Compile Data Set for Download or QSAR
Found 58 Enz. Inhib. hit(s) with all data for entry = 50048653
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50008735((+)-3-(tert-butyl)-(3S,4aS,13bS)-2,3,4,4a,8,9,13b,...)
Show SMILES CC(C)(C)[C@]1(O)CCN2C[C@H]3c4ccccc4CCc4cccc([C@@H]2C1)c34
Show InChI InChI=1S/C25H31NO/c1-24(2,3)25(27)13-14-26-16-21-19-9-5-4-7-17(19)11-12-18-8-6-10-20(23(18)21)22(26)15-25/h4-10,21-22,27H,11-16H2,1-3H3/t21-,22-,25-/m0/s1
Affinity DataIC50: 2nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM21398(4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...)
Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2
Affinity DataIC50: 6.60nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM31046(3-[4,5-dihydro-1H-imidazol-2-ylmethyl-(4-methylphe...)
Show SMILES Cc1ccc(cc1)N(CC1=NCCN1)c1cccc(O)c1
Show InChI InChI=1S/C17H19N3O/c1-13-5-7-14(8-6-13)20(12-17-18-9-10-19-17)15-3-2-4-16(21)11-15/h2-8,11,21H,9-10,12H2,1H3,(H,18,19)
Affinity DataIC50: 9nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026926(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C24H35N3O3/c1-30-21-9-3-2-8-20(21)26-16-14-25(15-17-26)12-6-7-13-27-22(28)18-24(19-23(27)29)10-4-5-11-24/h2-3,8-9H,4-7,10-19H2,1H3
Affinity DataIC50: 13nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026939(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3/c1-29-20-8-3-2-7-19(20)25-15-13-24(14-16-25)11-6-12-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8H,4-6,9-18H2,1H3
Affinity DataIC50: 19nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224641(CHEMBL305121)
Show SMILES Clc1cccc(c1)N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32ClN3O2/c24-19-6-5-7-20(16-19)26-14-12-25(13-15-26)10-3-4-11-27-21(28)17-23(18-22(27)29)8-1-2-9-23/h5-7,16H,1-4,8-15,17-18H2
Affinity DataIC50: 23nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224638(CHEMBL64084)
Show SMILES Cc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C24H35N3O2/c1-20-8-2-3-9-21(20)26-16-14-25(15-17-26)12-6-7-13-27-22(28)18-24(19-23(27)29)10-4-5-11-24/h2-3,8-9H,4-7,10-19H2,1H3
Affinity DataIC50: 44nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224633(CHEMBL64348)
Show SMILES [O-][N+](=O)c1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32N4O4/c28-21-17-23(9-3-4-10-23)18-22(29)26(21)12-6-5-11-24-13-15-25(16-14-24)19-7-1-2-8-20(19)27(30)31/h1-2,7-8H,3-6,9-18H2
Affinity DataIC50: 50nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026926(8-{4-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-butyl}-...)
Show SMILES COc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C24H35N3O3/c1-30-21-9-3-2-8-20(21)26-16-14-25(15-17-26)12-6-7-13-27-22(28)18-24(19-23(27)29)10-4-5-11-24/h2-3,8-9H,4-7,10-19H2,1H3
Affinity DataIC50: 51nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224573(CHEMBL292705)
Show SMILES COc1cccnc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H34N4O3/c1-30-19-7-6-10-24-22(19)26-15-13-25(14-16-26)11-4-5-12-27-20(28)17-23(18-21(27)29)8-2-3-9-23/h6-7,10H,2-5,8-9,11-18H2,1H3
Affinity DataIC50: 65nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50002338((Thioridazine)10-[2-(1-Methyl-piperidin-2-yl)-ethy...)
Show SMILES CSc1ccc2Sc3ccccc3N(CCC3CCCCN3C)c2c1
Show InChI InChI=1S/C21H26N2S2/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3
Affinity DataIC50: 85nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026917(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
Affinity DataIC50: 91nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026916(2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-2-a...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCCC3)C2=O)CC1
Show InChI InChI=1S/C22H31N3O3/c1-28-19-8-4-3-7-18(19)24-14-11-23(12-15-24)13-16-25-20(26)17-22(21(25)27)9-5-2-6-10-22/h3-4,7-8H,2,5-6,9-17H2,1H3
Affinity DataIC50: 92nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224631(CHEMBL59638)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C23H31N5O2/c24-18-19-6-5-9-25-22(19)27-14-12-26(13-15-27)10-3-4-11-28-20(29)16-23(17-21(28)30)7-1-2-8-23/h5-6,9H,1-4,7-8,10-17H2
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224636(CHEMBL64803)
Show SMILES Fc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32FN3O2/c24-19-7-1-2-8-20(19)26-15-13-25(14-16-26)11-5-6-12-27-21(28)17-23(18-22(27)29)9-3-4-10-23/h1-2,7-8H,3-6,9-18H2
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224633(CHEMBL64348)
Show SMILES [O-][N+](=O)c1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32N4O4/c28-21-17-23(9-3-4-10-23)18-22(29)26(21)12-6-5-11-24-13-15-25(16-14-24)19-7-1-2-8-20(19)27(30)31/h1-2,7-8H,3-6,9-18H2
Affinity DataIC50: 110nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-16-21(6-1-2-7-21)17-19(28)26(18)11-4-3-10-24-12-14-25(15-13-24)20-22-8-5-9-23-20/h5,8-9H,1-4,6-7,10-17H2
Affinity DataIC50: 120nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224573(CHEMBL292705)
Show SMILES COc1cccnc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H34N4O3/c1-30-19-7-6-10-24-22(19)26-15-13-25(14-16-26)11-4-5-12-27-20(28)17-23(18-21(27)29)8-2-3-9-23/h6-7,10H,2-5,8-9,11-18H2,1H3
Affinity DataIC50: 120nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224627(CHEMBL303078)
Show SMILES Clc1cccc(c1)N1CCN(CCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O2/c23-18-5-3-6-19(15-18)25-13-11-24(12-14-25)9-4-10-26-20(27)16-22(17-21(26)28)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
Affinity DataIC50: 150nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224641(CHEMBL305121)
Show SMILES Clc1cccc(c1)N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32ClN3O2/c24-19-6-5-7-20(16-19)26-14-12-25(13-15-26)10-3-4-11-27-21(28)17-23(18-22(27)29)8-1-2-9-23/h5-7,16H,1-4,8-15,17-18H2
Affinity DataIC50: 236nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026916(2-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-2-a...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCCC3)C2=O)CC1
Show InChI InChI=1S/C22H31N3O3/c1-28-19-8-4-3-7-18(19)24-14-11-23(12-15-24)13-16-25-20(26)17-22(21(25)27)9-5-2-6-10-22/h3-4,7-8H,2,5-6,9-17H2,1H3
Affinity DataIC50: 240nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224565(CHEMBL60154)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H32N4O2/c27-20-17-22(8-2-3-9-22)18-21(28)26(20)12-6-5-11-24-13-15-25(16-14-24)19-7-1-4-10-23-19/h1,4,7,10H,2-3,5-6,8-9,11-18H2
Affinity DataIC50: 275nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224585(CHEMBL303810)
Show SMILES Clc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H32ClN3O2/c24-19-7-1-2-8-20(19)26-15-13-25(14-16-26)11-5-6-12-27-21(28)17-23(18-22(27)29)9-3-4-10-23/h1-2,7-8H,3-6,9-18H2
Affinity DataIC50: 290nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224630(CHEMBL62967)
Show SMILES Cc1ccnc(n1)N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H33N5O2/c1-18-6-9-23-21(24-18)26-14-12-25(13-15-26)10-4-5-11-27-19(28)16-22(17-20(27)29)7-2-3-8-22/h6,9H,2-5,7-8,10-17H2,1H3
Affinity DataIC50: 350nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224631(CHEMBL59638)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C23H31N5O2/c24-18-19-6-5-9-25-22(19)27-14-12-26(13-15-27)10-3-4-11-28-20(29)16-23(17-21(28)30)7-1-2-8-23/h5-6,9H,1-4,7-8,10-17H2
Affinity DataIC50: 360nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224638(CHEMBL64084)
Show SMILES Cc1ccccc1N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C24H35N3O2/c1-20-8-2-3-9-21(20)26-16-14-25(15-17-26)12-6-7-13-27-22(28)18-24(19-23(27)29)10-4-5-11-24/h2-3,8-9H,4-7,10-19H2,1H3
Affinity DataIC50: 390nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026924(8-[4-(4-Phenyl-piperazin-1-yl)-butyl]-8-aza-spiro[...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C23H33N3O2/c27-21-18-23(10-4-5-11-23)19-22(28)26(21)13-7-6-12-24-14-16-25(17-15-24)20-8-2-1-3-9-20/h1-3,8-9H,4-7,10-19H2
Affinity DataIC50: 430nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026939(8-{3-[4-(2-Methoxy-phenyl)-piperazin-1-yl]-propyl}...)
Show SMILES COc1ccccc1N1CCN(CCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C23H33N3O3/c1-29-20-8-3-2-7-19(20)25-15-13-24(14-16-25)11-6-12-26-21(27)17-23(18-22(26)28)9-4-5-10-23/h2-3,7-8H,4-6,9-18H2,1H3
Affinity DataIC50: 430nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224634(CHEMBL58172)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CCC(C)(C)C2=O)CC1
Show InChI InChI=1S/C20H29N3O3/c1-20(2)9-8-18(24)23(19(20)25)15-12-21-10-13-22(14-11-21)16-6-4-5-7-17(16)26-3/h4-7H,8-15H2,1-3H3
Affinity DataIC50: 480nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224637(CHEMBL292730)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCN1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C22H29N5O2/c23-17-18-5-3-8-24-21(18)26-13-11-25(12-14-26)9-4-10-27-19(28)15-22(16-20(27)29)6-1-2-7-22/h3,5,8H,1-2,4,6-7,9-16H2
Affinity DataIC50: 540nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224628(CHEMBL60733)
Show SMILES O=C1CC2(CCCCCC2)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C22H33N5O2/c28-19-18-22(8-3-1-2-4-9-22)20(29)27(19)13-6-5-12-25-14-16-26(17-15-25)21-23-10-7-11-24-21/h7,10-11H,1-6,8-9,12-18H2
Affinity DataIC50: 570nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224632(CHEMBL62418)
Show SMILES O=C1CC2(CCCCC2)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-17-21(7-2-1-3-8-21)19(28)26(18)12-5-4-11-24-13-15-25(16-14-24)20-22-9-6-10-23-20/h6,9-10H,1-5,7-8,11-17H2
Affinity DataIC50: 630nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224640(CHEMBL61330)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ncccc1C#N
Show InChI InChI=1S/C21H27N5O2/c22-16-17-4-3-7-23-20(17)25-11-8-24(9-12-25)10-13-26-18(27)14-21(15-19(26)28)5-1-2-6-21/h3-4,7H,1-2,5-6,8-15H2
Affinity DataIC50: 640nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224730(CHEMBL64228)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC(C)(C)CC2=O)CC1
Show InChI InChI=1S/C20H29N3O3/c1-20(2)14-18(24)23(19(25)15-20)13-10-21-8-11-22(12-9-21)16-6-4-5-7-17(16)26-3/h4-7H,8-15H2,1-3H3
Affinity DataIC50: 660nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224567(CHEMBL60842)
Show SMILES CC12CC1(C)C(=O)N(CCCCN1CCN(CC1)c1ncccn1)C2=O
Show InChI InChI=1S/C19H27N5O2/c1-18-14-19(18,2)16(26)24(15(18)25)9-4-3-8-22-10-12-23(13-11-22)17-20-6-5-7-21-17/h5-7H,3-4,8-14H2,1-2H3
Affinity DataIC50: 680nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224629(CHEMBL302865)
Show SMILES O=C1CCC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C22H33N5O2/c28-19-6-9-22(7-1-2-8-22)18-20(29)27(19)13-4-3-12-25-14-16-26(17-15-25)21-23-10-5-11-24-21/h5,10-11H,1-4,6-9,12-18H2
Affinity DataIC50: 820nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50001884(2-[4-(4-Methyl-benzyl)-piperazin-1-yl]-1-(2-methyl...)
Show SMILES CN1CCN(CC1)C1=Nc2cc(Cl)ccc2Nc2ccccc12
Show InChI InChI=1S/C18H19ClN4/c1-22-8-10-23(11-9-22)18-14-4-2-3-5-15(14)20-16-7-6-13(19)12-17(16)21-18/h2-7,12,20H,8-11H2,1H3
Affinity DataIC50: 890nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224730(CHEMBL64228)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC(C)(C)CC2=O)CC1
Show InChI InChI=1S/C20H29N3O3/c1-20(2)14-18(24)23(19(25)15-20)13-10-21-8-11-22(12-9-21)16-6-4-5-7-17(16)26-3/h4-7H,8-15H2,1-3H3
Affinity DataIC50: 895nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224629(CHEMBL302865)
Show SMILES O=C1CCC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C22H33N5O2/c28-19-6-9-22(7-1-2-8-22)18-20(29)27(19)13-4-3-12-25-14-16-26(17-15-25)21-23-10-5-11-24-21/h5,10-11H,1-4,6-9,12-18H2
Affinity DataIC50: 930nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224565(CHEMBL60154)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCCCN1CCN(CC1)c1ccccn1
Show InChI InChI=1S/C22H32N4O2/c27-20-17-22(8-2-3-9-22)18-21(28)26(20)12-6-5-11-24-13-15-25(16-14-24)19-7-1-4-10-23-19/h1,4,7,10H,2-3,5-6,8-9,11-18H2
Affinity DataIC50: 960nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224634(CHEMBL58172)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CCC(C)(C)C2=O)CC1
Show InChI InChI=1S/C20H29N3O3/c1-20(2)9-8-18(24)23(19(20)25)15-12-21-10-13-22(14-11-21)16-6-4-5-7-17(16)26-3/h4-7H,8-15H2,1-3H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224642(CHEMBL61272)
Show SMILES O=C1C2C(C3CCC2C=C3)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C22H29N5O2/c28-20-18-16-4-5-17(7-6-16)19(18)21(29)27(20)11-2-1-10-25-12-14-26(15-13-25)22-23-8-3-9-24-22/h3-5,8-9,16-19H,1-2,6-7,10-15H2
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026928(8-[2-(4-Phenyl-piperazin-1-yl)-ethyl]-8-aza-spiro[...)
Show SMILES O=C1CC2(CCCC2)CC(=O)N1CCN1CCN(CC1)c1ccccc1
Show InChI InChI=1S/C21H29N3O2/c25-19-16-21(8-4-5-9-21)17-20(26)24(19)15-12-22-10-13-23(14-11-22)18-6-2-1-3-7-18/h1-3,6-7H,4-5,8-17H2
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224630(CHEMBL62967)
Show SMILES Cc1ccnc(n1)N1CCN(CCCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H33N5O2/c1-18-6-9-23-21(24-18)26-14-12-25(13-15-26)10-4-5-11-27-19(28)16-22(17-20(27)29)7-2-3-8-22/h6,9H,2-5,7-8,10-17H2,1H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224627(CHEMBL303078)
Show SMILES Clc1cccc(c1)N1CCN(CCCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H30ClN3O2/c23-18-5-3-6-19(15-18)25-13-11-24(12-14-25)9-4-10-26-20(27)16-22(17-21(26)28)7-1-2-8-22/h3,5-6,15H,1-2,4,7-14,16-17H2
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224639(CHEMBL59643)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCCCCC3)C2=O)CC1
Show InChI InChI=1S/C24H35N3O3/c1-30-21-10-6-5-9-20(21)26-16-13-25(14-17-26)15-18-27-22(28)19-24(23(27)29)11-7-3-2-4-8-12-24/h5-6,9-10H,2-4,7-8,11-19H2,1H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224632(CHEMBL62418)
Show SMILES O=C1CC2(CCCCC2)C(=O)N1CCCCN1CCN(CC1)c1ncccn1
Show InChI InChI=1S/C21H31N5O2/c27-18-17-21(7-2-1-3-8-21)19(28)26(18)12-5-4-11-24-13-15-25(16-14-24)20-22-9-6-10-23-20/h6,9-10H,1-5,7-8,11-17H2
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50224789(CHEMBL293962)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)C(C)CC(C)C2=O)CC1
Show InChI InChI=1S/C20H29N3O3/c1-15-14-16(2)20(25)23(19(15)24)13-10-21-8-11-22(12-9-21)17-6-4-5-7-18(17)26-3/h4-7,15-16H,8-14H2,1-3H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
TargetAlpha-1A/Alpha-1B/Alpha-1D adrenergic receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50026917(8-(2-(4-(2-methoxyphenyl)piperazin-1-yl)ethyl)-8-a...)
Show SMILES COc1ccccc1N1CCN(CCN2C(=O)CC3(CCCC3)CC2=O)CC1
Show InChI InChI=1S/C22H31N3O3/c1-28-19-7-3-2-6-18(19)24-13-10-23(11-14-24)12-15-25-20(26)16-22(17-21(25)27)8-4-5-9-22/h2-3,6-7H,4-5,8-17H2,1H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]WB-4101 binding to alpha-1-adrenergic receptor from rat cerebral cortex membranesMore data for this Ligand-Target Pair
TargetD(1A)/D(1B)/D(2)/D(3)/D(4) dopamine receptor(Rattus norvegicus (rat))
TBA

Curated by ChEMBL
LigandPNGBDBM50005132(4,4-Dimethyl-1-[4-(4-pyrimidin-2-yl-piperazin-1-yl...)
Show SMILES CC1(C)CC(=O)N(CCCCN2CCN(CC2)c2ncccn2)C(=O)C1
Show InChI InChI=1S/C19H29N5O2/c1-19(2)14-16(25)24(17(26)15-19)9-4-3-8-22-10-12-23(13-11-22)18-20-6-5-7-21-18/h5-7H,3-4,8-15H2,1-2H3
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of [3H]spiperone binding to dopamine receptor from rat corpus striatal membranesMore data for this Ligand-Target Pair
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