Compile Data Set for Download or QSAR
Found 8 Enz. Inhib. hit(s) with all data for entry = 6113
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109268(US8609698, 10)
Show SMILES OC(=O)c1ccc(nc1)-n1[nH]cc(-c2cncc(Br)c2)c1=O
Show InChI InChI=1S/C14H9BrN4O3/c15-10-3-9(4-16-6-10)11-7-18-19(13(11)20)12-2-1-8(5-17-12)14(21)22/h1-7,18H,(H,21,22)
Affinity DataIC50: 260nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109271(US8609698, 65)
Show SMILES Clc1cccc(Cl)c1NC(=O)NCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C21H16Cl2N6O2/c22-16-4-1-5-17(23)19(16)28-21(31)26-10-13-6-8-25-18(9-13)29-20(30)15(12-27-29)14-3-2-7-24-11-14/h1-9,11-12,27H,10H2,(H2,26,28,31)
Affinity DataIC50: 900nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109269(US8609698, 18)
Show SMILES CC(C)(C)NC(=O)c1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H19N5O2/c1-18(2,3)22-16(24)13-6-7-15(20-10-13)23-17(25)14(11-21-23)12-5-4-8-19-9-12/h4-11,21H,1-3H3,(H,22,24)
Affinity DataIC50: 910nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109272(US8609698, 80)
Show SMILES Cc1ccccc1NC(=O)OCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C22H19N5O3/c1-15-5-2-3-7-19(15)26-22(29)30-14-16-8-9-20(24-11-16)27-21(28)18(13-25-27)17-6-4-10-23-12-17/h2-13,25H,14H2,1H3,(H,26,29)
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109270(US8609698, 22)
Show SMILES O=c1c(c[nH]n1-c1ccc(Cn2cccc2)cn1)-c1cccnc1
Show InChI InChI=1S/C18H15N5O/c24-18-16(15-4-3-7-19-11-15)12-21-23(18)17-6-5-14(10-20-17)13-22-8-1-2-9-22/h1-12,21H,13H2
Affinity DataIC50: 3.24E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109273(US8609698, 89)
Show SMILES CC(C)(C)COc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C18H20N4O2/c1-18(2,3)12-24-14-6-7-16(20-10-14)22-17(23)15(11-21-22)13-5-4-8-19-9-13/h4-11,21H,12H2,1-3H3
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109267(US8609698, 8)
Show SMILES Cc1ccnc(c1)-n1[nH]cc(-c2cncc(c2)C#N)c1=O
Show InChI InChI=1S/C15H11N5O/c1-10-2-3-18-14(4-10)20-15(21)13(9-19-20)12-5-11(6-16)7-17-8-12/h2-5,7-9,19H,1H3
Affinity DataIC50: 5.20E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair
TargetTransmembrane prolyl 4-hydroxylase(Homo sapiens (Human))
Bayer Intellectual Property GmbH

US Patent
LigandPNGBDBM109266(US8609698, 5)
Show SMILES COCCNCc1ccc(nc1)-n1[nH]cc(-c2cccnc2)c1=O
Show InChI InChI=1S/C17H19N5O2/c1-24-8-7-19-9-13-4-5-16(20-10-13)22-17(23)15(12-21-22)14-3-2-6-18-11-14/h2-6,10-12,19,21H,7-9H2,1H3
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of the Activity of HIF Prolyl Hydroxylase is carried out as described [Oehme F., Jonghaus W., Narouz-Ott L., Huetter J., Flamme I., Anal. ...More data for this Ligand-Target Pair