Compile Data Set for Download or QSAR
maximum 50k data
Found 729 of ec50 data for polymerid = 1846,50006599
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM350321((S)-3-(1-((1-acryloylpyrrolidin-3-yl)oxy)isoquinol...)
Affinity DataEC50:  1.30nMAssay Description:Inhibition of human Btk in human Raji cells assessed as PhosY223 measured after 30 mins by cellular HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM250082(US9447106, 27b (peak 2) | US9556188, Compound 27a)
Affinity DataEC50:  2.40nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50245586(CHEMBL4077123)
Affinity DataEC50:  4.70nMAssay Description:Irreversible inhibition of recombinant full length wild-type 3'-FLAG-tagged BTK (unknown origin) expressed in HEK293T cells assessed as reduction in ...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataEC50:  5.80nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50559906(CHEMBL4798086)
Affinity DataEC50:  7.20nMAssay Description:Inhibition of human recombinant full length N-terminal His6-tagged BTK expressed in baculovirus infected Sf9 cells using fluorescein labeled Blk/Lynt...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50175583(ACP-196 | Acalabrutinib | US10239883, Example 6 | ...)
Affinity DataEC50:  9.20nMAssay Description:Inhibition of BTK in human whole bloodMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267472(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267473(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267474(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267475(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267476(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267477(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267478(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267480(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267481(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267483(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267485(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267491(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267492(4-(8-amino-3-((trans)-4-hydroxycyclohexyl)imidazo[...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267496(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo [1,...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267501(4-(8-amino-3-(tetrahydro-2H-pyran-4-yl)imidazo[1,5...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267502(4-(8-amino-3-((1R,5S,6S)-3-oxabicyc1o[3.1.0]hexan-...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267505(4-(8-amino-3-(tetrahydrofuran-3-yl)imidazo[1,5-a]p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267507(4-(8-amino-3-(2,2-dimethyltetrahydro-2H-pyran-4-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267511(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267512(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267513(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267514(4-(8-amino-3-((cis)-4-methoxycyclohexyl)imidazo [1...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267515(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267516(4-(8-amino-3-cyclopentylimidazo[1,5-a]pyrazin-1-yl...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267517((R)-4-(8-amino-3-(1-propionylpiperidin-3-yl) imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267518((R)-ethyl 3-(8-amino-1-(4-(pyridin-2-ylcarbamoyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267520((R)-4-(8-amino-3-(1-(3-methyloxetane-3 carbonyl)pi...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267521((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3 yl)imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267522((R)-4-(8-amino-3-(1-(cyclopropanecarbonyl) piperid...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267523((R)-4-(8-amino-3-(1-isobutyrylpiperidin-3-yl)imida...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267524((R)-4-(8-amino-3-(1-(3-hydroxy-2-(hydroxymethyl)-2...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267525((R)-4-(8-amino-3-(piperidin-3-yl)imidazo[1,5-a]pyr...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267527((R)-4-(8-amino-3-(1-(2-cyano-2-methylpropanoyl)pip...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267528((R)-4-(8-amino-3-(1-(3,3-difluorocyclobutanecarbon...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267532((R)-4-(8-amino-3-(1-(2-(3,4-dimethylphenylamino)-2...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267534((R)-4-(8-amino-3-(1-(3,3,3-trifluoro-2-oxopropanoy...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267535((R)-4-(8-amino-3-(1-(5-methyl-1,3,4-oxadiazole-2-c...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267536((R)-4-(8-amino-3-(1-(6-cyanonicotinoyl)piperidin-3...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267537((R)-4-(8-amino-3-(1-(4-cyanothiophene-2-carbonyl)p...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267538((R)-4-(8-amino-3-(1-(pyrrolidine-1-carbonyl)piperi...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267547(4-(8-amino-3-(1-aminopropan-2-yl)imidazo[1,5-a]pyr...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267549((R)-4-(8-amino-3-(1-phenethylpiperidin-3-yl)imidaz...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267553((R)-4-(8-amino-3-(1-ethylpiperidin-3-yl)imidazo[1,...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM267555((R)-4-(8-amino-3-(1-(cyclopropylmethyl)piperidin-3...)
Affinity DataEC50: <10nMpH: 7.2 T: 2°CAssay Description:Btk enzyme activity is measured using the IMAP (immobilized metal ion affinity-based fluorescence polarization) assay as outlined below. Btk enzyme (...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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