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Compile Data Set for Download or QSAR

Found 70 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 1906   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kJ/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14974
PNG
(CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...)
Show SMILES CN(C)CCCc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ccncn3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F3N6O/c1-19-8-9-21(16-26(19)37-27-24(7-4-11-34-27)25-10-12-33-18-35-25)28(39)36-23-15-20(6-5-13-38(2)3)14-22(17-23)29(30,31)32/h4,7-12,14-18H,5-6,13H2,1-3H3,(H,34,37)(H,36,39)
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n/an/a 1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14948
PNG
(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N5O2/c1-15-8-9-16(22(34)32-18-6-3-5-17(14-18)25(26,27)28)13-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33)
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n/an/a 1n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14974
PNG
(CHEMBL221484 | N-(3-(3-(Dimethylamino)propyl)-5-(t...)
Show SMILES CN(C)CCCc1cc(NC(=O)c2ccc(C)c(Nc3ncccc3-c3ccncn3)c2)cc(c1)C(F)(F)F
Show InChI InChI=1S/C29H29F3N6O/c1-19-8-9-21(16-26(19)37-27-24(7-4-11-34-27)25-10-12-33-18-35-25)28(39)36-23-15-20(6-5-13-38(2)3)14-22(17-23)29(30,31)32/h4,7-12,14-18H,5-6,13H2,1-3H3,(H,34,37)(H,36,39)
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n/an/a 2n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14948
PNG
(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N5O2/c1-15-8-9-16(22(34)32-18-6-3-5-17(14-18)25(26,27)28)13-21(15)35-23-19(7-4-11-30-23)20-10-12-31-24(29-2)33-20/h3-14H,1-2H3,(H,32,34)(H,29,31,33)
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n/an/a 3n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 4n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14984
PNG
(N-(5-Cyclohexyl-2-methoxyphenyl)-4-methyl-3-(3-(2-...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1OC)C1CCCCC1
Show InChI InChI=1S/C31H33N5O3/c1-20-11-12-23(29(37)35-26-18-22(13-14-27(26)38-3)21-8-5-4-6-9-21)19-28(20)39-30-24(10-7-16-33-30)25-15-17-34-31(32-2)36-25/h7,10-19,21H,4-6,8-9H2,1-3H3,(H,35,37)(H,32,34,36)
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n/an/a 4n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14995
PNG
(2-(Methylamino)pyrimidine 58 | N-(2-((3-(Dimethyla...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C(F)(F)F
Show InChI InChI=1S/C30H31F4N7O2/c1-35-29-37-14-12-24(39-29)21-7-5-13-36-28(21)43-20-9-10-23(31)22(18-20)27(42)38-25-17-19(30(32,33)34)8-11-26(25)41(4)16-6-15-40(2)3/h5,7-14,17-18H,6,15-16H2,1-4H3,(H,38,42)(H,35,37,39)
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Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14971
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-7-8-16(23(33)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)32-22-19(6-3-10-29-22)20-9-11-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 4n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM15001
PNG
(2-(Methylamino)triazine 64 | N-(2-((3-(Dimethylami...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C(C)C
Show InChI InChI=1S/C31H37FN8O2/c1-20(2)21-10-13-27(40(6)16-8-15-39(4)5)26(17-21)37-29(41)24-18-22(11-12-25(24)32)42-30-23(9-7-14-34-30)28-35-19-36-31(33-3)38-28/h7,9-14,17-20H,8,15-16H2,1-6H3,(H,37,41)(H,33,35,36,38)
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n/an/a 6n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14996
PNG
(2-(Methylamino)triazine 59 | 4-methyl-3-({3-[4-(me...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19F3N6O2/c1-14-8-9-15(21(34)32-17-6-3-5-16(12-17)24(25,26)27)11-19(14)35-22-18(7-4-10-29-22)20-30-13-31-23(28-2)33-20/h3-13H,1-2H3,(H,32,34)(H,28,30,31,33)
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n/an/a 10n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14983
PNG
(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O3/c1-18-5-6-19(16-25(18)41-27-21(4-3-10-34-27)22-9-11-35-28(33-2)37-22)26(39)36-23-17-20(29(30,31)32)7-8-24(23)38-12-14-40-15-13-38/h3-11,16-17H,12-15H2,1-2H3,(H,36,39)(H,33,35,37)
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n/an/a 10n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM15002
PNG
(2-(Methylamino)triazine 65 | N-(5-Cyclopropyl-2-((...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C1CC1
Show InChI InChI=1S/C31H35FN8O2/c1-33-31-36-19-35-28(38-31)23-7-5-14-34-30(23)42-22-11-12-25(32)24(18-22)29(41)37-26-17-21(20-8-9-20)10-13-27(26)40(4)16-6-15-39(2)3/h5,7,10-14,17-20H,6,8-9,15-16H2,1-4H3,(H,37,41)(H,33,35,36,38)
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n/an/a 13n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14985
PNG
(N-(5-Cyclohexyl-2-methoxyphenyl)-4-methyl-3-(3-(4-...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1OC)C1CCCCC1
Show InChI InChI=1S/C30H32N6O3/c1-19-11-12-22(28(37)35-24-16-21(13-14-25(24)38-3)20-8-5-4-6-9-20)17-26(19)39-29-23(10-7-15-32-29)27-33-18-34-30(31-2)36-27/h7,10-18,20H,4-6,8-9H2,1-3H3,(H,35,37)(H,31,33,34,36)
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n/an/a 22n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM15000
PNG
(2-(Methylamino)triazine 63 | N-(2-((3-(Dimethylami...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C(F)(F)F
Show InChI InChI=1S/C29H30F4N8O2/c1-34-28-37-17-36-25(39-28)20-7-5-12-35-27(20)43-19-9-10-22(30)21(16-19)26(42)38-23-15-18(29(31,32)33)8-11-24(23)41(4)14-6-13-40(2)3/h5,7-12,15-17H,6,13-14H2,1-4H3,(H,38,42)(H,34,36,37,39)
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Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14991
PNG
(2-(Methylamino)pyrimidine 54 | 4-chloro-3-({3-[2-(...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1Cl)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N6O2/c1-34-28-36-13-11-22(38-28)20-6-5-12-35-27(20)41-25-16-18(7-9-21(25)30)26(40)37-23-17-19(29(31,32)33)8-10-24(23)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM15019
PNG
(CHEMBL385178 | N-(4-phenoxyphenyl)-2-[(pyridin-4-y...)
Show SMILES O=C(Nc1ccc(Oc2ccccc2)cc1)c1cccnc1NCc1ccncc1
Show InChI InChI=1S/C24H20N4O2/c29-24(22-7-4-14-26-23(22)27-17-18-12-15-25-16-13-18)28-19-8-10-21(11-9-19)30-20-5-2-1-3-6-20/h1-16H,17H2,(H,26,27)(H,28,29)
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n/an/a 38n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM15020
PNG
(N-(4-phenoxyphenyl)-3-[(3-{4-[(3,4,5-trimethoxyphe...)
Show SMILES COc1cc(Nc2ncnc(n2)-c2cccnc2Nc2cccc(c2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc(OC)c1OC
Show InChI InChI=1S/C36H31N7O5/c1-45-30-20-26(21-31(46-2)32(30)47-3)42-36-39-22-38-34(43-36)29-13-8-18-37-33(29)40-25-10-7-9-23(19-25)35(44)41-24-14-16-28(17-15-24)48-27-11-5-4-6-12-27/h4-22H,1-3H3,(H,37,40)(H,41,44)(H,38,39,42,43)
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Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14992
PNG
(2-(Methylamino)pyrimidine 55 | 4-Methyl-3-(3-(2-(m...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2/c1-19-8-9-20(17-26(19)41-28-22(7-6-13-35-28)23-12-14-36-29(34-2)38-23)27(40)37-24-18-21(30(31,32)33)10-11-25(24)39-15-4-3-5-16-39/h6-14,17-18H,3-5,15-16H2,1-2H3,(H,37,40)(H,34,36,38)
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n/an/a 39n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14994
PNG
(2-(Methylamino)pyrimidine 57 | 2-Fluoro-5-(3-(2-(m...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26F4N6O2/c1-34-28-36-13-11-23(38-28)20-6-5-12-35-27(20)41-19-8-9-22(30)21(17-19)26(40)37-24-16-18(29(31,32)33)7-10-25(24)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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n/an/a 40n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14975
PNG
(N-[2-methoxy-5-(trifluoromethyl)phenyl]-4-methyl-3...)
Show SMILES COc1ccc(cc1NC(=O)c1ccc(C)c(Nc2ncccc2-c2ccncn2)c1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N5O2/c1-15-5-6-16(24(34)33-21-13-17(25(26,27)28)7-8-22(21)35-2)12-20(15)32-23-18(4-3-10-30-23)19-9-11-29-14-31-19/h3-14H,1-2H3,(H,30,32)(H,33,34)
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n/an/a 43n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14995
PNG
(2-(Methylamino)pyrimidine 58 | N-(2-((3-(Dimethyla...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C(F)(F)F
Show InChI InChI=1S/C30H31F4N7O2/c1-35-29-37-14-12-24(39-29)21-7-5-13-36-28(21)43-20-9-10-23(31)22(18-20)27(42)38-25-17-19(30(32,33)34)8-11-26(25)41(4)16-6-15-40(2)3/h5,7-14,17-18H,6,15-16H2,1-4H3,(H,38,42)(H,35,37,39)
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n/an/a 46n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14999
PNG
(2-(Methylamino)triazine 62 | 2-Fluoro-5-(3-(4-(met...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1ccc(F)c(c1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C28H25F4N7O2/c1-33-27-36-16-35-24(38-27)19-6-5-11-34-26(19)41-18-8-9-21(29)20(15-18)25(40)37-22-14-17(28(30,31)32)7-10-23(22)39-12-3-2-4-13-39/h5-11,14-16H,2-4,12-13H2,1H3,(H,37,40)(H,33,35,36,38)
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n/an/a 53n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14975
PNG
(N-[2-methoxy-5-(trifluoromethyl)phenyl]-4-methyl-3...)
Show SMILES COc1ccc(cc1NC(=O)c1ccc(C)c(Nc2ncccc2-c2ccncn2)c1)C(F)(F)F
Show InChI InChI=1S/C25H20F3N5O2/c1-15-5-6-16(24(34)33-21-13-17(25(26,27)28)7-8-22(21)35-2)12-20(15)32-23-18(4-3-10-30-23)19-9-11-29-14-31-19/h3-14H,1-2H3,(H,30,32)(H,33,34)
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n/an/a 58n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14977
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H17F3N4O2/c1-15-7-8-16(22(32)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)33-23-19(6-3-10-29-23)20-9-11-28-14-30-20/h2-14H,1H3,(H,31,32)
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n/an/a 59n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14998
PNG
(2-(Methylamino)triazine 61 | N-(2-((3-(Dimethylami...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N(C)CCCN(C)C)C(F)(F)F
Show InChI InChI=1S/C30H33F3N8O2/c1-19-9-10-20(16-25(19)43-28-22(8-6-13-35-28)26-36-18-37-29(34-2)39-26)27(42)38-23-17-21(30(31,32)33)11-12-24(23)41(5)15-7-14-40(3)4/h6,8-13,16-18H,7,14-15H2,1-5H3,(H,38,42)(H,34,36,37,39)
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n/an/a 59n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14990
PNG
(2-(Methylamino)pyrimidine 53 | 4-fluoro-3-({3-[2-(...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1F)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26F4N6O2/c1-34-28-36-13-11-22(38-28)20-6-5-12-35-27(20)41-25-16-18(7-9-21(25)30)26(40)37-23-17-19(29(31,32)33)8-10-24(23)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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n/an/a 62n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14986
PNG
(N-(5-Cyclohexyl-2-methoxyphenyl)-4-methyl-3-(3-(2-...)
Show SMILES CNc1cc(ccn1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1OC)C1CCCCC1
Show InChI InChI=1S/C32H34N4O3/c1-21-11-12-25(31(37)36-27-18-23(13-14-28(27)38-3)22-8-5-4-6-9-22)19-29(21)39-32-26(10-7-16-35-32)24-15-17-34-30(20-24)33-2/h7,10-20,22H,4-6,8-9H2,1-3H3,(H,33,34)(H,36,37)
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n/an/a 62n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM15018
PNG
(4-[2-(phenylamino)pyridin-3-yl]-N-(3,4,5-trimethox...)
Show SMILES COc1cc(Nc2ncnc(n2)-c2cccnc2Nc2ccccc2)cc(OC)c1OC
Show InChI InChI=1S/C23H22N6O3/c1-30-18-12-16(13-19(31-2)20(18)32-3)28-23-26-14-25-22(29-23)17-10-7-11-24-21(17)27-15-8-5-4-6-9-15/h4-14H,1-3H3,(H,24,27)(H,25,26,28,29)
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n/an/a 68n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (crystal)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14984
PNG
(N-(5-Cyclohexyl-2-methoxyphenyl)-4-methyl-3-(3-(2-...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1OC)C1CCCCC1
Show InChI InChI=1S/C31H33N5O3/c1-20-11-12-23(29(37)35-26-18-22(13-14-27(26)38-3)21-8-5-4-6-9-21)19-28(20)39-30-24(10-7-16-33-30)25-15-17-34-31(32-2)36-25/h7,10-19,21H,4-6,8-9H2,1-3H3,(H,35,37)(H,32,34,36)
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n/an/a 70n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM15020
PNG
(N-(4-phenoxyphenyl)-3-[(3-{4-[(3,4,5-trimethoxyphe...)
Show SMILES COc1cc(Nc2ncnc(n2)-c2cccnc2Nc2cccc(c2)C(=O)Nc2ccc(Oc3ccccc3)cc2)cc(OC)c1OC
Show InChI InChI=1S/C36H31N7O5/c1-45-30-20-26(21-31(46-2)32(30)47-3)42-36-39-22-38-34(43-36)29-13-8-18-37-33(29)40-25-10-7-9-23(19-25)35(44)41-24-14-16-28(17-15-24)48-27-11-5-4-6-12-27/h4-22H,1-3H3,(H,37,40)(H,41,44)(H,38,39,42,43)
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n/an/a 85n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14996
PNG
(2-(Methylamino)triazine 59 | 4-methyl-3-({3-[4-(me...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H19F3N6O2/c1-14-8-9-15(21(34)32-17-6-3-5-16(12-17)24(25,26)27)11-19(14)35-22-18(7-4-10-29-22)20-30-13-31-23(28-2)33-20/h3-13H,1-2H3,(H,32,34)(H,28,30,31,33)
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n/an/a 97n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14989
PNG
(2-(Methylamino)pyrimidine 52 | 3-({3-[2-(methylami...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cccc(c1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O2/c1-33-28-35-14-12-23(37-28)22-9-6-13-34-27(22)40-21-8-5-7-19(17-21)26(39)36-24-18-20(29(30,31)32)10-11-25(24)38-15-3-2-4-16-38/h5-14,17-18H,2-4,15-16H2,1H3,(H,36,39)(H,33,35,37)
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n/an/a 99n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14979
PNG
(N-(2-Methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3...)
Show SMILES COc1ccc(cc1NC(=O)c1ccc(C)c(Oc2ncccc2-c2ccncn2)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F3N4O3/c1-15-5-6-16(23(33)32-20-13-17(25(26,27)28)7-8-21(20)34-2)12-22(15)35-24-18(4-3-10-30-24)19-9-11-29-14-31-19/h3-14H,1-2H3,(H,32,33)
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n/an/a 100n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14979
PNG
(N-(2-Methoxy-5-(trifluoromethyl)phenyl)-4-methyl-3...)
Show SMILES COc1ccc(cc1NC(=O)c1ccc(C)c(Oc2ncccc2-c2ccncn2)c1)C(F)(F)F
Show InChI InChI=1S/C25H19F3N4O3/c1-15-5-6-16(23(33)32-20-13-17(25(26,27)28)7-8-21(20)34-2)12-22(15)35-24-18(4-3-10-30-24)19-9-11-29-14-31-19/h3-14H,1-2H3,(H,32,33)
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n/an/a 103n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14997
PNG
(2-(Methylamino)triazine 60 | 4-Methyl-3-(3-(4-(met...)
Show SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H28F3N7O2/c1-18-8-9-19(15-24(18)41-27-21(7-6-12-34-27)25-35-17-36-28(33-2)38-25)26(40)37-22-16-20(29(30,31)32)10-11-23(22)39-13-4-3-5-14-39/h6-12,15-17H,3-5,13-14H2,1-2H3,(H,37,40)(H,33,35,36,38)
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n/an/a 108n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14977
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1cccc(c1)C(F)(F)F
Show InChI InChI=1S/C24H17F3N4O2/c1-15-7-8-16(22(32)31-18-5-2-4-17(13-18)24(25,26)27)12-21(15)33-23-19(6-3-10-29-23)20-9-11-28-14-30-20/h2-14H,1H3,(H,31,32)
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n/an/a 153n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14973
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-4-5-16(23(33)31-18-8-6-17(7-9-18)24(25,26)27)13-21(15)32-22-19(3-2-11-29-22)20-10-12-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 177n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14976
PNG
(4-Methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O/c1-19-7-8-20(16-24(19)36-27-22(6-5-12-34-27)23-11-13-33-18-35-23)28(39)37-25-17-21(29(30,31)32)9-10-26(25)38-14-3-2-4-15-38/h5-13,16-18H,2-4,14-15H2,1H3,(H,34,36)(H,37,39)
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n/an/a 181n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14983
PNG
(4-Methyl-3-(3-(2-(methylamino)pyrimidin-4-yl)pyrid...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C29H27F3N6O3/c1-18-5-6-19(16-25(18)41-27-21(4-3-10-34-27)22-9-11-35-28(33-2)37-22)26(39)36-23-17-20(29(30,31)32)7-8-24(23)38-12-14-40-15-13-38/h3-11,16-17H,12-15H2,1-2H3,(H,36,39)(H,33,35,37)
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n/an/a 310n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14980
PNG
(4-Methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26F3N5O2/c1-19-7-8-20(16-26(19)39-28-22(6-5-12-34-28)23-11-13-33-18-35-23)27(38)36-24-17-21(29(30,31)32)9-10-25(24)37-14-3-2-4-15-37/h5-13,16-18H,2-4,14-15H2,1H3,(H,36,38)
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n/an/a 366n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14993
PNG
(2-(Methylamino)pyrimidine 56 | 2-methyl-3-({3-[2-(...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cccc(C(=O)Nc2cc(ccc2N2CCCCC2)C(F)(F)F)c1C
Show InChI InChI=1S/C30H29F3N6O2/c1-19-21(27(40)37-24-18-20(30(31,32)33)11-12-25(24)39-16-4-3-5-17-39)8-6-10-26(19)41-28-22(9-7-14-35-28)23-13-15-36-29(34-2)38-23/h6-15,18H,3-5,16-17H2,1-2H3,(H,37,40)(H,34,36,38)
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n/an/a 388n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14982
PNG
(4-Methyl-N-(2-morpholino-5-(trifluoromethyl)phenyl...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCOCC1)C(F)(F)F
Show InChI InChI=1S/C28H24F3N5O3/c1-18-4-5-19(15-25(18)39-27-21(3-2-9-33-27)22-8-10-32-17-34-22)26(37)35-23-16-20(28(29,30)31)6-7-24(23)36-11-13-38-14-12-36/h2-10,15-17H,11-14H2,1H3,(H,35,37)
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n/an/a 399n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14972
PNG
(4-Methyl-N-phenyl-3-(3-(pyrimidin-4-yl)pyridin-2-y...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C23H19N5O/c1-16-9-10-17(23(29)27-18-6-3-2-4-7-18)14-21(16)28-22-19(8-5-12-25-22)20-11-13-24-15-26-20/h2-15H,1H3,(H,25,28)(H,27,29)
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n/an/a 435n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14992
PNG
(2-(Methylamino)pyrimidine 55 | 4-Methyl-3-(3-(2-(m...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1C)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C30H29F3N6O2/c1-19-8-9-20(17-26(19)41-28-22(7-6-13-35-28)23-12-14-36-29(34-2)38-23)27(40)37-24-18-21(30(31,32)33)10-11-25(24)39-15-4-3-5-16-39/h6-14,17-18H,3-5,15-16H2,1-2H3,(H,37,40)(H,34,36,38)
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n/an/a 461n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14973
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-ylamino)-N...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H18F3N5O/c1-15-4-5-16(23(33)31-18-8-6-17(7-9-18)24(25,26)27)13-21(15)32-22-19(3-2-11-29-22)20-10-12-28-14-30-20/h2-14H,1H3,(H,29,32)(H,31,33)
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n/an/a 504n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14991
PNG
(2-(Methylamino)pyrimidine 54 | 4-chloro-3-({3-[2-(...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1Cl)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26ClF3N6O2/c1-34-28-36-13-11-22(38-28)20-6-5-12-35-27(20)41-25-16-18(7-9-21(25)30)26(40)37-23-17-19(29(31,32)33)8-10-24(23)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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n/an/a 675n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14978
PNG
(4-Methyl-3-(3-(pyrimidin-4-yl)pyridin-2-yloxy)-N-(...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1ccc(cc1)C(F)(F)F
Show InChI InChI=1S/C24H17F3N4O2/c1-15-4-5-16(22(32)31-18-8-6-17(7-9-18)24(25,26)27)13-21(15)33-23-19(3-2-11-29-23)20-10-12-28-14-30-20/h2-14H,1H3,(H,31,32)
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n/an/a 705n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Angiopoietin-1 receptor


(Homo sapiens (Human))
BDBM14972
PNG
(4-Methyl-N-phenyl-3-(3-(pyrimidin-4-yl)pyridin-2-y...)
Show SMILES Cc1ccc(cc1Nc1ncccc1-c1ccncn1)C(=O)Nc1ccccc1
Show InChI InChI=1S/C23H19N5O/c1-16-9-10-17(23(29)27-18-6-3-2-4-7-18)14-21(16)28-22-19(8-5-12-25-22)20-11-13-24-15-26-20/h2-15H,1H3,(H,25,28)(H,27,29)
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n/an/a 1.22E+3n/an/an/an/a7.522



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
3D
3D Structure (docked)
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14980
PNG
(4-Methyl-N-(2-(piperidin-1-yl)-5-(trifluoromethyl)...)
Show SMILES Cc1ccc(cc1Oc1ncccc1-c1ccncn1)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26F3N5O2/c1-19-7-8-20(16-26(19)39-28-22(6-5-12-34-28)23-11-13-33-18-35-23)27(38)36-24-17-21(29(30,31)32)9-10-25(24)37-14-3-2-4-15-37/h5-13,16-18H,2-4,14-15H2,1H3,(H,36,38)
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n/an/a 1.30E+3n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM14990
PNG
(2-(Methylamino)pyrimidine 53 | 4-fluoro-3-({3-[2-(...)
Show SMILES CNc1nccc(n1)-c1cccnc1Oc1cc(ccc1F)C(=O)Nc1cc(ccc1N1CCCCC1)C(F)(F)F
Show InChI InChI=1S/C29H26F4N6O2/c1-34-28-36-13-11-22(38-28)20-6-5-12-35-27(20)41-25-16-18(7-9-21(25)30)26(40)37-23-17-19(29(31,32)33)8-10-24(23)39-14-3-2-4-15-39/h5-13,16-17H,2-4,14-15H2,1H3,(H,37,40)(H,34,36,38)
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n/an/a 2.00E+3n/an/an/an/an/an/a



Amgen



Assay Description
The assay uses purified enzyme interacting with biotinylated peptide substrate. HTRF is based on the proximity of europium cryptate (donor fluorophor...


J Med Chem 50: 611-26 (2007)


Article DOI: 10.1021/jm061107l
BindingDB Entry DOI: 10.7270/Q2MC8X8S
More data for this
Ligand-Target Pair
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