Compile Data Set for Download or QSAR
Found 111 Enz. Inhib. hit(s) with all data for entry = 8467
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250600(US10167273, Example 79 | US10544126, Example 79 | ...)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-9-7-15(8-10-23)11-16-5-6-17(20)12-18(16)26-4/h5-6,12,15H,7-11H2,1-4H3
Affinity DataIC50: 50nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250620(US10167273, Example 99 | US10544126, Example 99 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C19H26ClN3O3S/c1-13-19(14(2)22(3)21-13)27(24,25)23-11-9-16(10-12-23)18(26-4)15-5-7-17(20)8-6-15/h5-8,16,18H,9-12H2,1-4H3
Affinity DataIC50: 60nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250599(US10167273, Example 78 | US10544126, Example 78 | ...)
Show SMILES COc1cc(Cl)ccc1CC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-18(13(2)21-20-12)26(23,24)22-8-6-14(7-9-22)10-15-4-5-16(19)11-17(15)25-3/h4-5,11,14H,6-10H2,1-3H3,(H,20,21)
Affinity DataIC50: 70nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250617(US10167273, Example 98 | US10544126, Example 96 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Affinity DataIC50: 80nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250612(US10167273, Example 91 | US10544126, Example 91 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H25ClFN3O3S/c1-13-18(14(2)23(3)22-13)28(25,26)24-9-7-19(21,8-10-24)12-15-5-6-16(20)11-17(15)27-4/h5-6,11H,7-10,12H2,1-4H3
Affinity DataIC50: 140nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250617(US10167273, Example 98 | US10544126, Example 96 | ...)
Show SMILES COC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Affinity DataIC50: 160nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250611(US10167273, Example 90 | US10544126, Example 90 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(F)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H23ClFN3O3S/c1-12-17(13(2)22-21-12)27(24,25)23-8-6-18(20,7-9-23)11-14-4-5-15(19)10-16(14)26-3/h4-5,10H,6-9,11H2,1-3H3,(H,21,22)
Affinity DataIC50: 170nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250595(US10167273, Example 74 | US10544126, Example 74 | ...)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-18(13(2)21(3)20-12)27(23,24)22-9-7-15(8-10-22)26-16-6-5-14(19)11-17(16)25-4/h5-6,11,15H,7-10H2,1-4H3
Affinity DataIC50: 170nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250594(US10167273, Example 73 | US10544126, Example 73 | ...)
Show SMILES COc1cc(Cl)ccc1OC1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C17H22ClN3O4S/c1-11-17(12(2)20-19-11)26(22,23)21-8-6-14(7-9-21)25-15-5-4-13(18)10-16(15)24-3/h4-5,10,14H,6-9H2,1-3H3,(H,19,20)
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250609(US10167273, Example 88 | US10544126, Example 88 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C19H26ClN3O4S/c1-13-18(14(2)22(3)21-13)28(25,26)23-9-7-19(24,8-10-23)12-15-5-6-16(20)11-17(15)27-4/h5-6,11,24H,7-10,12H2,1-4H3
Affinity DataIC50: 200nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250561(US10167273, Example 40 | US10544126, Example 40 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C17H19ClF3N3O3S/c1-10-16(11(2)23-22-10)28(25,26)24-7-5-13(6-8-24)27-15-4-3-12(18)9-14(15)17(19,20)21/h3-4,9,13H,5-8H2,1-2H3,(H,22,23)
Affinity DataIC50: 210nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250560(US10167273, Example 39 | US10544126, Example 39 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C(F)(F)F
Show InChI InChI=1S/C18H21ClF3N3O3S/c1-11-17(12(2)24(3)23-11)29(26,27)25-8-6-14(7-9-25)28-16-5-4-13(19)10-15(16)18(20,21)22/h4-5,10,14H,6-9H2,1-3H3
Affinity DataIC50: 210nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250544(US10167273, Example 23 | US10544126, Example 23 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C21H25N3O3S/c1-15-21(16(2)23(3)22-15)28(25,26)24-12-10-19(11-13-24)27-20-9-8-17-6-4-5-7-18(17)14-20/h4-9,14,19H,10-13H2,1-3H3
Affinity DataIC50: 220nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250555(US10167273, Example 34 | US10544126, Example 34 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C17H19ClN4O3S/c1-11-17(12(2)21-20-11)26(23,24)22-7-5-15(6-8-22)25-16-4-3-14(18)9-13(16)10-19/h3-4,9,15H,5-8H2,1-2H3,(H,20,21)
Affinity DataIC50: 240nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250626(US10167273, Example 107 | US10544126, Example 107 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
Affinity DataIC50: 310nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250552(US10167273, Example 31 | US10544126, Example 31 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1C#N
Show InChI InChI=1S/C18H21ClN4O3S/c1-12-18(13(2)22(3)21-12)27(24,25)23-8-6-16(7-9-23)26-17-5-4-15(19)10-14(17)11-20/h4-5,10,16H,6-9H2,1-3H3
Affinity DataIC50: 310nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250549(US10167273, Example 28 | US10544126, Example 28 | ...)
Show SMILES CCc1nn(C)c(CC)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C19H25Cl2N3O3S/c1-4-16-19(17(5-2)23(3)22-16)28(25,26)24-10-8-14(9-11-24)27-18-7-6-13(20)12-15(18)21/h6-7,12,14H,4-5,8-11H2,1-3H3
Affinity DataIC50: 320nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250632(US10167273, Example 111 | US10544126, Example 111 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C(F)F)c1ccc(Cl)cc1
Affinity DataIC50: 340nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250610(US10167273, Example 89 | US10544126, Example 89 | ...)
Show SMILES COc1cc(Cl)ccc1CC1(O)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C18H24ClN3O4S/c1-12-17(13(2)21-20-12)27(24,25)22-8-6-18(23,7-9-22)11-14-4-5-15(19)10-16(14)26-3/h4-5,10,23H,6-9,11H2,1-3H3,(H,20,21)
Affinity DataIC50: 410nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250626(US10167273, Example 107 | US10544126, Example 107 ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(F)c1ccc(Cl)cc1
Affinity DataIC50: 410nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250593(US10167273, Example 72 | US10544126, Example 72 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1
Show InChI InChI=1S/C18H23ClFN3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)17(20)11-15/h4-5,11,14H,6-10H2,1-3H3
Affinity DataIC50: 440nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250554(US10167273, Example 33 | US10544126, Example 33 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc2ccccc2c1
Show InChI InChI=1S/C20H23N3O3S/c1-14-20(15(2)22-21-14)27(24,25)23-11-9-18(10-12-23)26-19-8-7-16-5-3-4-6-17(16)13-19/h3-8,13,18H,9-12H2,1-2H3,(H,21,22)
Affinity DataIC50: 440nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250623(US10167273, Example 102 | US10544126, Example 102 ...)
Show SMILES CC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Affinity DataIC50: 470nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250535(US10167273, Example 14 | US10544126, Example 14 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Br)cc1F
Show InChI InChI=1S/C17H21BrFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
Affinity DataIC50: 470nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250551(US10167273, Example 30 | US10544126, Example 30 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1F
Show InChI InChI=1S/C17H21ClFN3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
Affinity DataIC50: 510nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250588(US10167273, Example 67 | US10544126, Example 67 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C17H22ClN3O2S/c1-12-17(13(2)20-19-12)24(22,23)21-9-7-15(8-10-21)11-14-3-5-16(18)6-4-14/h3-6,15H,7-11H2,1-2H3,(H,19,20)
Affinity DataIC50: 520nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250576(US10167273, Example 55 | US10544126, Example 55 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C18H24ClN3O2S/c1-13-18(14(2)21(3)20-13)25(23,24)22-10-8-16(9-11-22)12-15-4-6-17(19)7-5-15/h4-7,16H,8-12H2,1-3H3
Affinity DataIC50: 520nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250526(US10167273, Example 5 | US10544126, Example 5 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-17(13(2)20(3)19-12)25(22,23)21-10-8-16(9-11-21)24-15-6-4-14(18)5-7-15/h4-7,16H,8-11H2,1-3H3
Affinity DataIC50: 530nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250614(US10167273, Example 93 | US10544126, Example 93 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)C(C#N)c1ccc(Cl)cc1
Affinity DataIC50: 610nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250584(US10167273, Example 63 | US10544126, Example 63 | ...)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C21H28BrN3O4S/c1-5-29-20(26)21(14-17-6-8-18(22)9-7-17)10-12-25(13-11-21)30(27,28)19-15(2)23-24(4)16(19)3/h6-9H,5,10-14H2,1-4H3
Affinity DataIC50: 640nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250602(US10167273, Example 81 | US10544126, Example 81 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(F)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C18H22ClF2N3O2S/c1-12-17(13(2)23(3)22-12)27(25,26)24-8-6-18(21,7-9-24)11-14-4-5-15(19)10-16(14)20/h4-5,10H,6-9,11H2,1-3H3
Affinity DataIC50: 670nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250583(US10167273, Example 62 | US10544126, Example 62 | ...)
Show SMILES CCOC(=O)C1(Cc2ccc(Br)cc2)CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C
Show InChI InChI=1S/C20H26BrN3O4S/c1-4-28-19(25)20(13-16-5-7-17(21)8-6-16)9-11-24(12-10-20)29(26,27)18-14(2)22-23-15(18)3/h5-8H,4,9-13H2,1-3H3,(H,22,23)
Affinity DataIC50: 680nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250616(US10167273, Example 95 | US10544126, Example 95 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H24ClN3O3S/c1-12-18(13(2)21(3)20-12)26(24,25)22-10-8-15(9-11-22)17(23)14-4-6-16(19)7-5-14/h4-7,15,17,23H,8-11H2,1-3H3
Affinity DataIC50: 710nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250625(US10167273, Example 104 | US10544126, Example 104 ...)
Show SMILES CCOC(C1CCN(CC1)S(=O)(=O)c1c(C)n[nH]c1C)c1ccc(Cl)cc1
Affinity DataIC50: 720nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250605(US10167273, Example 84 | US10544126, Example 84 | ...)
Show SMILES COc1cc(Cl)cnc1OC1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C17H23ClN4O4S/c1-11-16(12(2)21(3)20-11)27(23,24)22-7-5-14(6-8-22)26-17-15(25-4)9-13(18)10-19-17/h9-10,14H,5-8H2,1-4H3
Affinity DataIC50: 720nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250604(US10167273, Example 83 | US10544126, Example 83 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C18H23ClFN3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)11-17(15)20/h4-5,11,14H,6-10H2,1-3H3
Affinity DataIC50: 730nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250592(US10167273, Example 71 | US10544126, Example 71 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(F)c2)CC1
Show InChI InChI=1S/C17H21ClFN3O2S/c1-11-17(12(2)21-20-11)25(23,24)22-7-5-13(6-8-22)9-14-3-4-15(18)16(19)10-14/h3-4,10,13H,5-9H2,1-2H3,(H,20,21)
Affinity DataIC50: 780nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250534(US10167273, Example 13 | US10544126, Example 13 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)cc1Cl
Show InChI InChI=1S/C17H21Cl2N3O3S/c1-11-17(12(2)21(3)20-11)26(23,24)22-8-6-14(7-9-22)25-16-5-4-13(18)10-15(16)19/h4-5,10,14H,6-9H2,1-3H3
Affinity DataIC50: 790nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250601(US10167273, Example 80 | US10544126, Example 80 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(F)(Cc2ccc(Cl)cc2F)CC1
Show InChI InChI=1S/C17H20ClF2N3O2S/c1-11-16(12(2)22-21-11)26(24,25)23-7-5-17(20,6-8-23)10-13-3-4-14(18)9-15(13)19/h3-4,9H,5-8,10H2,1-2H3,(H,21,22)
Affinity DataIC50: 810nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250525(US10167273, Example 4 | US10544126, Example 4 | US...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C18H25N3O3S/c1-13-5-7-16(8-6-13)24-17-9-11-21(12-10-17)25(22,23)18-14(2)19-20(4)15(18)3/h5-8,17H,9-12H2,1-4H3
Affinity DataIC50: 820nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250532(US10167273, Example 11 | US10544126, Example 11 | ...)
Show SMILES Cc1nn(C)c(Cl)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(C)cc1
Show InChI InChI=1S/C17H22ClN3O3S/c1-12-4-6-14(7-5-12)24-15-8-10-21(11-9-15)25(22,23)16-13(2)19-20(3)17(16)18/h4-7,15H,8-11H2,1-3H3
Affinity DataIC50: 860nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250585(US10167273, Example 64 | US10544126, Example 64 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)(CC1)C#N
Show InChI InChI=1S/C18H21ClN4O2S/c1-13-17(14(2)22-21-13)26(24,25)23-9-7-18(12-20,8-10-23)11-15-3-5-16(19)6-4-15/h3-6H,7-11H2,1-2H3,(H,21,22)
Affinity DataIC50: 890nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250574(US10167273, Example 53 | US10544126, Example 53 | ...)
Show SMILES CN(C1CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H25ClN4O2S/c1-13-18(14(2)22(4)20-13)26(24,25)23-11-9-17(10-12-23)21(3)16-7-5-15(19)6-8-16/h5-8,17H,9-12H2,1-4H3
Affinity DataIC50: 900nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250581(US10167273, Example 60 | US10544126, Example 60 | ...)
Show SMILES COCC1(Cc2ccc(Cl)cc2)CCN(CC1)S(=O)(=O)c1c(C)nn(C)c1C
Show InChI InChI=1S/C20H28ClN3O3S/c1-15-19(16(2)23(3)22-15)28(25,26)24-11-9-20(10-12-24,14-27-4)13-17-5-7-18(21)8-6-17/h5-8H,9-14H2,1-4H3
Affinity DataIC50: 900nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250586(US10167273, Example 65 | US10544126, Example 65 | ...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2Cl)(CC1)C#N
Show InChI InChI=1S/C18H20Cl2N4O2S/c1-12-17(13(2)23-22-12)27(25,26)24-7-5-18(11-21,6-8-24)10-14-3-4-15(19)9-16(14)20/h3-4,9H,5-8,10H2,1-2H3,(H,22,23)
Affinity DataIC50: 940nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250577(US10167273, Example 56 | US10544126, Example 56 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)c(Cl)c2)CC1
Show InChI InChI=1S/C18H23Cl2N3O2S/c1-12-18(13(2)22(3)21-12)26(24,25)23-8-6-14(7-9-23)10-15-4-5-16(19)17(20)11-15/h4-5,11,14H,6-10H2,1-3H3
Affinity DataIC50: 950nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250523(US10167273, Example 2 | US10544126, Example 2 | US...)
Show SMILES Cc1n[nH]c(C)c1S(=O)(=O)N1CCC(CC1)Oc1ccc(Cl)c(Cl)c1
Show InChI InChI=1S/C16H19Cl2N3O3S/c1-10-16(11(2)20-19-10)25(22,23)21-7-5-12(6-8-21)24-13-3-4-14(17)15(18)9-13/h3-4,9,12H,5-8H2,1-2H3,(H,19,20)
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250567(US10167273, Example 46 | US10544126, Example 46 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)Oc1c(F)cc(Cl)cc1F
Show InChI InChI=1S/C17H20ClF2N3O3S/c1-10-17(11(2)22(3)21-10)27(24,25)23-6-4-13(5-7-23)26-16-14(19)8-12(18)9-15(16)20/h8-9,13H,4-7H2,1-3H3
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250570(US10167273, Example 49 | US10544126, Example 49 | ...)
Show SMILES Cc1nn(C)c(C)c1S(=O)(=O)N1CCC(CC1)C(=O)c1ccc(Cl)cc1
Show InChI InChI=1S/C18H22ClN3O3S/c1-12-18(13(2)21(3)20-12)26(24,25)22-10-8-15(9-11-22)17(23)14-4-6-16(19)7-5-14/h4-7,15H,8-11H2,1-3H3
Affinity DataIC50: 1.00E+3nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
TargetProkineticin receptor 1(Homo sapiens (Human))
Takeda Pharmaceutical Co., Ltd

US Patent
LigandPNGBDBM250587(US10167273, Example 66 | US10544126, Example 66 | ...)
Show SMILES CCc1n[nH]c(CC)c1S(=O)(=O)N1CCC(Cc2ccc(Cl)cc2)CC1
Show InChI InChI=1S/C19H26ClN3O2S/c1-3-17-19(18(4-2)22-21-17)26(24,25)23-11-9-15(10-12-23)13-14-5-7-16(20)8-6-14/h5-8,15H,3-4,9-13H2,1-2H3,(H,21,22)
Affinity DataIC50: 1.01E+3nMpH: 7.4 T: 2°CAssay Description:Prokineticin receptor 1 (PKR1) antagonists may be functionally assessed by measurement of change in intracellular calcium levels induced by Gq mediat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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