18H,2-5,12H2,1H3
Affinity DataEC50:  120nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447721(CHEMBL3112981)
Show SMILES FC(F)(F)c1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H15Cl2F3N4O4S/c24-15-4-7-17(8-5-15)37(33,34)32-9-1-2-13-3-6-16(12-18(13)32)35-20-11-14(10-19(25)29-20)21-30-22(31-36-21)23(26,27)28/h3-8,10-12H,1-2,9H2
Affinity DataEC50:  110nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447722(CHEMBL3113011)
Show SMILES Clc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(cc2)C#N)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C26H20ClN5O4S/c27-23-12-19(26-30-25(31-36-26)18-5-6-18)13-24(29-23)35-20-8-7-17-2-1-11-32(22(17)14-20)37(33,34)21-9-3-16(15-28)4-10-21/h3-4,7-10,12-14,18H,1-2,5-6,11H2
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447723(CHEMBL3112997)
Show SMILES COC(=O)c1cc(Cl)nc(Oc2ccc3CCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C21H16Cl2N2O5S/c1-29-21(26)14-10-19(23)24-20(11-14)30-16-5-2-13-8-9-25(18(13)12-16)31(27,28)17-6-3-15(22)4-7-17/h2-7,10-12H,8-9H2,1H3
Affinity DataEC50:  30nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50435643(CHEMBL2391593)
Show SMILES CCOC(=O)c1cc(Cl)nc(Oc2cccc(NS(=O)(=O)c3ccc(Cl)cc3)c2)c1
Show InChI InChI=1S/C20H16Cl2N2O5S/c1-2-28-20(25)13-10-18(22)23-19(11-13)29-16-5-3-4-15(12-16)24-30(26,27)17-8-6-14(21)7-9-17/h3-12,24H,2H2,1H3
Affinity DataEC50:  20nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447724(CHEMBL3112995)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCSc2cc(Cl)c(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C24H17Cl3N4O4S2/c25-15-3-5-16(6-4-15)37(32,33)31-7-8-36-20-11-17(26)19(12-18(20)31)34-22-10-14(9-21(27)28-22)24-29-23(30-35-24)13-1-2-13/h3-6,9-13H,1-2,7-8H2
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447725(CHEMBL3112988)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3cc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H21Cl2N3O4S/c27-19-6-9-21(10-7-19)36(32,33)31-11-1-2-17-5-8-20(14-23(17)31)34-26-13-18(12-25(28)29-26)24-15-22(30-35-24)16-3-4-16/h5-10,12-16H,1-4,11H2
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447726(CHEMBL3113019)
Show SMILES Fc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C25H20ClFN4O4S/c26-18-6-9-20(10-7-18)36(32,33)31-11-1-2-15-5-8-19(14-21(15)31)34-23-13-17(12-22(27)28-23)25-29-24(30-35-25)16-3-4-16/h5-10,12-14,16H,1-4,11H2
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447727(CHEMBL3112999)
Show SMILES CCOC(=O)c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C23H20Cl2N2O5S/c1-2-31-23(28)16-12-21(25)26-22(13-16)32-18-8-5-15-4-3-11-27(20(15)14-18)33(29,30)19-9-6-17(24)7-10-19/h5-10,12-14H,2-4,11H2,1H3
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447728(CHEMBL3112998)
Show SMILES COC(=O)c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C22H18Cl2N2O5S/c1-30-22(27)15-11-20(24)25-21(12-15)31-17-7-4-14-3-2-10-26(19(14)13-17)32(28,29)18-8-5-16(23)6-9-18/h4-9,11-13H,2-3,10H2,1H3
Affinity DataEC50:  100nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447729(CHEMBL3113017)
Show SMILES Fc1ccc(cc1F)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H19ClF2N4O4S/c26-22-10-16(25-30-24(31-36-25)15-3-4-15)11-23(29-22)35-17-6-5-14-2-1-9-32(21(14)12-17)37(33,34)18-7-8-19(27)20(28)13-18/h5-8,10-13,15H,1-4,9H2
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447730(CHEMBL3113013)
Show SMILES COc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H23ClN4O5S/c1-34-19-8-10-21(11-9-19)37(32,33)31-12-2-3-16-6-7-20(15-22(16)31)35-24-14-18(13-23(27)28-24)26-29-25(30-36-26)17-4-5-17/h6-11,13-15,17H,2-5,12H2,1H3
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447731(CHEMBL3113012)
Show SMILES Fc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H20ClFN4O4S/c26-22-12-17(25-29-24(30-35-25)16-3-4-16)13-23(28-22)34-19-8-5-15-2-1-11-31(21(15)14-19)36(32,33)20-9-6-18(27)7-10-20/h5-10,12-14,16H,1-4,11H2
Affinity DataEC50:  90nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447732(CHEMBL3112993)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2cc(Cl)c(Oc3cc(cc(Cl)n3)-c3nnc(o3)C3CC3)cc12
Show InChI InChI=1S/C25H19Cl3N4O4S/c26-17-5-7-18(8-6-17)37(33,34)32-9-1-2-15-10-19(27)21(13-20(15)32)35-23-12-16(11-22(28)29-23)25-31-30-24(36-25)14-3-4-14/h5-8,10-14H,1-4,9H2
Affinity DataEC50:  80nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447733(CHEMBL3112991)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2cc(Cl)c(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H19Cl3N4O4S/c26-17-5-7-18(8-6-17)37(33,34)32-9-1-2-15-10-19(27)21(13-20(15)32)35-23-12-16(11-22(28)29-23)25-30-24(31-36-25)14-3-4-14/h5-8,10-14H,1-4,9H2
Affinity DataEC50:  80nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447734(CHEMBL3112987)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nnc(o3)C3CC3)cc12
Show InChI InChI=1S/C25H20Cl2N4O4S/c26-18-6-9-20(10-7-18)36(32,33)31-11-1-2-15-5-8-19(14-21(15)31)34-23-13-17(12-22(27)28-23)25-30-29-24(35-25)16-3-4-16/h5-10,12-14,16H,1-4,11H2
Affinity DataEC50:  80nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447735(CHEMBL3112982)
Show SMILES CCc1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C24H20Cl2N4O4S/c1-2-22-28-24(34-29-22)16-12-21(26)27-23(13-16)33-18-8-5-15-4-3-11-30(20(15)14-18)35(31,32)19-9-6-17(25)7-10-19/h5-10,12-14H,2-4,11H2,1H3
Affinity DataEC50:  80nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447736(CHEMBL3113015)
Show SMILES Cc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C26H23ClN4O4S/c1-16-4-10-21(11-5-16)36(32,33)31-12-2-3-17-8-9-20(15-22(17)31)34-24-14-19(13-23(27)28-24)26-29-25(30-35-26)18-6-7-18/h4-5,8-11,13-15,18H,2-3,6-7,12H2,1H3
Affinity DataEC50:  80nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447737(CHEMBL3112992)
Show SMILES Fc1cc2CCCN(c2cc1Oc1cc(cc(Cl)n1)-c1nnc(o1)C1CC1)S(=O)(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C25H19Cl2FN4O4S/c26-17-5-7-18(8-6-17)37(33,34)32-9-1-2-15-10-19(28)21(13-20(15)32)35-23-12-16(11-22(27)29-23)25-31-30-24(36-25)14-3-4-14/h5-8,10-14H,1-4,9H2
Affinity DataEC50:  70nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447738(CHEMBL3113018)
Show SMILES Clc1cc(cc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)c(Cl)c2)n1)-c1nc(no1)C1CC1
Show InChI InChI=1S/C25H19Cl3N4O4S/c26-19-8-7-18(13-20(19)27)37(33,34)32-9-1-2-14-5-6-17(12-21(14)32)35-23-11-16(10-22(28)29-23)25-30-24(31-36-25)15-3-4-15/h5-8,10-13,15H,1-4,9H2
Affinity DataEC50:  70nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447739(CHEMBL3112994)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCOc2cc(Cl)c(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C24H17Cl3N4O5S/c25-15-3-5-16(6-4-15)37(32,33)31-7-8-34-20-11-17(26)19(12-18(20)31)35-22-10-14(9-21(27)28-22)24-29-23(30-36-24)13-1-2-13/h3-6,9-13H,1-2,7-8H2
Affinity DataEC50:  60nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447740(CHEMBL3112984)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(CC4CC4)no3)cc12
Show InChI InChI=1S/C26H22Cl2N4O4S/c27-19-6-9-21(10-7-19)37(33,34)32-11-1-2-17-5-8-20(15-22(17)32)35-25-14-18(13-23(28)29-25)26-30-24(31-36-26)12-16-3-4-16/h5-10,13-16H,1-4,11-12H2
Affinity DataEC50:  60nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447741(CHEMBL3113000)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C24H18Cl2N4O4S/c25-17-4-7-19(8-5-17)35(31,32)30-10-9-14-3-6-18(13-20(14)30)33-22-12-16(11-21(26)27-22)24-28-23(29-34-24)15-1-2-15/h3-8,11-13,15H,1-2,9-10H2
Affinity DataEC50:  60nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447742(CHEMBL3113002)
Show SMILES Clc1ccc(cc1)S(=O)(=O)N1CCCc2ccc(Oc3cc(cc(Cl)n3)-c3nc(no3)C3CC3)cc12
Show InChI InChI=1S/C25H20Cl2N4O4S/c26-18-6-9-20(10-7-18)36(32,33)31-11-1-2-15-5-8-19(14-21(15)31)34-23-13-17(12-22(27)28-23)25-29-24(30-35-25)16-3-4-16/h5-10,12-14,16H,1-4,11H2
Affinity DataEC50:  50nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50447743(CHEMBL3113001)
Show SMILES CC(C)c1noc(n1)-c1cc(Cl)nc(Oc2ccc3CCCN(c3c2)S(=O)(=O)c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C25H22Cl2N4O4S/c1-15(2)24-29-25(35-30-24)17-12-22(27)28-23(13-17)34-19-8-5-16-4-3-11-31(21(16)14-19)36(32,33)20-9-6-18(26)7-10-20/h5-10,12-15H,3-4,11H2,1-2H3
Affinity DataEC50:  50nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair
TargetGlucose-dependent insulinotropic receptor(Homo sapiens (Human))
Amgen Inc

Curated by ChEMBL
LigandPNGBDBM50435665(CHEMBL2391602)
Show SMILES Cc1ccc(cc1)S(=O)(=O)Nc1cccc(Oc2nc(C)cc(C)c2C#N)c1
Show InChI InChI=1S/C21H19N3O3S/c1-14-7-9-19(10-8-14)28(25,26)24-17-5-4-6-18(12-17)27-21-20(13-22)15(2)11-16(3)23-21/h4-12,24H,1-3H3
Affinity DataEC50:  310nMAssay Description:Agonist activity at human GPR119 expressed in HEK293 cells assessed as cAMP accumulation after 30 minsMore data for this Ligand-Target Pair