Affinity DataKi: 5.30nM ΔG°: -47.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: >100nM ΔG°: >-40.0kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 203nM ΔG°: -38.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 205nM ΔG°: -38.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 271nM ΔG°: -37.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 338nM ΔG°: -36.9kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 410nM ΔG°: -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using matrix metalloproteinases.More data for this Ligand-Target Pair
Affinity DataKi: 410nM ΔG°: -36.5kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataKi: 671nM ΔG°: -35.2kJ/molepH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataIC50: 37nMpH: 6.8 T: 2°CAssay Description:Enzyme assay using human matrix metalloproteases or ADAMTS.More data for this Ligand-Target Pair
Affinity DataIC50: 5.13E+5nMpH: 7.0 T: 2°CAssay Description:The inhibition potency (IC50) was measured by fluorescent enzymatic assays. The compounds were evaluated for their ability to inhibit the hydrolysis ...More data for this Ligand-Target Pair
Affinity DataKi: 43nM ΔG°: -41.6kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 43nM ΔG°: -41.6kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 800nM ΔG°: -34.4kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.30E+3nM ΔG°: -33.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nM ΔG°: -32.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 1.90E+3nM ΔG°: -32.3kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataKi: 2.70E+3nM ΔG°: -31.5kJ/molepH: 7.4 T: 2°CAssay Description:A continuous assay was used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin), which is quenched by en...More data for this Ligand-Target Pair
Affinity DataIC50: 800nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Affinity DataIC50: 650nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Affinity DataIC50: 730nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Affinity DataIC50: 900nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30E+3nMpH: 7.4 T: 2°CAssay Description:Recombinant human MMP-8 was purchased as an active form enzyme (Sino Biological Inc.). The enzyme activity was detected with the same fluorogenic pep...More data for this Ligand-Target Pair
Affinity DataKi: 0.600nM ΔG°: -52.6kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
Affinity DataKi: 700nM ΔG°: -35.1kJ/molepH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMP-2, MMP-3, and MMP-8 has been determined by continuously monitoring the hydrolysis of the fluorescent ...More data for this Ligand-Target Pair
Affinity DataKi: 1.87E+3nM ΔG°: -32.7kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
Affinity DataKi: 1.96E+3nM ΔG°: -32.6kJ/molepH: 7.5 T: 2°CAssay Description:The compounds were tested for enzyme inhibition using fluorescence resonance energy transfer (FRET) assay. Fluorescence measurements were performed i...More data for this Ligand-Target Pair
Affinity DataIC50: 57nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
Affinity DataIC50: 7.40nMpH: 7.5 T: 2°CAssay Description:Inhibition of the matrix metalloproteinases MMPs has been determined by continuously monitoring the hydrolysis of the fluorescent substrate. The hydr...More data for this Ligand-Target Pair
Affinity DataIC50: 54nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Affinity DataIC50: 5.22E+3nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Affinity DataIC50: 804nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Affinity DataIC50: <5.10nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair
Affinity DataIC50: 17.9nMpH: 7.5Assay Description:A continuous assay is used in which the substrate is a synthetic peptide containing a fluorescent group (7-methoxycoumarin, Mca), which is quenched b...More data for this Ligand-Target Pair