Compile Data Set for Download or QSAR
Found 65 Enz. Inhib. hit(s) with all data for entry = 979
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301710(US9597310, 1 | [(S)-6-Hydroxy-2,3-dihydro-benzofur...)
Show SMILES COCCOc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C28H27FO7/c1-32-12-13-33-18-2-4-19(5-3-18)35-24-11-9-23(29)28-22(24)8-10-25(28)36-20-6-7-21-17(14-27(30)31)16-34-26(21)15-20/h2-7,9,11,15,17,25H,8,10,12-14,16H2,1H3,(H,30,31)/t17-,25-/m1/s1
Affinity DataEC50:  7nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301712(US9597310, 2 | [(S)-6-{(R)-7-Fluoro-4-[4-(3-hydrox...)
Show SMILES CC(C)(O)CCOc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C30H31FO7/c1-30(2,34)13-14-35-19-3-5-20(6-4-19)37-25-12-10-24(31)29-23(25)9-11-26(29)38-21-7-8-22-18(15-28(32)33)17-36-27(22)16-21/h3-8,10,12,16,18,26,34H,9,11,13-15,17H2,1-2H3,(H,32,33)/t18-,26-/m1/s1
Affinity DataEC50:  5nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301713(US9597310, 3 | [(S)-6-{(R)-7-Fluoro-4-[4-(2-hydrox...)
Show SMILES CC(C)(O)COc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C29H29FO7/c1-29(2,33)16-35-18-3-5-19(6-4-18)36-24-12-10-23(30)28-22(24)9-11-25(28)37-20-7-8-21-17(13-27(31)32)15-34-26(21)14-20/h3-8,10,12,14,17,25,33H,9,11,13,15-16H2,1-2H3,(H,31,32)/t17-,25-/m1/s1
Affinity DataEC50:  13nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301714(US9597310, 4 | [(S)-6-{(R)-7-Fluoro-4-[4-(3-methan...)
Show SMILES CS(=O)(=O)CCCOc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C29H29FO8S/c1-39(33,34)14-2-13-35-19-3-5-20(6-4-19)37-25-12-10-24(30)29-23(25)9-11-26(29)38-21-7-8-22-18(15-28(31)32)17-36-27(22)16-21/h3-8,10,12,16,18,26H,2,9,11,13-15,17H2,1H3,(H,31,32)/t18-,26-/m1/s1
Affinity DataEC50:  15nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301715(US9597310, 5 | {(S)-6-[(R)-7-Fluoro-4-hydroxy-inda...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(CN4CCOCC4)cc3)ccc12
Show InChI InChI=1S/C30H30FNO6/c31-25-8-10-26(37-21-3-1-19(2-4-21)17-32-11-13-35-14-12-32)24-7-9-27(30(24)25)38-22-5-6-23-20(15-29(33)34)18-36-28(23)16-22/h1-6,8,10,16,20,27H,7,9,11-15,17-18H2,(H,33,34)/t20-,27-/m1/s1
Affinity DataEC50:  25nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301716(US9597310, 6 | {(S)-6-[(R)-4-(3-Acetylamino-phenox...)
Show SMILES CC(=O)Nc1cccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c1
Show InChI InChI=1S/C27H24FNO6/c1-15(30)29-17-3-2-4-18(12-17)34-23-10-8-22(28)27-21(23)7-9-24(27)35-19-5-6-20-16(11-26(31)32)14-33-25(20)13-19/h2-6,8,10,12-13,16,24H,7,9,11,14H2,1H3,(H,29,30)(H,31,32)/t16-,24-/m1/s1
Affinity DataEC50:  8nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301717(US9597310, 7 | {(S)-6-[(R)-7-Fluoro-4-(4-hydroxy-p...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(O)cc3)ccc12
Show InChI InChI=1S/C26H23FO6/c1-30-25(29)12-15-14-31-24-13-18(6-7-19(15)24)33-23-10-8-20-22(11-9-21(27)26(20)23)32-17-4-2-16(28)3-5-17/h2-7,9,11,13,15,23,28H,8,10,12,14H2,1H3/t15-,23-/m1/s1
Affinity DataEC50:  55nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301718(US9597310, 8 | {(S)-6-[(R)-4-(4-Acetylamino-phenox...)
Show SMILES CC(=O)Nc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C27H24FNO6/c1-15(30)29-17-2-4-18(5-3-17)34-23-11-9-22(28)27-21(23)8-10-24(27)35-19-6-7-20-16(12-26(31)32)14-33-25(20)13-19/h2-7,9,11,13,16,24H,8,10,12,14H2,1H3,(H,29,30)(H,31,32)/t16-,24-/m1/s1
Affinity DataEC50:  34nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301719(US9597310, 9 | [(S)-6-{(R)-7-Fluoro-4-[4-(pyrrolid...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)C(=O)N3CCCC3)ccc12
Show InChI InChI=1S/C30H28FNO6/c31-24-10-12-25(37-20-5-3-18(4-6-20)30(35)32-13-1-2-14-32)23-9-11-26(29(23)24)38-21-7-8-22-19(15-28(33)34)17-36-27(22)16-21/h3-8,10,12,16,19,26H,1-2,9,11,13-15,17H2,(H,33,34)/t19-,26-/m1/s1
Affinity DataEC50:  18nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301720(US9597310, 10 | {(S)-6-[(R)-7-Fluoro-4-(4-imidazol...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)-n3ccnc3)ccc12
Show InChI InChI=1S/C28H23FN2O5/c29-23-8-10-24(35-19-3-1-18(2-4-19)31-12-11-30-16-31)22-7-9-25(28(22)23)36-20-5-6-21-17(13-27(32)33)15-34-26(21)14-20/h1-6,8,10-12,14,16-17,25H,7,9,13,15H2,(H,32,33)/t17-,25-/m1/s1
Affinity DataEC50:  11nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301721(US9597310, 11 | {(S)-6-[(R)-4-(2,3-Dihydro-benzofu...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4OCCc4c3)ccc12
Show InChI InChI=1S/C27H23FO6/c28-21-5-8-23(33-17-2-6-22-15(11-17)9-10-31-22)20-4-7-24(27(20)21)34-18-1-3-19-16(12-26(29)30)14-32-25(19)13-18/h1-3,5-6,8,11,13,16,24H,4,7,9-10,12,14H2,(H,29,30)/t16-,24-/m1/s1
Affinity DataEC50:  6nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301722(US9597310, 12 | {(S)-6-[(R)-7-Fluoro-4-(4-morpholi...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(CN4CCOCC4)cc3)ccc12
Show InChI InChI=1S/C31H32FNO6/c1-35-30(34)16-21-19-37-29-17-23(6-7-24(21)29)39-28-10-8-25-27(11-9-26(32)31(25)28)38-22-4-2-20(3-5-22)18-33-12-14-36-15-13-33/h2-7,9,11,17,21,28H,8,10,12-16,18-19H2,1H3/t21-,28-/m1/s1
Affinity DataEC50:  18nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301723(US9597310, 13 | [(S)-6-{(R)-7-Fluoro-4-[4-(1H-tetr...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)-c3nnn[nH]3)ccc12
Show InChI InChI=1S/C26H21FN4O5/c27-20-8-10-21(35-16-3-1-14(2-4-16)26-28-30-31-29-26)19-7-9-22(25(19)20)36-17-5-6-18-15(11-24(32)33)13-34-23(18)12-17/h1-6,8,10,12,15,22H,7,9,11,13H2,(H,32,33)(H,28,29,30,31)/t15-,22-/m1/s1
Affinity DataEC50:  282nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301724(US9597310, 14 | [(S)-6-{(R)-4-[3-(Acetylamino-meth...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3cccc(CNC(C)=O)c3)ccc12
Show InChI InChI=1S/C29H28FNO6/c1-17(32)31-15-18-4-3-5-20(12-18)36-25-11-9-24(30)29-23(25)8-10-26(29)37-21-6-7-22-19(13-28(33)34-2)16-35-27(22)14-21/h3-7,9,11-12,14,19,26H,8,10,13,15-16H2,1-2H3,(H,31,32)/t19-,26-/m1/s1
Affinity DataEC50:  23nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301725(US9597310, 15 | [(S)-6-{(R)-7-Fluoro-4-[4-(2-methy...)
Show SMILES Cn1nnc(n1)-c1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C27H23FN4O5/c1-32-30-27(29-31-32)15-2-4-17(5-3-15)36-22-11-9-21(28)26-20(22)8-10-23(26)37-18-6-7-19-16(12-25(33)34)14-35-24(19)13-18/h2-7,9,11,13,16,23H,8,10,12,14H2,1H3,(H,33,34)/t16-,23-/m1/s1
Affinity DataEC50:  3nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301726(US9597310, 16 | {(S)-6-[(R)-7-fluoro-4-{2-[(S)-tet...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccnc(O[C@H]4CCOC4)c3)ccc12
Show InChI InChI=1S/C28H26FNO7/c29-22-4-6-23(35-18-7-9-30-26(13-18)37-19-8-10-33-15-19)21-3-5-24(28(21)22)36-17-1-2-20-16(11-27(31)32)14-34-25(20)12-17/h1-2,4,6-7,9,12-13,16,19,24H,3,5,8,10-11,14-15H2,(H,31,32)/t16-,19+,24-/m1/s1
Affinity DataEC50:  9nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301727(US9597310, 17 | {(S)-6-[(R)-7-Fluoro-4-(4-imidazol...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)-n3ccnc3)ccc12
Show InChI InChI=1S/C29H25FN2O5/c1-34-28(33)14-18-16-35-27-15-21(6-7-22(18)27)37-26-10-8-23-25(11-9-24(30)29(23)26)36-20-4-2-19(3-5-20)32-13-12-31-17-32/h2-7,9,11-13,15,17-18,26H,8,10,14,16H2,1H3/t18-,26-/m1/s1
Affinity DataEC50:  23nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301728(US9597310, 18 | {(S)-6-[(R)-4-(2,3-Dihydro-benzofu...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4OCCc4c3)ccc12
Show InChI InChI=1S/C28H25FO6/c1-31-27(30)13-17-15-33-26-14-19(2-4-20(17)26)35-25-8-5-21-24(9-6-22(29)28(21)25)34-18-3-7-23-16(12-18)10-11-32-23/h2-4,6-7,9,12,14,17,25H,5,8,10-11,13,15H2,1H3/t17-,25-/m1/s1
Affinity DataEC50:  31nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301729(US9597310, 19 | {(S)-6-[(R)-4-(4-Ethylcarbamoyl-ph...)
Show SMILES CCNC(=O)c1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(=O)OC)COc3c2)cc1
Show InChI InChI=1S/C29H28FNO6/c1-3-31-29(33)17-4-6-19(7-5-17)36-24-13-11-23(30)28-22(24)10-12-25(28)37-20-8-9-21-18(14-27(32)34-2)16-35-26(21)15-20/h4-9,11,13,15,18,25H,3,10,12,14,16H2,1-2H3,(H,31,33)/t18-,25-/m1/s1
Affinity DataEC50:  12nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301730(US9597310, 20 | {(S)-6-[(R)-4-{3,5-Difluoro-4-[1-(...)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1c(F)cc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1F
Show InChI InChI=1S/C32H29F3N2O6/c1-32(2,40)16-37-14-18(13-36-37)30-24(34)10-20(11-25(30)35)43-26-8-6-23(33)31-22(26)5-7-27(31)42-19-3-4-21-17(9-29(38)39)15-41-28(21)12-19/h3-4,6,8,10-14,17,27,40H,5,7,9,15-16H2,1-2H3,(H,38,39)/t17-,27-/m1/s1
Affinity DataEC50:  7nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301731(US9597310, 21 | [(S)-6-{(R)-7-Fluoro-4-[4-(1H-tetr...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)-c3nnn[nH]3)ccc12
Show InChI InChI=1S/C27H23FN4O5/c1-34-25(33)12-16-14-35-24-13-18(6-7-19(16)24)37-23-10-8-20-22(11-9-21(28)26(20)23)36-17-4-2-15(3-5-17)27-29-31-32-30-27/h2-7,9,11,13,16,23H,8,10,12,14H2,1H3,(H,29,30,31,32)/t16-,23-/m1/s1
Affinity DataEC50:  6nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301732(US9597310, 22 | [(S)-6-{(R)-7-Fluoro-4-[4-(2-methy...)
Show SMILES Cc1ncc(s1)-c1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C29H24FNO5S/c1-16-31-14-27(37-16)17-2-4-19(5-3-17)35-24-11-9-23(30)29-22(24)8-10-25(29)36-20-6-7-21-18(12-28(32)33)15-34-26(21)13-20/h2-7,9,11,13-14,18,25H,8,10,12,15H2,1H3,(H,32,33)/t18-,25-/m1/s1
Affinity DataEC50:  5nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301733(US9597310, 23 | [(S)-6-{(R)-7-Fluoro-4-[5-(4-hydro...)
Show SMILES CC(C)(O)CCCc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)nc1
Show InChI InChI=1S/C30H32FNO6/c1-30(2,35)13-3-4-18-5-12-27(32-16-18)38-24-11-9-23(31)29-22(24)8-10-25(29)37-20-6-7-21-19(14-28(33)34)17-36-26(21)15-20/h5-7,9,11-12,15-16,19,25,35H,3-4,8,10,13-14,17H2,1-2H3,(H,33,34)/t19-,25-/m1/s1
Affinity DataEC50:  84nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301734(US9597310, 24 | {(S)-6-[(R)-7-Fluoro-4-(2-oxo-1,2,...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4CCC(=O)Nc4c3)ccc12
Show InChI InChI=1S/C28H24FNO6/c29-21-7-9-23(35-17-3-1-15-2-10-26(31)30-22(15)12-17)20-6-8-24(28(20)21)36-18-4-5-19-16(11-27(32)33)14-34-25(19)13-18/h1,3-5,7,9,12-13,16,24H,2,6,8,10-11,14H2,(H,30,31)(H,32,33)/t16-,24-/m1/s1
Affinity DataEC50:  10nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301735(US9597310, 25 | {(S)-6-[(R)-4-(Benzo[d][1,3]dioxol...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4OCOc4c3)ccc12
Show InChI InChI=1S/C26H21FO7/c27-19-5-8-20(33-16-2-6-21-24(11-16)32-13-31-21)18-4-7-22(26(18)19)34-15-1-3-17-14(9-25(28)29)12-30-23(17)10-15/h1-3,5-6,8,10-11,14,22H,4,7,9,12-13H2,(H,28,29)/t14-,22-/m1/s1
Affinity DataEC50:  6nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301736(US9597310, 26 | {(S)-6-[(R)-4-(2,3-Dihydrobenzo[b]...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4OCCOc4c3)ccc12
Show InChI InChI=1S/C27H23FO7/c28-20-5-8-21(34-17-2-6-22-25(13-17)32-10-9-31-22)19-4-7-23(27(19)20)35-16-1-3-18-15(11-26(29)30)14-33-24(18)12-16/h1-3,5-6,8,12-13,15,23H,4,7,9-11,14H2,(H,29,30)/t15-,23-/m1/s1
Affinity DataEC50:  6nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301737(US9597310, 27 | [(S)-6-{(R)-7-Fluoro-4-[5-(3-hydro...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(OCCC(C)(C)O)cn3)ccc12
Show InChI InChI=1S/C30H32FNO7/c1-30(2,34)12-13-36-20-5-11-27(32-16-20)39-24-10-8-23(31)29-22(24)7-9-25(29)38-19-4-6-21-18(14-28(33)35-3)17-37-26(21)15-19/h4-6,8,10-11,15-16,18,25,34H,7,9,12-14,17H2,1-3H3/t18-,25-/m1/s1
Affinity DataEC50:  9nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301738(((S)-6-{(R)-7-Fluoro-4-[4-(4-hydroxy-4-methylpenty...)
Show SMILES CC(C)(O)CCCc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C31H33FO6/c1-31(2,35)15-3-4-19-5-7-21(8-6-19)37-26-14-12-25(32)30-24(26)11-13-27(30)38-22-9-10-23-20(16-29(33)34)18-36-28(23)17-22/h5-10,12,14,17,20,27,35H,3-4,11,13,15-16,18H2,1-2H3,(H,33,34)/t20-,27-/m1/s1
Affinity DataEC50:  20nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301739(US9597310, 29 | {(S)-6-[(R)-7-Fluoro-4-{5-[(S)-tet...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(O[C@H]4CCOC4)cn3)ccc12
Show InChI InChI=1S/C29H28FNO7/c1-33-28(32)12-17-15-35-26-13-18(2-4-21(17)26)37-25-7-5-22-24(8-6-23(30)29(22)25)38-27-9-3-19(14-31-27)36-20-10-11-34-16-20/h2-4,6,8-9,13-14,17,20,25H,5,7,10-12,15-16H2,1H3/t17-,20+,25-/m1/s1
Affinity DataEC50:  12nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301740(((S)-6-{(R)-7-Fluoro-4-[1-(3-hydroxy-3-methylbutyl...)
Show SMILES CC(C)(O)CCn1ncc2cc(Oc3ccc(F)c4[C@@H](CCc34)Oc3ccc4[C@H](CC(O)=O)COc4c3)ccc12
Show InChI InChI=1S/C31H31FN2O6/c1-31(2,37)11-12-34-25-8-4-20(13-18(25)16-33-34)39-26-10-7-24(32)30-23(26)6-9-27(30)40-21-3-5-22-19(14-29(35)36)17-38-28(22)15-21/h3-5,7-8,10,13,15-16,19,27,37H,6,9,11-12,14,17H2,1-2H3,(H,35,36)/t19-,27-/m1/s1
Affinity DataEC50:  13nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301741(2-(3,5-Difluoro-4-(3-(methylsulfonyl)propoxy)pheny...)
Show SMILES CC(C)(O)Cn1cc(cn1)-c1cc(F)c(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c(F)c1
Show InChI InChI=1S/C32H29F3N2O6/c1-32(2,40)16-37-14-19(13-36-37)17-9-24(34)31(25(35)10-17)43-26-8-6-23(33)30-22(26)5-7-27(30)42-20-3-4-21-18(11-29(38)39)15-41-28(21)12-20/h3-4,6,8-10,12-14,18,27,40H,5,7,11,15-16H2,1-2H3,(H,38,39)/t18-,27-/m1/s1
Affinity DataEC50:  58nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301742(((S)-6-{(R)-7-Fluoro-4-[4-(2-methylthiazol-4-yl)ph...)
Show SMILES Cc1nc(cs1)-c1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C29H24FNO5S/c1-16-31-24(15-37-16)17-2-4-19(5-3-17)35-25-11-9-23(30)29-22(25)8-10-26(29)36-20-6-7-21-18(12-28(32)33)14-34-27(21)13-20/h2-7,9,11,13,15,18,26H,8,10,12,14H2,1H3,(H,32,33)/t18-,26-/m1/s1
Affinity DataEC50:  13nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301743(((S)-6-{(R)-7-Fluoro-4-[4-(3-hydroxy-3-methylbutyl...)
Show SMILES CC(C)(O)CCn1ccc2cc(Oc3ccc(F)c4[C@@H](CCc34)Oc3ccc4[C@H](CC(O)=O)COc4c3)ccc12
Show InChI InChI=1S/C32H32FNO6/c1-32(2,37)12-14-34-13-11-19-15-21(4-8-26(19)34)39-27-10-7-25(33)31-24(27)6-9-28(31)40-22-3-5-23-20(16-30(35)36)18-38-29(23)17-22/h3-5,7-8,10-11,13,15,17,20,28,37H,6,9,12,14,16,18H2,1-2H3,(H,35,36)/t20-,28-/m1/s1
Affinity DataEC50:  45nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301744(2-Methyl-1-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaboro...)
Show SMILES CC(C)(O)Cn1cc(cn1)B1OC(C)(C)C(C)(C)O1
Show InChI InChI=1S/C13H23BN2O3/c1-11(2,17)9-16-8-10(7-15-16)14-18-12(3,4)13(5,6)19-14/h7-8,17H,9H2,1-6H3
Affinity DataEC50:  6nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301745(US9597310, 35 | [(S)-6-((R)-7-Fluoro-4-{4-[(tetrah...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(CC4CCOCC4)cc3)ccc12
Show InChI InChI=1S/C31H31FO6/c32-26-8-10-27(37-22-3-1-19(2-4-22)15-20-11-13-35-14-12-20)25-7-9-28(31(25)26)38-23-5-6-24-21(16-30(33)34)18-36-29(24)17-23/h1-6,8,10,17,20-21,28H,7,9,11-16,18H2,(H,33,34)/t21-,28-/m1/s1
Affinity DataEC50:  5nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301746(3,5-Difluoro-4-(1-(2-hydroxy-2-methylpropyl)-1H-py...)
Show SMILES CC(C)(O)CCn1ncc2ccc(Oc3ccc(F)c4[C@@H](CCc34)Oc3ccc4[C@H](CC(O)=O)COc4c3)cc12
Show InChI InChI=1S/C31H31FN2O6/c1-31(2,37)11-12-34-25-14-20(4-3-18(25)16-33-34)39-26-10-8-24(32)30-23(26)7-9-27(30)40-21-5-6-22-19(13-29(35)36)17-38-28(22)15-21/h3-6,8,10,14-16,19,27,37H,7,9,11-13,17H2,1-2H3,(H,35,36)/t19-,27-/m1/s1
Affinity DataEC50:  8nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301747(1-{4-[2,6-Difluoro-4-(4,4,5,5-tetramethyl-[1,3,2]d...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(OCC4(O)CCOCC4)c(F)c3)ccc12
Show InChI InChI=1S/C31H30F2O8/c32-23-5-8-25(40-19-2-6-26(24(33)14-19)39-17-31(36)9-11-37-12-10-31)22-4-7-27(30(22)23)41-20-1-3-21-18(13-29(34)35)16-38-28(21)15-20/h1-3,5-6,8,14-15,18,27,36H,4,7,9-13,16-17H2,(H,34,35)/t18-,27-/m1/s1
Affinity DataEC50:  8nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301748(3,5-Difluoro-4-[1-(2-hydroxy-2-methylpropyl-1H-pyr...)
Show SMILES Cn1ccnc1-c1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1
Show InChI InChI=1S/C29H25FN2O5/c1-32-13-12-31-29(32)17-2-4-19(5-3-17)36-24-11-9-23(30)28-22(24)8-10-25(28)37-20-6-7-21-18(14-27(33)34)16-35-26(21)15-20/h2-7,9,11-13,15,18,25H,8,10,14,16H2,1H3,(H,33,34)/t18-,25-/m1/s1
Affinity DataEC50:  41nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301749(US9597310, 39 | [(S)-6-((R)-4-{2,5-Difluoro-4-[3-(...)
Show SMILES CS(=O)(=O)CCCOc1cc(F)c(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1F
Show InChI InChI=1S/C29H27F3O8S/c1-41(35,36)10-2-9-37-26-13-22(32)27(14-21(26)31)40-23-8-6-20(30)29-19(23)5-7-24(29)39-17-3-4-18-16(11-28(33)34)15-38-25(18)12-17/h3-4,6,8,12-14,16,24H,2,5,7,9-11,15H2,1H3,(H,33,34)/t16-,24-/m1/s1
Affinity DataEC50:  23nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301750(US9597310, 40 | {(S)-6-[(R)-4-(4-bromo-phenoxy)-7-...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(Br)cc3)ccc12
Show InChI InChI=1S/C26H22BrFO5/c1-30-25(29)12-15-14-31-24-13-18(6-7-19(15)24)33-23-10-8-20-22(11-9-21(28)26(20)23)32-17-4-2-16(27)3-5-17/h2-7,9,11,13,15,23H,8,10,12,14H2,1H3/t15-,23-/m1/s1
Affinity DataEC50:  733nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301751(((S)-6-{(R)-4-[2-Cyano-5-(4-hydroxy-4-methylpentyl...)
Show SMILES CC(C)(O)CCCc1ccc(C#N)c(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c1
Show InChI InChI=1S/C32H32FNO6/c1-32(2,37)13-3-4-19-5-6-20(17-34)28(14-19)40-26-12-10-25(33)31-24(26)9-11-27(31)39-22-7-8-23-21(15-30(35)36)18-38-29(23)16-22/h5-8,10,12,14,16,21,27,37H,3-4,9,11,13,15,18H2,1-2H3,(H,35,36)/t21-,27-/m1/s1
Affinity DataEC50:  85nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301752(((S)-6-{(R)-4-[2-Cyano-5-(3-hydroxy-3-methylbutoxy...)
Show SMILES CC(C)(O)CCOc1ccc(C#N)c(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c1
Show InChI InChI=1S/C31H30FNO7/c1-31(2,36)11-12-37-20-4-3-18(16-33)27(14-20)40-25-10-8-24(32)30-23(25)7-9-26(30)39-21-5-6-22-19(13-29(34)35)17-38-28(22)15-21/h3-6,8,10,14-15,19,26,36H,7,9,11-13,17H2,1-2H3,(H,34,35)/t19-,26-/m1/s1
Affinity DataEC50:  120nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301753(US9597310, 43 | [(S)-6-{(R)-7-Fluoro-4-[5-(4-hydro...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(\C=C\CC(C)(C)O)cn3)ccc12
Show InChI InChI=1S/C31H32FNO6/c1-31(2,35)14-4-5-19-6-13-28(33-17-19)39-25-12-10-24(32)30-23(25)9-11-26(30)38-21-7-8-22-20(15-29(34)36-3)18-37-27(22)16-21/h4-8,10,12-13,16-17,20,26,35H,9,11,14-15,18H2,1-3H3/b5-4+/t20-,26-/m1/s1
Affinity DataEC50:  18nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301754(((S)-6-{(R)-4-[3-Cyano-4-(3-hydroxy-3-methylbutoxy...)
Show SMILES CC(C)(O)CCOc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)cc1C#N
Show InChI InChI=1S/C31H30FNO7/c1-31(2,36)11-12-37-25-8-4-20(13-18(25)16-33)39-26-10-7-24(32)30-23(26)6-9-27(30)40-21-3-5-22-19(14-29(34)35)17-38-28(22)15-21/h3-5,7-8,10,13,15,19,27,36H,6,9,11-12,14,17H2,1-2H3,(H,34,35)/t19-,27-/m1/s1
Affinity DataEC50:  7nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301755(((S)-6-{(R)-7-Fluoro-4-[2-fluoro-5-(3-hydroxy-3-me...)
Show SMILES CC(C)(O)CCOc1ccc(F)c(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c1
Show InChI InChI=1S/C30H30F2O7/c1-30(2,35)11-12-36-18-4-7-22(31)27(14-18)39-24-10-8-23(32)29-21(24)6-9-25(29)38-19-3-5-20-17(13-28(33)34)16-37-26(20)15-19/h3-5,7-8,10,14-15,17,25,35H,6,9,11-13,16H2,1-2H3,(H,33,34)/t17-,25-/m1/s1
Affinity DataEC50:  29nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301756(((S)-6-{(R)-7-Fluoro-4-[2-fluoro-5-(tetrahydro-2H-...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3cc(OC4CCOCC4)ccc3F)ccc12
Show InChI InChI=1S/C30H28F2O7/c31-23-5-2-19(37-18-9-11-35-12-10-18)15-28(23)39-25-8-6-24(32)30-22(25)4-7-26(30)38-20-1-3-21-17(13-29(33)34)16-36-27(21)14-20/h1-3,5-6,8,14-15,17-18,26H,4,7,9-13,16H2,(H,33,34)/t17-,26-/m1/s1
Affinity DataEC50:  62nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301757(((S)-6-{(R)-4-[2-Cyano-4-(3-hydroxy-3-methylbutoxy...)
Show SMILES CC(C)(O)CCOc1ccc(Oc2ccc(F)c3[C@@H](CCc23)Oc2ccc3[C@H](CC(O)=O)COc3c2)c(c1)C#N
Show InChI InChI=1S/C31H30FNO7/c1-31(2,36)11-12-37-20-4-8-25(18(13-20)16-33)40-26-10-7-24(32)30-23(26)6-9-27(30)39-21-3-5-22-19(14-29(34)35)17-38-28(22)15-21/h3-5,7-8,10,13,15,19,27,36H,6,9,11-12,14,17H2,1-2H3,(H,34,35)/t19-,27-/m1/s1
Affinity DataEC50:  8nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301758(US9597310, 48 | {(S)-6-[(R)-4-(2,3-Dihydrobenzo[b]...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc4OCCOc4c3)ccc12
Show InChI InChI=1S/C28H25FO7/c1-31-27(30)12-16-15-34-25-13-17(2-4-19(16)25)36-24-8-5-20-22(9-6-21(29)28(20)24)35-18-3-7-23-26(14-18)33-11-10-32-23/h2-4,6-7,9,13-14,16,24H,5,8,10-12,15H2,1H3/t16-,24-/m1/s1
Affinity DataEC50:  9nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301759(((S)-6-{(R)-4-[4-(3,6-Dihydro-2H-pyran-4-yl)-pheno...)
Show SMILES COC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(cc3)C3CCOCC3)ccc12
Show InChI InChI=1S/C31H31FO6/c1-34-30(33)16-21-18-36-29-17-23(6-7-24(21)29)38-28-10-8-25-27(11-9-26(32)31(25)28)37-22-4-2-19(3-5-22)20-12-14-35-15-13-20/h2-7,9,11,17,20-21,28H,8,10,12-16,18H2,1H3/t21-,28-/m1/s1
Affinity DataEC50:  17nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetFree fatty acid receptor 1(Homo sapiens (Human))
Boehringer Ingelheim International GmbH

US Patent
LigandPNGBDBM301760(((S)-6-{(R)-7-Fluoro-4-[2-fluoro-4-(tetrahydro-2H-...)
Show SMILES OC(=O)C[C@@H]1COc2cc(O[C@@H]3CCc4c3c(F)ccc4Oc3ccc(OC4CCOCC4)cc3F)ccc12
Show InChI InChI=1S/C30H28F2O7/c31-23-5-8-25(39-26-6-2-19(14-24(26)32)37-18-9-11-35-12-10-18)22-4-7-27(30(22)23)38-20-1-3-21-17(13-29(33)34)16-36-28(21)15-20/h1-3,5-6,8,14-15,17-18,27H,4,7,9-13,16H2,(H,33,34)/t17-,27-/m1/s1
Affinity DataEC50:  4nMAssay Description:IP1 accumulation measurements using the IPOne assay system 1321N1 cells stably expressing human GPR40 receptor (Euroscreen, Belgium) are seeded 24 h ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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