Compile Data Set for Download or QSAR
Found 52 Enz. Inhib. hit(s) with all data for entry = 50047986
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200009(CHEMBL3923414)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCOCC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H27ClN6O5S/c1-14-21(29-22(26-14)17(13-20(23)27-29)25-7-6-24-15(2)30)16-4-5-18(33-3)19(12-16)35(31,32)28-8-10-34-11-9-28/h4-5,12-13,25H,6-11H2,1-3H3,(H,24,30)
Affinity DataIC50: 0.980nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200098(CHEMBL3930509)
Show SMILES COc1ccc(cc1S(=O)(=O)N(C)C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C20H25ClN6O4S/c1-12-19(14-6-7-16(31-5)17(10-14)32(29,30)26(3)4)27-20(24-12)15(11-18(21)25-27)23-9-8-22-13(2)28/h6-7,10-11,23H,8-9H2,1-5H3,(H,22,28)
Affinity DataIC50: 2.40nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200012(CHEMBL3958915)
Show SMILES CCC(CO)NS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCc3ccnc(CC)c3)cc(Cl)nn12
Show InChI InChI=1S/C26H31ClN6O4S/c1-5-19-11-17(9-10-28-19)14-29-21-13-24(27)31-33-25(16(3)30-26(21)33)18-7-8-22(37-4)23(12-18)38(35,36)32-20(6-2)15-34/h7-13,20,29,32,34H,5-6,14-15H2,1-4H3
Affinity DataIC50: 5.30nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 6.10nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199891(CHEMBL3920652)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCC(O)CC2)ccn1
Show InChI InChI=1S/C27H31ClN6O4S/c1-4-20-13-18(7-10-29-20)16-30-22-15-25(28)32-34-26(17(2)31-27(22)34)19-5-6-23(38-3)24(14-19)39(36,37)33-11-8-21(35)9-12-33/h5-7,10,13-15,21,30,35H,4,8-9,11-12,16H2,1-3H3
Affinity DataIC50: 6.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200000(CHEMBL3911522)
Show SMILES CCC(CO)NS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H29ClN6O5S/c1-5-16(12-30)28-35(32,33)19-10-15(6-7-18(19)34-4)21-13(2)26-22-17(11-20(23)27-29(21)22)25-9-8-24-14(3)31/h6-7,10-11,16,25,28,30H,5,8-9,12H2,1-4H3,(H,24,31)
Affinity DataIC50: 7.20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200097(CHEMBL3939697)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCC=C)ccn1
Show InChI InChI=1S/C25H27ClN6O3S/c1-5-10-29-36(33,34)22-13-18(7-8-21(22)35-4)24-16(3)30-25-20(14-23(26)31-32(24)25)28-15-17-9-11-27-19(6-2)12-17/h5,7-9,11-14,28-29H,1,6,10,15H2,2-4H3
Affinity DataIC50: 8.60nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199889(CHEMBL3957128)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCN(C)C)ccn1
Show InChI InChI=1S/C26H32ClN7O3S/c1-6-20-13-18(9-10-28-20)16-29-21-15-24(27)32-34-25(17(2)31-26(21)34)19-7-8-22(37-5)23(14-19)38(35,36)30-11-12-33(3)4/h7-10,13-15,29-30H,6,11-12,16H2,1-5H3
Affinity DataIC50: 9nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200004(CHEMBL3959713)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2cccc(c2)S(=O)(=O)N(C)C)ccn1
Show InChI InChI=1S/C23H25ClN6O2S/c1-5-18-11-16(9-10-25-18)14-26-20-13-21(24)28-30-22(15(2)27-23(20)30)17-7-6-8-19(12-17)33(31,32)29(3)4/h6-13,26H,5,14H2,1-4H3
Affinity DataIC50: 13nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199998(CHEMBL3902513)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCC(CO)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H31ClN6O5S/c1-15-23(31-24(28-15)19(13-22(25)29-31)27-9-8-26-16(2)33)18-4-5-20(36-3)21(12-18)37(34,35)30-10-6-17(14-32)7-11-30/h4-5,12-13,17,27,32H,6-11,14H2,1-3H3,(H,26,33)
Affinity DataIC50: 15nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200101(CHEMBL3947384)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NC2CCC(N)CC2)ccn1
Show InChI InChI=1S/C28H34ClN7O3S/c1-4-21-13-18(11-12-31-21)16-32-23-15-26(29)34-36-27(17(2)33-28(23)36)19-5-10-24(39-3)25(14-19)40(37,38)35-22-8-6-20(30)7-9-22/h5,10-15,20,22,32,35H,4,6-9,16,30H2,1-3H3
Affinity DataIC50: 16nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200005(CHEMBL3929556)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCOC)ccn1
Show InChI InChI=1S/C25H29ClN6O4S/c1-5-19-12-17(8-9-27-19)15-28-20-14-23(26)31-32-24(16(2)30-25(20)32)18-6-7-21(36-4)22(13-18)37(33,34)29-10-11-35-3/h6-9,12-14,28-29H,5,10-11,15H2,1-4H3
Affinity DataIC50: 17nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200105(CHEMBL3894217)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCOCC2)ccn1
Show InChI InChI=1S/C26H29ClN6O4S/c1-4-20-13-18(7-8-28-20)16-29-21-15-24(27)31-33-25(17(2)30-26(21)33)19-5-6-22(36-3)23(14-19)38(34,35)32-9-11-37-12-10-32/h5-8,13-15,29H,4,9-12,16H2,1-3H3
Affinity DataIC50: 18nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200103(CHEMBL3948449)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)n2cccn2)ccn1
Show InChI InChI=1S/C25H24ClN7O3S/c1-4-19-12-17(8-10-27-19)15-28-20-14-23(26)31-33-24(16(2)30-25(20)33)18-6-7-21(36-3)22(13-18)37(34,35)32-11-5-9-29-32/h5-14,28H,4,15H2,1-3H3
Affinity DataIC50: 19nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200096(CHEMBL3893537)
Show SMILES COc1ccc(cc1S(=O)(=O)NCC=C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H25ClN6O4S/c1-5-8-25-33(30,31)18-11-15(6-7-17(18)32-4)20-13(2)26-21-16(12-19(22)27-28(20)21)24-10-9-23-14(3)29/h5-7,11-12,24-25H,1,8-10H2,2-4H3,(H,23,29)
Affinity DataIC50: 20nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199892(CHEMBL3889874)
Show SMILES COc1ccc(cc1S(=O)(=O)NCCO)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C20H25ClN6O5S/c1-12-19(14-4-5-16(32-3)17(10-14)33(30,31)24-8-9-28)27-20(25-12)15(11-18(21)26-27)23-7-6-22-13(2)29/h4-5,10-11,23-24,28H,6-9H2,1-3H3,(H,22,29)
Affinity DataIC50: 22nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199996(CHEMBL3915835)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCc3ccncc3)cc(Cl)nn12
Show InChI InChI=1S/C21H21ClN6O2S/c1-14-20(16-5-4-6-17(11-16)31(29,30)27(2)3)28-21(25-14)18(12-19(22)26-28)24-13-15-7-9-23-10-8-15/h4-12,24H,13H2,1-3H3
Affinity DataIC50: 26nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199999(CHEMBL3986552)
Show SMILES COc1ccc(cc1S(=O)(=O)NC1CCC(N)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H32ClN7O4S/c1-14-23(32-24(29-14)19(13-22(25)30-32)28-11-10-27-15(2)33)16-4-9-20(36-3)21(12-16)37(34,35)31-18-7-5-17(26)6-8-18/h4,9,12-13,17-18,28,31H,5-8,10-11,26H2,1-3H3,(H,27,33)
Affinity DataIC50: 27nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200007(CHEMBL3925101)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N(C)C)ccn1
Show InChI InChI=1S/C24H27ClN6O3S/c1-6-18-11-16(9-10-26-18)14-27-19-13-22(25)29-31-23(15(2)28-24(19)31)17-7-8-20(34-5)21(12-17)35(32,33)30(3)4/h7-13,27H,6,14H2,1-5H3
Affinity DataIC50: 27nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200100(CHEMBL3905730)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCc3ccnc(C)c3)cc(Cl)nn12
Show InChI InChI=1S/C22H23ClN6O2S/c1-14-10-16(8-9-24-14)13-25-19-12-20(23)27-29-21(15(2)26-22(19)29)17-6-5-7-18(11-17)32(30,31)28(3)4/h5-12,25H,13H2,1-4H3
Affinity DataIC50: 34nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200104(CHEMBL3969997)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCC(CO)CC2)ccn1
Show InChI InChI=1S/C28H33ClN6O4S/c1-4-22-13-20(7-10-30-22)16-31-23-15-26(29)33-35-27(18(2)32-28(23)35)21-5-6-24(39-3)25(14-21)40(37,38)34-11-8-19(17-36)9-12-34/h5-7,10,13-15,19,31,36H,4,8-9,11-12,16-17H2,1-3H3
Affinity DataIC50: 42nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200001(CHEMBL3921556)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCC(O)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C23H29ClN6O5S/c1-14-22(30-23(27-14)18(13-21(24)28-30)26-9-8-25-15(2)31)16-4-5-19(35-3)20(12-16)36(33,34)29-10-6-17(32)7-11-29/h4-5,12-13,17,26,32H,6-11H2,1-3H3,(H,25,31)
Affinity DataIC50: 44nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199887(CHEMBL3914714)
Show SMILES CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C19H23ClN6O3S/c1-12-18(14-6-5-7-15(10-14)30(28,29)25(3)4)26-19(23-12)16(11-17(20)24-26)22-9-8-21-13(2)27/h5-7,10-11,22H,8-9H2,1-4H3,(H,21,27)
Affinity DataIC50: 54nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200008(CHEMBL3898792)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NC2CC2)ccn1
Show InChI InChI=1S/C25H27ClN6O3S/c1-4-18-11-16(9-10-27-18)14-28-20-13-23(26)30-32-24(15(2)29-25(20)32)17-5-8-21(35-3)22(12-17)36(33,34)31-19-6-7-19/h5,8-13,19,28,31H,4,6-7,14H2,1-3H3
Affinity DataIC50: 56nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199995(CHEMBL3938589)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)N2CCCCC2)ccn1
Show InChI InChI=1S/C27H31ClN6O3S/c1-4-21-14-19(10-11-29-21)17-30-22-16-25(28)32-34-26(18(2)31-27(22)34)20-8-9-23(37-3)24(15-20)38(35,36)33-12-6-5-7-13-33/h8-11,14-16,30H,4-7,12-13,17H2,1-3H3
Affinity DataIC50: 59nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200011(CHEMBL3933495)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCc3cccnc3)cc(Cl)nn12
Show InChI InChI=1S/C21H21ClN6O2S/c1-14-20(16-7-4-8-17(10-16)31(29,30)27(2)3)28-21(25-14)18(11-19(22)26-28)24-13-15-6-5-9-23-12-15/h4-12,24H,13H2,1-3H3
Affinity DataIC50: 75nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200010(CHEMBL3965171)
Show SMILES COc1ccc(cc1S(=O)(=O)NCCN(C)C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H30ClN7O4S/c1-14-21(30-22(27-14)17(13-20(23)28-30)25-9-8-24-15(2)31)16-6-7-18(34-5)19(12-16)35(32,33)26-10-11-29(3)4/h6-7,12-13,25-26H,8-11H2,1-5H3,(H,24,31)
Affinity DataIC50: 94nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199886(CHEMBL3939491)
Show SMILES COc1ccc(cc1S(=O)(=O)NC1CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H25ClN6O4S/c1-12-20(14-4-7-17(32-3)18(10-14)33(30,31)27-15-5-6-15)28-21(25-12)16(11-19(22)26-28)24-9-8-23-13(2)29/h4,7,10-11,15,24,27H,5-6,8-9H2,1-3H3,(H,23,29)
Affinity DataIC50: 106nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200095(CHEMBL3932492)
Show SMILES COCCNS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H27ClN6O5S/c1-13-20(15-5-6-17(33-4)18(11-15)34(30,31)25-9-10-32-3)28-21(26-13)16(12-19(22)27-28)24-8-7-23-14(2)29/h5-6,11-12,24-25H,7-10H2,1-4H3,(H,23,29)
Affinity DataIC50: 135nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199964(CHEMBL3924835)
Show SMILES Cl.CN(C)S(=O)(=O)c1cccc(c1)-c1c(C)nc2c(NCc3ccccn3)cc(Cl)nn12
Show InChI InChI=1S/C21H21ClN6O2S/c1-14-20(15-7-6-9-17(11-15)31(29,30)27(2)3)28-21(25-14)18(12-19(22)26-28)24-13-16-8-4-5-10-23-16/h4-12,24H,13H2,1-3H3
Affinity DataIC50: 145nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199997(CHEMBL3948269)
Show SMILES CNCCNS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H28ClN7O4S/c1-13-20(15-5-6-17(33-4)18(11-15)34(31,32)26-10-7-23-3)29-21(27-13)16(12-19(22)28-29)25-9-8-24-14(2)30/h5-6,11-12,23,25-26H,7-10H2,1-4H3,(H,24,30)
Affinity DataIC50: 147nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200002(CHEMBL3959992)
Show SMILES COc1ccc(cc1S(=O)(=O)n1cccn1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H22ClN7O4S/c1-13-20(29-21(26-13)16(12-19(22)27-29)24-9-8-23-14(2)30)15-5-6-17(33-3)18(11-15)34(31,32)28-10-4-7-25-28/h4-7,10-12,24H,8-9H2,1-3H3,(H,23,30)
Affinity DataIC50: 163nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200022(CHEMBL3978329)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCCCC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C23H29ClN6O4S/c1-15-22(30-23(27-15)18(14-21(24)28-30)26-10-9-25-16(2)31)17-7-8-19(34-3)20(13-17)35(32,33)29-11-5-4-6-12-29/h7-8,13-14,26H,4-6,9-12H2,1-3H3,(H,25,31)
Affinity DataIC50: 189nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199890(CHEMBL3942710)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)cc2)ccn1
Show InChI InChI=1S/C22H22ClN5O/c1-4-17-11-15(9-10-24-17)13-25-19-12-20(23)27-28-21(14(2)26-22(19)28)16-5-7-18(29-3)8-6-16/h5-12,25H,4,13H2,1-3H3
Affinity DataIC50: 444nMAssay Description:Inhibition of PI4KB (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199899(CHEMBL3901551)
Show SMILES CC(C)(C)OC(=O)CCNC(=O)Nc1nc2CCc3cnc(nc3-c2s1)-c1ccccc1Cl
Show InChI InChI=1S/C23H24ClN5O3S/c1-23(2,3)32-17(30)10-11-25-21(31)29-22-27-16-9-8-13-12-26-20(28-18(13)19(16)33-22)14-6-4-5-7-15(14)24/h4-7,12H,8-11H2,1-3H3,(H2,25,27,29,31)
Affinity DataIC50: 450nMAssay Description:Inhibition of N-terminal GST-tagged PI4KA (875 to 2044 residues) (unknown origin) expressed in Sf21 cells using soluble lipid PI-diC8 by fluorescence...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200101(CHEMBL3947384)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NC2CCC(N)CC2)ccn1
Show InChI InChI=1S/C28H34ClN7O3S/c1-4-21-13-18(11-12-31-21)16-32-23-15-26(29)34-36-27(17(2)33-28(23)36)19-5-10-24(39-3)25(14-19)40(37,38)35-22-8-6-20(30)7-9-22/h5,10-15,20,22,32,35H,4,6-9,16,30H2,1-3H3
Affinity DataIC50: 553nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199999(CHEMBL3986552)
Show SMILES COc1ccc(cc1S(=O)(=O)NC1CCC(N)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H32ClN7O4S/c1-14-23(32-24(29-14)19(13-22(25)30-32)28-11-10-27-15(2)33)16-4-9-20(36-3)21(12-16)37(34,35)31-18-7-5-17(26)6-8-18/h4,9,12-13,17-18,28,31H,5-8,10-11,26H2,1-3H3,(H,27,33)
Affinity DataIC50: 660nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199889(CHEMBL3957128)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCN(C)C)ccn1
Show InChI InChI=1S/C26H32ClN7O3S/c1-6-20-13-18(9-10-28-20)16-29-21-15-24(27)32-34-25(17(2)31-26(21)34)19-7-8-22(37-5)23(14-19)38(35,36)30-11-12-33(3)4/h7-10,13-15,29-30H,6,11-12,16H2,1-5H3
Affinity DataIC50: 1.13E+3nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200010(CHEMBL3965171)
Show SMILES COc1ccc(cc1S(=O)(=O)NCCN(C)C)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H30ClN7O4S/c1-14-21(30-22(27-14)17(13-20(23)28-30)25-9-8-24-15(2)31)16-6-7-18(34-5)19(12-16)35(32,33)26-10-11-29(3)4/h6-7,12-13,25-26H,8-11H2,1-5H3,(H,24,31)
Affinity DataIC50: 4.86E+3nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase beta(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199899(CHEMBL3901551)
Show SMILES CC(C)(C)OC(=O)CCNC(=O)Nc1nc2CCc3cnc(nc3-c2s1)-c1ccccc1Cl
Show InChI InChI=1S/C23H24ClN5O3S/c1-23(2,3)32-17(30)10-11-25-21(31)29-22-27-16-9-8-13-12-26-20(28-18(13)19(16)33-22)14-6-4-5-7-15(14)24/h4-7,12H,8-11H2,1-3H3,(H2,25,27,29,31)
Affinity DataIC50: 8.00E+3nMAssay Description:Inhibition of full length PI4KB (unknown origin) expressed in Sf21 cells using soluble lipid PI-diC8 by fluorescence polarization assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199998(CHEMBL3902513)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCC(CO)CC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C24H31ClN6O5S/c1-15-23(31-24(28-15)19(13-22(25)29-31)27-9-8-26-16(2)33)18-4-5-20(36-3)21(12-18)37(34,35)30-10-6-17(14-32)7-11-30/h4-5,12-13,17,27,32H,6-11,14H2,1-3H3,(H,26,33)
Affinity DataIC50: 8.19E+3nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kalpha (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kdelta (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kbeta (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase type 2-alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI4K2A (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of PI3Kgamma (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200000(CHEMBL3911522)
Show SMILES CCC(CO)NS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H29ClN6O5S/c1-5-16(12-30)28-35(32,33)19-10-15(6-7-18(19)34-4)21-13(2)26-22-17(11-20(23)27-29(21)22)25-9-8-24-14(3)31/h6-7,10-11,16,25,28,30H,5,8-9,12H2,1-4H3,(H,24,31)
Affinity DataIC50: 1.23E+4nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199888(CHEMBL3976651)
Show SMILES CCc1cc(CNc2cc(Cl)nn3c(c(C)nc23)-c2ccc(OC)c(c2)S(=O)(=O)NCCO)ccn1
Show InChI InChI=1S/C24H27ClN6O4S/c1-4-18-11-16(7-8-26-18)14-27-19-13-22(25)30-31-23(15(2)29-24(19)31)17-5-6-20(35-3)21(12-17)36(33,34)28-9-10-32/h5-8,11-13,27-28,32H,4,9-10,14H2,1-3H3
Affinity DataIC50: 1.34E+4nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50199997(CHEMBL3948269)
Show SMILES CNCCNS(=O)(=O)c1cc(ccc1OC)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C21H28ClN7O4S/c1-13-20(15-5-6-17(33-4)18(11-15)34(31,32)26-10-7-23-3)29-21(27-13)16(12-19(22)28-29)25-9-8-24-14(2)30/h5-6,11-12,23,25-26H,7-10H2,1-4H3,(H,24,30)
Affinity DataIC50: 1.71E+4nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
TargetPhosphatidylinositol 4-kinase alpha(Homo sapiens (Human))
Academy of Sciences of the Czech Republic

Curated by ChEMBL
LigandPNGBDBM50200009(CHEMBL3923414)
Show SMILES COc1ccc(cc1S(=O)(=O)N1CCOCC1)-c1c(C)nc2c(NCCNC(C)=O)cc(Cl)nn12
Show InChI InChI=1S/C22H27ClN6O5S/c1-14-21(29-22(26-14)17(13-20(23)27-29)25-7-6-24-15(2)30)16-4-5-18(33-3)19(12-16)35(31,32)28-8-10-34-11-9-28/h4-5,12-13,25H,6-11H2,1-3H3,(H,24,30)
Affinity DataIC50: 4.80E+4nMAssay Description:Inhibition of PI4KA (unknown origin) by ADP-Glo kinase assayMore data for this Ligand-Target Pair
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