Compile Data Set for Download or QSAR
Found 6 Enz. Inhib. hit(s) with all data for entry = 6108
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109200(US8604028, 56)
Show SMILES CC1=NC(C)=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1
Show InChI InChI=1S/C16H13N5O/c1-8-11(7-17)14(15(19-3)9(2)21-8)13-6-10-12(22-13)4-5-20-16(10)18/h4-6,11,14H,1-2H3,(H2,18,20)
Affinity DataIC50: 23nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109201(US8604028, 57)
Show SMILES CC1=NC(C(F)F)=C(C#N)C(C1[N+]#[C-])c1cc2c(N)nccc2o1
Show InChI InChI=1S/C16H11F2N5O/c1-7-13(21-2)12(9(6-19)14(23-7)15(17)18)11-5-8-10(24-11)3-4-22-16(8)20/h3-5,12-13,15H,1H3,(H2,20,22)
Affinity DataIC50: 37nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109202(US8604028, 61)
Show SMILES CC1=NC(=C([N+]#[C-])C(C1C#N)c1cc2c(N)nccc2o1)c1ccc(Cl)cc1
Show InChI InChI=1S/C21H14ClN5O/c1-11-15(10-23)18(17-9-14-16(28-17)7-8-26-21(14)24)20(25-2)19(27-11)12-3-5-13(22)6-4-12/h3-9,15,18H,1H3,(H2,24,26)
Affinity DataIC50: 43nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109203(US8604028, 65)
Show SMILES CC1=NC2=C(C(C1[N+]#[C-])c1cc3c(NC(=O)c4ccccc4)nccc3o1)C(=O)OC2
Show InChI InChI=1S/C23H16N4O4/c1-12-20(24-2)19(18-15(26-12)11-30-23(18)29)17-10-14-16(31-17)8-9-25-21(14)27-22(28)13-6-4-3-5-7-13/h3-10,19-20H,11H2,1H3,(H,25,27,28)
Affinity DataIC50: 142nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109205(US8604028, 72)
Show SMILES Nc1nccc2oc(cc12)[C@@H]1C2C(=O)OCC2=NC(=C1[N+]#[C-])c1ccc(Cl)cc1
Show InChI InChI=1S/C21H13ClN4O3/c1-24-19-17(15-8-12-14(29-15)6-7-25-20(12)23)16-13(9-28-21(16)27)26-18(19)10-2-4-11(22)5-3-10/h2-8,16-17H,9H2,(H2,23,25)/t16?,17-/m1/s1
Affinity DataIC50: 260nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109204(US8604028, 70)
Show SMILES CC1=C(C#N)[C@@H](c2cc3c(N)nccc3o2)C([N+]#[C-])=C2COCCN12
Show InChI InChI=1S/C18H15N5O2/c1-10-12(8-19)16(17(21-2)13-9-24-6-5-23(10)13)15-7-11-14(25-15)3-4-22-18(11)20/h3-4,7,16H,5-6,9H2,1H3,(H2,20,22)/t16-/m0/s1
Affinity DataIC50: 610nMpH: 7.0 T: 2°CAssay Description:Tyrosine kinase activity assay (NADH Read-Out)using human c-Met protein (Invitrogen, Carlsbad, Calif., USA). The amount of phosphorylated substrate ...More data for this Ligand-Target Pair