Affinity DataEC50: <0.0100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0170nMAssay Description:Evaluated for agonist activity at cloned mammalian Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0170nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0180nMAssay Description:Evaluated for agonist activity at cloned mammalian Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0190nMAssay Description:Evaluated for agonist activity at cloned mammalian Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0200nMAssay Description:Effective concentration of peptide at 50% maximal cAMP generationMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0300nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 2 hrs by AlphaScr...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0316nMAssay Description:Agonist activity at human MC4R expressed in high doxycyclin-treated HEK293 cell membranes assessed as increase in cAMP production after 15 mins by HT...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Effective concentration for intracellular cAMP accumulation in L-cells expressing Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0400nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: >0.0501nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0570nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Agonist activity at human Melanocortin-4 receptor as peptide required for 50% maximal cAMP release (n > or =2)More data for this Ligand-Target Pair
Affinity DataEC50: 0.0600nMAssay Description:Agonist activity at human FLAG-tagged MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 2 hrs by AlphaScr...More data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Intracellular level of cAMP in cells expressing the melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as stimulation of intracellular cAMP levelMore data for this Ligand-Target Pair
Affinity DataEC50: <0.100nMAssay Description:Effective concentration determined against melanocortin-4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.100nMAssay Description:Agonist activity at human Melanocortin-4 receptor as peptide required for 50% maximal cAMP release (n > or =2)More data for this Ligand-Target Pair
Affinity DataEC50: 0.110nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in CHO cells by cAMP responsive beta lactamase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.110nMAssay Description:Agonist activity at human MC4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at human Melanocortin-4 receptor as peptide required for 50% maximal cAMP release (n > or =2)More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Antagonist activity at human MC4R expressed in HEK2936E cells assessed as cAMP production in presence of IBMX by time resolved fluorescence assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using low doxycycline assessed as stimulation of intracellular c...More data for this Ligand-Target Pair
Affinity DataEC50: 0.130nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as increase in cAMP production incubated for 2 hrs by AlphaScreen assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.132nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.140nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 0.150nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 0.160nMAssay Description:Agonist activity at human Melanocortin-4 receptor as peptide required for 50% maximal cAMP release (n > or =2)More data for this Ligand-Target Pair
Affinity DataEC50: 0.170nMAssay Description:Intracellular levels of cAMP in HEK 293 cells expressing human melanocortin 4 receptor (hMC4R)More data for this Ligand-Target Pair
Affinity DataEC50: 0.170nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 0.178nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.189nMpH: 7.5 T: 2°CAssay Description:Accumulation of intracellular cAMP was examined as a measure of the ability of the peptides of the present invention to elicit a functional response ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.190nMAssay Description:Effective concentration against human melanocortin-4 receptor More data for this Ligand-Target Pair
Affinity DataEC50: 0.190nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at human MC4RMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at human recombinant MC4 receptor expressed in BHK570 cells assessed as induction of cMAP accumulation in presence of 0.1% human ser...More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Effective concentration required for intracellular cAMP accumulation by Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Effective concentration for intracellular cAMP accumulation in human melanocortin 4 receptor expressing HEK 293 cells; (N = 4)More data for this Ligand-Target Pair
Affinity DataEC50: 0.200nMAssay Description:Agonist activity at human MC4R expressed in HEK293 cells assessed as induction of intracellular cAMP accumulation after 3 minsMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Evaluated for agonist activity at cloned mammalian Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Agonist activity at wild type human melanocortin-4 receptor expressed in HEK293 cells co-transfected with CRE/beta-galactosidase reporter gene assess...More data for this Ligand-Target Pair
Affinity DataEC50: 0.210nMAssay Description:Effective concentration required for the biological activity against human Melanocortin 4 receptorMore data for this Ligand-Target Pair
Affinity DataEC50: 0.219nMAssay Description:Agonist activity at human melanocortin receptor 4 expressed in human T-REx-293 cells using high doxycycline assessed as stimulation of intracellular ...More data for this Ligand-Target Pair
Affinity DataEC50: 0.230nMAssay Description:Agonist activity at human MC4 receptorMore data for this Ligand-Target Pair