Compile Data Set for Download or QSAR
Found 35 Enz. Inhib. hit(s) with all data for entry = 50044261
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010507(CHEMBL3264374)
Show SMILES Cc1cc(C)cc(c1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C24H26N4O/c1-17-13-18(2)15-20(14-17)19-7-10-28(11-8-19)12-9-25-24(29)23-16-26-21-5-3-4-6-22(21)27-23/h3-7,13-16H,8-12H2,1-2H3,(H,25,29)
Affinity DataKi:  1.10nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010505(CHEMBL3264372)
Show SMILES Fc1cc(F)cc(c1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C22H20F2N4O/c23-17-11-16(12-18(24)13-17)15-5-8-28(9-6-15)10-7-25-22(29)21-14-26-19-3-1-2-4-20(19)27-21/h1-5,11-14H,6-10H2,(H,25,29)
Affinity DataKi:  2.60nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010506(CHEMBL3264373)
Show SMILES Cc1cc(C)cc(c1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C23H27N5O/c1-17-13-18(2)15-19(14-17)28-11-9-27(10-12-28)8-7-24-23(29)22-16-25-20-5-3-4-6-21(20)26-22/h3-6,13-16H,7-12H2,1-2H3,(H,24,29)
Affinity DataKi:  3.70nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010503(CHEMBL3264364)
Show SMILES O=C(NCCN1CCC(=CC1)c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C22H22N4O/c27-22(21-16-24-19-8-4-5-9-20(19)25-21)23-12-15-26-13-10-18(11-14-26)17-6-2-1-3-7-17/h1-10,16H,11-15H2,(H,23,27)
Affinity DataKi:  3.80nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010515(CHEMBL3264376)
Show SMILES O=C(NCCN1CCC(=CC1)c1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C24H24N2O/c27-24(23-11-10-20-8-4-5-9-22(20)18-23)25-14-17-26-15-12-21(13-16-26)19-6-2-1-3-7-19/h1-12,18H,13-17H2,(H,25,27)
Affinity DataKi:  6.10nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010523(CHEMBL3264384)
Show SMILES Fc1cc(F)cc(c1)C1=CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H22F2N2O/c25-22-14-21(15-23(26)16-22)18-7-10-28(11-8-18)12-9-27-24(29)20-6-5-17-3-1-2-4-19(17)13-20/h1-7,13-16H,8-12H2,(H,27,29)
Affinity DataKi:  7.30nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010513(CHEMBL3264370)
Show SMILES Cc1ccc(cc1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C23H24N4O/c1-17-6-8-18(9-7-17)19-10-13-27(14-11-19)15-12-24-23(28)22-16-25-20-4-2-3-5-21(20)26-22/h2-10,16H,11-15H2,1H3,(H,24,28)
Affinity DataKi:  7.60nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010525(CHEMBL3264386)
Show SMILES Cc1cc(C)cc(c1)C1=CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C26H28N2O/c1-19-15-20(2)17-25(16-19)22-9-12-28(13-10-22)14-11-27-26(29)24-8-7-21-5-3-4-6-23(21)18-24/h3-9,15-18H,10-14H2,1-2H3,(H,27,29)
Affinity DataKi:  8.10nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010511(CHEMBL3264368)
Show SMILES Clc1ccc(cc1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C22H21ClN4O/c23-18-7-5-16(6-8-18)17-9-12-27(13-10-17)14-11-24-22(28)21-15-25-19-3-1-2-4-20(19)26-21/h1-9,15H,10-14H2,(H,24,28)
Affinity DataKi:  9.30nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010504(CHEMBL3264371)
Show SMILES Fc1cc(F)cc(c1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C21H21F2N5O/c22-15-11-16(23)13-17(12-15)28-9-7-27(8-10-28)6-5-24-21(29)20-14-25-18-3-1-2-4-19(18)26-20/h1-4,11-14H,5-10H2,(H,24,29)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010509(CHEMBL3264366)
Show SMILES Fc1ccc(cc1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C22H21FN4O/c23-18-7-5-16(6-8-18)17-9-12-27(13-10-17)14-11-24-22(28)21-15-25-19-3-1-2-4-20(19)26-21/h1-9,15H,10-14H2,(H,24,28)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010524(CHEMBL3264385)
Show SMILES Cc1cc(C)cc(c1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C25H29N3O/c1-19-15-20(2)17-24(16-19)28-13-11-27(12-14-28)10-9-26-25(29)23-8-7-21-5-3-4-6-22(21)18-23/h3-8,15-18H,9-14H2,1-2H3,(H,26,29)
Affinity DataKi:  21nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010514(CHEMBL3264375)
Show SMILES O=C(NCCN1CCN(CC1)c1ccccc1)c1ccc2ccccc2c1
Show InChI InChI=1S/C23H25N3O/c27-23(21-11-10-19-6-4-5-7-20(19)18-21)24-12-13-25-14-16-26(17-15-25)22-8-2-1-3-9-22/h1-11,18H,12-17H2,(H,24,27)
Affinity DataKi:  25nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010510(CHEMBL3264367)
Show SMILES Clc1ccc(cc1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C21H22ClN5O/c22-16-5-7-17(8-6-16)27-13-11-26(12-14-27)10-9-23-21(28)20-15-24-18-3-1-2-4-19(18)25-20/h1-8,15H,9-14H2,(H,23,28)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010512(CHEMBL3264369)
Show SMILES Cc1ccc(cc1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C22H25N5O/c1-17-6-8-18(9-7-17)27-14-12-26(13-15-27)11-10-23-22(28)21-16-24-19-4-2-3-5-20(19)25-21/h2-9,16H,10-15H2,1H3,(H,23,28)
Affinity DataKi:  27nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010522(CHEMBL3264383)
Show SMILES Fc1cc(F)cc(c1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C23H23F2N3O/c24-20-14-21(25)16-22(15-20)28-11-9-27(10-12-28)8-7-26-23(29)19-6-5-17-3-1-2-4-18(17)13-19/h1-6,13-16H,7-12H2,(H,26,29)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010499(CHEMBL3264363)
Show SMILES O=C(NCCN1CCN(CC1)c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C21H23N5O/c27-21(20-16-23-18-8-4-5-9-19(18)24-20)22-10-11-25-12-14-26(15-13-25)17-6-2-1-3-7-17/h1-9,16H,10-15H2,(H,22,27)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010521(CHEMBL3264382)
Show SMILES Cc1ccc(cc1)C1=CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C25H26N2O/c1-19-6-8-21(9-7-19)22-12-15-27(16-13-22)17-14-26-25(28)24-11-10-20-4-2-3-5-23(20)18-24/h2-12,18H,13-17H2,1H3,(H,26,28)
Affinity DataKi:  32nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010517(CHEMBL3264378)
Show SMILES Fc1ccc(cc1)C1=CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H23FN2O/c25-23-9-7-19(8-10-23)20-11-14-27(15-12-20)16-13-26-24(28)22-6-5-18-3-1-2-4-21(18)17-22/h1-11,17H,12-16H2,(H,26,28)
Affinity DataKi:  34nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010519(CHEMBL3264380)
Show SMILES Clc1ccc(cc1)C1=CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H23ClN2O/c25-23-9-7-19(8-10-23)20-11-14-27(15-12-20)16-13-26-24(28)22-6-5-18-3-1-2-4-21(18)17-22/h1-11,17H,12-16H2,(H,26,28)
Affinity DataKi:  43nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010518(CHEMBL3264379)
Show SMILES Clc1ccc(cc1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C23H24ClN3O/c24-21-7-9-22(10-8-21)27-15-13-26(14-16-27)12-11-25-23(28)20-6-5-18-3-1-2-4-19(18)17-20/h1-10,17H,11-16H2,(H,25,28)
Affinity DataKi:  51nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010516(CHEMBL3264377)
Show SMILES Fc1ccc(cc1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C23H24FN3O/c24-21-7-9-22(10-8-21)27-15-13-26(14-16-27)12-11-25-23(28)20-6-5-18-3-1-2-4-19(18)17-20/h1-10,17H,11-16H2,(H,25,28)
Affinity DataKi:  54nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010508(CHEMBL3264365)
Show SMILES Fc1ccc(cc1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C21H22FN5O/c22-16-5-7-17(8-6-16)27-13-11-26(12-14-27)10-9-23-21(28)20-15-24-18-3-1-2-4-19(18)25-20/h1-8,15H,9-14H2,(H,23,28)
Affinity DataKi:  63nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010490(CHEMBL3264396)
Show SMILES Cc1cc(C)cc(c1)C1=CCN(CCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C23H24N2O2/c1-16-13-17(2)15-19(14-16)18-7-9-24(10-8-18)11-12-25-22(26)20-5-3-4-6-21(20)23(25)27/h3-7,13-15H,8-12H2,1-2H3
Affinity DataKi:  105nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010520(CHEMBL3264381)
Show SMILES Cc1ccc(cc1)N1CCN(CCNC(=O)c2ccc3ccccc3c2)CC1
Show InChI InChI=1S/C24H27N3O/c1-19-6-10-23(11-7-19)27-16-14-26(15-17-27)13-12-25-24(28)22-9-8-20-4-2-3-5-21(20)18-22/h2-11,18H,12-17H2,1H3,(H,25,28)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010528(CHEMBL3264394)
Show SMILES Fc1cc(F)cc(c1)C1=CCN(CCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H18F2N2O2/c22-16-11-15(12-17(23)13-16)14-5-7-24(8-6-14)9-10-25-20(26)18-3-1-2-4-19(18)21(25)27/h1-5,11-13H,6-10H2
Affinity DataKi:  425nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010570(CHEMBL3264395)
Show SMILES Cc1cc(C)cc(c1)N1CCN(CCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C22H25N3O2/c1-16-13-17(2)15-18(14-16)24-10-7-23(8-11-24)9-12-25-21(26)19-5-3-4-6-20(19)22(25)27/h3-6,13-15H,7-12H2,1-2H3
Affinity DataKi:  496nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010527(CHEMBL3264390)
Show SMILES Clc1ccc(cc1)C1=CCN(CCN2C(=O)c3ccccc3C2=O)CC1
Show InChI InChI=1S/C21H19ClN2O2/c22-17-7-5-15(6-8-17)16-9-11-23(12-10-16)13-14-24-20(25)18-3-1-2-4-19(18)21(24)26/h1-9H,10-14H2
Affinity DataKi:  631nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010526(CHEMBL3264387)
Show SMILES O=C1N(CCN2CCC(=CC2)c2ccccc2)C(=O)c2ccccc12
Show InChI InChI=1S/C21H20N2O2/c24-20-18-8-4-5-9-19(18)21(25)23(20)15-14-22-12-10-17(11-13-22)16-6-2-1-3-7-16/h1-10H,11-15H2
Affinity DataKi:  706nMAssay Description:Displacement of [3H]-8-OH-OPAT from human recombinant 5HT1A receptor expressed in CHO cells after 60 mins by liquid scintillation counting analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010505(CHEMBL3264372)
Show SMILES Fc1cc(F)cc(c1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C22H20F2N4O/c23-17-11-16(12-18(24)13-17)15-5-8-28(9-6-15)10-7-25-22(29)21-14-26-19-3-1-2-4-20(19)27-21/h1-5,11-14H,6-10H2,(H,25,29)
Affinity DataIC50: 95nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010507(CHEMBL3264374)
Show SMILES Cc1cc(C)cc(c1)C1=CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C24H26N4O/c1-17-13-18(2)15-20(14-17)19-7-10-28(11-8-19)12-9-25-24(29)23-16-26-21-5-3-4-6-22(21)27-23/h3-7,13-16H,8-12H2,1-2H3,(H,25,29)
Affinity DataIC50: 172nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010506(CHEMBL3264373)
Show SMILES Cc1cc(C)cc(c1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C23H27N5O/c1-17-13-18(2)15-19(14-17)28-11-9-27(10-12-28)8-7-24-23(29)22-16-25-20-5-3-4-6-21(20)26-22/h3-6,13-16H,7-12H2,1-2H3,(H,24,29)
Affinity DataIC50: 383nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010503(CHEMBL3264364)
Show SMILES O=C(NCCN1CCC(=CC1)c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C22H22N4O/c27-22(21-16-24-19-8-4-5-9-20(19)25-21)23-12-15-26-13-10-18(11-14-26)17-6-2-1-3-7-17/h1-10,16H,11-15H2,(H,23,27)
Affinity DataIC50: 460nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010504(CHEMBL3264371)
Show SMILES Fc1cc(F)cc(c1)N1CCN(CCNC(=O)c2cnc3ccccc3n2)CC1
Show InChI InChI=1S/C21H21F2N5O/c22-15-11-16(23)13-17(12-15)28-9-7-27(8-10-28)6-5-24-21(29)20-14-25-18-3-1-2-4-19(18)26-20/h1-4,11-14H,5-10H2,(H,24,29)
Affinity DataIC50: 1.14E+3nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 1A(Rattus norvegicus (rat))
University of Li£ge

Curated by ChEMBL
LigandPNGBDBM50010499(CHEMBL3264363)
Show SMILES O=C(NCCN1CCN(CC1)c1ccccc1)c1cnc2ccccc2n1
Show InChI InChI=1S/C21H23N5O/c27-21(20-16-23-18-8-4-5-9-19(18)24-20)22-10-11-25-12-14-26(15-13-25)17-6-2-1-3-7-17/h1-9,16H,10-15H2,(H,22,27)
Affinity DataIC50: 1.68E+3nMAssay Description:Agonist activity at Wistar rat brain 5HT1A receptor assessed as inhibition of firing rate of dorsal raphe nucleus by electrophysiological analysisMore data for this Ligand-Target Pair