Compile Data Set for Download or QSAR
maximum 50k data
Found 65 of ph data with Target = 'Inhibitor of nuclear factor kappa-B kinase subunit beta'
LigandPNGBDBM27444(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27445(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(4-me...)
Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27452(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-[(2-me...)
Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27447(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM27446(5-(5,6-dimethoxy-1H-1,3-benzodiazol-1-yl)-3-(oxola...)
Affinity DataIC50: >1.58E+4nMpH: 7.4 T: 2°CAssay Description:IKK kinase activity was assessed using a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. The reaction was initiated by the addi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28543(N,3-dimethyl-11-phenyl-1,3,5,8,12-pentaazatricyclo...)
Affinity DataIC50:  34nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28544(N,12-dimethyl-4-phenyl-5-oxa-3,7,10,12-tetraazatri...)
Affinity DataIC50:  11nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28545(N,12-dimethyl-4-phenyl-5-thia-3,7,10,12-tetraazatr...)
Affinity DataIC50:  6nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28546(N,5,12-trimethyl-4-phenyl-3,5,7,10,12-pentaazatric...)
Affinity DataIC50:  520nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM28547(N,12-dimethyl-4-(methylsulfanyl)-5-thia-3,7,10,12-...)
Affinity DataIC50:  28nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28548(4-methanesulfonyl-N,12-dimethyl-5-thia-3,7,10,12-t...)
Affinity DataIC50:  81nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28549(4-N,8-N,12-trimethyl-5-thia-3,7,10,12-tetraazatric...)
Affinity DataIC50:  920nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28550(4-N-benzyl-8-N,12-dimethyl-5-thia-3,7,10,12-tetraa...)
Affinity DataIC50:  1.50E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28551(2-{[12-methyl-8-(methylamino)-5-thia-3,7,10,12-tet...)
Affinity DataIC50:  300nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28552(N,12-dimethyl-4-(1,2,3,6-tetrahydropyridin-1-yl)-5...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28553(N,12-dimethyl-4-(piperidin-1-yl)-5-thia-3,7,10,12-...)
Affinity DataIC50:  210nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28554(4-(azepan-1-yl)-N,12-dimethyl-5-thia-3,7,10,12-tet...)
Affinity DataIC50:  130nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28555(N,12-dimethyl-8-(methylamino)-5-thia-3,7,10,12-tet...)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28556(N-ethyl-12-methyl-8-(methylamino)-5-thia-3,7,10,12...)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28557(N-cyclopentyl-12-methyl-8-(methylamino)-5-thia-3,7...)
Affinity DataIC50:  160nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28558(N,N-diethyl-12-methyl-8-(methylamino)-5-thia-3,7,1...)
Affinity DataIC50:  2.50E+3nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28559(12-methyl-8-(methylamino)-N-(thiophen-2-ylmethyl)-...)
Affinity DataIC50:  15nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28560(4-(4-fluorophenyl)-N,12-dimethyl-5-thia-3,7,10,12-...)
Affinity DataIC50:  26nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28561(N-ethyl-4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10...)
Affinity DataIC50:  39nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28562(4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10,12-tetr...)
Affinity DataIC50:  180nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28563(N-(2-{[4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10,...)
Affinity DataIC50:  33nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28564(2-[(2-{[4-(4-fluorophenyl)-12-methyl-5-thia-3,7,10...)
Affinity DataIC50:  75nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28565(4-(4-fluorophenyl)-12-methyl-N-[2-(piperidin-1-yl)...)
Affinity DataIC50:  56nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28566(N-({2-fluoro-5-[12-methyl-8-(methylamino)-5-thia-3...)
Affinity DataIC50:  53nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28567(N-({2-fluoro-5-[12-methyl-8-(methylamino)-5-thia-3...)
Affinity DataIC50:  32nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28571(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50:  16nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28568(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50:  22nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28569(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50:  5nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM28570(N-({3-[12-methyl-8-(methylamino)-5-thia-3,7,10,12-...)
Affinity DataIC50:  25nMpH: 7.5 T: 2°CAssay Description:Assays measuring the enzyme catalyzed phosphorylation of GST-I-kappa-B-alpha were performed by adding enzyme at room temperature to substrate solutio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM236557(US9365572, 5)
Affinity DataIC50: >1.00E+4nMpH: 7.5 T: 2°CAssay Description:Agents: 1-fold kinase buffer without MnCl2: 50 mM HEPES, pH 7.5, 0.0015% Brij-35, 10 mM MgCl2, 2 mM DTT. 1-fold kinase buffer with MnCl2: 50 mM HEPES...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
LigandPNGBDBM26083(2-(carbamoylamino)-5-[2-(2-fluorophenyl)ethynyl]th...)
Affinity DataIC50:  620nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26097(2-(carbamoylamino)-5-[2-(3-methanesulfonamidopheny...)
Affinity DataIC50:  454nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26096(5-acetylenyl-3-thiophenecarboxamide, 1t | methyl N...)
Affinity DataIC50:  4.40E+3nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26095(2-(carbamoylamino)-5-(2-{3-[2-(dimethylamino)aceta...)
Affinity DataIC50:  1.88E+3nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26094(2-(carbamoylamino)-5-{2-[3-(2,2,2-trifluoroacetami...)
Affinity DataIC50:  980nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26093(2-(carbamoylamino)-5-[2-(3-acetamidophenyl)ethynyl...)
Affinity DataIC50:  964nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26092(5-[2-(3-benzamidophenyl)ethynyl]-2-(carbamoylamino...)
Affinity DataIC50:  704nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26091(5-acetylenyl-3-thiophenecarboxamide, 1o | N-(3-{2-...)
Affinity DataIC50:  1.85E+3nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26077(2-(carbamoylamino)-5-[2-(thiophen-3-yl)ethynyl]thi...)
Affinity DataIC50:  420nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26078(2-(carbamoylamino)-5-{2-[5-(hydroxymethyl)thiophen...)
Affinity DataIC50:  195nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26079(2-(carbamoylamino)-5-{2-[5-(1-hydroxypropyl)thioph...)
Affinity DataIC50:  465nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26080(2-(carbamoylamino)-5-{2-[5-(1-hydroxy-2-methylprop...)
Affinity DataIC50:  563nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26081(2-(carbamoylamino)-5-[2-(5-cyanothiophen-3-yl)ethy...)
Affinity DataIC50:  333nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26082(2-(carbamoylamino)-5-[2-(3-fluorophenyl)ethynyl]th...)
Affinity DataIC50:  331nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM26098(3-amino-5-(thiophen-3-yl)thiophene-2-carboxamide |...)
Affinity DataIC50:  1.12E+4nMpH: 7.6 T: 2°CAssay Description:The inhibitory effect of test compounds on kinase activity was measured using a biotinylated I-Kappa-B-alpha peptide and increasing doses of inhibito...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 65 total ) | Next | Last >>
Jump to: