Compile Data Set for Download or QSAR

Found 184 hits Enz. Inhib. hit(s) with all data for assayid = 1 entry = 9817   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490738 (US10968236, Compound I-66) Show SMILES OC(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1)(C(F)(F)F)C(F)(F)F Show InChI InChI=1S/C22H13F8N3O2/c23-12-2-1-3-13(24)17(12)14-8-15(18-16(33-14)9-31-19(18)34)32-11-6-4-10(5-7-11)20(35,21(25,26)27)22(28,29)30/h1-8,35H,9H2,(H,31,34)(H,32,33)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490739 (US10968236, Compound I-67) Show SMILES CCNC(=O)C(C)(C)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C25H24F2N4O2/c1-4-28-24(33)25(2,3)14-8-10-15(11-9-14)30-19-12-18(21-16(26)6-5-7-17(21)27)31-20-13-29-23(32)22(19)20/h5-12H,4,13H2,1-3H3,(H,28,33)(H,29,32)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490739 (US10968236, Compound I-67) Show SMILES CCNC(=O)C(C)(C)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C25H24F2N4O2/c1-4-28-24(33)25(2,3)14-8-10-15(11-9-14)30-19-12-18(21-16(26)6-5-7-17(21)27)31-20-13-29-23(32)22(19)20/h5-12H,4,13H2,1-3H3,(H,28,33)(H,29,32)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490742 (US10968236, Compound I-70) Show SMILES CC1(C)COc2cc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3F)ccc12 Show InChI InChI=1S/C23H19F2N3O2/c1-23(2)11-30-19-8-12(6-7-13(19)23)27-17-9-16(20-14(24)4-3-5-15(20)25)28-18-10-26-22(29)21(17)18/h3-9H,10-11H2,1-2H3,(H,26,29)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490746 (US10968236, Compound I-74) Show SMILES Fc1cccc(C#N)c1-c1cc(Nc2ccc(nc2)N2C[C@@H]3COC[C@@H]3C2)c2C(=O)NCc2n1 Show InChI InChI=1S/C25H21FN6O2/c26-18-3-1-2-14(7-27)23(18)19-6-20(24-21(31-19)9-29-25(24)33)30-17-4-5-22(28-8-17)32-10-15-12-34-13-16(15)11-32/h1-6,8,15-16H,9-13H2,(H,29,33)(H,30,31)/t15-,16+	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490747 (US10968236, Compound I-75) Show SMILES Fc1cccc(C#N)c1-c1cc(Nc2ccc(nc2)N2CCC3(CC3)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C26H23FN6O/c27-18-3-1-2-16(13-28)23(18)19-12-20(24-21(32-19)15-30-25(24)34)31-17-4-5-22(29-14-17)33-10-8-26(6-7-26)9-11-33/h1-5,12,14H,6-11,15H2,(H,30,34)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490747 (US10968236, Compound I-75) Show SMILES Fc1cccc(C#N)c1-c1cc(Nc2ccc(nc2)N2CCC3(CC3)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C26H23FN6O/c27-18-3-1-2-16(13-28)23(18)19-12-20(24-21(32-19)15-30-25(24)34)31-17-4-5-22(29-14-17)33-10-8-26(6-7-26)9-11-33/h1-5,12,14H,6-11,15H2,(H,30,34)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490748 (US10968236, Compound I-76) Show SMILES Fc1cccc(C#N)c1-c1cc(Nc2ccc(cn2)N2C[C@@H]3COC[C@@H]3C2)c2C(=O)NCc2n1 Show InChI InChI=1S/C25H21FN6O2/c26-18-3-1-2-14(7-27)23(18)19-6-20(24-21(30-19)9-29-25(24)33)31-22-5-4-17(8-28-22)32-10-15-12-34-13-16(15)11-32/h1-6,8,15-16H,9-13H2,(H,29,33)(H,28,30,31)/t15-,16+	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490749 (US10968236, Compound I-77) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc3C(=O)C4(CC4)Oc3c2)c2C(=O)NCc2n1 Show InChI InChI=1S/C23H15F2N3O3/c24-13-2-1-3-14(25)19(13)15-9-16(20-17(28-15)10-26-22(20)30)27-11-4-5-12-18(8-11)31-23(6-7-23)21(12)29/h1-5,8-9H,6-7,10H2,(H,26,30)(H,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490750 (US10968236, Compound I-78) Show SMILES CC(O)(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O2/c1-20(32,21(24,25)26)10-5-6-16(27-8-10)30-14-7-13(17-11(22)3-2-4-12(17)23)29-15-9-28-19(31)18(14)15/h2-8,32H,9H2,1H3,(H,28,31)(H,27,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490751 (US10968236, Compound I-79) Show SMILES Fc1cccc(C#N)c1-c1cc(Nc2ccc(nc2)N2CCOC3(CC3)C2)c2C(=O)NCc2n1 Show InChI InChI=1S/C25H21FN6O2/c26-17-3-1-2-15(11-27)22(17)18-10-19(23-20(31-18)13-29-24(23)33)30-16-4-5-21(28-12-16)32-8-9-34-25(14-32)6-7-25/h1-5,10,12H,6-9,13-14H2,(H,29,33)(H,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490752 (US10968236, Compound I-80) Show SMILES CC1(C)COc2cc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)ccc12 Show InChI InChI=1S/C24H19FN4O2/c1-24(2)12-31-20-8-14(6-7-15(20)24)28-18-9-17(29-19-11-27-23(30)22(18)19)21-13(10-26)4-3-5-16(21)25/h3-9H,11-12H2,1-2H3,(H,27,30)(H,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490753 (US10968236, Compound I-81) Show SMILES CCNC(=O)C(C)(C)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)cc1 Show InChI InChI=1S/C26H24FN5O2/c1-4-29-25(34)26(2,3)16-8-10-17(11-9-16)31-20-12-19(32-21-14-30-24(33)23(20)21)22-15(13-28)6-5-7-18(22)27/h5-12H,4,14H2,1-3H3,(H,29,34)(H,30,33)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490753 (US10968236, Compound I-81) Show SMILES CCNC(=O)C(C)(C)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)cc1 Show InChI InChI=1S/C26H24FN5O2/c1-4-29-25(34)26(2,3)16-8-10-17(11-9-16)31-20-12-19(32-21-14-30-24(33)23(20)21)22-15(13-28)6-5-7-18(22)27/h5-12H,4,14H2,1-3H3,(H,29,34)(H,30,33)(H,31,32)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490754 (US10968236, Compound I-82) Show SMILES C[C@](O)(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O2/c1-20(32,21(24,25)26)10-5-6-16(27-8-10)30-14-7-13(17-11(22)3-2-4-12(17)23)29-15-9-28-19(31)18(14)15/h2-8,32H,9H2,1H3,(H,28,31)(H,27,29,30)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490754 (US10968236, Compound I-82) Show SMILES C[C@](O)(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O2/c1-20(32,21(24,25)26)10-5-6-16(27-8-10)30-14-7-13(17-11(22)3-2-4-12(17)23)29-15-9-28-19(31)18(14)15/h2-8,32H,9H2,1H3,(H,28,31)(H,27,29,30)/t20-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490755 (US10968236, Compound I-83) Show SMILES C[C@@](O)(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O2/c1-20(32,21(24,25)26)10-5-6-16(27-8-10)30-14-7-13(17-11(22)3-2-4-12(17)23)29-15-9-28-19(31)18(14)15/h2-8,32H,9H2,1H3,(H,28,31)(H,27,29,30)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490755 (US10968236, Compound I-83) Show SMILES C[C@@](O)(c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2F)nc1)C(F)(F)F Show InChI InChI=1S/C21H15F5N4O2/c1-20(32,21(24,25)26)10-5-6-16(27-8-10)30-14-7-13(17-11(22)3-2-4-12(17)23)29-15-9-28-19(31)18(14)15/h2-8,32H,9H2,1H3,(H,28,31)(H,27,29,30)/t20-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490758 (US10968236, Compound I-86) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc3CS(=O)(=O)Cc3c2)c2C(=O)NCc2n1 Show InChI InChI=1S/C21H15F2N3O3S/c22-14-2-1-3-15(23)19(14)16-7-17(20-18(26-16)8-24-21(20)27)25-13-5-4-11-9-30(28,29)10-12(11)6-13/h1-7H,8-10H2,(H,24,27)(H,25,26)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490759 (US10968236, Compound I-87) Show SMILES OC1C2(CC2)CN(CC11CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)nc1 Show InChI InChI=1S/C28H25FN6O2/c29-18-3-1-2-16(11-30)23(18)19-10-20(24-21(33-19)13-32-25(24)36)34-22-5-4-17(12-31-22)35-14-27(6-7-27)26(37)28(15-35)8-9-28/h1-5,10,12,26,37H,6-9,13-15H2,(H,32,36)(H,31,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490759 (US10968236, Compound I-87) Show SMILES OC1C2(CC2)CN(CC11CC1)c1ccc(Nc2cc(nc3CNC(=O)c23)-c2c(F)cccc2C#N)nc1 Show InChI InChI=1S/C28H25FN6O2/c29-18-3-1-2-16(11-30)23(18)19-10-20(24-21(33-19)13-32-25(24)36)34-22-5-4-17(12-31-22)35-14-27(6-7-27)26(37)28(15-35)8-9-28/h1-5,10,12,26,37H,6-9,13-15H2,(H,32,36)(H,31,33,34)	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490760 (US10968236, Compound I-88) Show SMILES OC1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17?,26-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490760 (US10968236, Compound I-88) Show SMILES OC1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17?,26-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490761 (US10968236, Compound I-89) Show SMILES OC1CO[C@@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17?,26-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490761 (US10968236, Compound I-89) Show SMILES OC1CO[C@@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17?,26-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490762 (US10968236, Compound I-90) Show SMILES O[C@H]1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490762 (US10968236, Compound I-90) Show SMILES O[C@H]1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490763 (US10968236, Compound I-91) Show SMILES O[C@@H]1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Tyrosine-protein kinase JAK2 (Homo sapiens (Human))	BDBM490763 (US10968236, Compound I-91) Show SMILES O[C@@H]1CO[C@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26+/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490764 (US10968236, Compound I-92) Show SMILES O[C@H]1CO[C@@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26+/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490765 (US10968236, Compound I-93) Show SMILES O[C@@H]1CO[C@@]2(CCN(C2)c2ccc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3C#N)nc2)C1 Show InChI InChI=1S/C26H23FN6O3/c27-18-3-1-2-15(10-28)23(18)19-8-20(24-21(31-19)12-30-25(24)35)32-22-5-4-16(11-29-22)33-7-6-26(14-33)9-17(34)13-36-26/h1-5,8,11,17,34H,6-7,9,12-14H2,(H,30,35)(H,29,31,32)/t17-,26-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490631 (US10968236, Compound I-1) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc3CCNc3c2)n1 Show InChI InChI=1S/C20H15F2N5O/c21-12-2-1-3-13(22)16(12)18-26-15-9-24-20(28)17(15)19(27-18)25-11-5-4-10-6-7-23-14(10)8-11/h1-5,8,23H,6-7,9H2,(H,24,28)(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490632 (US10968236, Compound I-2) Show SMILES CC1(C)CNc2cc(Nc3nc(nc4CNC(=O)c34)-c3c(F)cccc3F)ccc12 Show InChI InChI=1S/C22H19F2N5O/c1-22(2)10-26-15-8-11(6-7-12(15)22)27-20-18-16(9-25-21(18)30)28-19(29-20)17-13(23)4-3-5-14(17)24/h3-8,26H,9-10H2,1-2H3,(H,25,30)(H,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490676 (US10968236, Compound I-3) Show SMILES CC1(C)Cc2ccc(Nc3nc(nc4CNC(=O)c34)-c3c(F)cccc3F)cc2N1 Show InChI InChI=1S/C22H19F2N5O/c1-22(2)9-11-6-7-12(8-15(11)29-22)26-20-18-16(10-25-21(18)30)27-19(28-20)17-13(23)4-3-5-14(17)24/h3-8,29H,9-10H2,1-2H3,(H,25,30)(H,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490677 (US10968236, Compound I-4) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2C[C@@H]3CC[C@H](C2)O3)c2C(=O)NCc2n1 Show InChI InChI=1S/C24H21F2N5O2/c25-16-2-1-3-17(26)22(16)18-8-19(23-20(29-18)10-28-24(23)32)30-21-7-4-13(9-27-21)31-11-14-5-6-15(12-31)33-14/h1-4,7-9,14-15H,5-6,10-12H2,(H,28,32)(H,27,29,30)/t14-,15+	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490678 (US10968236, Compound I-5) Show SMILES Fc1cccc(F)c1-c1nc2CNC(=O)c2c(Nc2ccc(cc2)C(=O)N2CC3CCC(C2)O3)n1 Show InChI InChI=1S/C25H21F2N5O3/c26-17-2-1-3-18(27)20(17)22-30-19-10-28-24(33)21(19)23(31-22)29-14-6-4-13(5-7-14)25(34)32-11-15-8-9-16(12-32)35-15/h1-7,15-16H,8-12H2,(H,28,33)(H,29,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490679 (US10968236, Compound I-6) Show SMILES CC(O)(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C21H16F2N4O4/c1-21(31,20(29)30)10-5-7-11(8-6-10)25-18-16-14(9-24-19(16)28)26-17(27-18)15-12(22)3-2-4-13(15)23/h2-8,31H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490680 (US10968236, Compound I-7) Show SMILES C[C@@](O)(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C21H16F2N4O4/c1-21(31,20(29)30)10-5-7-11(8-6-10)25-18-16-14(9-24-19(16)28)26-17(27-18)15-12(22)3-2-4-13(15)23/h2-8,31H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)/t21-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490681 (US10968236, Compound I-8) Show SMILES C[C@](O)(C(O)=O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C21H16F2N4O4/c1-21(31,20(29)30)10-5-7-11(8-6-10)25-18-16-14(9-24-19(16)28)26-17(27-18)15-12(22)3-2-4-13(15)23/h2-8,31H,9H2,1H3,(H,24,28)(H,29,30)(H,25,26,27)/t21-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490683 (US10968236, Compound I-10) Show SMILES CC1(C)CNc2nc(Nc3cc(nc4CNC(=O)c34)-c3c(F)cccc3F)ccc12 Show InChI InChI=1S/C22H19F2N5O/c1-22(2)10-26-20-11(22)6-7-17(29-20)28-15-8-14(18-12(23)4-3-5-13(18)24)27-16-9-25-21(30)19(15)16/h3-8H,9-10H2,1-2H3,(H,25,30)(H2,26,27,28,29)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490684 (US10968236, Compound I-12) Show SMILES OCC(CO)Oc1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C21H18F2N4O4/c22-14-2-1-3-15(23)17(14)19-26-16-8-24-21(30)18(16)20(27-19)25-11-4-6-12(7-5-11)31-13(9-28)10-29/h1-7,13,28-29H,8-10H2,(H,24,30)(H,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490686 (US10968236, Compound I-14) Show SMILES CCNC(=O)C(C)(O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C23H21F2N5O3/c1-3-26-22(32)23(2,33)12-7-9-13(10-8-12)28-20-18-16(11-27-21(18)31)29-19(30-20)17-14(24)5-4-6-15(17)25/h4-10,33H,3,11H2,1-2H3,(H,26,32)(H,27,31)(H,28,29,30)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490687 (US10968236, Compound I-15) Show SMILES CCNC(=O)[C@@](C)(O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C23H21F2N5O3/c1-3-26-22(32)23(2,33)12-7-9-13(10-8-12)28-20-18-16(11-27-21(18)31)29-19(30-20)17-14(24)5-4-6-15(17)25/h4-10,33H,3,11H2,1-2H3,(H,26,32)(H,27,31)(H,28,29,30)/t23-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490688 (US10968236, Compound I-16) Show SMILES CCNC(=O)[C@](C)(O)c1ccc(Nc2nc(nc3CNC(=O)c23)-c2c(F)cccc2F)cc1 Show InChI InChI=1S/C23H21F2N5O3/c1-3-26-22(32)23(2,33)12-7-9-13(10-8-12)28-20-18-16(11-27-21(18)31)29-19(30-20)17-14(24)5-4-6-15(17)25/h4-10,33H,3,11H2,1-2H3,(H,26,32)(H,27,31)(H,28,29,30)/t23-/m1/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490689 (US10968236, Compound I-17) Show SMILES Fc1cccc(F)c1-c1cc(Nc2cc3NCCc3cn2)c2C(=O)NCc2n1 Show InChI InChI=1S/C20H15F2N5O/c21-11-2-1-3-12(22)18(11)14-6-15(19-16(26-14)9-25-20(19)28)27-17-7-13-10(8-24-17)4-5-23-13/h1-3,6-8,23H,4-5,9H2,(H,25,28)(H,24,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490690 (US10968236, Compound I-18) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc3OCCCNc3n2)c2C(=O)NCc2n1 Show InChI InChI=1S/C21H17F2N5O2/c22-11-3-1-4-12(23)18(11)13-9-14(19-15(26-13)10-25-21(19)29)27-17-6-5-16-20(28-17)24-7-2-8-30-16/h1,3-6,9H,2,7-8,10H2,(H,25,29)(H2,24,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490692 (US10968236, Compound I-20) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc(cn2)N2CCC3(CC3)CC2)c2C(=O)NCc2n1 Show InChI InChI=1S/C25H23F2N5O/c26-16-2-1-3-17(27)22(16)18-12-19(23-20(30-18)14-29-24(23)33)31-21-5-4-15(13-28-21)32-10-8-25(6-7-25)9-11-32/h1-5,12-13H,6-11,14H2,(H,29,33)(H,28,30,31)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490693 (US10968236, Compound I-21) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc3cc[nH]c3n2)c2C(=O)NCc2n1 Show InChI InChI=1S/C20H13F2N5O/c21-11-2-1-3-12(22)17(11)13-8-14(18-15(25-13)9-24-20(18)28)26-16-5-4-10-6-7-23-19(10)27-16/h1-8H,9H2,(H,24,28)(H2,23,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490694 (US10968236, Compound I-22) Show SMILES Fc1cccc(F)c1-c1cc(Nc2ccc3CCNc3n2)c2C(=O)NCc2n1 Show InChI InChI=1S/C20H15F2N5O/c21-11-2-1-3-12(22)17(11)13-8-14(18-15(25-13)9-24-20(18)28)26-16-5-4-10-6-7-23-19(10)27-16/h1-5,8H,6-7,9H2,(H,24,28)(H2,23,25,26,27)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair
Non-receptor tyrosine-protein kinase TYK2 (Homo sapiens (Human))	BDBM490695 (US10968236, Compound I-23) Show SMILES CC1(C)COc2cc(Nc3nc(nc4CNC(=O)c34)-c3c(F)cccc3F)ccc12 Show InChI InChI=1S/C22H18F2N4O2/c1-22(2)10-30-16-8-11(6-7-12(16)22)26-20-18-15(9-25-21(18)29)27-19(28-20)17-13(23)4-3-5-14(17)24/h3-8H,9-10H2,1-2H3,(H,25,29)(H,26,27,28)	PDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	<10	n/a	n/a	n/a	n/a	n/a	n/a	n/a	n/a
Nimbus Lakshmi, Inc. US Patent					Assay Description Tyk2 & JAK2: The caliper machine employs an off chip mobility shift assay to detect phosphorylated peptide substrates from kinase assays, using micro...				US Patent US10968236 (2021)
					More data for this Ligand-Target Pair

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