Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with all data for entry = 50046750
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50030836(CHEMBL3355639)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc2ccc(nn12)-c1cccc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C22H19N3O4S2/c1-30(26,27)17-7-5-15(6-8-17)21-14-23-22-12-11-20(24-25(21)22)16-3-2-4-19(13-16)31(28,29)18-9-10-18/h2-8,11-14,18H,9-10H2,1H3
Affinity DataIC50: 400nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50129589(CHEMBL3628223)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnn2ccc(nc12)-c1cccc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C22H19N3O4S2/c1-30(26,27)17-7-5-15(6-8-17)20-14-23-25-12-11-21(24-22(20)25)16-3-2-4-19(13-16)31(28,29)18-9-10-18/h2-8,11-14,18H,9-10H2,1H3
Affinity DataIC50: 500nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50129559(CHEMBL3234071)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc2ccc(nn12)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C20H17N3O4S2/c1-28(24,25)16-8-6-14(7-9-16)19-13-21-20-11-10-18(22-23(19)20)15-4-3-5-17(12-15)29(2,26)27/h3-13H,1-2H3
Affinity DataIC50: 900nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50129562(CHEMBL3628220)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnn2ccc(cc12)-c1cccc(c1)S(=O)(=O)C1CC1
Show InChI InChI=1S/C23H20N2O4S2/c1-30(26,27)19-7-5-16(6-8-19)22-15-24-25-12-11-18(14-23(22)25)17-3-2-4-21(13-17)31(28,29)20-9-10-20/h2-8,11-15,20H,9-10H2,1H3
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50129560(CHEMBL3628216)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnc2ccc(cn12)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C21H18N2O4S2/c1-28(24,25)18-9-6-15(7-10-18)20-13-22-21-11-8-17(14-23(20)21)16-4-3-5-19(12-16)29(2,26)27/h3-14H,1-2H3
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair
TargetPotassium voltage-gated channel subfamily H member 2(Homo sapiens (Human))
University of Cape Town

Curated by ChEMBL
LigandPNGBDBM50129561(CHEMBL3628219)
Show SMILES CS(=O)(=O)c1ccc(cc1)-c1cnn2ccc(cc12)-c1cccc(c1)S(C)(=O)=O
Show InChI InChI=1S/C21H18N2O4S2/c1-28(24,25)18-8-6-15(7-9-18)20-14-22-23-11-10-17(13-21(20)23)16-4-3-5-19(12-16)29(2,26)27/h3-14H,1-2H3
Affinity DataIC50: 3.30E+4nMAssay Description:Inhibition of human ERG potassium channel by ionworks patch-clamp electrophysiology assayMore data for this Ligand-Target Pair