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Found 35 of ph data with Target = 'Neutrophil collagenase'
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92447(Inhibitor, 17)
Affinity DataKi:  5.30nM ΔG°:  -47.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi: >100nM ΔG°: >-40.0kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92445(Inhibitor, 10 | US8691753, 105)
Affinity DataKi:  203nM ΔG°:  -38.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92448(Inhibitor, 18)
Affinity DataKi:  205nM ΔG°:  -38.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92441(RXP470, 1 | RXP470, Compound 4)
Affinity DataKi:  271nM ΔG°:  -37.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92449(Inhibitor, 19)
Affinity DataKi:  338nM ΔG°:  -36.9kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)
Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92443(MMP Inhibitor, 3 | Thiophene derivative, compound ...)
Affinity DataKi:  410nM ΔG°:  -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92446(Inhibitor, 16)
Affinity DataKi:  671nM ΔG°:  -35.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM27878(13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...)
Affinity DataIC50:  7.40nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM92442(MMP Inhibitor, 2)
Affinity DataIC50:  37nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM29018((1S,5S,7R)-3-N-hydroxy-7-N-[(4-phenylphenyl)methyl...)
Affinity DataIC50:  5.13E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  43nM ΔG°:  -41.6kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26550(2-{[4-(but-2-yn-1-yloxy)benzene](methyl)sulfonamid...)
Affinity DataKi:  43nM ΔG°:  -41.6kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26545(1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}piperidin...)
Affinity DataKi:  800nM ΔG°:  -34.4kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26551(4-(but-2-yn-1-yloxy)-N-methyl-N-(2-sulfanylethyl)b...)
Affinity DataKi:  1.30E+3nM ΔG°:  -33.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  1.90E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26543((3R)-1-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}pyrr...)
Affinity DataKi:  1.90E+3nM ΔG°:  -32.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26554(3-{[4-(but-2-yn-1-yloxy)benzene]sulfonyl}propane-1...)
Affinity DataKi:  2.70E+3nM ΔG°:  -31.5kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM237180((D-Pyr)-(D-Cys)-Bip-Arg)
Affinity DataIC50:  800nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM237181((D-Pyr)-(D-Cys)-Bip-Lys)
Affinity DataIC50:  650nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM237179((D-Pyr)-(D-Cys)-Bip-(D-Cys))
Affinity DataIC50:  730nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM237178(Arg-(D-Cys)-Bip-Arg)
Affinity DataIC50:  900nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM237177(Arg-Cys-(D-Bip)-(D-Arg))
Affinity DataIC50:  2.30E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM12072((R)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  0.600nM ΔG°:  -52.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM12073((S)-[1-(4-Methoxybiphenyl-4-sulfonylamino)-2-methy...)
Affinity DataKi:  700nM ΔG°:  -35.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26791(benzimidazole analog., 17 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  1.87E+3nM ΔG°:  -32.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM26789(benzimidazole analog., 15 | tert-butyl (3S,4S)-3-(...)
Affinity DataKi:  1.96E+3nM ΔG°:  -32.6kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM27877(N-{[2-(2-amino-3,4-dioxocyclobut-1-en-1-yl)-1,2,3,...)
Affinity DataIC50:  57nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM27878(13-(carbamoylmethyl)-3-oxo-N-[(3-oxo-3,4-dihydro-2...)
Affinity DataIC50:  7.40nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM194646(US9206139, 5)
Affinity DataIC50:  54nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM194645(US9206139, 4)
Affinity DataIC50:  5.22E+3nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM194644(US9206139, 3)
Affinity DataIC50:  804nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM194639(US9206139, 2)
Affinity DataIC50: <5.10nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNeutrophil collagenase(Homo sapiens (Human))
Commissariat Á

LigandPNGBDBM194638(US9206139, 1)
Affinity DataIC50:  17.9nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent