Compile Data Set for Download or QSAR
Found 43 Enz. Inhib. hit(s) with all data for entry = 8181
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47165(US8957103, C1 | US9364459, I)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCO)c2ccccc12
Show InChI InChI=1S/C24H24N2O6/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)25-23(20)28)16-13-26(9-6-10-27)17-8-5-4-7-15(16)17/h4-5,7-8,11-13,27H,6,9-10H2,1-3H3,(H,25,28,29)
Affinity DataIC50: 2nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235821(US9364459, H)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCO)c2ccccc12
Show InChI InChI=1S/C23H22N2O6/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)24-22(19)27)15-12-25(8-9-26)16-7-5-4-6-14(15)16/h4-7,10-12,26H,8-9H2,1-3H3,(H,24,27,28)
Affinity DataIC50: 3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399331(CHEMBL2180882 | US9364459, C)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cnccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-8-22-13-9-21-5-4-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 10nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399333(CHEMBL2177142 | US9364459, D)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccncc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-9-22-13-4-5-21-8-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 23nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399334(CHEMBL2180878 | US9364459, B)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ncccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)17(13)28-3)15-16(20(25)23-19(15)24)12-9-22-18-11(12)5-4-6-21-18/h4-9H,1-3H3,(H,21,22)(H,23,24,25)
Affinity DataIC50: 37nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399331(CHEMBL2180882 | US9364459, C)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cnccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-8-22-13-9-21-5-4-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 48nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399333(CHEMBL2177142 | US9364459, D)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccncc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-9-22-13-4-5-21-8-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 50nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 90nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235820(US9364459, G)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH3+])c2ccccc12
Show InChI InChI=1S/C24H25N3O5/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)26-23(20)28)16-13-27(10-6-9-25)17-8-5-4-7-15(16)17/h4-5,7-8,11-13H,6,9-10,25H2,1-3H3,(H,26,28,29)/p+1
Affinity DataIC50: 129nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399334(CHEMBL2180878 | US9364459, B)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ncccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)17(13)28-3)15-16(20(25)23-19(15)24)12-9-22-18-11(12)5-4-6-21-18/h4-9H,1-3H3,(H,21,22)(H,23,24,25)
Affinity DataIC50: 132nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235821(US9364459, H)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCO)c2ccccc12
Show InChI InChI=1S/C23H22N2O6/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)24-22(19)27)15-12-25(8-9-26)16-7-5-4-6-14(15)16/h4-7,10-12,26H,8-9H2,1-3H3,(H,24,27,28)
Affinity DataIC50: 153nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 166nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50309549(3-(5-Fluoro-1H-indol-3-yl)-4-(3,4,5-trimethoxyphen...)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccc(F)cc12
Show InChI InChI=1S/C21H17FN2O5/c1-27-15-6-10(7-16(28-2)19(15)29-3)17-18(21(26)24-20(17)25)13-9-23-14-5-4-11(22)8-12(13)14/h4-9,23H,1-3H3,(H,24,25,26)
Affinity DataIC50: 182nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235819(US9364459, F)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CC[NH3+])c2ccccc12
Show InChI InChI=1S/C23H23N3O5/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)25-22(19)27)15-12-26(9-8-24)16-7-5-4-6-14(15)16/h4-7,10-12H,8-9,24H2,1-3H3,(H,25,27,28)/p+1
Affinity DataIC50: 195nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399332(CHEMBL2180881 | US9364459, E)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cccnc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)18(13)28-3)15-16(20(25)23-19(15)24)11-9-22-12-5-4-6-21-17(11)12/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 215nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235819(US9364459, F)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CC[NH3+])c2ccccc12
Show InChI InChI=1S/C23H23N3O5/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)25-22(19)27)15-12-26(9-8-24)16-7-5-4-6-14(15)16/h4-7,10-12H,8-9,24H2,1-3H3,(H,25,27,28)/p+1
Affinity DataIC50: 227nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399332(CHEMBL2180881 | US9364459, E)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cccnc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)18(13)28-3)15-16(20(25)23-19(15)24)11-9-22-12-5-4-6-21-17(11)12/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 373nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235821(US9364459, H)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCO)c2ccccc12
Show InChI InChI=1S/C23H22N2O6/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)24-22(19)27)15-12-25(8-9-26)16-7-5-4-6-14(15)16/h4-7,10-12,26H,8-9H2,1-3H3,(H,24,27,28)
Affinity DataIC50: 554nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47165(US8957103, C1 | US9364459, I)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCO)c2ccccc12
Show InChI InChI=1S/C24H24N2O6/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)25-23(20)28)16-13-26(9-6-10-27)17-8-5-4-7-15(16)17/h4-5,7-8,11-13,27H,6,9-10H2,1-3H3,(H,25,28,29)
Affinity DataIC50: 556nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235825(US9364459, M)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C27H29N3O6/c1-33-21-14-17(15-22(34-2)25(21)35-3)23-24(27(32)28-26(23)31)19-16-30(20-7-5-4-6-18(19)20)9-8-29-10-12-36-13-11-29/h4-7,14-16H,8-13H2,1-3H3,(H,28,31,32)
Affinity DataIC50: 657nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47165(US8957103, C1 | US9364459, I)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCO)c2ccccc12
Show InChI InChI=1S/C24H24N2O6/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)25-23(20)28)16-13-26(9-6-10-27)17-8-5-4-7-15(16)17/h4-5,7-8,11-13,27H,6,9-10H2,1-3H3,(H,25,28,29)
Affinity DataIC50: 920nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235820(US9364459, G)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH3+])c2ccccc12
Show InChI InChI=1S/C24H25N3O5/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)26-23(20)28)16-13-27(10-6-9-25)17-8-5-4-7-15(16)17/h4-5,7-8,11-13H,6,9-10,25H2,1-3H3,(H,26,28,29)/p+1
Affinity DataIC50: 1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235823(US9364459, K)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C26H29N3O5/c1-28(2)11-8-12-29-15-18(17-9-6-7-10-19(17)29)23-22(25(30)27-26(23)31)16-13-20(32-3)24(34-5)21(14-16)33-4/h6-7,9-10,13-15H,8,11-12H2,1-5H3,(H,27,30,31)
Affinity DataIC50: 1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235824(US9364459, L)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCCCC2)c2ccccc12
Show InChI InChI=1S/C28H31N3O5/c1-34-22-15-18(16-23(35-2)26(22)36-3)24-25(28(33)29-27(24)32)20-17-31(21-10-6-5-9-19(20)21)14-13-30-11-7-4-8-12-30/h5-6,9-10,15-17H,4,7-8,11-14H2,1-3H3,(H,29,32,33)
Affinity DataIC50: 1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235822(US9364459, J)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN(C)C)c2ccccc12
Show InChI InChI=1S/C25H27N3O5/c1-27(2)10-11-28-14-17(16-8-6-7-9-18(16)28)22-21(24(29)26-25(22)30)15-12-19(31-3)23(33-5)20(13-15)32-4/h6-9,12-14H,10-11H2,1-5H3,(H,26,29,30)
Affinity DataIC50: 1.00E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM47167(CHEMBL201511 | US8957103, Z1 | US9364459, A)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccccc12
Show InChI InChI=1S/C21H18N2O5/c1-26-15-8-11(9-16(27-2)19(15)28-3)17-18(21(25)23-20(17)24)13-10-22-14-7-5-4-6-12(13)14/h4-10,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 1.10E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235824(US9364459, L)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCCCC2)c2ccccc12
Show InChI InChI=1S/C28H31N3O5/c1-34-22-15-18(16-23(35-2)26(22)36-3)24-25(28(33)29-27(24)32)20-17-31(21-10-6-5-9-19(20)21)14-13-30-11-7-4-8-12-30/h5-6,9-10,15-17H,4,7-8,11-14H2,1-3H3,(H,29,32,33)
Affinity DataIC50: 1.21E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235824(US9364459, L)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCCCC2)c2ccccc12
Show InChI InChI=1S/C28H31N3O5/c1-34-22-15-18(16-23(35-2)26(22)36-3)24-25(28(33)29-27(24)32)20-17-31(21-10-6-5-9-19(20)21)14-13-30-11-7-4-8-12-30/h5-6,9-10,15-17H,4,7-8,11-14H2,1-3H3,(H,29,32,33)
Affinity DataIC50: 1.24E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235822(US9364459, J)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN(C)C)c2ccccc12
Show InChI InChI=1S/C25H27N3O5/c1-27(2)10-11-28-14-17(16-8-6-7-9-18(16)28)22-21(24(29)26-25(22)30)15-12-19(31-3)23(33-5)20(13-15)32-4/h6-9,12-14H,10-11H2,1-5H3,(H,26,29,30)
Affinity DataIC50: 1.30E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235820(US9364459, G)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH3+])c2ccccc12
Show InChI InChI=1S/C24H25N3O5/c1-30-18-11-14(12-19(31-2)22(18)32-3)20-21(24(29)26-23(20)28)16-13-27(10-6-9-25)17-8-5-4-7-15(16)17/h4-5,7-8,11-13H,6,9-10,25H2,1-3H3,(H,26,28,29)/p+1
Affinity DataIC50: 1.50E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399332(CHEMBL2180881 | US9364459, E)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cccnc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)18(13)28-3)15-16(20(25)23-19(15)24)11-9-22-12-5-4-6-21-17(11)12/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 1.52E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235823(US9364459, K)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C26H29N3O5/c1-28(2)11-8-12-29-15-18(17-9-6-7-10-19(17)29)23-22(25(30)27-26(23)31)16-13-20(32-3)24(34-5)21(14-16)33-4/h6-7,9-10,13-15H,8,11-12H2,1-5H3,(H,27,30,31)
Affinity DataIC50: 1.53E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235819(US9364459, F)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CC[NH3+])c2ccccc12
Show InChI InChI=1S/C23H23N3O5/c1-29-17-10-13(11-18(30-2)21(17)31-3)19-20(23(28)25-22(19)27)15-12-26(9-8-24)16-7-5-4-6-14(15)16/h4-7,10-12H,8-9,24H2,1-3H3,(H,25,27,28)/p+1
Affinity DataIC50: 1.89E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399331(CHEMBL2180882 | US9364459, C)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2cnccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-8-22-13-9-21-5-4-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 1.90E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235826(US9364459, N)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH+]2CC[NH+](C)CC2)c2ccccc12
Show InChI InChI=1S/C29H34N4O5/c1-31-12-14-32(15-13-31)10-7-11-33-18-21(20-8-5-6-9-22(20)33)26-25(28(34)30-29(26)35)19-16-23(36-2)27(38-4)24(17-19)37-3/h5-6,8-9,16-18H,7,10-15H2,1-4H3,(H,30,34,35)/p+2
Affinity DataIC50: 2.83E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235826(US9364459, N)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH+]2CC[NH+](C)CC2)c2ccccc12
Show InChI InChI=1S/C29H34N4O5/c1-31-12-14-32(15-13-31)10-7-11-33-18-21(20-8-5-6-9-22(20)33)26-25(28(34)30-29(26)35)19-16-23(36-2)27(38-4)24(17-19)37-3/h5-6,8-9,16-18H,7,10-15H2,1-4H3,(H,30,34,35)/p+2
Affinity DataIC50: 3.24E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235822(US9364459, J)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN(C)C)c2ccccc12
Show InChI InChI=1S/C25H27N3O5/c1-27(2)10-11-28-14-17(16-8-6-7-9-18(16)28)22-21(24(29)26-25(22)30)15-12-19(31-3)23(33-5)20(13-15)32-4/h6-9,12-14H,10-11H2,1-5H3,(H,26,29,30)
Affinity DataIC50: 3.58E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399333(CHEMBL2177142 | US9364459, D)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ccncc12
Show InChI InChI=1S/C20H17N3O5/c1-26-14-6-10(7-15(27-2)18(14)28-3)16-17(20(25)23-19(16)24)12-9-22-13-4-5-21-8-11(12)13/h4-9,22H,1-3H3,(H,23,24,25)
Affinity DataIC50: 6.27E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235825(US9364459, M)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C27H29N3O6/c1-33-21-14-17(15-22(34-2)25(21)35-3)23-24(27(32)28-26(23)31)19-16-30(20-7-5-4-6-18(19)20)9-8-29-10-12-36-13-11-29/h4-7,14-16H,8-13H2,1-3H3,(H,28,31,32)
Affinity DataIC50: 9.20E+3nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetGlycogen synthase kinase-3 beta(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM50399334(CHEMBL2180878 | US9364459, B)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1c[nH]c2ncccc12
Show InChI InChI=1S/C20H17N3O5/c1-26-13-7-10(8-14(27-2)17(13)28-3)15-16(20(25)23-19(15)24)12-9-22-18-11(12)5-4-6-21-18/h4-9H,1-3H3,(H,21,22)(H,23,24,25)
Affinity DataIC50: 1.00E+4nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235826(US9364459, N)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCC[NH+]2CC[NH+](C)CC2)c2ccccc12
Show InChI InChI=1S/C29H34N4O5/c1-31-12-14-32(15-13-31)10-7-11-33-18-21(20-8-5-6-9-22(20)33)26-25(28(34)30-29(26)35)19-16-23(36-2)27(38-4)24(17-19)37-3/h5-6,8-9,16-18H,7,10-15H2,1-4H3,(H,30,34,35)/p+2
Affinity DataIC50: 1.00E+4nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235825(US9364459, M)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCN2CCOCC2)c2ccccc12
Show InChI InChI=1S/C27H29N3O6/c1-33-21-14-17(15-22(34-2)25(21)35-3)23-24(27(32)28-26(23)31)19-16-30(20-7-5-4-6-18(19)20)9-8-29-10-12-36-13-11-29/h4-7,14-16H,8-13H2,1-3H3,(H,28,31,32)
Affinity DataIC50: 1.00E+4nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Johannes Gutenberg-Universität Mainz

US Patent
LigandPNGBDBM235823(US9364459, K)
Show SMILES COc1cc(cc(OC)c1OC)C1=C(C(=O)NC1=O)c1cn(CCCN(C)C)c2ccccc12
Show InChI InChI=1S/C26H29N3O5/c1-28(2)11-8-12-29-15-18(17-9-6-7-10-19(17)29)23-22(25(30)27-26(23)31)16-13-20(32-3)24(34-5)21(14-16)33-4/h6-7,9-10,13-15H,8,11-12H2,1-5H3,(H,27,30,31)
Affinity DataIC50: 1.00E+4nMAssay Description:The effect of test compounds on the activity of the protein kinases GSK-3β, VEGFR-2 and FLT-3 was evaluated based on half maximal inhibitory con...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid