Compile Data Set for Download or QSAR
Found 74 Enz. Inhib. hit(s) with all data for entry = 980
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239042(US10028934, Compound 42 | US10478423, Cpd. 42 | US...)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301791(N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-(1-meth...)
Show SMILES CN1CCC(CC1)Nc1ccccc1C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-22(14-16-34)30-26-10-6-5-9-25(26)29(35)31-28-24-12-11-23(19-27(24)32-33-28)37-18-17-36-20-21-7-3-2-4-8-21/h2-12,19,22,30H,13-18,20H2,1H3,(H2,31,32,33,35)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239023(US10028934, Compound 32 | US10478423, Cpd. 32 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239012(US10028934, Compound 10 | US10478423, Cpd. 10 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOc3ccccc3)ccc12
Show InChI InChI=1S/C27H29N5O3/c1-31-13-15-32(16-14-31)21-9-7-20(8-10-21)27(33)28-26-24-12-11-23(19-25(24)29-30-26)35-18-17-34-22-5-3-2-4-6-22/h2-12,19H,13-18H2,1H3,(H2,28,29,30,33)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239017(US10028934, Compound 11 | US10478423, Cpd. 11 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1
Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239040(US10028934, Compound 14 | US10478423, Cpd. 14 | US...)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239023(US10028934, Compound 32 | US10478423, Cpd. 32 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(F)cc3)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)23-8-4-21(5-9-23)28(35)30-27-25-11-10-24(18-26(25)31-32-27)37-17-16-36-19-20-2-6-22(29)7-3-20/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239029(US10028934, Compound 15 | US10478423, Cpd. 15 | US...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239022(US10028934, Compound 33 | US10478423, Cpd. 33 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239030(US10028934, Compound 16 | US10478423, Cpd. 16 | US...)
Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301795(N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methy...)
Show SMILES CN1CCC(CC1)c1c(C)ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c1N
Show InChI InChI=1S/C30H35N5O3/c1-20-8-10-25(28(31)27(20)22-12-14-35(2)15-13-22)30(36)32-29-24-11-9-23(18-26(24)33-34-29)38-17-16-37-19-21-6-4-3-5-7-21/h3-11,18,22H,12-17,19,31H2,1-2H3,(H2,32,33,34,36)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239022(US10028934, Compound 33 | US10478423, Cpd. 33 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-12-14-37(15-13-36)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)40-17-16-39-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239043(US10028934, Compound 20 | US10478423, Cpd. 20 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239038(US10028934, Compound 27 | US10478423, Cpd. 27 | US...)
Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1
Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)
Affinity DataIC50: 50nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239041(US10028934, Compound 41 | US10478423, Cpd. 41 | US...)
Show SMILES CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O4/c1-34(25-14-16-35(2,37)17-15-25)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)39-19-18-38-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
Affinity DataIC50: 52nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239043(US10028934, Compound 20 | US10478423, Cpd. 20 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CCNCC1
Show InChI InChI=1S/C27H29N5O3/c33-27(21-6-8-22(9-7-21)32-14-12-28-13-15-32)29-26-24-11-10-23(18-25(24)30-31-26)35-17-16-34-19-20-4-2-1-3-5-20/h1-11,18,28H,12-17,19H2,(H2,29,30,31,33)
Affinity DataIC50: 52nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239042(US10028934, Compound 42 | US10478423, Cpd. 42 | US...)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccc(cc3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O4/c1-37(39)14-12-36(13-15-37)23-8-4-21(5-9-23)28(38)33-27-25-11-10-24(18-26(25)34-35-27)41-17-16-40-19-20-2-6-22(7-3-20)29(30,31)32/h2-11,18H,12-17,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 55nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301794(N-[6-(2-Benzyloxy) 1H-indazol-3-yl]-4-(1-methyl-pi...)
Show SMILES CN1CCN(CC1)Oc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-32-13-15-33(16-14-32)37-23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 55nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239024(US10028934, Compound 34 | US10478423, Cpd. 34 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3cccc(c3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-11-13-37(14-12-36)23-7-5-21(6-8-23)28(38)33-27-25-10-9-24(18-26(25)34-35-27)40-16-15-39-19-20-3-2-4-22(17-20)29(30,31)32/h2-10,17-18H,11-16,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 56nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301794(N-[6-(2-Benzyloxy) 1H-indazol-3-yl]-4-(1-methyl-pi...)
Show SMILES CN1CCN(CC1)Oc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-32-13-15-33(16-14-32)37-23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 56nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239024(US10028934, Compound 34 | US10478423, Cpd. 34 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3cccc(c3)C(F)(F)F)ccc12
Show InChI InChI=1S/C29H30F3N5O3/c1-36-11-13-37(14-12-36)23-7-5-21(6-8-23)28(38)33-27-25-10-9-24(18-26(25)34-35-27)40-16-15-39-19-20-3-2-4-22(17-20)29(30,31)32/h2-10,17-18H,11-16,19H2,1H3,(H2,33,34,35,38)
Affinity DataIC50: 58nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301791(N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-(1-meth...)
Show SMILES CN1CCC(CC1)Nc1ccccc1C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H33N5O3/c1-34-15-13-22(14-16-34)30-26-10-6-5-9-25(26)29(35)31-28-24-12-11-23(19-27(24)32-33-28)37-18-17-36-20-21-7-3-2-4-8-21/h2-12,19,22,30H,13-18,20H2,1H3,(H2,31,32,33,35)
Affinity DataIC50: 61nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239031(US10028934, Compound 17 | US10478423, Cpd. 17 | US...)
Show SMILES CN(C)CCCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H35N5O3/c1-33(2)16-7-17-34(3)24-12-10-23(11-13-24)29(35)30-28-26-15-14-25(20-27(26)31-32-28)37-19-18-36-21-22-8-5-4-6-9-22/h4-6,8-15,20H,7,16-19,21H2,1-3H3,(H2,30,31,32,35)
Affinity DataIC50: 62nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239028(US10028934, Compound 39 | US10478423, Cpd. 39 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC\C=C\c3ccccc3)ccc12
Show InChI InChI=1S/C28H29N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-14,20H,15-19H2,1H3,(H2,29,30,31,34)/b8-5+
Affinity DataIC50: 62nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239036(US10028934, Compound 25 | US10478423, Cpd. 25 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NCCN2CCOCC2)cc1
Show InChI InChI=1S/C29H33N5O4/c35-29(23-6-8-24(9-7-23)30-12-13-34-14-16-36-17-15-34)31-28-26-11-10-25(20-27(26)32-33-28)38-19-18-37-21-22-4-2-1-3-5-22/h1-11,20,30H,12-19,21H2,(H2,31,32,33,35)
Affinity DataIC50: 74nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239029(US10028934, Compound 15 | US10478423, Cpd. 15 | US...)
Show SMILES CN(C)C1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O3/c1-34(2)24-14-16-35(17-15-24)25-10-8-23(9-11-25)30(36)31-29-27-13-12-26(20-28(27)32-33-29)38-19-18-37-21-22-6-4-3-5-7-22/h3-13,20,24H,14-19,21H2,1-2H3,(H2,31,32,33,36)
Affinity DataIC50: 76nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239026(US10028934, Compound 40 | US10478423, Cpd. 40 | US...)
Show SMILES COc1ccc(COCCOc2ccc3c(NC(=O)c4ccc(cc4)N4CCN(C)CC4)n[nH]c3c2)cc1
Show InChI InChI=1S/C29H33N5O4/c1-33-13-15-34(16-14-33)23-7-5-22(6-8-23)29(35)30-28-26-12-11-25(19-27(26)31-32-28)38-18-17-37-20-21-3-9-24(36-2)10-4-21/h3-12,19H,13-18,20H2,1-2H3,(H2,30,31,32,35)
Affinity DataIC50: 88nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239037(US10028934, Compound 26 | US10478423, Cpd. 26 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NC2CCOCC2)cc1
Show InChI InChI=1S/C28H30N4O4/c33-28(21-6-8-22(9-7-21)29-23-12-14-34-15-13-23)30-27-25-11-10-24(18-26(25)31-32-27)36-17-16-35-19-20-4-2-1-3-5-20/h1-11,18,23,29H,12-17,19H2,(H2,30,31,32,33)
Affinity DataIC50: 90nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239038(US10028934, Compound 27 | US10478423, Cpd. 27 | US...)
Show SMILES CN1CCC(CNc2ccc(cc2)C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)CC1
Show InChI InChI=1S/C30H35N5O3/c1-35-15-13-22(14-16-35)20-31-25-9-7-24(8-10-25)30(36)32-29-27-12-11-26(19-28(27)33-34-29)38-18-17-37-21-23-5-3-2-4-6-23/h2-12,19,22,31H,13-18,20-21H2,1H3,(H2,32,33,34,36)
Affinity DataIC50: 91nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239018(US10028934, Compound 21 | US10478423, Cpd. 21 | US...)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C26H28N4O3/c1-30(2)17-19-8-10-21(11-9-19)26(31)27-25-23-13-12-22(16-24(23)28-29-25)33-15-14-32-18-20-6-4-3-5-7-20/h3-13,16H,14-15,17-18H2,1-2H3,(H2,27,28,29,31)
Affinity DataIC50: 104nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239030(US10028934, Compound 16 | US10478423, Cpd. 16 | US...)
Show SMILES CN(C)CCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H33N5O3/c1-32(2)15-16-33(3)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(19-26(25)30-31-27)36-18-17-35-20-21-7-5-4-6-8-21/h4-14,19H,15-18,20H2,1-3H3,(H2,29,30,31,34)
Affinity DataIC50: 106nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301795(N-[6-(2-Benzyloxy-ethoxy)-1H-indazol-3-yl]-4-methy...)
Show SMILES CN1CCC(CC1)c1c(C)ccc(C(=O)Nc2n[nH]c3cc(OCCOCc4ccccc4)ccc23)c1N
Show InChI InChI=1S/C30H35N5O3/c1-20-8-10-25(28(31)27(20)22-12-14-35(2)15-13-22)30(36)32-29-24-11-9-23(18-26(24)33-34-29)38-17-16-37-19-21-6-4-3-5-7-21/h3-11,18,22H,12-17,19,31H2,1-2H3,(H2,32,33,34,36)
Affinity DataIC50: 109nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239017(US10028934, Compound 11 | US10478423, Cpd. 11 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O3/c1-32-13-15-33(16-14-32)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)36-18-17-35-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 113nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239040(US10028934, Compound 14 | US10478423, Cpd. 14 | US...)
Show SMILES C[N+]1([O-])CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C28H31N5O4/c1-33(35)15-13-32(14-16-33)23-9-7-22(8-10-23)28(34)29-27-25-12-11-24(19-26(25)30-31-27)37-18-17-36-20-21-5-3-2-4-6-21/h2-12,19H,13-18,20H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 118nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239037(US10028934, Compound 26 | US10478423, Cpd. 26 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NC2CCOCC2)cc1
Show InChI InChI=1S/C28H30N4O4/c33-28(21-6-8-22(9-7-21)29-23-12-14-34-15-13-23)30-27-25-11-10-24(18-26(25)31-32-27)36-17-16-35-19-20-4-2-1-3-5-20/h1-11,18,23,29H,12-17,19H2,(H2,30,31,32,33)
Affinity DataIC50: 124nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239018(US10028934, Compound 21 | US10478423, Cpd. 21 | US...)
Show SMILES CN(C)Cc1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C26H28N4O3/c1-30(2)17-19-8-10-21(11-9-19)26(31)27-25-23-13-12-22(16-24(23)28-29-25)33-15-14-32-18-20-6-4-3-5-7-20/h3-13,16H,14-15,17-18H2,1-2H3,(H2,27,28,29,31)
Affinity DataIC50: 134nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239039(US10028934, Compound 28 | US10478423, Cpd. 28 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CC(C1)N1CCCC1
Show InChI InChI=1S/C30H33N5O3/c36-30(23-8-10-24(11-9-23)35-19-25(20-35)34-14-4-5-15-34)31-29-27-13-12-26(18-28(27)32-33-29)38-17-16-37-21-22-6-2-1-3-7-22/h1-3,6-13,18,25H,4-5,14-17,19-21H2,(H2,31,32,33,36)
Affinity DataIC50: 136nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239031(US10028934, Compound 17 | US10478423, Cpd. 17 | US...)
Show SMILES CN(C)CCCN(C)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C29H35N5O3/c1-33(2)16-7-17-34(3)24-12-10-23(11-13-24)29(35)30-28-26-15-14-25(20-27(26)31-32-28)37-19-18-36-21-22-8-5-4-6-9-22/h4-6,8-15,20H,7,16-19,21H2,1-3H3,(H2,30,31,32,35)
Affinity DataIC50: 146nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301796(N-[6-(2-Benzyloxy-ethoxy)-H-indazol-3-yl]-4-morpho...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H28N4O4/c32-27(21-7-4-8-22(17-21)31-11-13-33-14-12-31)28-26-24-10-9-23(18-25(24)29-30-26)35-16-15-34-19-20-5-2-1-3-6-20/h1-10,17-18H,11-16,19H2,(H2,28,29,30,32)
Affinity DataIC50: 162nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239025(US10028934, Compound 30 | US10478423, Cpd. 30 | US...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3F)ccc12
Show InChI InChI=1S/C28H30FN5O3/c1-33-12-14-34(15-13-33)22-8-6-20(7-9-22)28(35)30-27-24-11-10-23(18-26(24)31-32-27)37-17-16-36-19-21-4-2-3-5-25(21)29/h2-11,18H,12-17,19H2,1H3,(H2,30,31,32,35)
Affinity DataIC50: 166nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239013(US10028934, Compound 2 | US10478423, Cpd. 2 | US94...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(Oc3ccccc3)ccc12
Show InChI InChI=1S/C25H25N5O2/c1-29-13-15-30(16-14-29)19-9-7-18(8-10-19)25(31)26-24-22-12-11-21(17-23(22)27-28-24)32-20-5-3-2-4-6-20/h2-12,17H,13-16H2,1H3,(H2,26,27,28,31)
Affinity DataIC50: 172nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239041(US10028934, Compound 41 | US10478423, Cpd. 41 | US...)
Show SMILES CN(C1CC[N+](C)([O-])CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C30H35N5O4/c1-34(25-14-16-35(2,37)17-15-25)24-10-8-23(9-11-24)30(36)31-29-27-13-12-26(20-28(27)32-33-29)39-19-18-38-21-22-6-4-3-5-7-22/h3-13,20,25H,14-19,21H2,1-2H3,(H2,31,32,33,36)
Affinity DataIC50: 180nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239036(US10028934, Compound 25 | US10478423, Cpd. 25 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(NCCN2CCOCC2)cc1
Show InChI InChI=1S/C29H33N5O4/c35-29(23-6-8-24(9-7-23)30-12-13-34-14-16-36-17-15-34)31-28-26-11-10-25(20-27(26)32-33-28)38-19-18-37-21-22-4-2-1-3-5-22/h1-11,20,30H,12-19,21H2,(H2,31,32,33,35)
Affinity DataIC50: 197nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239011(US10028934, Compound 6 | US10478423, Cpd. 6 | US94...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OC3CCN(Cc4ccccc4)CC3)ccc12
Show InChI InChI=1S/C31H36N6O2/c1-35-17-19-37(20-18-35)25-9-7-24(8-10-25)31(38)32-30-28-12-11-27(21-29(28)33-34-30)39-26-13-15-36(16-14-26)22-23-5-3-2-4-6-23/h2-12,21,26H,13-20,22H2,1H3,(H2,32,33,34,38)
Affinity DataIC50: 248nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239010(US10028934, Compound 7 | US10478423, Cpd. 7 | US94...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCC#Cc3ccccc3)ccc12
Show InChI InChI=1S/C28H27N5O2/c1-32-15-17-33(18-16-32)23-11-9-22(10-12-23)28(34)29-27-25-14-13-24(20-26(25)30-31-27)35-19-5-8-21-6-3-2-4-7-21/h2-4,6-7,9-14,20H,15-19H2,1H3,(H2,29,30,31,34)
Affinity DataIC50: 249nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM301796(N-[6-(2-Benzyloxy-ethoxy)-H-indazol-3-yl]-4-morpho...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1cccc(c1)N1CCOCC1
Show InChI InChI=1S/C27H28N4O4/c32-27(21-7-4-8-22(17-21)31-11-13-33-14-12-31)28-26-24-10-9-23(18-25(24)29-30-26)35-16-15-34-19-20-5-2-1-3-6-20/h1-10,17-18H,11-16,19H2,(H2,28,29,30,32)
Affinity DataIC50: 260nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239039(US10028934, Compound 28 | US10478423, Cpd. 28 | US...)
Show SMILES O=C(Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12)c1ccc(cc1)N1CC(C1)N1CCCC1
Show InChI InChI=1S/C30H33N5O3/c36-30(23-8-10-24(11-9-23)35-19-25(20-35)34-14-4-5-15-34)31-29-27-13-12-26(18-28(27)32-33-29)38-17-16-37-21-22-6-2-1-3-7-22/h1-3,6-13,18,25H,4-5,14-17,19-21H2,(H2,31,32,33,36)
Affinity DataIC50: 306nMAssay Description:i. Enzyme The assay has been performed using KIT cytoplasmic domain product and purified in house as GST fused protein. The KIT protein (4.5 microM) ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239032(US10028934, Compound 18 | US10478423, Cpd. 18 | US...)
Show SMILES CC(C)(C)OC(=O)N1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCCOCc3ccccc3)ccc12
Show InChI InChI=1S/C32H37N5O5/c1-32(2,3)42-31(39)37-17-15-36(16-18-37)25-11-9-24(10-12-25)30(38)33-29-27-14-13-26(21-28(27)34-35-29)41-20-19-40-22-23-7-5-4-6-8-23/h4-14,21H,15-20,22H2,1-3H3,(H2,33,34,35,38)
Affinity DataIC50: 414nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
TargetReceptor-type tyrosine-protein kinase FLT3 [K633Q](Homo sapiens (Human))
Nerviano Medical Sciences srl

US Patent
LigandPNGBDBM239009(US10028934, Compound 1 | US10478423, Cpd. 1 | US94...)
Show SMILES CN1CCN(CC1)c1ccc(cc1)C(=O)Nc1n[nH]c2cc(OCc3ccccc3)ccc12
Show InChI InChI=1S/C26H27N5O2/c1-30-13-15-31(16-14-30)21-9-7-20(8-10-21)26(32)27-25-23-12-11-22(17-24(23)28-29-25)33-18-19-5-3-2-4-6-19/h2-12,17H,13-16,18H2,1H3,(H2,27,28,29,32)
Affinity DataIC50: 428nMAssay Description:i. Enzyme The assay was performed using FLT3 cytoplasmic domain product and purified in house as GST fused protein. The FLT3 protein (1 microM) was p...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
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