Compile Data Set for Download or QSAR
Found 89 Enz. Inhib. hit(s) with all data for entry = 50047140
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150632(CHEMBL3770838)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(B(O)O)c(OC)c1
Show InChI InChI=1S/C26H44BNO4/c1-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-26(29)28-22-23-19-20-24(27(30)31)25(21-23)32-2/h10-11,19-21,30-31H,3-9,12-18,22H2,1-2H3,(H,28,29)/b11-10-
Affinity DataIC50: 32nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150639(CHEMBL3770079)
Show SMILES COc1cc(CNC(=O)CCCCCCCc2ccccc2)ccc1B(O)O
Show InChI InChI=1S/C22H30BNO4/c1-28-21-16-19(14-15-20(21)23(26)27)17-24-22(25)13-9-4-2-3-6-10-18-11-7-5-8-12-18/h5,7-8,11-12,14-16,26-27H,2-4,6,9-10,13,17H2,1H3,(H,24,25)
Affinity DataIC50: 34nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150637(CHEMBL3770653)
Show SMILES OB(O)c1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C15H13BClNO3/c17-13-7-4-11(5-8-13)6-9-15(19)18-14-3-1-2-12(10-14)16(20)21/h1-10,20-21H,(H,18,19)/b9-6+
Affinity DataIC50: 41nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150630(CHEMBL3770603)
Show SMILES CCCCCCCC\C=C/CCCCCCCC(=O)NCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C25H42BNO3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-25(28)27-22-23-18-20-24(21-19-23)26(29)30/h9-10,18-21,29-30H,2-8,11-17,22H2,1H3,(H,27,28)/b10-9-
Affinity DataIC50: 47nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150582(CHEMBL3771141)
Show SMILES OB(O)c1ccc(cc1)C(=O)Nc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C19H16BNO3/c22-19(16-6-10-17(11-7-16)20(23)24)21-18-12-8-15(9-13-18)14-4-2-1-3-5-14/h1-13,23-24H,(H,21,22)
Affinity DataIC50: 150nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150578(CHEMBL3769906)
Show SMILES OB(O)c1ccc(cc1)C(=O)NCCCCCc1ccccc1
Show InChI InChI=1S/C18H22BNO3/c21-18(16-10-12-17(13-11-16)19(22)23)20-14-6-2-5-9-15-7-3-1-4-8-15/h1,3-4,7-8,10-13,22-23H,2,5-6,9,14H2,(H,20,21)
Affinity DataIC50: 180nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Show SMILES COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
Affinity DataIC50: 190nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150577(CHEMBL3769611)
Show SMILES OB(O)c1ccc(CNC(=O)CCc2ccccc2)cc1
Show InChI InChI=1S/C16H18BNO3/c19-16(11-8-13-4-2-1-3-5-13)18-12-14-6-9-15(10-7-14)17(20)21/h1-7,9-10,20-21H,8,11-12H2,(H,18,19)
Affinity DataIC50: 230nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150624(CHEMBL3770697)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C21H28BNO3/c24-21(17-19-12-14-20(15-13-19)22(25)26)23-16-8-3-1-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-15,25-26H,1-3,5,8-9,16-17H2,(H,23,24)
Affinity DataIC50: 250nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150634(CHEMBL3770435)
Show SMILES Oc1ccc(CC(=O)NCCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C21H27NO2/c23-20-14-12-19(13-15-20)17-21(24)22-16-8-3-1-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-15,23H,1-3,5,8-9,16-17H2,(H,22,24)
Affinity DataIC50: 260nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM20488((2E)-3-(4-chlorophenyl)-N-(3-methoxyphenyl)prop-2-...)
Show SMILES COc1cccc(NC(=O)\C=C\c2ccc(Cl)cc2)c1
Show InChI InChI=1S/C16H14ClNO2/c1-20-15-4-2-3-14(11-15)18-16(19)10-7-12-5-8-13(17)9-6-12/h2-11H,1H3,(H,18,19)/b10-7+
Affinity DataIC50: 270nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in CHO cells assessed as inhibition of capsiacin-induced Ca2+ flux by Fluo-3 dye bas...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150631(CHEMBL3770620)
Show SMILES OB(O)c1ccc(CC(=O)NCc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H20BNO3/c24-21(14-16-8-12-20(13-9-16)22(25)26)23-15-17-6-10-19(11-7-17)18-4-2-1-3-5-18/h1-13,25-26H,14-15H2,(H,23,24)
Affinity DataIC50: 280nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150627(CHEMBL3769572)
Show SMILES OB(O)c1ccc(CNC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C20H18BNO3/c23-20(22-14-15-6-12-19(13-7-15)21(24)25)18-10-8-17(9-11-18)16-4-2-1-3-5-16/h1-13,24-25H,14H2,(H,22,23)
Affinity DataIC50: 330nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150624(CHEMBL3770697)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C21H28BNO3/c24-21(17-19-12-14-20(15-13-19)22(25)26)23-16-8-3-1-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-15,25-26H,1-3,5,8-9,16-17H2,(H,23,24)
Affinity DataIC50: 370nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150584(CHEMBL3771004)
Show SMILES OB(O)c1ccc(NC(=O)CCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C20H26BNO3/c23-20(22-19-15-13-18(14-16-19)21(24)25)12-8-3-1-2-5-9-17-10-6-4-7-11-17/h4,6-7,10-11,13-16,24-25H,1-3,5,8-9,12H2,(H,22,23)
Affinity DataIC50: 390nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150544(CHEMBL3770115)
Show SMILES OB(O)c1ccc(CNC(=O)CCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C21H28BNO3/c24-21(23-17-19-13-15-20(16-14-19)22(25)26)12-8-3-1-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16,25-26H,1-3,5,8-9,12,17H2,(H,23,24)
Affinity DataIC50: 470nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150544(CHEMBL3770115)
Show SMILES OB(O)c1ccc(CNC(=O)CCCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C21H28BNO3/c24-21(23-17-19-13-15-20(16-14-19)22(25)26)12-8-3-1-2-5-9-18-10-6-4-7-11-18/h4,6-7,10-11,13-16,25-26H,1-3,5,8-9,12,17H2,(H,23,24)
Affinity DataIC50: 500nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150623(CHEMBL3771001)
Show SMILES OB(O)c1ccc(NC(=O)\C=C\c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H13BClNO3/c17-13-6-1-11(2-7-13)3-10-15(19)18-14-8-4-12(5-9-14)16(20)21/h1-10,20-21H,(H,18,19)/b10-3+
Affinity DataIC50: 560nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150587(CHEMBL3769734)
Show SMILES OB(O)c1ccc(NC(=O)CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C18H22BNO3/c21-18(20-17-13-11-16(12-14-17)19(22)23)10-6-2-5-9-15-7-3-1-4-8-15/h1,3-4,7-8,11-14,22-23H,2,5-6,9-10H2,(H,20,21)
Affinity DataIC50: 570nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150545(CHEMBL3769782)
Show SMILES OB(O)c1ccc(cc1)C(=O)NCCCCc1ccccc1
Show InChI InChI=1S/C17H20BNO3/c20-17(15-9-11-16(12-10-15)18(21)22)19-13-5-4-8-14-6-2-1-3-7-14/h1-3,6-7,9-12,21-22H,4-5,8,13H2,(H,19,20)
Affinity DataIC50: 580nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150628(CHEMBL3769510)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H24BNO3/c22-19(15-17-10-12-18(13-11-17)20(23)24)21-14-6-2-5-9-16-7-3-1-4-8-16/h1,3-4,7-8,10-13,23-24H,2,5-6,9,14-15H2,(H,21,22)
Affinity DataIC50: 630nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150586(CHEMBL3770207)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C17H20BNO3/c1-17(2,3)13-6-10-15(11-7-13)19-16(20)12-4-8-14(9-5-12)18(21)22/h4-11,21-22H,1-3H3,(H,19,20)
Affinity DataIC50: 750nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150625(CHEMBL3771273)
Show SMILES CC(C)(C)c1ccc(cc1)C(=O)Nc1ccc(cc1)B(O)O
Show InChI InChI=1S/C17H20BNO3/c1-17(2,3)13-6-4-12(5-7-13)16(20)19-15-10-8-14(9-11-15)18(21)22/h4-11,21-22H,1-3H3,(H,19,20)
Affinity DataIC50: 780nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,14-15H
Affinity DataIC50: 790nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150521(CHEMBL3769556)
Show SMILES OB(O)c1ccc(CNC(=O)CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H24BNO3/c22-19(10-6-2-5-9-16-7-3-1-4-8-16)21-15-17-11-13-18(14-12-17)20(23)24/h1,3-4,7-8,11-14,23-24H,2,5-6,9-10,15H2,(H,21,22)
Affinity DataIC50: 1.08E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150626(CHEMBL3771003)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCc2ccccc2)cc1
Show InChI InChI=1S/C18H22BNO3/c21-18(14-16-9-11-17(12-10-16)19(22)23)20-13-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-12,22-23H,4-5,8,13-14H2,(H,20,21)
Affinity DataIC50: 1.17E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150633(CHEMBL3769407)
Show SMILES O=C(Cc1ccccc1)NCCCCCCCc1ccccc1
Show InChI InChI=1S/C21H27NO/c23-21(18-20-15-9-5-10-16-20)22-17-11-3-1-2-6-12-19-13-7-4-8-14-19/h4-5,7-10,13-16H,1-3,6,11-12,17-18H2,(H,22,23)
Affinity DataIC50: 1.21E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150638(CHEMBL3769949)
Show SMILES COc1cc(CNC(=O)CCCCCc2ccccc2)ccc1B(O)O
Show InChI InChI=1S/C20H26BNO4/c1-26-19-14-17(12-13-18(19)21(24)25)15-22-20(23)11-7-3-6-10-16-8-4-2-5-9-16/h2,4-5,8-9,12-14,24-25H,3,6-7,10-11,15H2,1H3,(H,22,23)
Affinity DataIC50: 1.32E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150623(CHEMBL3771001)
Show SMILES OB(O)c1ccc(NC(=O)\C=C\c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C15H13BClNO3/c17-13-6-1-11(2-7-13)3-10-15(19)18-14-8-4-12(5-9-14)16(20)21/h1-10,20-21H,(H,18,19)/b10-3+
Affinity DataIC50: 1.39E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150579(CHEMBL3770848)
Show SMILES OB(O)c1ccc(CNC(=O)\C=C\c2ccc(Cl)cc2)cc1
Show InChI InChI=1S/C16H15BClNO3/c18-15-8-3-12(4-9-15)5-10-16(20)19-11-13-1-6-14(7-2-13)17(21)22/h1-10,21-22H,11H2,(H,19,20)/b10-5+
Affinity DataIC50: 1.51E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150638(CHEMBL3769949)
Show SMILES COc1cc(CNC(=O)CCCCCc2ccccc2)ccc1B(O)O
Show InChI InChI=1S/C20H26BNO4/c1-26-19-14-17(12-13-18(19)21(24)25)15-22-20(23)11-7-3-6-10-16-8-4-2-5-9-16/h2,4-5,8-9,12-14,24-25H,3,6-7,10-11,15H2,1H3,(H,22,23)
Affinity DataIC50: 1.53E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150639(CHEMBL3770079)
Show SMILES COc1cc(CNC(=O)CCCCCCCc2ccccc2)ccc1B(O)O
Show InChI InChI=1S/C22H30BNO4/c1-28-21-16-19(14-15-20(21)23(26)27)17-24-22(25)13-9-4-2-3-6-10-18-11-7-5-8-12-18/h5,7-8,11-12,14-16,26-27H,2-4,6,9-10,13,17H2,1H3,(H,24,25)
Affinity DataIC50: 1.77E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150581(CHEMBL3769907)
Show SMILES OB(O)c1ccc(cc1)C(=O)NCc1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C20H18BNO3/c23-20(18-10-12-19(13-11-18)21(24)25)22-14-15-6-8-17(9-7-15)16-4-2-1-3-5-16/h1-13,24-25H,14H2,(H,22,23)
Affinity DataIC50: 1.86E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150636(CHEMBL3770436)
Show SMILES CC(C)(C)c1ccc(NC(=O)Nc2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C17H21BN2O3/c1-17(2,3)12-4-8-14(9-5-12)19-16(21)20-15-10-6-13(7-11-15)18(22)23/h4-11,22-23H,1-3H3,(H2,19,20,21)
Affinity DataIC50: 1.95E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150520(CHEMBL3771217)
Show SMILES CC(C)(C)c1ccc(NC(=O)NCc2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C18H23BN2O3/c1-18(2,3)14-6-10-16(11-7-14)21-17(22)20-12-13-4-8-15(9-5-13)19(23)24/h4-11,23-24H,12H2,1-3H3,(H2,20,21,22)
Affinity DataIC50: 1.99E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150626(CHEMBL3771003)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCc2ccccc2)cc1
Show InChI InChI=1S/C18H22BNO3/c21-18(14-16-9-11-17(12-10-16)19(22)23)20-13-5-4-8-15-6-2-1-3-7-15/h1-3,6-7,9-12,22-23H,4-5,8,13-14H2,(H,20,21)
Affinity DataIC50: 2.19E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150628(CHEMBL3769510)
Show SMILES OB(O)c1ccc(CC(=O)NCCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H24BNO3/c22-19(15-17-10-12-18(13-11-17)20(23)24)21-14-6-2-5-9-16-7-3-1-4-8-16/h1,3-4,7-8,10-13,23-24H,2,5-6,9,14-15H2,(H,21,22)
Affinity DataIC50: 2.53E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150583(CHEMBL3770604)
Show SMILES OB(O)c1ccc(cc1)C(=O)NCc1ccccc1
Show InChI InChI=1S/C14H14BNO3/c17-14(16-10-11-4-2-1-3-5-11)12-6-8-13(9-7-12)15(18)19/h1-9,18-19H,10H2,(H,16,17)
Affinity DataIC50: 2.87E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150521(CHEMBL3769556)
Show SMILES OB(O)c1ccc(CNC(=O)CCCCCc2ccccc2)cc1
Show InChI InChI=1S/C19H24BNO3/c22-19(10-6-2-5-9-16-7-3-1-4-8-16)21-15-17-11-13-18(14-12-17)20(23)24/h1,3-4,7-8,11-14,23-24H,2,5-6,9-10,15H2,(H,21,22)
Affinity DataIC50: 2.89E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26134((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
Affinity DataIC50: 2.92E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150520(CHEMBL3771217)
Show SMILES CC(C)(C)c1ccc(NC(=O)NCc2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C18H23BN2O3/c1-18(2,3)14-6-10-16(11-7-14)21-17(22)20-12-13-4-8-15(9-5-13)19(23)24/h4-11,23-24H,12H2,1-3H3,(H2,20,21,22)
Affinity DataIC50: 4.13E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150522(CHEMBL3771315)
Show SMILES COc1cc(CNC(=O)Nc2ccc(cc2)C(C)(C)C)ccc1B(O)O
Show InChI InChI=1S/C19H25BN2O4/c1-19(2,3)14-6-8-15(9-7-14)22-18(23)21-12-13-5-10-16(20(24)25)17(11-13)26-4/h5-11,24-25H,12H2,1-4H3,(H2,21,22,23)
Affinity DataIC50: 4.28E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150586(CHEMBL3770207)
Show SMILES CC(C)(C)c1ccc(NC(=O)c2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C17H20BNO3/c1-17(2,3)13-6-10-15(11-7-13)19-16(20)12-4-8-14(9-5-12)18(21)22/h4-11,21-22H,1-3H3,(H,19,20)
Affinity DataIC50: 5.50E+3nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150631(CHEMBL3770620)
Show SMILES OB(O)c1ccc(CC(=O)NCc2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C21H20BNO3/c24-21(14-16-8-12-20(13-9-16)22(25)26)23-15-17-6-10-19(11-7-17)18-4-2-1-3-5-18/h1-13,25-26H,14-15H2,(H,23,24)
Affinity DataIC50: 5.53E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150627(CHEMBL3769572)
Show SMILES OB(O)c1ccc(CNC(=O)c2ccc(cc2)-c2ccccc2)cc1
Show InChI InChI=1S/C20H18BNO3/c23-20(22-14-15-6-12-19(13-7-15)21(24)25)18-10-8-17(9-11-18)16-4-2-1-3-5-16/h1-13,24-25H,14H2,(H,22,23)
Affinity DataIC50: 7.11E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150522(CHEMBL3771315)
Show SMILES COc1cc(CNC(=O)Nc2ccc(cc2)C(C)(C)C)ccc1B(O)O
Show InChI InChI=1S/C19H25BN2O4/c1-19(2,3)14-6-8-15(9-7-14)22-18(23)21-12-13-5-10-16(20(24)25)17(11-13)26-4/h5-11,24-25H,12H2,1-4H3,(H2,21,22,23)
Affinity DataIC50: 8.11E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26134((4-nonylphenyl)boranediol | Phenylboronic Acid, 13)
Show SMILES CCCCCCCCCc1ccc(cc1)B(O)O
Show InChI InChI=1S/C15H25BO2/c1-2-3-4-5-6-7-8-9-14-10-12-15(13-11-14)16(17)18/h10-13,17-18H,2-9H2,1H3
Affinity DataIC50: 9.10E+3nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150580(CHEMBL3770113)
Show SMILES OB(O)c1ccc(cc1)C(=O)NCCc1ccc(O)cc1
Show InChI InChI=1S/C15H16BNO4/c18-14-7-1-11(2-8-14)9-10-17-15(19)12-3-5-13(6-4-12)16(20)21/h1-8,18,20-21H,9-10H2,(H,17,19)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM26132((4-phenylphenyl)boranediol | Phenylboronic Acid, 1...)
Show SMILES OB(O)c1ccc(cc1)-c1ccccc1
Show InChI InChI=1S/C12H11BO2/c14-13(15)12-8-6-11(7-9-12)10-4-2-1-3-5-10/h1-9,14-15H
Affinity DataIC50: 1.00E+4nMAssay Description:Antagonist activity at recombinant human TRPV1 channel expressed in HEK293 cells assessed as inhibition of capsiacin-induced Ca2+ flux preincubated f...More data for this Ligand-Target Pair
TargetFatty-acid amide hydrolase 1 [30-579](Rattus norvegicus (rat))
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50150635(CHEMBL3770337)
Show SMILES CC(C)(C)c1ccc(NC(=O)Cc2ccc(cc2)B(O)O)cc1
Show InChI InChI=1S/C18H22BNO3/c1-18(2,3)14-6-10-16(11-7-14)20-17(21)12-13-4-8-15(9-5-13)19(22)23/h4-11,22-23H,12H2,1-3H3,(H,20,21)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of rat brain FAAH assessed as hydrolysis of [14C]AEA to [14C]Ethanolamine incubated for 30 mins by scintillation counting methodMore data for this Ligand-Target Pair
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